Sandrine V. Pierre, a Marshall University researcher, has received a $1.36 million NIH grant to study the regulatory mechanism of salt handling by the kidney and its impact on cardiovascular function.
A $992,000 VA Merit Review grant will fund research on non-neuronal activity after binge drinking to understand its impact on synaptic dysfunction and alcohol use disorder. The study aims to identify novel mechanisms, specifically astrocytes, involved in the dysregulation of neuronal activity.
A recent study published in eNeuro found that male-derived brain cells exhibit a stronger synaptogenic response to thrombospondin-2 compared to female-derived cells. This difference is driven by how neurons respond to the protein, resulting in varying synaptic formation mechanisms between sexes.
Researchers found that a maternal diet rich in canola oil, compared to corn oil, protected mice from breast cancer development. The study showed slower-growing and smaller tumors in offspring whose mothers were fed canola oil.
Marshall University prof Brandon J. Henderson receives $1.8 million NIH grant to study vaping nicotine addiction in adolescents. The research aims to understand how e-cigarettes alter neurobiology and trigger nicotine addiction.
A Marshall University researcher has received a $400K NIH grant to investigate sex-dependent interactions in brain cell development, aiming to develop targeted therapies for individuals with autism and schizophrenia. The research will uncover novel roles of sex and hormones in brain development, shedding light on neurological dysfunction.
Researchers at Marshall University found that green apple vape flavor enhances nicotine reward by promoting high-sensitivity nAChRs. This could lead to heightened drug-seeking behavior and addiction risk, particularly among adolescents.
A Marshall University researcher has been awarded a $444,000 grant to investigate the role of sodium pump signaling in fat cells and its potential as a treatment for uremic cardiomyopathy. The study aims to reveal more about oxidative stress and its impact on disease progression.
New research from Marshall University finds that production of peptide NaKtide in fat cells inhibits sodium pump function, preventing the development of cardiomyopathy associated with renal failure. The study also suggests targeting adipocytes may serve as a viable clinical strategy for preventing and treating the condition.
A study by Marshall University researcher M. Jeremiah Matson found that higher humidity and warmer temperatures reduce the stability of SARS-CoV-2 in human nasal mucus and sputum. Viral RNA was consistently detectable, while infectious virus was detectable for shorter periods.
Researchers at Marshall University discover a sequence in Na/K-ATPase essential for stem cell differentiation and organogenesis. The study provides the first genetic evidence of this functionality, revealing a previously unrecognized common mechanism underlying animal embryonic development.
Dr. Shakirov and collaborators identified genes NOP2A, RPL5A, and RPL5B as crucial for controlling telomere length in Arabidopsis thaliana, a small flowering plant. This discovery provides new insights into the connection between ribosome biogenesis and telomere length control.
Researchers at Marshall University found that universal maternal toxicology screening, including gabapentin, led to increased identification of co-exposure and improved timely treatment for newborns experiencing withdrawal symptoms. This resulted in shorter hospital stays, averaging 48 days compared to 58 days before the screening began.
A new clinical trial at Marshall University is investigating the use of biologic augmentation in ACL reconstruction surgery. The study aims to assess improvements in pain, failure rates and clinical outcomes using a minimally invasive technique combining bone marrow concentrate, autograft bone and demineralized bone matrix.
Marshall University has received a five-year, $17 million award from the National Institutes of Health (NIH) to continue its biomedical research efforts in West Virginia. The WV-INBRE program aims to enhance biomedical research capacity and provide access to resources for undergraduate students.
Pierre will explore a new Na/K-ATPase/Src pathway to limit cardiac dysfunction in hopes of developing new therapeutic interventions. The study aims to test two distinct interventions in both acute and chronic phases of myocardial infarction.
Researchers at Marshall University found that tart cherry consumption reduced mean pain levels by 34.7% compared to a placebo group, with no impact on the effectiveness of aromatase inhibitor treatments for non-metastatic breast cancer patients.
New research from Marshall University establishes adipocyte Na/K-ATPase signaling worsens obesity and related diseases, including neurodegeneration and NASH. Targeting the signaling pathway with NaKtide improves metabolic profile and demonstrates therapeutic potential.
