Human Reproduction
Articles tagged with Human Reproduction
The 28th European Congress of Endocrinology (ECE) starts tomorrow
New UH tool measures whether lactating mothers’ psychological needs are being met
Elevated blood sugar levels during pregnancy may result in poorer birth outcomes
A recent study found that failing the glucose challenge test was associated with babies having higher birth weights, a risk factor for future obesity and diabetes. Women diagnosed with gestational diabetes were also more likely to give birth to large babies.
New research links prenatal chemical exposure to chromosomal abnormalities in adult sperm
A human study found that prenatal and childhood exposure to persistent environmental chemicals may influence sperm chromosomal integrity decades later. Higher levels of PCBs and PFASs were associated with extra chromosomes in adulthood, increasing the risk of miscarriages and congenital birth defects.
Birth after uterus transplant
A single-center study demonstrates uterus transplant feasibility in multidisciplinary centers, supporting its use for women with absolute uterine factor infertility. Ongoing reporting and data sharing will refine risk estimates and optimize patient counseling.
Melatonin application increases effectiveness of autologous ovarian tissue transplantation, study reveals
Researchers found that melatonin increased vascularization and reduced apoptosis in ovarian grafts, improving their viability. The study used an absorbable sponge to apply melatonin to autologous ovarian tissue transplants in rats, revealing its potential as a treatment option for fertility preservation in young cancer patients.
Placental contractions may occur in 6 in 10 healthy pregnancies
Researchers found placental contractions in 60% of healthy pregnancies, changing the shape of the placenta and lasting longer than uterine contractions. These findings lay groundwork for future studies on placental function and may lead to improved ways to identify potential pregnancy problems.
Muscle strength in early pregnancy linked to risk of hypertensive disorders of pregnancy
A cohort study of 6,802 pregnant women found an inverse association between grip strength and the risk of hypertensive disorders of pregnancy. The study suggests that relative grip strength may be a useful tool for risk stratification of HDP.
World Hormone Day 2026
The European Society of Endocrinology organizes World Hormone Day to educate the public about hormone-related health issues. Global endocrine disorders affect millions worldwide, emphasizing the need for proper hormone balance.
New research uncovers hidden risks of chemical mixtures
A new EU project study found that combined exposures to man-made chemicals can lead to measurable biological effects not explained by individual substances, underestimating overall risk. The research identified a continuous exposure pathway from environment to people, including breast milk and umbilical cord blood.
New model helps understand why most human pregnancies are singletons
A new model predicts that the selection of a single follicle for maturation during human pregnancy is entirely random, contrary to prior theories. The model suggests that once one follicle is selected, estradiol levels start rising, causing FSH levels to fall below the threshold, and unselected follicles die off.
Stem cell model of human embryo produces yolk sac without hypoblasts or genetic trickery
Researchers at University of Michigan created a stem cell model that produces a yolk-sac-like structure in a human embryo, mimicking early pregnancy loss. The model uses mechanical signals to guide development and does not require genetic manipulation.
Prepregnancy care and counseling
Primary care-based discussions on reproductive goals, immunizations, and risk-reducing interventions optimize pregnancy outcomes. Prepregnancy counseling reduces maternal morbidity and mortality, while also promoting healthy fetal development.
Largest study of pregnancy sickness uncovers six new genetic links
A massive genetic study has uncovered six new genes linked to pregnancy sickness, hyperemesis gravidarum (HG), in over 10,000 women. The findings point to biological mechanisms behind HG and potential new treatment pathways, with several medications identified as potential targets.
Cell-by-cell analysis offers clues to pregnancy risks
Researchers mapped the maternal-fetal interface in unprecedented detail, identifying new cell types and insights into conditions such as preeclampsia and preterm birth. The study found a previously unknown cell type that responds to cannabis, which may explain its association with poorer pregnancy outcomes.
Researchers make big step toward safe, reversible male contraception
Researchers at Cornell University have made a breakthrough in developing a safe and reversible male contraceptive. By targeting meiosis with the small molecule inhibitor JQ1, they successfully stopped sperm production without affecting fertility or offspring health. The study shows promise for a non-hormonal, long-acting, and 100% effe...
