YAP1 controls angiogenesis by expressing genes involved in blood vessel formation, and its activity is regulated by PHD2 and VHL under normal oxygen conditions. In hypoxic conditions, YAP1's nuclear localization enables it to interact with HIF1α, leading to increased expression of pro-angiogenic proteins.
A new universal influenza B vaccine protects against different strains and offers robust and sustained cross-immune protection. The double-layered protein nanoparticle vaccine is constructed with a stabilized portion of the influenza virus and induces broadly reactive immune responses.
Scientists have uncovered how the innate immune system detects HIV-1, even at very small amounts, and activates a two-step molecular strategy to combat the virus. This discovery could lead to new methods for treating HIV and vaccines, as well as insights into other diseases like Alzheimer's.
The Replica Exchange Grand Canonical (REGC) method describes how surfaces change in contact with reactive gas phases under different temperature and pressure conditions. The approach identifies 25 thermodynamically stable surface phases and predicts stability phase diagrams for real systems.
Researchers at the University of Southampton have gained new insight into an antibody's flexibility and its impact on immune response. They found that a more compact, rigid antibody is more active than a flexible one, enabling stronger anti-cancer effects.
Researchers at the University of Basel developed a method to determine how risk is perceived within a society. The study found that threat and fortune are the most prominent components of risk, with threat being more closely associated with older people and women. The results also indicate that there are universal correlations in risk ...
New study reveals how GABA A receptor antibodies inhibit neurotransmitter binding, leading to hyperexcitability and symptoms like twitching and seizures. The findings pave the way for developing effective therapies and further investigations into other diseases.
Researchers at Aarhus University have developed an easy and inexpensive method for linking molecules to DNA sequences with desired functions. The method uses sulfonyl azides to introduce various functionalities, avoiding the need for expensive and unstable special phosphoramidites.
A recent study published in PAIN found that mindfulness meditation can reduce pain intensity and unpleasantness by separating pain from the sense of self. Participants who practiced mindfulness reported a significant reduction in pain levels after undergoing painful heat stimuli.
A team led by Dr. Johan Duchêne investigated commercial antibodies against ACKR1, refuting a previous study that claimed its expression on macrophages and monocytes. The study emphasizes the significance of antibody specificity and demonstrates the importance of publishing corrections in scientific research.
Researchers found brain ripples in all areas of the human cortex, synchronizing distant elements of memory upon recollection. The ripples involve brief, high-frequency oscillations that promote neural interactions and potentially support interaction between distant locations.
Employment for people with disabilities reached an all-time high in June 2022, increasing to 34.9% of the labor force, surpassing pre-pandemic levels. The employment-to-population ratio and labor force participation rate also rose significantly, reflecting the need for individuals and families to pick up extra income due to inflation.
Researchers created a device that converts the stiffness of a substance into electrical signals, allowing for real-time diagnosis of breast cancer with up to 95.8% accuracy. The device combines with AI technology to learn stiffness levels and distributions of tumors.
Researchers have designed an energy-efficient silicon-based non-volatile switch that manipulates light to control information flow in data centers. This technology reduces energy needs by 70-fold compared to traditional switches, making data centers more environmentally friendly.
Researchers have successfully mapped the potential energy surfaces of individual water molecules in liquid water at room temperature and normal pressure. This breakthrough uses X-ray analysis and statistical modeling to reveal the complex behavior of water molecules, shedding light on their role as a solvent.
In a new study, researchers found that microglia cells are responsible for neuronal death in a mitochondrial disease mouse model. Suppressing these cells with the drug Pexidartinib increased life expectancy and reduced motor problems. Further research is needed to understand the specific process by which microglia attack neurons.
A study of 56,000 older adults found that health-related social needs were associated with significantly higher rates of acute care utilization. Unreliable transportation was particularly linked to hospital stays and emergency department visits.
Moffitt researchers have identified key splicing variants associated with clear cell renal cell carcinoma outcomes and developed a survival risk tool based on their combined expression levels. The study found that altered splicing variants may play a crucial role in disease development and progression, enabling the creation of a non-in...
Researchers create micrometer-sized particles with modular structure and magnetic readout process, allowing tailored applications and non-real-time temperature tracking. The new temperature indicator stores maximum temperature reached in the past, suitable for tracing material temperature history.
Researchers assessed buprenorphine coverage and prior authorization requirements in US commercial formularies from 2017 to 2021. The study found that coverage and requirements changed over time, with more stringent regulations in place by 2021.
