Risk Factors
Articles tagged with Risk Factors
Exposure to air pollutants and Lewy body and Parkinson disease–related dementias
Efficacy and safety of digitalis glycosides in heart failure
Digoxin in patients with symptomatic rheumatic heart disease
Physician-reported safety outcomes of AI-generated hospital course summaries
Workforce and staffing at 988 suicide & crisis lifeline centers
The study found that most 988 Lifeline centers struggle to find resources for full-time staffing, posing risks to staff well-being and service quality. Critical financing and operational strategies will be needed to support recruitment and retention to sustain high-quality 988 Lifeline services.
Housing insecurity, incident geriatric conditions, and mortality in community-living older persons
A cohort study found that poor housing affordability was associated with higher risks of frailty, disability, dementia, and mortality, while poor housing quality was linked to increased risks of frailty, disability, and mortality. Housing insecurity is identified as a clinically relevant social determinant of health among older persons.
GLP-1 receptor agonists or SGLT2 inhibitors and nonarteritic anterior ischemic optic neuropathy
A large cohort study found a modestly increased risk of nonarteritic anterior ischemic optic neuropathy associated with GLP-1 receptor agonist use. In contrast, SGLT2 inhibitor use was not linked to an increased risk. The findings warrant heightened vigilance for GLP-1 RA users.
Care coordination and hospitalization in older adults with or at risk for cardiovascular disease
A randomized clinical trial found that proactive outreach for care coordination did not lead to better outcomes compared to usual care post-hospitalization coordination. Many participants declined the offer. The study suggests that current strategies may need to be reassessed.
Bowel and ovarian cancer cases rising among younger adults in England
Cancer cases are on the rise among younger adults in England, with a significant increase in bowel and ovarian cancer rates. The study found that excess weight is a key contributor, but it's unlikely to fully explain this trend, as trends in risk factors such as smoking and diet have been stable or improving over the past decade.
Bereavement and risk of cardiovascular disease before and during the COVID-19 pandemic
A cohort study found that bereavement was associated with increased cardiovascular disease risk both before and during the COVID-19 pandemic. The strongest association was observed for partner or sibling loss during the pandemic, highlighting the importance of targeted clinical monitoring and preventive care for bereaved individuals.
Extreme climate events increase heart disease risk, new study reveals
A new study reveals a strong link between extreme climate events and the incidence of heart disease among middle-aged and older adults in 157 Chinese cities. Exposure to extreme heat, cold, and precipitation increases the risk of cardiovascular disease, with higher BMI-related risks associated with temperature intensity and cold-induce...
AI can use a photo of the eye to estimate retinal age, flag risk for major diseases
A Tohoku University research group developed an AI model that estimates retinal age from a fundus photograph, reflecting biological aging and potential disease risk. The model is non-invasive and can be used as a screening aid, identifying patients who may need further health assessments.
Firearm storage and carrying practices and suicidal behaviors in US Army service members
A retrospective cross-sectional study found significant associations between unsecured firearm storage and heightened suicide risk in US Army service members. Carrying a weapon other than a firearm also linked to elevated suicide risk, suggesting that any type of weapon carrying behavior may indicate increased vulnerability.
Heavy drinking, alcohol use disorder, and obesity
A nationally representative study found nearly 1 in 10 U.S. adults with heavy drinking and obesity conditions, highlighting the need for preventive efforts in younger and middle-aged adults without insurance or Medicaid coverage to curb rising rates of alcohol-associated liver disease deaths.
Having more kids associated with reduced risk of stroke and brain damage, research co-led by UT Health San Antonio shows
A new study co-led by UT Health San Antonio found that having three or more live births is associated with a reduced risk of stroke and brain damage in women. The research suggests that reproductive factors, such as the number of live births, may be an important predictive factor in assessing stroke risk in women.
Excessive napping may be a warning sign of underlying or developing health conditions in older adults
A study of 1,338 older adults found that longer, more frequent, and morning naps were associated with higher mortality rates. Excessive daytime napping was linked to increased risk of neurodegeneration, cardiovascular diseases, and greater morbidity.
