Plastic pollution is increasingly being recognized as more than an environmental problem. Tiny plastic particles can enter living organisms, circulate through biological systems, and potentially reach reproductive tissues. A new review now brings together growing evidence that polystyrene nanoplastics may affect male and female reproductive health in different ways while also posing risks to developing offspring .
The review, published in New Contaminants , examines research on polystyrene nanoplastics, or PSNPs, one of the most widely studied forms of nanoplastic. The researchers screened 285 publications and ultimately included 114 peer-reviewed studies focused on reproductive toxicity.
“Our analysis shows that reproductive toxicity from polystyrene nanoplastics is not limited to a single organ or biological pathway,” said corresponding author Chunhua Zhan of the University of South China. “Evidence from experimental models suggests effects on male and female reproductive systems as well as embryo and offspring development. Understanding these mechanisms is essential for evaluating potential health risks and identifying priorities for future research.”
In males, experimental studies have linked PSNP exposure with testicular damage, disruption of the blood testis barrier, lower sperm count and motility, abnormal sperm morphology, and changes in testosterone levels . In females, reported effects include altered ovarian function, hormonal disruption, reduced follicle development, lower oocyte production, and impaired embryo implantation.
The review also highlights potential consequences for the next generation. Across animal models, parental PSNP exposure has been associated with reduced fertilization success, developmental abnormalities, impaired larval or embryonic development, and lower survival. Some studies also indicate that PSNPs can cross biological barriers and affect placental or embryonic processes.
At the molecular level, the researchers identified oxidative stress as a central mechanism connecting many of these effects . PSNP exposure can increase reactive oxygen species and disturb cellular redox balance. This process may activate signaling pathways associated with inflammation, cell death, hormonal disruption, and tissue damage. Other important mechanisms identified in the review include endocrine disruption, inflammation, autophagy, and apoptosis.
The authors also point to two areas that may be especially important for future research: environmentally aged nanoplastics and combined exposure to nanoplastics with other pollutants . Laboratory studies suggest that PSNPs can interact with contaminants such as arsenic, phthalates, and pharmaceutical residues, potentially producing stronger biological effects than exposure to a single pollutant alone.
However, the researchers caution against directly translating findings from laboratory animals to people. Definitive evidence that PSNP exposure causes reproductive disorders in humans is still lacking , and many experimental studies use particle concentrations or materials that do not fully reflect real-world exposure. Better standardized detection methods, realistic exposure models, and human epidemiological studies are therefore urgently needed.
The authors conclude that improving nanoplastic monitoring, reducing plastic pollution, and investigating realistic human exposure will be important steps toward understanding and potentially reducing reproductive and developmental risks.
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Journal reference: Huang L, Liu W, Zhan C. 2026. Polystyrene nanoplastics as emerging reproductive toxicants: sex-specific effects, offspring risks, and molecular mechanisms. New Contaminants 2: e025 doi: 10.48130/newcontam-0026-0022
https://www.maxapress.com/article/doi/10.48130/newcontam-0026-0022
About the Journal:
New Contaminants (e-ISSN 3069-7603) is an open-access journal focusing on research related to emerging pollutants and their remediation.
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New Contaminants
Literature review
Polystyrene nanoplastics as emerging reproductive toxicants: sex-specific effects, offspring risks, and molecular mechanisms
14-Sep-2026