Researchers found young adults living alone experienced negative mental and physical health impacts from job loss, while those with parents fared better. Fathers' job losses also led to worse outcomes for young adults living at home.
A study of 11,500 athletes found that about 8% experienced persistent symptoms after contracting COVID-19, which can affect training and competing. The study highlights the need for personalized assessment before resuming training and competition in athletes.
A team of scientists has developed a single-cell map of the human heart, identifying molecular alterations in failing hearts at unprecedented resolution. This breakthrough uses Cripsr technology to profile human tissue samples, revealing novel therapeutic targets for heart failure and other cardiovascular diseases.
Researchers developed a two-step approach using whole exome sequencing to predict which patients respond to cancer immunotherapy. The study identified six genes, including KRAS and BRAF, that are enriched in patients who responded to treatment.
Researchers have identified over 1,500 genetic differences between migratory and non-migratory hoverflies, shedding light on the genetic pathways involved in migration. The study reveals suites of genes being activated in concert, including insulin signalling for longevity and pathways for immunity.
A recent study found that 49% of transgender and gender-diverse patients who undergo gender-affirming genital surgery travel outside their home state, resulting in significantly higher out-of-pocket medical expenses. The average out-of-state patient pays $2,645, compared to $1,781 for in-state patients.
Scientists found that narwhals experience a large increase in the energetic cost of diving while their heart rate is paradoxically reduced, leading to a significant physiological challenge. The study reveals that prolonged exposure to seismic noise disrupts the normal physiological response of narwhals.
Fossilized brains of a 500-million-year-old marine predator, Stanleycaris, have revealed new insights into the evolution of arthropod brain structure. The two-segmented head and brain of Stanleycaris suggest that this trait may be more ancient than previously thought.
Researchers at AMOLF developed a soft robot that uses a 'hysteretic valve' to respond to changes in its environment, mimicking the movement of living organisms. The robot's natural gait and tactile responses were achieved through the use of air pressure, eliminating the need for computer control.
Researchers aim to develop a gene therapy that could suppress HIV replication and eliminate the need for life-long antiretroviral therapy. The study uses an AAV vector to produce leronlimab, a monoclonal antibody blocking HIV entry into immune cells.
A team of researchers has discovered a wide range of nitriles, key molecular precursors for life, in the interstellar molecular cloud G+0.693-0.027 near the Milky Way center. The study provides important insights into the chemical ingredients available in the nebula that give rise to our planetary system.
A new study from Australian National University finds that electric vehicles can handle the distances required to travel to essential services in remote and regional Australia. The results show that 93% of residents could do these trips with even lower-range electric vehicles, without needing to recharge en route.
A new study finds that brief online art viewing can lower negative mood and anxiety while increasing subjective well-being. The effects are comparable to those of visiting physical art galleries or engaging in nature experiences.
The American Society for Nutrition (ASN) emphasizes that all methodologies in nutrition research contribute to the discipline and advance health and well-being. The ASN-commissioned white paper reviews various methodologies used in nutrition research, highlighting their strengths, limitations, and interpretations.
The IPBES assessment report reveals that billions of people rely on wild species for food, energy, and income, with 10,000 species harvested for human consumption. However, the report warns that unsustainable use is threatening the survival of these species, driven by drivers such as land changes, climate change, and pollution.
Researchers developed smart textiles that sense wearer's posture and motions using a novel fabrication process called thermoforming, which improves pressure sensor precision. The technology has potential applications in healthcare and rehabilitation, such as tracking gait or monitoring pressure on diabetic patients' feet.
A randomized controlled trial found that establishing specialized help desks for women in local police stations in Madhya Pradesh, India led to increased registration of cases of gender-based violence. The presence of female officers was particularly effective in making the police more responsive to women's security needs.
A new study suggests that the relationship between siblings' educational outcomes is influenced by both genetic and environmental factors. The research found that individuals with older siblings are more likely to excel academically, highlighting the complex interplay between nature and nurture.
Researchers found that people under chronic stress are more inclined to forgive, while those experiencing everyday stress are less likely. The ability to forgive promotes authenticity and is positively correlated with it, but the strength of this correlation varies depending on stress levels.
A new study found that people with severe speaking difficulties pay more attention to hand gestures when their verbal communication is impeded. This highlights the importance of incorporating gestures into therapy for individuals with aphasia.