Korean women with CVD face gaps in risk factor control
A study analyzing Korean National Health and Nutrition Examination Survey data reveals higher awareness and treatment of major risk factors among Korean women with CVD, but lower control rates. Sex differences were observed in most management indicators, with men having more risk factors on average.
Hidden epidemic: Metabolic disorders drive the next wave of liver cancer
The study reveals that metabolic dysfunction-associated steatotic liver disease (MASLD) is emerging as a major contributor to liver cancer worldwide and in China. Researchers call for integrated global prevention and early detection strategies to address this growing burden.
Colorectal cancer and mortality risk among older adults with vs without adenoma on prior colonoscopy
Adults aged 75 or older without adenoma on prior colonoscopy have lower risk of subsequent colorectal cancer and CRC death. Despite this, those with prior adenoma may consider deprioritizing surveillance colonoscopy relative to other health concerns.
US trends in long-term opioid therapy
Long-term opioid therapy prescription rates declined in the US from 2015 to 2023, despite a growing population of older adults receiving these treatments. Approximately 4-5 million patients were prescribed long-term opioids in 2023, with Medicare covering a larger proportion, raising concerns about safety.
Second primary invasive melanoma rate in Queensland reaches plateau after decades-long rise
A landmark study of 100,000 Queensland residents found that the incidence of second primary invasive cutaneous melanomas has plateaued after a decades-long rise. The stabilization is attributed to the cumulative impact of long-running sun safety campaigns and increased skin cancer surveillance.
Postacute sequelae following omicron COVID-19 in patients with cancer
Among highly boosted patients with cancer, overall postacute sequelae risk was not elevated compared to noninfected patients; hospitalized COVID-19 patients remained at increased risk despite therapeutics. Vaccination and boosting remain important in mitigating long COVID among immunocompromised patients
Cancer treatment: Understanding risks and side effects
Researchers used machine learning methods to identify safe time windows for outpatient stem cell therapy in multiple myeloma patients. The study found that this approach can predict adverse events and enable more precise risk assessment.
Extended low-dose apixaban and superficial vein thrombosis
Extended low-dose apixaban effectively reduced symptomatic superficial vein thrombosis (SuVT) risk. Patients with enduring risk factors for SuVT benefited from this anticoagulation strategy.
Serum neurofilament light chain and cardiovascular outcomes in patients with atrial fibrillation
Patients with atrial fibrillation have a higher risk of adverse cardiovascular events, including stroke, heart attack, and cardiac arrest. Serum neurofilament light chain levels can serve as a biomarker for cardiovascular risk in these patients.
Pregnancy-associated spontaneous coronary artery dissection
The study found that women with pregnancy-associated spontaneous coronary artery dissection (P-SCAD) have a higher risk of cardiovascular events, including dissections and aneurysms. Women with P-SCAD also experienced less recovery in left ventricular ejection fraction compared to those without P-SCAD.
EMPEROR-preserved risk model and outcomes in the FINEARTS-HF trial
The EMPEROR-Preserved risk model demonstrated good performance in the FINEARTS-HF trial, showing that baseline risk does not modify the relative treatment effect of finerenone. Finerenone has been shown to have a significant benefit for heart failure patients.
Evolocumab to reduce first major cardiovascular events in patients without known significant atherosclerosis and with diabetes
In high-risk patients without known significant atherosclerosis and with diabetes, evolocumab significantly reduced the risk of a first major cardiovascular event. The study found that evolocumab was effective in preventing cardiovascular events in these patient populations.
Prescription drug promotion by social media influencers
A systematic scoping review found that social media influencer promotion of prescription drugs carries risks of inaccurate or misleading advice. The study emphasizes the need for updated guidelines and digital literacy initiatives to safeguard public health.
Childhood mortality by parental cause of death
A statewide cohort study found childhood mortality is significantly higher among children bereaved by parental drug overdose, homicide, and suicide. Parental homicide was associated with the highest risk of mortality in children, highlighting the need for research into potential explanations such as family restructuring and mental health.
Effects of exercise and intensive vascular risk reduction on cognitive function in older adults
A multicenter randomized clinical trial found no significant differences in cognitive improvement between exercise, intensive pharmacological reduction of cardiovascular risk factors, or both in older adults. The study results challenge current recommendations on lifestyle modifications for dementia prevention.
