As the Internet of Things and 5G technologies advance, the demand for high-quality wound management, real-time health monitoring, and intelligent human-machine interaction continues to grow. Electronic skin (e-skin) that mimics the flexibility, self-healing, and multimodal sensing of human skin has become a key research direction in flexible electronics. However, traditional rigid sensors made of metals and semiconductors fail to meet the requirements for long-term comfort, real-time monitoring, and seamless integration.
A team of material scientists led by Xugang Dang from Shaanxi University of Science and Technology and Manhui Zheng from Wenzhou Medical University in China has developed a natural biomass-derived multimodal conductive e-skin patch (CCMP) that integrates smart wound dressing with wearable bioelectronics. The patch enables real-time wireless monitoring of physiological signals and significantly accelerates wound healing. Their work was published in Nano Research on June 9, 2026.
“We developed a natural biomass-derived multimodal conductive e-skin patch that combines smart wound dressings with skin bioelectronics for multimodal physiological signal monitoring on a portable wireless wearable platform. This e-skin patch offers a comprehensive solution for precision wound management and intelligent healthcare applications,” said Xugang Dang, corresponding author of the paper and a professor at Shaanxi University of Science and Technology.
The CCMP patch is fabricated by integrating aminated multi-walled carbon nanotubes (MWCNTs-NH₂) and dopamine into a carboxymethyl starch/carboxymethyl chitosan/polyvinyl alcohol matrix through supramolecular assembly. The patch exhibits high electrical conductivity (24.1 S/m), efficient photothermal conversion, strong antioxidant activity (>96.5%), and effective antibacterial performance. Notably, it achieves an ultra-high swelling capacity of 1374%, allowing rapid absorption of wound exudate while maintaining a moist healing environment.
The CCMP patch demonstrated an exceptional 99% wound healing rate within 14 days in a rat full-thickness wound model. It also significantly reduced pro-inflammatory factor levels and promoted vascular regeneration. By integrating the patch with a miniaturized electronic chip, the team built a portable wireless wearable system that transmits real-time wound micro-motion, temperature, strain, respiration, and bioelectric signals via Bluetooth to computers or mobile devices.
“This study pioneers a novel approach for wireless wound monitoring systems, advancing human-friendly e-skin patch development from single-functional devices to a human-machine-environment intelligent symbiosis system,” added Manhui Zheng, co-corresponding author from Wenzhou Medical University.
The research represents a significant step toward next-generation flexible e-skin systems that are shape-adaptive, highly sensitive, multifunctional, and cost-effective, opening new avenues for personalized medical electronics in intelligent wound care and health monitoring.
Xugang Dang and Yufei Fei contributed equally to this work. Other contributors include Haijun Wang, Xuechuan Wang, and Meiyuan Tao. The work was supported by the Shaanxi Provincial Department of Education Scientific Research Program, the “Scientists + Engineers” Talent Team Construction Project of Xianyang City, and the Shandong Province Key Research and Development Plan.
DOI Link:
https://doi.org/10.26599/NR.2026.94908706
About Nano Research
Nano Research is a peer-reviewed, open access, international and interdisciplinary research journal, sponsored by Tsinghua University and the Chinese Chemical Society, published by Tsinghua University Press on the platform SciOpen. It publishes original high-quality research and significant review articles on all aspects of nanoscience and nanotechnology, ranging from basic aspects of the science of nanoscale materials to practical applications of such materials. After 18 years of development, it has become one of the most influential academic journals in the nano field. Nano Research has published more than 1,000 papers every year from 2022, with its cumulative count surpassing 8,000 articles. In 2025 InCites Journal Citation Reports, its 2025 IF is 9.4 (8.3, 5 years), and it continues to be the Q1 area among the four subject classifications. Nano Research Award, established by Nano Research together with TUP and Springer Nature in 2013, and Nano Research Young Innovators (NR45) Awards, established by Nano Research in 2018, have become international academic awards with global influence.
Nano Research
Natural biomass-derived conductive e-skin patch for integrated skin-interfacing wearable bioelectronics and smart wound healing
9-Jun-2026