About the Study : This large-scale study established that a U-shaped association exists between LVEDD and mortality in HF, suggesting that both abnormally small and abnormally large ventricles signify high risk, likely through distinct mechanisms. These findings support the integration of LV size assessment into routine risk stratification to guide personalized management.
Corresponding Authors : Jiefu Yang, MD, Department of Cardiology, Beijing Hospital, National Center for Gerontology, National Clinical Research Center for Gerontology, The Key Laboratory of Geriatrics of NHC, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences yangjiefu2011@126.com & Peking Union Medical College, Beijing 100730, China ( huoyong@263.net.cn ).
10.1001/jamacardio.2026.2779
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JAMA Cardiology