Articles tagged with Cardiology
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The European Society of Cardiology has published a new update to its guidelines for managing lipid levels in patients to reduce cardiovascular risk. The guidance recommends the use of new cardiovascular risk prediction algorithms, SCORE2 and SCORE2-OP, to help clinicians treat patients with the right medications. Statins are also recom...
The European Society of Cardiology recommends systematically screening for mental health symptoms during cardiovascular care and assessing cardiovascular risk in those with mental health conditions. People living with both conditions have worse health outcomes due to the interplay between mental health and cardiovascular disease.
The VICTORION-Difference trial found that inclisiran significantly increased the proportion of patients achieving guideline-recommended LDL-C goals at 90 days compared to placebo, with a mean percentage reduction of −59.45% in the inclisiran group.
A recent study found that a minimalist approach to transcatheter aortic valve implantation (TAVI) is noninferior to the standard approach, with around 80% of patients able to be safely managed without sedation. The ACURATE neo2 valve was superior to Evolut valves in reducing pacemaker implantation and improving outcomes.
A study found that extended apixaban treatment lowered VTE recurrence by 87% in high-risk patients with provoked thromboembolism. The therapy also demonstrated a low risk of major bleeding, making it an effective option for these patients.
In-hospital initiation of SGLT2 inhibitors did not significantly reduce short-term risk of cardiovascular death or worsening heart failure in patients admitted for heart failure. However, combining trial data shows positive effects of SGLT2 inhibitors on reducing early risk of cardiovascular death or worsening HF and all-cause mortality.
The REBOOT trial found that beta-blocker therapy had no significant impact on all-cause death, reinfarction, or heart failure admission in patients with myocardial infarction and left ventricular ejection fraction (LVEF) ≥40%. In contrast, a meta-analysis suggests potential benefits for patients with mildly reduced LVEF (40–49%).
The BaxHTN trial found baxdrostat 1 mg and 2 mg significantly reduced seated SBP in patients with uncontrolled or resistant hypertension. The medication showed substantial ambulatory SBP reductions and controlled SBP rates of 40% after 12 weeks.
A comprehensive cardiovascular screening program for men aged 60-64 years did not significantly reduce all-cause death, according to a new study. However, the program was associated with a higher incidence of severe bleeding, particularly intracranial and gastrointestinal bleeding.
A large trial found that mavacamten treatment did not improve patient-reported health status or peak oxygen consumption in patients with symptomatic nonobstructive hypertrophic cardiomyopathy. The study included 580 patients and lasted for 48 weeks, but no significant differences were observed between the mavacamten and placebo groups.
In patients with symptomatic obstructive hypertrophic cardiomyopathy, aficamten showed significant improvements in exercise capacity and symptoms compared to metoprolol. The MAPLE-HCM trial found that aficamten increased peak oxygen uptake by 2.3 mL/kg/min, resulting in a better outcome than metoprolol.
A pooled analysis of two trials found vericiguat improved outcomes for patients with heart failure and reduced ejection fraction. The medication significantly reduced the risk of cardiovascular mortality, heart failure hospitalization and all-cause mortality across a broad range of patients.
The KARDIA-3 trial found a 5-mmHg reduction in systolic blood pressure with zilebesiran 300 mg, but the difference was not statistically significant. The therapy has potential for informing future trials on improving cardiovascular outcomes in patients with uncontrolled hypertension.
The DIGIT-HF trial found that digitoxin significantly reduced the risk of composite mortality and hospitalisation for worsening heart failure among patients with advanced heart failure and reduced ejection fraction. Patients who received digitoxin had a lower rate of all-cause death and hospitalisations compared to those on placebo.
The new guidelines provide clear practical recommendations for diagnosing and treating patients with valvular heart disease, emphasizing the importance of shared decision-making and patient-centered care. The updated guidance aims to reduce under-treatment, especially in the elderly, and promote more equitable access to high-quality care.
The ESSENCE-TIMI 73b trial found olezarsen to substantially lower triglyceride levels, achieving normal levels in over 80% of patients. The treatment also showed efficacy in reducing other lipoproteins with no significant effect on LDL-C.
Patients with atrial fibrillation who live in neighborhoods with poor access to full-service grocery stores face sharply higher odds of stroke and death. Food desert residence is linked to a 2.21-times higher risk of ischemic stroke and a 3.84-times higher risk of death over five years.
The European Society of Cardiology's flagship meeting showcased groundbreaking research and updates on global health, with a record number of late-breaking science sessions and publications in top journals. The congress also highlighted the importance of cardiovascular disease awareness and screening.
A secondary analysis of the AZALEA-TIMI 71 trial found abelacimab consistently reduces bleeding risk compared to rivaroxaban regardless of kidney function. Larger studies are needed to characterize abelacimab's efficacy in stroke prevention for atrial fibrillation patients with chronic kidney disease.