Extreme heat from climate change linked to smaller babies
A study published in BMC Medicine found that extreme heat exposure is associated with low birth weight, affecting 18% of babies. Climate change is projected to increase this burden by 8-10% by the 2060s.
University of Cincinnati opens state-of-the-art zebrafish research facility to study infertility
The University of Cincinnati has opened a zebrafish research facility to investigate the effects of environmental contaminants on human fertility. The lab will use zebrafish as a model organism to understand molecular mechanisms behind reproductive biology and infertility.
Reducing the risk of recurrent preterm births using probiotics
Researchers found that early pregnancy probiotics containing Clostridium butyricum significantly reduced the recurrence rate of spontaneous preterm delivery, a major cause of neonatal illness and death. The study suggests that probiotic therapy may offer a simple strategy to prevent premature births in women at high risk.
Choosing embryos based on genetic predictions raises new ethical and legal concerns
Countries are taking different approaches to regulating polygenic embryo testing, which raises new ethical and legal concerns. The technology has expanded from screening for monogenic diseases to assessing complex traits like intelligence and disease risk, but its clinical value is uncertain due to environmental influences.
Pregnancy-associated spontaneous coronary artery dissection
The study found that women with pregnancy-associated spontaneous coronary artery dissection (P-SCAD) have a higher risk of cardiovascular events, including dissections and aneurysms. Women with P-SCAD also experienced less recovery in left ventricular ejection fraction compared to those without P-SCAD.
Human sperm may get lost in space
Researchers found that simulated microgravity reduces the number of human sperm able to navigate through channels like the reproductive tract. Progesterone helps overcome this effect.
Simple antiseptic can reduce newborn infections
A Cochrane review found that chlorhexidine application to umbilical cord stumps likely reduces infections by 29% and may lower mortality rates, particularly in LMICs. Umbilical cord care is crucial for preventing infection and promoting healthy healing.
Living in historically redlined neighborhoods may reduce one’s ability to conceive
Two studies led by Boston University School of Public Health researchers found that people living in redlined neighborhoods were less likely to conceive than those in favorable areas. The findings suggest that historical practices like redlining continue to influence reproductive health disparities in present-day communities of color.
The hidden cost of sperm storage: Ejaculates found to deteriorate across the animal kingdom
A study led by Oxford University researchers reveals that sperm stored for extended periods deteriorates quickly, regardless of male age. Regular ejaculation has been shown to improve sperm quality in humans and animals alike.
Major step towards a first global system to track health before pregnancy
Researchers identified key health indicators for a new global system to monitor people's health before pregnancy. The study found that mental health, physical health, supportive relationships, and finances are prioritized by both healthcare professionals and the general public.
News media representations contribute to stigma around childlessness
Research analyzes news articles on childlessness, identifying themes that perpetuate stigma and structural imbalances, highlighting the need for media literacy initiatives and equitable health communication
IVF not linked to higher overall cancer rates, but study shows differences in some cancers
A large Australian study of over 417,000 women found that fertility treatments were not linked to higher overall cancer rates, but some cancers were slightly more common, while others were less common. Women who received fertility treatment were more likely to develop uterine and ovarian cancer, as well as melanoma, but the overall ris...
Contraception without hormones: Goethe University researches alternatives to “the pill”
Researchers at Goethe University are developing non-hormonal contraceptives to address declining pill use and side effects. The PREVENT project aims to create safe and effective alternatives, focusing on small molecules that block proteins in sperm or egg cells.
Antifibrotic drug shows promise for premature ovarian insufficiency
Researchers found that an approved antifibrotic drug, finerenone, can reduce ovarian fibrosis and promote follicle growth in women with premature ovarian insufficiency. Clinical trials showed that finerenone improved follicle development and mature oocyte quality in women with POI.
Fertility preservation in people with cancer
The article summarizes updated recommendations on fertility preservation in people with cancer, considering potential health risks to offspring and treatment side effects. Clinicians should inform patients about available options before treatment initiation.
