Articles tagged with Cardiology
A new preclinical study by Amsterdam UMC researchers overturns a key assumption in the biological pacemaker field. They show that transcription factor TBX18 does not generate true pacemaker activity, while ion channel Hcn2 produces robust pacemaker function in the heart.
The American College of Cardiology has selected 47 clinicians to participate in its inaugural Fuster Prevention Forum, which focuses on early cardiovascular disease prevention. Participants will gain skills to enact change and foster a culture of prevention in their communities.
A new study published in JAMA found no significant difference between sodium bicarbonate and placebo in sustaining return of spontaneous circulation. The findings suggest that routine administration of sodium bicarbonate for patients with in-hospital cardiac arrest may not be necessary.
Researchers at RCSI University of Medicine and Health Sciences have developed an artificial model of the mitral heart valve that faithfully mimics its complex mechanical behavior. The study could help researchers better understand valve disease and develop new treatment approaches.
Senescent cells that stop dividing but don't die can become abnormally active, causing inflammation and instability in blood vessel plaques. The study found that losing key regulatory proteins activates the CD38 enzyme, leading to a higher risk of blood clots and cardiovascular events.
A new study by Karolinska Institutet shows that daily smartphone-based heart rhythm monitoring can reduce same-day cardioversion cancellations by 94.7% and save significant healthcare resources. The method, called CORAI, uses photoplethysmography to measure small changes in blood flow, allowing for accurate heart rhythm assessment.
The first national audit of advanced heart failure referrals reveals significant gaps in access to life-prolonging therapies, particularly for women. Women represent just 1 in 3 referrals, despite comparable disease burden.
Researchers from The University of Osaka found that treatment with five mRNAs effectively promoted cardiac repair and extended survival in mice with heart failure. The study showed that simultaneous administration of five therapeutic mRNAs reduced heart tissue damage and improved heart function.
Researchers used RNA therapy to target a genetic mutation causing heart failure, reducing protein aggregation and improving cellular abnormalities. The study provides insight into the biological mechanisms underlying treatment response and may accelerate the development of personalized treatments for genetic heart disease.
A new study found that a simple angiogram scoring system can identify patients whose heart muscle is still alive even when a major artery has been completely blocked. This breakthrough could change how cardiac patients are treated and help doctors make faster, more informed decisions.
Researchers developed an AI-based score from standard ECGs that reflect biological development on a spectrum rather than in fixed categories. The Electrocardiographic Sex Index (ESI) captures step-by-step changes of normal growth and hormonal changes, offering a more precise way to account for developmental stage.
A new study projects that climate change will significantly increase the risk of heat-related cardiovascular disease in the US by 2050. The Pacific Northwest and Southern/Midwestern states are expected to experience the highest and steepest increases, respectively. Targeted interventions for vulnerable communities are crucial to mitiga...
The Mount Sinai Health System has opened the Carolyn Rowan Center for Women’s Health and Wellness, which brings together multidisciplinary clinical expertise, structured care pathways, and leading-edge research to deliver personalized, comprehensive care for women. The Center offers guided multi-visit experiences and coordinated care o...
Researchers explore contrast-enhanced ultrasonography as a safer alternative to invasive hepatic venous pressure gradient for assessing portal hypertension. CEUS uses microbubble-based ultrasound contrast agents to track blood flow through the liver and surrounding vessels.
Researchers developed a new cardiac MRI-based measurement, eRVEF, to assess tricuspid regurgitation and improve mortality risk prediction. The study found that eRVEF predicted adverse outcomes better than traditional measures.
Roxana Mehran is recognized for her impactful work on improving outcomes for patients undergoing interventional procedures. She has contributed to major trials, including the TWILIGHT trial, and advocates for women in medicine through initiatives like Women As One.
The ARTICA meta-analysis investigated the safety and effectiveness of coronary revascularisation in patients undergoing TAVI, providing comprehensive insights into the optimal role of PCI. The findings suggest a potential benefit of selective, physiology-informed PCI in patients with severe aortic stenosis and CAD undergoing TAVI.
Researchers developed cardiac organoids to address limitations of cell-based therapies in myocardial infarction. These three-dimensional tissue constructs integrate into host tissue, improve cardiac function, and reduce scar size without arrhythmogenic effects.
A subgroup analysis of the CHAMPION-AF trial reveals that left atrial appendage closure (LAAC) efficacy and safety are not affected by age, suggesting it can be considered for suitable candidates regardless of age. The choice between LAAC and DOAC should be made on an individualized basis in a shared decision-making process with patients.