The new species, Meraxes gigas, has disproportional short arms like T. rex and evolved independently to have such characteristics. The team proposes that the short arms may have supported reproductive behavior or helped with movement, offering a unique survival advantage.
A recent letter to Science warns that a drastic reduction of Swedish wolf population could exacerbate inbreeding and genetic erosion. The authors advocate for increasing population size and securing connectivity with neighboring populations to improve conservation.
Researchers at UC San Diego and Scripps Research developed a wastewater sequencing tool to track regional infection dynamics. This approach proved effective in identifying emerging variants and predicting COVID-19 surges, enabling early detection of cases and informing public health interventions.
Researchers using 'blastoids' - in vitro models of the blastocyst - discovered that early embryonic signals induce placental development and prepare the uterus. The findings may contribute to a better understanding of human fertility and potentially improve IVF procedures, fertility drugs, and contraceptives.
A new production method for styrene has been developed by researchers at Tsinghua University, improving the stability and dehydrogenation activity of the process. The method uses fully exposed platinum cluster catalysts, which exhibit high activity and selectivity in producing styrene.
A long-term high-fat diet has been shown to cause significant weight gain and metabolic disorders in mice, leading to anxiety, depression, and worsening Alzheimer's disease. The study suggests a clear link between chronic obesity and diabetes with cognitive decline.
Researchers observe a significant increase in electrical conductivity when mica is thinned down to few molecular layers, exhibiting semiconductor-like behavior. The findings suggest that thin mica flakes have the potential to be used in two-dimensional electronic devices with exceptional stability and durability.
Researchers at Max Planck Institute identified two classes of molecules boosting plant immunity. These compounds drive critical defense-control hubs and could be used as natural immunostimulants for crop diseases.
During the California pandemic, a significant decrease in life expectancy was observed for both 2020 and 2021 compared to pre-pandemic periods. The study found that the life expectancy gap by income level increased, with the poorest populations experiencing more pronounced declines in life expectancy.
Researchers found that mere exposure to a human-like robot is not enough to make people believe it is capable of thoughts and emotions. Human-like behavior is crucial for being perceived as an intentional agent. The study aims to inform the design of social robots in the future.
Researchers have discovered a lone Quercus tardifolia tree in Big Bend National Park, Texas, which was thought to be extinct. The tree's poor condition highlights the urgent need for conservation efforts to protect its genetic variation and adapt it to environmental changes.
Swansea University's nanomaterials researcher, Professor Christian Klinke, has secured £250,000 in funding to recruit early-career scientists. The new appointments will strengthen the research group's focus on nanocrystalline materials used in solar cells and LEDs.
A study reveals over 50 common toads in UK woodlands, defying expectations of their terrestrial lifestyle. The discovery highlights the importance of tree cavities as a habitat for amphibians and encourages conservation efforts.
A study by the University of Tsukuba found that elementary school teachers prioritize culturally relevant pedagogies to respect JLL students' backgrounds in PE classes. The researchers identified three main themes: lesson planning, interacting with parents, and accommodating cultural differences.
A Baycrest study found that expert knowledge helps memorize new information by providing a mental organizational structure. Experts grouped birds based on specific features, while non-experts relied on superficial characteristics like color. This structure supports memory and may mitigate age-related decline.
Researchers have found that high levels of iron can generate toxic free radicals, which damage lipids and ultimately lead to cell death. The team is exploring the use of compounds like JKE-1674 to induce ferroptosis in prostate cancer cells, making them more vulnerable to treatment.
A UMass Amherst researcher will investigate the link between ambient environmental factors and male fertility, focusing on air pollution and temperature. Her study aims to identify risks associated with these exposures and inform medical and behavioral interventions for men before fertility treatment.
A new strategy using nanoparticles restores damaged stem cells, enabling them to grow new tissues again. The approach, which uses specially formulated 'backpacks' to deliver medicine, shows promise for treating gestational diabetes and other pregnancy complications.
A recent study by Elizabeth Kessler, MD, found that older patients with advanced bladder cancer prioritize open communication with their care providers about treatment expectations and quality of life changes. The research also highlights the importance of involving families in care planning and aligning care with patients' core priori...
Researchers generated simple kidney-like structures called organoids and used them to identify potential drugs for adult-onset polycystic kidney disease. They found nine compounds that inhibited cyst growth without stunting overall growth.