Yawns in healthy fetuses might indicate mild distress
A study published in PLOS One found that fetuses who yawned more frequently during pregnancy had a lower birth weight, suggesting mild fetal distress. The research observed healthy fetuses between 23-31 weeks and recorded their yawning behavior using ultrasound.
Pre-pregnancy parental overweight/obesity linked to next generation’s heightened fatty liver disease risk
Research published in the journal Gut found that pre-pregnancy parental overweight and obesity are independently associated with increased odds of developing metabolic dysfunction associated steatotic liver disease (MASLD) in children by age 24. Cumulative excess weight in childhood significantly influences this risk, with children who...
New drug candidate prevents preterm birth in preclinical studies
New research shows that Rytvela, an anti-inflammatory drug candidate, decreases premature birth and infant mortality when administered after the onset of preterm labor in a preclinical mouse model. The treatment prolongs gestation and fetal growth while allowing newborn organs to develop in utero.
Second pregnancy uniquely alters the female brain
Researchers at Amsterdam UMC found that a second pregnancy changes the female brain in unique ways, altering brain networks involved in attention and sensory cues. The study also linked structural brain changes to maternal mental health, providing new insights into postpartum depression.
Senescence behind the aggressive nature of postpartum breast cancer
A study reveals that senescence plays a paradoxical role in postpartum breast cancer, promoting tumor formation while also aiding tissue repair. Targeting senescent cells during mammary gland involution could potentially reduce the risk of this form of cancer.
Babies are exposed to more “forever chemicals” before birth than previously known, new study finds
Researchers used advanced chemical detection to estimate a newborn's total PFAS exposure, detecting 42 confirmed or putatively identified PFAS chemicals in umbilical cord blood. The study found that infants are exposed to a wide range of PFAS before birth, including perfluorinated chemicals and fluorotelomers.
How reproductive injustice in early modern Europe could mirror that of today
Historian Erin Maglaque examines early modern Europe's reproductive unfreedom, including single motherhood, foundling hospitals, and wet nursing. She finds that these systems perpetuated structural violence against poor women and their children.
A clearer view for IVF: New "invisible" culture dishes improve embryo selection
Researchers have developed a new hydrogel dish that sharpens embryo imaging, allowing for more accurate embryo selection in IVF. This breakthrough addresses a major challenge in the field, enabling embryologists to promote healthier growth without sacrificing visibility.
Reproduction in space, an environment hostile to human biology
The lack of widely accepted standards for managing reproductive health risks in space is a pressing concern. Limited reliable data from human studies shows that space can be hostile to human biology, with conditions like altered gravity, cosmic radiation, and circadian disruption affecting reproductive processes.
University of Cincinnati study: New treatment guidelines needed for chronic kidney disease patients
A new study from the University of Cincinnati College of Medicine emphasizes the need for updated treatment guidelines on reproductive health among patients with chronic kidney disease (CKD). The survey of 104 nephrologists found that sexual and menstrual health were rarely discussed, highlighting barriers to counseling.
Stroke prevention and treatment during and after pregnancy are key to women’s health
A new American Heart Association scientific statement highlights the importance of aggressive blood pressure control, early recognition of stroke symptoms, and prompt treatment for pregnant and postpartum women. Controlling blood pressure before and after delivery can help save lives and improve outcomes for mothers and their babies.
Scientists find hidden diversity inside common brain parasite
A study by UC Riverside scientists reveals that the cysts of Toxoplasma gondii contain multiple distinct subtypes of parasites, each with different biological roles. This discovery offers new insights into how the parasite causes disease and why it has been difficult to treat.
Most common methods of inducing labour similarly effective
A new review of over 100 clinical trials found that 13 common labor induction methods are similarly effective, with low-dose vaginal misoprostol being the most commonly used and safest. However, some methods showed better success rates for specific outcomes, such as oxytocin with amniotomy for achieving vaginal birth within 24 hours.
Systems-level approach in primary care improves alcohol screening, counseling, and pregnancy-intention records
Alcohol screening increased from 61% to 81%, and intervention among positive screens rose from 22% to 67%. Practices improved documentation of pregnancy intention, using the AUDIT-C tool more frequently. This approach empowers local staff to lead care improvement efforts.