Long-term cardiometabolic outcomes in children with metabolically healthy and unhealthy obesity
Children with metabolically healthy obesity at treatment initiation have an increased risk of type 2 diabetes, hypertension, and dyslipidemia. Reduction in BMI z score is associated with reduced cardiometabolic risk, suggesting treatment should be recommended for these children as well.
Extreme urban heat and emergency department visits in older adults
Research suggests significant heat-health risks observed among socioeconomically vulnerable populations. This study underscores the importance of developing targeted heat warning strategies to mitigate these risks and prevent emergency department visits among older adults.
Tobacco smoking and lung cancer risk after negative baseline low-dose computed tomography findings
A cohort study found that smokers with negative baseline low-dose computed tomography findings had a significantly increased long-term lung cancer risk, becoming apparent only after two years of screening. This suggests supporting extended initial screening intervals and personalized long-term monitoring based on smoking history.
Meat consumption and cognitive health by APOE genotype
A new study published in JAMA Network Open suggests that high meat consumption is associated with better cognitive trajectories and lower dementia risk among individuals with the APOE 34/44 genotype. The finding contradicts previous expectations, highlighting potential clinical and public health relevance for this population.
Colorectal cancer risk with negative colonoscopy or nonadherence after positive fecal occult blood test screening
A decrease in colorectal cancer incidence was observed among individuals with negative screening colonoscopy results, particularly men, suggesting risk-based follow-up strategies. Nonadherence to scheduled colonoscopies increased the risk of CRC, highlighting the need for targeted interventions to improve early detection.
Adherence to healthy lifestyle and risk of cardiometabolic diseases in individuals with hypertension
Maintaining a healthy lifestyle, including a high-quality diet, moderate exercise, and low alcohol consumption, was associated with lower cardiometabolic disease risk. The study found that adhering to these healthy behaviors reduced the risk of major cardiometabolic diseases independent of medication use.
Holding vs continuing GLP-1/GIP agonists before upper endoscopy
Continuing GLP-1/GIP agonists before upper endoscopy increased clinically significant residual gastric volume, but did not elevate adverse event risk. Clear liquids the day prior to the procedure may mitigate this risk.
Adverse childhood experiences and treatment-resistant depression
A cohort study found that adverse childhood experiences (ACEs) were associated with an increased risk of treatment-resistant depression in adults. Preventing ACEs and incorporating ACE history into clinical assessment may help identify individuals at elevated risk for treatment resistance.
Digital media use and child health and development
A systematic review and meta-analysis found consistent associations between digital media use and risks to child health and development, particularly social media use. The study highlights the need for multifaceted policies and interventions to mitigate potential harms from digital media exposure.
Lower music volume levels in fitness class and perceived exercise intensity
A comparative effectiveness study found that lower music volume levels in group fitness classes did not significantly impact perceived exercise intensity. The research suggests implementing safer sound practices and increased awareness on hearing protection to minimize the risk of noise-induced hearing loss.
Insufficient sleep among US adolescents across behavioral risk groups
A study found insufficient sleep among US adolescents, with trends suggesting environmental and structural factors are driving the issue, rather than specific behaviors. The findings highlight the need for population-level interventions to address widespread sleep loss.
Catheter ablation and oral anticoagulation for secondary stroke prevention in atrial fibrillation
A recent study found that standard therapy plus catheter ablation did not significantly reduce the risk of primary composite end point in patients with atrial fibrillation and a recent stroke history. The observed event rate was lower than anticipated, suggesting underpowered detection of clinically meaningful differences.
Cognitive and neuropsychiatric function in former American football players
A cross-sectional study of former American football players found prior participation to be associated with worse later-life cognitive and neuropsychiatric function. The findings support a dose-response association with years and level of play, providing context for clinicians and researchers assessing symptom risk among former players.
Fertility preservation in people with cancer
The article summarizes updated recommendations on fertility preservation in people with cancer, considering potential health risks to offspring and treatment side effects. Clinicians should inform patients about available options before treatment initiation.
