Fatal medication errors peak in July among new medical residents, especially in counties with teaching hospitals. Increased supervision and education on medication safety may reduce these errors.
Scientists identified a novel enzyme, PEAK1, that regulates cell proliferation, shape and migration. The discovery may provide a new target for future anti-cancer therapies.
Researchers have identified a genetic cause of inherited conditions causing severe fetal abnormalities, potentially leading to treatments for related disorders. The study found that the faulty gene stops cells' 'antennae' from transmitting information.
Researchers found zebrafish possess an enzyme linked to cortisol, which may aid in understanding its function in the human brain. The discovery could provide new avenues for investigating diseases related to cortisol imbalance.
The US Navy has selected Scripps Institution of Oceanography to operate a new scientific research vessel, advancing science and education in the decades ahead. The Ocean Class ship will lead ocean expeditions advancing knowledge on global climate change, submarine warfare, and more.
The American Society for Microbiology will honor Scripps Institution of Oceanography pioneer Claude ZoBell's contributions to marine microbiology. The event, held on May 22, recognizes ZoBell's pioneering research career and his work laying the foundation for the field.
Researchers have developed a tiny silicon chip that can detect specific chemicals and map their location, potentially alerting emergency responders to hazardous situations. The sensor works by manipulating the shape of pores on the silicon flake to respond to specific chemical traits.
Research finds common intestinal bacteria promote tumor growth in genetically susceptible mice, but an inhibiting protein enzyme suppresses growth, increasing survival time. The study's findings could lead to a new form of treatment for familial adenomatous polyposis, a genetic condition that increases the risk of colon cancer.
Researchers identified central, unifying elements of wisdom, including its uniqueness to humans, experiential nature, and personal quality. The study provides insight into the characteristic qualities of wisdom, shedding light on its distinctiveness from intelligence and spirituality.
Researchers discovered that human embryonic stem cells (hESCs) and lineage-committed cells have drastically different epigenomic landscapes. The unique epigenome of each cell type directs the cell to interpret its genetic information differently in response to environmental factors, influencing their development and function.
Researchers propose a multi-faceted approach to avoid exceeding the 2-degree C temperature threshold, including reducing methane, hydrofluorocarbons, and other greenhouse gases. They advocate for aggressive simultaneous pursuit of strategies to stabilize CO2 concentrations and implement warming-neutral pollution laws.
Researchers found that both men and women who had higher depression scores consumed almost 12 servings of chocolate per month. Chocolate consumption was not associated with other antioxidant-rich foods or energy intake.
A study by David Victor finds that fossil-fuel subsidies undermine energy security and worsen the environment. Most subsidies are a waste of money, and their removal could provide $550 billion annually for more beneficial programs.
Researchers at University of California, San Diego developed a new solar concentrator design that minimizes materials, alignment, and assembly costs. The innovative system collects sunlight with thousands of small lenses imprinted on a common sheet, reducing the need for individual photovoltaic cells.
Researchers found that mice lacking the FIH protein process fat differently, resulting in improved health outcomes on a high-fat diet. The lean mice exhibit enhanced insulin sensitivity and lower cholesterol levels compared to their normal littermates.
Researchers discovered a network of genes responsible for initiating and managing primary cilia formation. The study may lead to new therapies for ciliopathies, a group of genetic diseases caused by defects in primary cilia function or structure.
Researchers at the University of California - San Diego developed a smart delivery system capable of delivering lauric-acid-filled nano-scale bombs directly to skin-dwelling bacteria that cause common acne. This treatment has the potential to avoid undesirable side effects associated with current treatments.
Researchers investigating lunar reflector performance report decreased signal strength during full moon, suggesting dust may be a culprit. The issue arises from uneven heating of glass cubes left behind by Apollo astronauts, which distorts the shape of reflected laser pulses.
Researchers found truncated peptides form active ion channels causing cell death and memory loss, contradicting previous effective treatments. A new approach aims to control these ion channels for an effective treatment.
A study published in the Journal of Gastroenterology found that the current ALT threshold value for detecting liver disease in children is unknown, leading to incorrect interpretations. Researchers developed sex-specific thresholds using data from the National Health and Examination Survey, which improved detection rates by 70-80%.
Rival bacterial colonies use a toxic protein called sibling lethal factor to outcompete each other for limited nutrients. The protein kills cells at the edge of a colony closest to a competing group, creating a lopsided growth pattern and preserving scarce resources.
College-educated mothers in the US are spending more time coordinating and driving their children to organized activities, trading nine hours of leisure time per week. The phenomenon, dubbed 'the rug rat race,' is linked to increased competition in college admissions.
Researchers found that poor sleep patterns influence the spread of adolescent drug use in social networks, with teens at the center of the network being more vulnerable. Healthy sleep habits can have a positive impact on reducing drug use and other behaviors.
A new combination drug treatment has been found to be effective in controlling parasitic worms, reducing the need for repeated treatments and minimizing drug resistance. The dual therapy uses a protein crystal made by bacteria, which works by a different mechanism than existing levamisole-like drugs.
Professor Terry August, a Rady School of Management faculty member, has received a prestigious CAREER award from the National Science Foundation for his research on software security. The $530,000 award will support his project to analyze the relationship between government policy, economic incentives and software security.
Researchers from UC San Diego and Harvard found that cooperative behavior is contagious and spreads through a social network. When people benefit from kindness, they are more likely to help others, creating a cascade of cooperation.
