A fat cell grows up
A team of scientists found an intermediate state during the formation of fat cells, induced by hormones related to cortisol. This transition state could be targeted for new therapies to combat obesity and metabolic disorders.
A team of scientists found an intermediate state during the formation of fat cells, induced by hormones related to cortisol. This transition state could be targeted for new therapies to combat obesity and metabolic disorders.
T-ALL is caused by interplay of various factors including genetic errors that disrupt white blood cell formation. The study identifies PTPN2 as a tumor suppressor gene lost in leukemia patients, contributing to cancerous cell proliferation.
A new study by researchers found that measuring bone density before starting ADT can help prevent fractures and reduce costs. Another study suggests that CTCA can identify patients who need more invasive testing for heart disease.
A study of patients undergoing elective facial plastic surgery found that older patients and those currently being treated for depression are more likely to be satisfied with the results. However, optimism and pessimism do not appear to be related to satisfaction.
A new study from UCLA's Pediatric Epilepsy Surgery Program found significant improvements in surgical outcomes for pediatric epilepsy patients over the past two decades. The researchers attribute the success to advancements in diagnostic technology and experience in selection and operations.
A study published by Greek researchers found that electrical muscle stimulation (EMS) can prevent critical illness polyneuromyopathy (CIPNM), a common complication of ICU stay. EMS reduced the risk of CIPNM and improved muscle strength in patients, shortening weaning periods and ICU stays.
Researchers link bacterial spacing to photosynthesis, providing new insights into ancient fossils and the evolution of life. By studying microbial mats, they discovered a consistent one-centimeter spacing that records the maximum distance bacteria can compete for nutrients.
A recent study from Stanford University found that DFA testing for H1N1 influenza is unreliable in critically ill patients. The test was more accurate in non-critical cases, with a 26% positive rate in ICU patients compared to an 82% positive rate in non-ICU patients.
A new study suggests that reducing nitrogen pollution in the Sacramento-San Joaquin Bay-Delta could help restore the endangered California delta smelt population. The research found that high levels of nitrogen from wastewater treatment plants are affecting the food web and altering the ecology of the system.
The US Navy has selected Scripps Institution of Oceanography to operate a new scientific research vessel, advancing science and education in the decades ahead. The Ocean Class ship will lead ocean expeditions advancing knowledge on global climate change, submarine warfare, and more.
Scientists have developed an immune-deficient mouse model to study CCHF virus behavior in humans, a significant step towards vaccine and antiviral development. The model can help evaluate the safety and effectiveness of potential treatments, addressing the lack of suitable animal models for testing.
A recent study found that teenagers with treatment-resistant depression can become symptom-free within six months of switching medications or combining a medicine switch with cognitive behavioral therapy. Those who showed improvement in symptoms early on were more likely to experience lasting benefits.
A new international trial is testing a 1-a-day combined 'polypill' to reduce the risk of heart attacks and strokes. The Red Heart Pill contains low-dose aspirin, statins, and blood pressure-lowering medicines, potentially saving millions of lives across the world by making cardiovascular drugs more accessible to low-income countries.
A recent study published in Pediatrics found a connection between exposure to organophosphate pesticides and symptoms of Attention-Deficit Hyperactivity Disorder (ADHD) in children. The research, which focused on 1,139 children from the general U.S. population, measured pesticide levels in their urine and found that exposure to common ...
Researchers at UCLA developed two PET scanning probes that target different cells in the immune system with high specificity. The probes work better when used together, revealing the extent and cellular composition of an immune response and its effects on various diseases, including cancer and auto-immune disorders.
Two surgical techniques for female stress incontinence were found to be equivalent in efficacy but differed in side effects. The retropubic procedure had a higher rate of urinary dysfunction requiring surgery compared to the transobturator procedure. These findings will help guide care for women undergoing stress-incontinence surgery.
A systematic review and meta-analysis found that consuming processed meat, such as bacon or sausages, increases the risk of heart disease and type 2 diabetes by 42% and 19%, respectively. In contrast, unprocessed red meat is not associated with these health risks.
Researchers found that vaccinia immunization reduces HIV replication, suggesting it could provide protection against subsequent infection. The decline of smallpox vaccination in the mid-20th century may have led to a loss of this protection, contributing to HIV's rapid contemporary spread.