Heat and pregnancy
The article discusses current evidence on risks of ambient heat to pregnant women, including hot weather and occupational exposures. Effective strategies for managing heat-related risks are also highlighted as critical for maintaining maternal health.
Adolescent cannabis use and risk of psychotic, bipolar, depressive, and anxiety disorders
A cohort study found that adolescent cannabis use is associated with an increased risk of developing psychiatric disorders, particularly psychotic and bipolar conditions. The study's results inform the development of interventions and policies to prevent or delay adolescent cannabis use.
Cardiovascular events in women with prior cervical high-grade squamous intraepithelial lesion
A nationwide study found that adolescents and young adults with prior cervical high-grade squamous intraepithelial lesion (HSIL) are at a higher risk of cardiovascular events and mortality. The study suggests that women with prior HSIL should be more closely monitored for cardiovascular disease and prevention strategies should be imple...
Spirituality and harmful or hazardous alcohol and other drug use
A meta-analysis of 55 studies found a significant protective association between spirituality and hazardous alcohol and drug use. The study suggests that spiritual practices may be effective in preventing or reducing the risks associated with these substances.
Joint and independent associations of gestational diabetes and depression with childhood obesity
Cohort study finds prenatal depression and gestational diabetes independently increase childhood obesity risk, while children exposed to both face the greatest risk, highlighting need for universal screening and targeted interventions.
Mask-wearing during COVID-19 linked to reduced air pollution–triggered heart attack risk in Japan
A nationwide Japanese study of 270,000 patients found that widespread mask-wearing during the pandemic significantly lowered PM2.5-associated risk of MINOCA, a non-obstructive type of heart attack. The study suggests that simple protective measures like mask use can mitigate cardiovascular risks associated with air pollution.
Machine-learned biomarker identifies those at high risk for liver cancer
A study by RIKEN researchers identifies a MYCN-driven biomarker that predicts the risk of liver cancer. The biomarker, known as the MYCN niche score, uses machine learning to analyze gene expression patterns and indicates whether a tumor-free liver is at high risk for developing tumors.
Enhancing mortality risk prediction by integrating CKM syndrome stages and CKD-based substaging: evidence from a nationwide cohort study
A nationwide cohort study found that chronic kidney disease significantly heightens mortality risk, even at moderate levels, and exceeds traditional metabolic risk factors. Maintaining renal function and early detection of CKD are critical for reducing both all-cause and cardiovascular mortality.
Availability of higher-level neonatal care in rural and urban US hospitals
Access to higher-level neonatal care is limited at rural birth hospitals, where less than 20% offer this care compared to 74% of urban hospitals. Urban birth hospitals are expanding higher-level neonatal care, exacerbating geographic disparities in access to care for high-risk infants.
New-onset nonarteritic anterior ischemic optic neuropathy and initiators of semaglutide in US veterans with type 2 diabetes
A nationwide cohort study found that semaglutide initiators had a significantly higher risk of developing nonarteritic anterior ischemic optic neuropathy compared to sodium-glucose cotransporter-2 inhibitor initiators. The absolute risk was low, but clinicians and patients should be aware of this rare but evident increased risk.
US South Asians face elevated heart risk at age 45 despite healthier habits
A new study finds that US South Asians have higher rates of prediabetes, diabetes, and hypertension than other population groups, despite healthier diets and exercise habits. The study identifies a critical window in the 40s when risk is already high, but disease is still preventable with early intervention.
GLP-1 receptor agonists plus progestins and endometrial cancer risk in nonmalignant uterine diseases
A cohort study found combined GLP-1RA and progestin therapy reduces endometrial cancer risk in women with benign uterine pathology or endometrial hyperplasia. The study suggests potential benefits of this treatment approach for nonmalignant uterine diseases.
Risk factors for the development of food allergy in infants and children
A meta-analysis of childhood food allergy risk factors reveals a combination of major and minor factors, including genetics and antibiotic exposure. The study provides insights into the complex interplay of these factors in the development of food allergies in infants and children.
Coffee and tea intake, dementia risk, and cognitive function
A study published in JAMA found that higher consumption of caffeinated coffee and tea is associated with a reduced risk of dementia. Moderate intake levels showed the most pronounced association, with better cognitive function also observed.