Routine H pylori screening after acute myocardial infarction does not significantly reduce the risk of upper gastrointestinal bleeding. The study found no notable benefit in screening for this condition, contradicting previous expectations.
Researchers developed an AI model that makes individualized treatment recommendations for atrial fibrillation patients, potentially revolutionizing stroke and bleeding prevention. The model reclassified up to half of AF patients from receiving anticoagulants under current guidelines.
Women's participation in cardiovascular trials remained low during this period, limiting generalizability of trial outcomes and perpetuating inequities in care. The study highlights persistent challenges in representation, emphasizing the need for increased female inclusion.
Discontinuing oral anticoagulant therapy after catheter ablation for atrial fibrillation reduces the risk of stroke, systemic embolism, and major bleeding compared to continued direct oral anticoagulant therapy. The study found that long-term discontinuation of anticoagulation therapy resulted in a lower composite outcome of these events.
A study published in JAMA found that fractional flow reserve-guided complete revascularization during index procedure resulted in a significant reduction in composite of all-cause death, nonfatal myocardial infarction, any revascularization, and stroke at 1 year. Reduced repeat revascularization was the main driver of this benefit.
Studies show semaglutide and tirzepatide significantly reduce the risk of hospitalization for heart failure or all-cause mortality. These medications offer a promising treatment option for patients with cardiometabolic heart failure with preserved ejection fraction.
A bivalent RSV prefusion F protein-based vaccine was found to lower all-cause cardiorespiratory hospitalization rates in adults aged 60 or older. Although the effect on all-cause cardiovascular hospitalization was not statistically significant, the study suggests potential downstream cardiorespiratory benefits of RSV immunization.
A recent study found that clonal hematopoiesis of indeterminate potential (CHIP) significantly increases the risk of developing new-onset myocarditis and pericarditis among middle-aged adults. Targeting CHIP and its downstream pathways may offer a promising approach for preventing or treating these conditions.
The study analyzed cross-sectional surveys in 22 African countries to identify key factors affecting cardiovascular health. It found that cardiovascular disease is a significant public health concern in the region, with high rates of risk factors such as hypertension and diabetes.
A recent analysis of the DANFLU-2 trial found that high-dose inactivated influenza vaccine was associated with a lower risk of incident myocarditis or pericarditis compared to standard-dose vaccine. The study suggests no dose-response association and causal link between vaccination and cardiac events.
A new study published in JAMA Cardiology found that microaxial flow pump treatment significantly improves survival rates in patients with infarct-related cardiogenic shock. The study revealed that early systolic blood pressure levels can help identify patients most likely to benefit from this life-saving treatment.
A new study found that high-dose influenza vaccines significantly reduce the incidence of cardiorespiratory hospitalizations in older adults. The results show a lower risk of heart failure hospitalizations among those who received the high-dose vaccine, indicating potential benefits for this population.
A meta-analysis of 8 clinical trials found TAVI to be an effective alternative for patients at low-to-intermediate risk with severe symptomatic aortic stenosis, reducing the 1-year incidence of all-cause death or stroke. Long-term follow-up is needed to evaluate the sustainability of these findings.
A remote randomized clinical trial found that mail-based atrial fibrillation screening with an electrocardiogram patch increased AF diagnosis in older patients at moderate to high risk of stroke over 2.5 years. The study suggests that this method could be a potential strategy for stroke prevention.
Dr. Roxana Mehran is recognized for her exceptional contributions to cardiovascular medicine, including designing and implementing randomized clinical trials and outcomes research projects. She has also focused on personalized medicine and developed individual risk scores for bleeding and acute kidney injury.
A study found that physiology-guided complete revascularization in older patients (75 years+) with myocardial infarction and multivessel disease provides sustained benefit at 3 years compared to culprit-lesion-only treatment. This approach may improve outcomes for elderly patients with complex coronary artery disease.
Barbara Casadei has been appointed as the next Editor in Chief of JAMA Cardiology, bringing her expertise in cardiovascular research to the role. She aims to broaden the journal's global impact and drive the evolution of cardiology.
A simulation study suggests that deploying food delivery riders to deliver defibrillation can reduce automated external defibrillator response times by approximately three minutes, reducing patient waiting time for defibrillation. The approach offers a cost-effective and scalable strategy for improving cardiac arrest outcomes in high-d...
A case series of 19 patients has successfully undergone partial heart transplant, enabling valve growth and representing a novel approach to congenital heart disease treatment. Careful follow-up and monitoring are crucial for the continued expansion of this procedure.
The American College of Cardiology recommends flu, COVID-19, RSV vaccinations and others for adults with heart disease to reduce risks of infection, hospitalization, and death. Vaccination has been shown to be highly effective in reducing these risks, yet only 30% of primary care physicians assess patients' vaccination status.
