Researchers at Marshall University have identified a cellular signaling pathway in fat cells that may play a role in the development of atherosclerosis, offering a potential new target for treatment. Blocking this pathway in fat cells reduced the formation of atherosclerotic plaque and decreased inflammation in blood vessels.
Researchers found that adolescent binge alcohol exposure caused lasting changes in brain function, disrupting communication between astrocytes and synapses, and persisting into adulthood. Improving astrocyte function partially recovered these effects, suggesting a potential new approach for addressing persistent behavioral effects.
Wei Xu, a Marshall University researcher, has received two NIH grants to investigate new approaches for combating antibiotic-resistant bacterial infections. His projects focus on CAUTIs and Group A Streptococcus skin infections, with potential breakthroughs in biomarkers and therapies that prevent biofilm formation.
A new international review provides comprehensive clinical recommendations for the use of incretin-based medications in women of reproductive age. The guidelines address critical knowledge gaps, including contraception, preconception care, pregnancy, breastfeeding, and postpartum management.
Spatial arthroscopy integrates surgical video feeds with advanced hardware and software systems, enabling a heads-up display that keeps surgeons focused on the field. This technology improves ergonomics and opens doors to future capabilities like voice commands and automated documentation.
Researchers found that gut luminal exosomes from older animals carried molecular signals associated with insulin resistance, inflammation and disruption of the gut barrier. Transferring these to young animals elicited similar effects, while transferring exosomes from young animals to older animals mitigated metabolic aging findings.
A new study found that more than 91% of patients returned to their pre-injury activity levels after undergoing an advanced ACL reconstruction technique. The procedure, which combines biologic augmentation with internal stabilization, demonstrated low graft rerupture rates and strong functional outcomes.
A potential association between COVID-19 and increased lung cancer risk has been identified through a study integrating human clinical data with mechanistic research. The study found that SARS-CoV-2 may contribute to long-term lung disease by promoting inflammation, fibrosis, and tumor-related pathways.
A new medical technology development initiative, DBS Lead Lock, aims to refine deep brain stimulation lead fixation for improved precision and efficiency. The project, in collaboration with the Marshall Advanced Manufacturing Center, is currently in prototype development.
A comprehensive review highlights the need for individualized approaches to OSA in older adults, considering distinct physiological changes that may alter how OSA develops and responds to therapy. The authors emphasize prioritizing symptom burden and patient-centered goals over traditional thresholds.
Researchers developed G2PDeep, a web-based platform integrating six molecular data types to predict complex health outcomes. The platform enables better identification of omics-based molecular markers and improves personalized treatment strategies.
A new study finds that untreated obstructive sleep apnea accelerates cardiovascular aging, leading to higher mortality rates. Researchers used a long-term mouse model to demonstrate the chronic physiological stress created by sleep apnea fundamentally alters cardiovascular structure and function.
A new study found that chronic kidney disease accelerates cognitive decline through interconnected damage to the heart and brain, with men experiencing greater impairment than women. The research also highlights the need for tailored strategies to prevent progression to neurological disorders.
A new study by Marshall University researchers found that patients undergoing knee surgery using a minimally invasive needle arthroscopy technique used significantly fewer opioids after surgery compared to those treated with standard arthroscopy. The smaller-scope approach led to less pain, better early knee function, and lower opioid ...
A new study reveals a strong connection between social media addiction and poor sleep quality among high school graduates in Bangladesh. Higher levels of social media addiction were closely associated with poorer sleep quality, particularly in female participants.
A new review published in Sleep Medicine Reviews sheds light on the biological mechanisms behind obstructive sleep apnea's effects on heart disease, diabetes, and other age-related conditions. OSA-induced stressors trigger cellular senescence, accelerating molecular aging.
Dr. Wei Li's four-year NIH R01 grant investigates the role of sodium/potassium ATPase in regulating platelet activation and thrombosis risk. The study aims to identify new therapeutic targets to reduce blood clot formation and improve patient outcomes.
Researchers discovered that indole, a key tryptophan metabolite produced by gut bacteria, can restore enteroendocrine cells in the intestines, which are diminished in obesity. The study suggests that microbial metabolites derived from dietary tryptophan may hold promise as a novel therapy for obesity-associated metabolic complications.
A new study found that certain flavorings, including vanilla and cherry, can drive reinforcement-related behaviors similar to those associated with nicotine exposure in adolescents. The study suggests that these flavorings can modulate the brain's dopamine system and increase dependence, especially among youth.
Researchers have discovered that blow flies can detect forces with high sensitivity, not only magnitude but also rate of change, which is crucial for balance and locomotion. The study's findings have promising implications for the design of next-generation walking robots.
Researchers developed a treatment strategy to address fentanyl-xylazine overdoses, combining naloxone with atipamezole to improve recovery outcomes in animal models. The co-administration of naloxone and atipamezole restored consciousness and physiological parameters in rats exposed to fentanyl and xylazine.
A new review reveals obstructive sleep apnea (OSA) affects memory and brain function, with OSA patients experiencing notable impairments in visual and verbal working memory. Disease severity and duration are strongly linked to poorer memory performance.
A new review from Marshall University researchers highlights emerging connections between gut health and sleep apnea, pointing to potential new therapeutic approaches for managing this common disorder. Alterations in gut microbiota composition have been consistently observed in individuals with sleep apnea, inducing systemic inflammati...
A new study found that exosomes from children with pediatric obstructive sleep apnea (OSA) disrupted blood-brain barrier integrity, leading to cognitive impairments. The research suggests a broader impact on barrier function and identifies potential biomarkers for OSA-related neurocognitive dysfunction.
Researchers found that disrupting bacterial metabolism can help the body tolerate infection and heal more effectively. By inhibiting a specific metabolic pathway, they successfully reduced tissue damage in a mouse model of necrotizing skin infection.