Researchers from Marshall University found that consuming two ounces of walnuts daily for two weeks changes gene expression in confirmed breast cancers, slowing growth and reducing survival risk. The study involved 10 women with breast lumps, who were randomized to walnut or control groups.
A Marshall University researcher has been awarded a nearly $500,000 NIH grant to investigate the role of thymidine phosphorylase in thrombosis. The study aims to clarify the pathways mediating TYMP-enhanced platelet activation and establish pharmacological inhibition as a novel anti-thrombotic therapy.
A Marshall University study found significant differences in umbilical cord blood metal levels between urban and rural newborns. Copper and molybdenum were higher in urban samples, while no marked differences occurred for other elements. The study suggests a potential link between prenatal exposure to toxins and neonatal outcomes.
The International Journal of Molecular Sciences has released a special issue to commemorate Zijian Xie's 20-year-old discovery of the scaffolding/signaling function of the Na/K-ATPase sodium pump. This significant finding has had tremendous applications in biology and medicine.
A team led by W. Christopher Risher discovered that the α2δ-1 receptor is necessary for synapse structure and brain connectivity, implicating astrocyte-to-neuron signaling in psychiatric disorders such as autism and addiction.
Researchers at Marshall University Joan C. Edwards School of Medicine discovered dynamic signals from sense organs are crucial for normal leg movements. The findings suggest mechanisms to make prosthetic joints more adaptable, enabling more natural movements in amputees.
Researchers at Marshall University identified GPR68 as a target for studying T cell activation and pro-inflammatory functions. The study found that blocking the GPR68 pathway may be a potential therapy for chronic inflammatory diseases.
A study published in Scientific Reports reveals that the Na/K-ATPase oxidant amplification loop plays a key role in aging and may be targeted for anti-aging interventions. Researchers successfully demonstrated the therapeutic potential of pNaKtide, a synthetic peptide, in improving impaired physiological functions.
The Marshall University Joan C. Edwards School of Medicine has received a five-year, $10.78 million grant from the National Institutes of Health to investigate obesity and its related disorders. The funding will support research focused on inflammatory bowel disease, colon cancer, and obesity in West Virginia and central Appalachia.
The Marshall University Joan C. Edwards School of Medicine has launched a new program to improve access to diabetes care in West Virginia, thanks to a $1.5 million grant from the Merck Foundation. The program aims to address healthcare disparities among vulnerable populations and promote health equity.
Researchers at Marshall University found that patients who recover from invasive pneumococcal pneumonia have a significantly shortened lifespan compared to life expectancy tables. The study suggests that pneumococcal vaccination is crucial for all adults over 65 and younger adults with chronic diseases.
The study demonstrates that pNaKtide attenuates the development of experimental nonalcoholic fatty liver disease (NAFLD) and atherosclerosis in mice fed a Western diet. The researchers found improvements in insulin sensitivity, dyslipidemia, and cholesterol levels.
Researchers at Marshall University have discovered a peptide, pNaKtide, that can reduce oxidant stress and ameliorate experimental uremic cardiomyopathy. This finding has significant implications for treating patients with kidney disease, which affects millions of people worldwide.
The Marshall University Joan C. Edwards School of Medicine has received a $2.39 million grant from the National Institutes of Health to study the regulation of glutamine absorption in relation to inflammatory bowel disease. The project aims to develop better nutritional therapies for IBD, which is linked to an increased risk of colon c...
Researchers at Marshall University have found that blocking small cell lung cancer tumors' blood supply can delay their growth and regrowth after treatment. Synthetic molecules like MG624 show promise in delaying cancer relapse and improving patient outcomes.
4th-year student Jennifer C. Miller co-authored an article with professor Inder Sehgal on a veterinary pharmacy course at Marshall University. The study found that the course effectively educated students about pet therapeutics and built enthusiasm for veterinary pharmacotherapy in pharmacy programs across the nation.
Researchers at Marshall University have identified a novel mechanism for blocking the signal by which the cellular sodium-potassium pump amplifies oxidants, leading to obesity and metabolic syndrome. The study, published in Science Advances, suggests that the Na/K-ATPase might be a therapeutic target for treating these conditions.