A meta-analysis of 10-year data from 4 randomized trials found no significant difference in all-cause mortality between DES PCI and CABG. Long-term follow-up supports considering both approaches for suitable patients.
Mount Sinai physicians will offer expert guidance and resources to keep pickleball players safe and healthy at more locations than ever before. The partnership aims to promote physical and mental well-being, as well as boost longevity through pickleball.
A new AI-powered cardiopulmonary resuscitation instructor has been developed to support bystanders during out-of-hospital cardiac arrests. The study suggests that this technology could be a scalable public health intervention to save lives.
Pregnancy-related cardiovascular complications account for 20-30% of maternal deaths in the US. Researchers analyzed claims data to find that underlying cardiovascular risk drives these events, rather than older age. This may encourage doctors to address cardiovascular health before pregnancy.
A Concordia-designed simulator models hemodynamics in reduced gravity environments, revealing key differences in blood flow and pressure patterns. The system successfully reproduced effective CPR on Earth and generated consistent blood flow under both normal and hypogravity conditions.
A recent study published in Scientific Reports found that swimming is more effective than running in promoting healthy heart growth and improving heart muscle strength. Swimming promoted greater modulation of microRNAs, which control various heart adaptations, compared to running training.
Deaths from non-ischemic CS have risen sharply in the US, while ischemic CS deaths declined between 1999-2020. Researchers warn of a growing public health challenge that requires policy initiatives and targeted trials.
A multi-center retrospective cohort study examined how cangrelor is used in real-world clinical practice around the time of surgery following PCI. The study found that varying dosing patterns can affect outcomes, with higher infusion rates associated with increased bleeding events and lower infusion rates linked to higher major adverse...
A novel blood return system has been shown to significantly reduce blood loss during pulmonary embolism procedures, with a median reduction of 97%. The study found that the system improved procedural efficiency and maintained hemodynamic efficacy without added therapies or major complications.
Researchers found that elevated Lipoprotein(a) levels are associated with a higher risk of major adverse cardiovascular events, including stroke and death. Patients with high Lp(a) levels should work closely with their healthcare provider to aggressively lower LDL cholesterol and manage other cardiovascular risk factors.
A novel detection algorithm using finger cuff technology detected moderate-to-severe aortic stenosis with a sensitivity of 90.5% and 100% in African American patients, showing excellent performance for screening purposes.
New findings suggest that clopidogrel monotherapy is associated with a lower risk of net adverse clinical events compared to aspirin monotherapy, even in patients at high risk of bleeding. This benefit is more pronounced in patients with high bleeding risk and complex procedures.
A new study found that COVID-19 significantly worsens cardiovascular outcomes, leading to higher one-year mortality rates in patients with severe heart attacks. Patients who survived a heart attack and experienced COVID-19 had a 25% higher one-year mortality rate compared to those without COVID-19.
The CARPOOL study demonstrates radial-to-peripheral access achieves comparable procedural success rates to traditional common femoral artery access for lower extremity peripheral artery disease revascularization. However, the R2P group had higher major adverse limb events at six months due to target vessel revascularization.
Seven original research studies on cardiometabolic therapies, structural heart disease, peripheral intervention, and shock care are published simultaneously by JSCAI at SCAI 2026. These findings highlight the intersection of cardiometabolic management and structural heart care, with implications for patient outcomes.
A new study found that electronic provider notifications significantly increased aortic valve replacement rates and improved survival among older patients with severe symptomatic aortic stenosis. The DETECT-AS trial showed that clinicians who received automated email alerts with abnormal heart ultrasound results detected AS were more l...
The MitraClip procedure has been shown to be safe and effective for patients with mitral annular calcification, improving symptoms and quality of life. Despite higher mortality rates, patients with MAC experienced significant reductions in mitral regurgitation and improvements in quality of life, indicating a promising treatment option.
Partial heart transplantation replaces only defective valves and related structures, eliminating need for repeat replacements. This procedure can provide thousands of additional valve transplants annually, benefiting young patients worldwide.
The STEMI-DTU trial analyzed secondary endpoints, finding that major bleeding and vascular complications were associated with increased mortality in the control group. The study provided insight into the importance of technique and bleeding complications in heart attack treatments.