Marshall University researcher Brandon Henderson has secured a $1.85 million NIH grant to study the impact of synthetic coolants in vaping products on nicotine addiction. The five-year research project will explore how synthetic coolants influence addiction-related behaviors, particularly among adolescents.
The grant will be used to investigate the genetic mechanisms underlying fentanyl addiction, with a focus on identifying genes and brain mechanisms that contribute to vulnerability and resistance to addiction. The research aims to pave the way for the development of novel, more effective treatments for fentanyl addiction.
The study, led by Marshall University Joan C. Edwards School of Medicine, aims to determine if fertilized ACL surgery enables athletes to return to play sooner. Patients will undergo various tests and assessments before, during, and after surgery.
A study by Marshall University Joan C. Edwards School of Medicine reveals that collaborative EHR optimization efforts can significantly improve departmental productivity. The research found notable enhancements in monthly charges and payments, with improvements attributed to accommodations, creations, discoveries, and modifications.
A new study published in eNeuro explores the intricate interplay between brain regions involved in nicotine's effects on the human brain. Researchers discovered that the medial habenula experiences fluctuations in activity based on factors such as dosage and sex, highlighting a nuanced relationship.
A study published in Arthroplasty Today found that robotic-assisted knee revision surgery significantly influences the function of the knee replacement. The computer system can help predict implant size and balance the knee for stability, leading to improved patient outcomes.
A groundbreaking study found that combining partial normoxic recovery with senolytic Navitoclax significantly reduced sleepiness and improved cognitive function in mice with OSA. This suggests targeting accelerated senescence may be a promising avenue for improving treatment outcomes.
A recent study published in The Journal of Orthopaedics found that patients who underwent partial meniscectomy using a needle arthroscopic technique experienced significantly less pain and improved patient-reported outcomes at two weeks after surgery. However, differences were not sustained at six weeks.
A Marshall University study found that a virtual sex education tool improved reproductive health knowledge scores and measures of self-efficacy among adolescent girls. The online curriculum, www.marshallteentalk.org, was designed to provide accurate and accessible reproductive health information.
A Marshall University researcher has received a $388,500 NIH grant to study the effects of binge drinking on brain development and its long-term cognitive consequences. The two-year grant will allow her team to identify mechanisms that drive changes in brain function and explore novel targets for prevention and treatment.
A new study led by Marshall University researchers has revealed that the Xie model for NKA receptor/signaling is a key player in regulating sodium balance. The study found that NKA signaling tonically inhibits sodium reabsorption in the renal proximal tubule, shedding light on a novel mechanism of body salt handling.
A recent study by researchers at Marshall University Joan C. Edwards School of Medicine found that daily reading improved language development in infants 12 months and younger. Infants who received consistent daily reading started showing improvements in language scores as early as nine months of age.
A retrospective study found associations between vitamin D levels and fine motor development delays, as well as thyroid hormones with cognitive development. Certain metals were also linked to language, cognitive, or motor skill development.
Researchers found that participants who remained in treatment programs less than 90 days had significantly higher initial cortisol levels, indicating a higher risk of early discontinuation. Lower cortisol levels were associated with longer treatment retention.
A new study by Marshall University researchers found that inhibiting Na+/K+ ATPase alpha 1 subunit proteins dramatically inhibited in vivo thrombosis in male mice. The study suggests that targeting this protein could lead to a novel anti-thrombotic therapy with fewer side effects.
Researchers found that a thymidine phosphorylase (TYMP) inhibitor could help slow thrombosis in COVID-19 patients by targeting the SARS-CoV-2 spike protein. The gene's increased expression is linked to D-dimer levels and COVID-19 severity.
Researchers analyzed data from over 50 years of US medical schools to identify trends in gender equality in rank and tenure. Despite consistent increases, current trends do not predict achieving gender parity for four decades in some ranks.
Price E. Dickson, Ph.D., received a $407,000 NIH grant to investigate the genetic mechanisms driving social reward and cocaine addiction. The study aims to identify genetic signatures associated with preference for social interactions over addictive drugs.
A new study by Marshall University researchers reveals that prescription drug brand names in the US are increasingly using uncommon letters. The study found that letters A, V, X, and Z are more frequently used than expected, while letters E, H, T, and S are underrepresented.
After examining documented cases of second ACL injuries, researchers found that patients can be divided into three functional subgroups based on the Rule of Thirds concept. This biomechanical classification may help identify athletes at risk for further injury and accelerate their return to play after ACL reconstruction.
Researchers at Marshall University Joan C. Edwards School of Medicine are studying the role of obesity and oxidative stress in Alzheimer's disease. Obesity is a key predictive factor for Alzheimer's disease, which affects 14 million Americans by 2060.
A recent study published in Pharmacology & Therapeutics provides an in-depth description of the anti-cancer activity of sustained release capsaicin formulations. The research team found that capsaicin displayed robust growth-inhibitory activity in a diverse array of human cancers, but its clinical applications were hindered by poor sol...
Researchers at Marshall University's Joan C. Edwards School of Medicine have successfully applied robotic arm technology to revision total knee arthroplasty, achieving well-aligned components and excellent range of motion in patients. The study utilizes computer-assisted technology to improve component positioning and reduce the burden...
A new study published in iScience reveals that fat cells play a central role in cognitive decline and neurodegeneration by controlling the systemic response to brain function. Targeting fat cells may improve outcomes for neurodegenerative disorders, according to researchers at Marshall University.
The study aims to identify the health complications and modifiable risk factors of women with MetS and substance use disorder. By analyzing decade-long data from a research database, researchers hope to develop interventions that improve maternal health and reduce related pregnancy complications.