A study published in Plant Biotechnology Journal found that algae can produce human therapeutic proteins such as VEGF, HMGB1, and fibronectin at levels comparable to mammalian cell cultures. This could significantly reduce the cost of expensive treatments for diseases like Multiple Sclerosis and Type 1 diabetes.
A team of researchers, including UC San Diego's Richard Norris, presents new evidence linking an asteroid impact to the mass extinction that wiped out dinosaurs and other organisms 65.5 million years ago. The study highlights a unique layer of debris in deep-sea sediments that correlates with abrupt environmental changes.
The study provides a comprehensive atlas of transcription factor combinations, indicating which factors can combine to determine cell fate. The researchers identified nearly 1,000 different pairs of TF proteins that can be wired together, representing the blueprint of all possible combinations that direct gene expression in mammals.
A team of scientists at UC San Diego identified a protein called Sestrin as a natural inhibitor of aging and age-related pathologies in fruit flies. Sestrin regulates the AMP-dependent protein kinase (AMPK) and Target of Rapamycin (TOR) signaling pathway, which controls aging and metabolism.
Researchers have discovered a Bt protein that is highly effective at curing intestinal parasitic roundworm infections in humans. The Cry5B protein produced by the Bt bacterium is three times better than tribendimidine and shows promise as an alternative to existing treatments.
Researchers found that exergames significantly improved mood and mental health-related quality of life in older adults with subsyndromal depression. The study suggests encouraging results from using video games to improve symptoms, with over one-third of participants experiencing a 50-percent or greater reduction of depressive symptoms.
A new special issue of Oceanography presents groundbreaking research on seamounts, highlighting the importance of these underwater mountains for marine life and global ocean health. The study reveals devastating impacts from overfishing and habitat destruction, emphasizing the need for sustainable management practices.
Damage to Gulf of California habitats can be reversed through conservation efforts, as protected areas have shown increased biomass and flourishing fish populations. Key protection strategies include reducing or eliminating fishing activity in critical spawning aggregation areas and sensitive nursery habitats.
Researchers identified a key protein that controls bacterial cell division and found the biological clock's role in regulating this process. The study's findings provide insights into the evolution of circadian clocks between prokaryotic and eukaryotic cells.
A new study of nematode worms with identical genes and environments found that chance played a role in the development of their gut, defying traditional explanations. Researchers attribute variations among organisms to differences in genes or environment, but this study adds random variation to the mix.
A signaling protein, GM-CSF, plays a vital role in fighting bacterial infections and inflammation in the intestinal tract. Its deficiency is linked to increased susceptibility to persistent gut infection, severe inflammation, and disease duration.
Researchers developed biological probes that can stick to and light up tumors in mice, allowing for more accurate tumor removal and improved survival rates. The probes enabled surgeons to visualize areas of tumors they wouldn't ordinarily see, reducing cancer cells by 90% on average.
Researchers at UC San Diego have identified the region in vertebrates where adult blood stem cells arise during embryonic development. This discovery is a critical step towards developing safer and more effective stem cell therapies for patients with leukemia, multiple myeloma, and other diseases.
A defective signaling pathway for PPAR-γ contributes to cystic fibrosis disease severity. Correction of the pathway reduces symptoms in mice, suggesting a potential therapeutic target.
Researchers found that amyloid beta peptides induce calcium waves in astrocyte networks, which could clarify what causes Alzheimer's disease and suggest new drug targets. The study provides a potential link between the accumulation of Amyloid beta fragments and sustained disruption of calcium balance within cells.
A novel anti-cancer drug has been developed by binding to a molecular switch found in cancer cells and blood vessels, keeping it in the 'off' position. The new approach uses scaffold-based chemistry and supercomputer technology to identify potential drug candidates that can halt tumor growth.
A Scripps-led study found that extremely long waves originating along Pacific coasts may destabilize Antarctic ice shelves. The researchers propose that infragravity waves could initiate ice shelf collapse by opening crevasses and reducing ice integrity.
A biologist at UC San Diego discovered a 'stop' signal in honey bee communication that warns nest mates about dangers. The signal reduces recruitment to dangerous food patches and is an example of negative feedback in superorganisms.
Researchers at the University of California, San Diego, have discovered that HIV RNA in seminal plasma is transmitted during sex, not HIV DNA. This finding has significant implications for developing prevention strategies, including vaccines and microbicides to prevent the spread of sexually transmitted HIV.
A recent study found that the majority of TB-HIV co-infection cases in San Diego are now among Hispanics, highlighting a significant shift in the disease's ethnic makeup. The results emphasize the need for targeted binational prevention efforts to address the widening health disparities.
Researchers found that a negative mood imparts a warm glow to familiar stimuli, while a happy mood eliminates this preference for familiarity. This discovery has applications in various fields, including parenting, marketing, and politics.
The CYCORE project aims to aggregate data from clinical trials, patient records, and behavioral data to study cancer treatment effectiveness. By analyzing this data, researchers hope to better understand which treatments work best for specific patients and develop more effective prevention and recovery strategies.
Researchers at University of California, San Diego have identified a signaling protein called RON that helps pancreatic cancer cells survive and resist chemotherapy. The study provides new insights into pancreatic cancer development and suggests combining RON-targeted therapy with other treatments to combat tumor resistance.
A study published in the journal Cancer found that prostate cancer treatment decisions are influenced by the type of healthcare facility where patients receive care. Patients treated in county hospitals are more likely to undergo surgery, while those in private facilities tend to receive radiation or hormone therapy.