Researchers found a connection between high TMAO levels and faster rates of aneurysm expansion, as well as greater risk for needing surgery. Targeting TMAO levels may help prevent and treat aneurysmal disease beyond surgery.
The Society for Cardiovascular Angiography & Interventions (SCAI) has published a new position statement providing best-practice guidance for the treatment of patent ductus arteriosus (PDA) in premature infants using transcatheter occlusion. The guidance emphasizes patient selection, pre-procedural planning, and post-procedure follow-u...
A study led by Lancaster University found that social and environmental factors impact a patient's physical readiness for surgery. Patients from socioeconomically deprived areas tend to have lower cardiorespiratory fitness, which can lead to poorer surgical outcomes.
NewYork-Presbyterian/Weill Cornell Medical Center has been recognized as a mitral valve repair reference center by the Mitral Foundation for three consecutive years. The award highlights the institution's commitment to delivering high-quality care and advancing best practices in surgical treatment of mitral valve disease.
The American Heart Association (AHA) and the American College of Cardiology (ACC) have published a new set of clinical practice guidelines for left atrial appendage occlusion (LAAO) to guide stroke prevention in non-valvular atrial fibrillation (NVAF) patients. The guidelines provide specific recommendations for clinicians, patients, a...
A study of 1,081 elderly patients with AFMR found that TEER minimally invasive valve repair significantly lowered mortality and hospitalization rates compared to standard medical therapy alone. The procedure's success was also linked to the degree of residual mitral regurgitation after surgery.
A new online tool calculates a person's 'heart age' based on cardiovascular disease risk factors, revealing significant gaps among certain groups. On average, women had a heart age of 55.4, while men had an average heart age of 56.7, with disparities found among those with lower incomes or education.
A coordinated approach is needed to address the scientific value of trial representation of the intended use population. The study aims to provide a strategic framework to ensure scientific validity by operationalizing broad representation at all levels.
At ESC Congress 2025, over 40 pivotal studies will be presented, addressing major clinical questions and unmet needs in global cardiovascular care. The trials focus on innovative treatments for conditions like chronic Chagas cardiomyopathy and hypertrophic cardiomyopathy.
A study in the Canadian Journal of Cardiology finds that delaying chest compressions to prevent tongue swallowing can lead to poor outcomes, including death or severe brain injury. The research exposes media-fueled misconceptions and emphasizes the importance of immediate CPR training.
The Mount Sinai Hospital has been listed among the nation's top 20 hospitals for care excellence by U.S. News & World Report for 2025-26, with top-10 rankings in five specialties and top-20 rankings in nine. The hospital was also rated High Performing in all 22 procedures and conditions assessed by U.S. News.
The 250,000-square-foot facility provides greater availability to high-quality integrated care, addressing the region's increasing demand for innovative diagnostic and treatment services. The pavilion brings together a broad range of nationally ranked clinical programs, including cancer clinics, neurology, and surgery.
Researchers from FAU's Schmidt College of Medicine recommend using high-potency statins as the primary pharmacologic approach in treating and preventing cardiovascular disease. Lifestyle changes, such as regular physical activity and a healthy diet, are also crucial in reducing cardiovascular risk.
This study found that moderate to vigorous-intensity physical activity declined from early adulthood to midlife, with notable demographic differences. Black women experienced the lowest physical activity across adulthood and highest risk of low physical activity post-CVD.
A large clinical study found that high-tech oxygen level monitoring during heart surgery did not lower the risk of serious complications afterward. Fewer pneumonia cases were reported in patients with advanced monitoring, but this difference may have been coincidental.
Research warns that GLP-1 drugs may not provide the long-term health benefit of improved heart and lung function. While they help with weight loss, patients may experience significant muscle loss, which can increase cardiovascular disease risk. Doctors are urging additional research to better understand the effects of these drugs.
Delays in hypertension diagnosis were common, associated with delayed treatment initiation and adverse cardiovascular outcomes. The study highlights the need for earlier identification and intervention to improve treatment and patient outcomes.
A study of over 7,600 Brazilian women found that early menarche increases risk for metabolic and heart problems, while late menarche may protect against obesity but increase certain heart issues. Understanding age at first period can help doctors identify high-risk patients and guide personalized screening and prevention efforts.
Researchers developed a new diagnostic method using Doppler ultrasound waveform to estimate toe brachial index (TBI), providing faster and more accurate results for early detection of peripheral artery disease (PAD). The study found eTBI to be consistent with standard TBI, detecting effectiveness of treatments in improving blood flow.
Researchers developed an AI model that screens for cardiac amyloidosis with high accuracy, outperforming existing methods. The tool analyzes routine heart ultrasound images to quickly detect the condition and differentiate it from other heart issues.
Researchers highlight a significant gap in detecting symptoms and preventive measures before myocardial infarctions, with distinct differences found between age groups and genders.