Transcatheter arterialization of the deep veins (TADV) significantly improves quality of life in patients with severe CLTI, reducing concerns about poor circulation and daily activities. Six months post-procedure, patients showed a 50% reduction in circulation concerns, improved sleep patterns, and reduced foot wound symptoms.
A new sub-study suggests that using a sirolimus-eluting balloon can reduce the number of stents needed, making it a safe and effective way to treat certain heart attacks or unstable chest pain. At one year, the rates of target vessel failure and cardiac death were low and similar between the two groups.
Researchers found a significant increase in TAVR search volume and a decline in SAVR searches over the past decade, reflecting a shift towards minimally invasive therapies. The study also highlighted disparities in awareness across rural and low-volume treatment areas.
A new transcatheter mitral valve replacement (TMVR) procedure has shown significant benefits for patients with severe mitral regurgitation, reducing symptoms and improving quality of life. The study found that the treatment sustained clinical improvements over one year, with no major complications.
A registry analysis found that while men and women with acute myocardial infarction-related cardiogenic shock differ in treatment options, clinical decisions are driven by objective markers of illness severity rather than sex. The study suggests significant differences in how treatment options are discussed with patients and caregivers.
Tirzepatide significantly reduces cardiovascular risk in high-risk patients, including those undergoing percutaneous coronary intervention (PCI) and transcatheter aortic valve replacement (TAVR). The study found tirzepatide consistently reduced major adverse cardiovascular events and mortality across multiple time points.
Researchers found that patients with single-vessel runoff maintained excellent patency through three years, and could safely benefit from minimally invasive treatment. The study results showed no significant difference in outcomes for patients with one or more vessels running blood to the lower leg.
The CERAMICS registry found that most patients survived hospital discharge, with 71% overall survival and 60% of those in the most severe stage E shock. Early use of a small heart pump improves outcomes in patients experiencing cardiogenic shock after a heart attack and stenting procedure.
A study found that higher midlife cardiorespiratory fitness is strongly associated with later onset of chronic disease, lower overall disease burden, and longer life expectancy. Adults with higher fitness levels developed fewer chronic diseases and spent more years free from serious illness.
A new global allocation system is being proposed to address inequities in organ allocation for heart transplants. The proposal aims to reduce disparities and ensure no viable donor heart goes unused globally.
The American College of Cardiology recognized 20 individuals from eight countries for earning the Fellow of ACC (FACC) designation. The award reflects a strong commitment to improving patient care and advancing cardiovascular research.
Researchers created a new polymer electrode that conforms to the skin, is comfortable, and can pick up ECG signals without gel or adhesives. The technology performed comparably to existing sensors in proof-of-concept testing, showcasing its potential for practical and cost-effective health monitoring applications.
A study analyzing Korean National Health and Nutrition Examination Survey data reveals higher awareness and treatment of major risk factors among Korean women with CVD, but lower control rates. Sex differences were observed in most management indicators, with men having more risk factors on average.
A study from Umeå University found that visualizing ultrasound images of atherosclerosis, combined with a motivational dialogue, increases motivation to improve lifestyle habits and take preventive medication. This results in lower estimated risk of cardiovascular disease and better development of risk factors over time.
Alexandra J. Lansky, MD, MSCAI, has been reappointed to a second five-year term as Editor-in-Chief of JSCAI, the official peer-reviewed journal of SCAI. The journal has rapidly expanded its global reach and established itself as a trusted source for original research, clinical guidance, and educational content in interventional cardiol...
Researchers at University Hospitals Cleveland Medical Center have introduced a new, non-invasive treatment option for patients with refractory ventricular tachycardia, a life-threatening heart condition. The therapy uses precision-targeted radiation to neutralize damaged heart tissue and is offered at select centers worldwide.
The conference brings together leading experts to examine emerging trends and evidence-based approaches to preventing and managing heart disease. Cardiometabolic disease accounts for a significant burden in the Asia-Pacific region, with rapid urbanization, digitalization, and uneven health-system capacity contributing to this issue.
The Society for Cardiovascular Angiography & Interventions and Canadian Association of Interventional Cardiology will host a joint conference featuring the latest clinical data, procedural guidance, and advanced expertise. The event aims to empower clinicians with rigorous data, practical education, and leadership development.
Treatment with i.v. furosemide plus HSS significantly decreased serum levels of inflammatory biomarkers IL-6, sST2, hsTnT, galectin-3, and NT-proBNP. The study found that this combination therapy modulated some miRNA expression and was associated with reduced miR181b expression compared to furosemide alone.