About The Study: From this large, multisite registry, results reveal that women with pregnancy-associated spontaneous coronary artery dissection (P-SCAD) had greater median ages at gestation, greater history of assisted reproductive technology use, and greater instances of multigravida and preeclampsia than women with non–pregnancy-associated SCAD (NP-SCAD) and the general reproductive-aged U.S. population. With high percentages of vascular imaging among
participants, women with P-SCAD had less fibromuscular dysplasia but similar rates of extracoronary abnormalities including dissection and aneurysms as women with NP-SCAD. In this contemporary cohort, women with P-SCAD continue to represent a higher-risk phenotype with predominantly conservative management; however, they had less left ventricular ejection fraction recovery.
Corresponding Author: To contact the corresponding author, Agnes Koczo, MD, MS, email koczoa@upmc.edu .
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(doi:10.1001/jamacardio.2026.1009)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
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Media advisory: This study is being presented at the American College of Cardiology 75th Annual Scientific Session & Expo.
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JAMA Cardiology