Study reveals genetic factors influencing pregnancy loss
A Johns Hopkins University-led team analyzed genetic data from nearly 140,000 IVF embryos and found robust connections between specific variations in a mother's DNA and her risk of miscarriage. The study identified key genes that govern chromosome pairing and cohesion, shedding new light on human reproduction.
Exposure to wildfire smoke late in pregnancy may raise autism risk in children
A new study published in Environmental Science & Technology found that exposure to wildfire smoke during the third trimester may raise the risk of autism diagnoses in children. Mothers who were exposed to more than 10 days of wildfire smoke had a 23% higher risk of their child being diagnosed with autism by age 5.
Pregnant women with IBD show heightened inflammation in vaginal mucosa
A new study found pregnant individuals with IBD have higher levels of pro-inflammatory cytokines in their vaginal mucosa than healthy controls. However, a higher intake of vegetables and lower added sugars was associated with lower inflammation and increased beneficial microbe Lactobacillus crispatus.
States with abortion restrictions have worse outcomes for patients using fertility treatment
A study by Oregon Health & Science University found that states with abortion restrictions have worse maternal health outcomes for patients using fertility treatment. The research analyzed over 400,000 births conceived through fertility treatments and found a statistically significant increase in serious maternal health complications.
Why this little-known birth control option deserves more attention
A new study found that only a quarter of reproductive health experts prescribe self-administered injectable contraceptives, despite its safety and effectiveness. The study identified barriers such as concerns about patient ability, medication availability, and lack of standardized counseling approaches.
Number and timing of children linked to biological aging
The study found that women with two to three children tend to live the longest, while those with an above-average number of children have shorter lifespan. Pregnancies between ages 24 and 38 were also linked to more favorable aging patterns.
Examining private equity’s role in fertility care
Researchers found that over half of IVF cycles in the US were performed at clinics affiliated with private equity firms, sparking concerns about the impact on quality and accessibility. The study's authors emphasize the need for further research to understand the benefits and risks of this business model.
Combined oral contraceptive use among people with migraine with aura persists, despite cautions
A new study found that a sizable minority of people with migraine with aura still receive estrogen-containing birth control pills and hormone therapy, despite treatment contraindications. The study highlights the need for updated research on stroke risks associated with these medications among people with this type of migraine.
Studies reveal Asian and Singaporean women with PCOS may experience longer reproductive lifespans and more favorable reproductive outcomes than peers without PCOS
Researchers found that Asian and Singaporean women with PCOS have better reproductive outcomes, including higher pregnancy rates and oocyte retrieval per cycle, compared to women without PCOS. Women with PCOS tend to maintain a higher ovarian reserve as they age, allowing for more robust responses to fertility treatment.
Study reveals silent mental health crisis among new parents
A study of 349 new parents found intrusive thoughts and psychotic-like experiences more prevalent than thought, causing severe distress linked to higher parenting stress and lower satisfaction. The research highlights the need for normalisation, stigma reduction, and targeted support for affected parents.
Ancient genetics and modern pollutants could provide a clue to endometriosis risk
A new study suggests that genetic differences passed down from ancient human ancestors and exposure to common chemicals could explain why some women are more likely to develop endometriosis. Researchers identified six genetic variants linked to the condition, which also occur in genes sensitive to modern pollutants.
New evidence questions the benefit of calcium supplements in pregnancy for preventing pre-eclampsia
A Cochrane review found no significant effect of calcium supplementation on pre-eclampsia, contradicting long-held assumptions. The review excluded small and unreliable studies that previously suggested benefits of calcium supplementation.
Widely used pesticides may lower sperm count
Researchers have found a correlation between exposure to widely used pesticides and lower sperm quality in male rodents. The review of 21 studies indicates that neonicotinoid pesticides may disrupt hormones and damage testicular tissue, leading to potential harm to human reproductive health.
New research confirms HPV vaccination prevents cervical cancer
Two new Cochrane reviews show that HPV vaccines are effective in preventing cervical cancer and pre-cancerous changes, especially when given to young people before they are exposed to the virus. Girls vaccinated before the age of 16 were found to be 80% less likely to develop cervical cancer.