Researchers Jane Siegel and Jeff Perdue are leading an initiative to develop business-centric measures of cloud computing benefits and risks. The goal is to provide chief information officers with a standardized method for comparing internal and external providers.
The lake's surface waters have warmed by 3 degrees F since 1900, driving a decline in productivity and impacting the fishery. The research provides a detailed record of temperature and its impacts on a tropical African ecosystem.
A study by the University of Washington found that Google Flu Trends is less accurate in estimating laboratory-confirmed influenza cases compared to CDC surveillance. The analysis revealed a 25% error margin during the 2003-04 flu season, with greatest deviations occurring during periods of high media attention or unexpected activity.
A new article proposes a three-pronged strategy to address conflicts of interest in clinical guideline development, emphasizing intellectual and financial conflicts equally. The approach aims to balance expert insights with the avoidance of inappropriate influence from experts with financial or intellectual conflicts.
A study by Cardiff University found that climate change is putting trout and salmon at risk due to warmer water and lower river levels. The research, published in Global Change Biology, suggests that both species face major problems if climate warming continues.
A meta-analysis of over 1 million people found that both low kidney filtration rate (GFR) and high albumin: creatinine ratio independently predict mortality risk in the general population. Low GFRs were associated with increased risks, with those below 60 mL/min/1•73 m² experiencing a 57% increased risk of death.
Researchers found that male African cichlid fish exhibit a fear response when fighting their own reflections, characterized by increased activity in the amygdala region of the brain. This discovery suggests that fish may have more complex cognitive abilities than previously thought.
The Helmholtz Centre for Infection Research has received a grant from the Bill & Melinda Gates Foundation to develop nanoparticles that release vaccine active ingredients through skin perspiration, potentially bypassing traditional vaccines. The project aims to stimulate mucosal immune responses and prevent infectious diseases.
New images reveal electrons flowing primarily along crystal grain boundaries, providing clues to the origin of superconductivity in pnictides. The discovery may help physicists develop better high-temperature superconductors that could save energy and enable innovative applications.
Researchers at Virginia Tech have constructed a powerful phylogenetic tree for the gamma-proteobacteria using hundreds of genes and integrating more information than traditional single-gene approaches. The consensus tree provides a tool for predicting shared biology and analyzing bacterial adaptations to their environments.
Dr. Gregory Downey received the Recognition Award for Scientific Accomplishments for his outstanding contributions to respiratory disease research. He has published over 190 papers and is a leading expert in innate immunity, lung injury, and repair.
A comprehensive study identifies significant cognitive and anatomic differences in Alzheimer's disease patients with and without the APOE ε4 gene, affecting memory, attention, language, and executive function. The findings have important implications for early diagnosis, treatment, and personalized medicine approaches.
Researchers found that ICU-acquired infection rates do not correlate with death rates for at-risk patients, despite being used as a measure of quality in hospital report cards. Hospitals with high infection rates had similar survival rates to those with low infection rates, highlighting the limitations of using these rates as a metric.
Researchers at Duke University Medical Center have found a new mechanism by which CD8+ T cells control HIV. The discovery highlights the antiviral activity of prothymosin-alpha, a tiny protein that stimulates interferon production to block viral replication.
A new study by the Hebrew SeniorLife Institute for Aging Research has found a link between altered blood flow in the brain and slow gait and falls in elderly people. Seniors with abnormal blood flow changes were more likely to experience falls, highlighting the importance of exercise and treatment for high blood pressure in preventing ...
Providing oral health education to mothers and families is essential for teaching children healthy habits and preventing early childhood tooth decay. A general dentist can provide families with oral health literature designed to educate both the parent and child, promoting a positive self-image and improving their quality of life.
Researchers at Caltech have found a way to improve the efficiency of wind farms by using vertical-axis turbines in strategic arrays. By studying the vortices left behind by schools of fish, they discovered that alternating turbine rotations and staggering their placement can increase energy extraction up to 10 times.
Researchers from North Carolina State University developed a software tool that translates traditional computer programs for efficient use on graphics processing units (GPUs), significantly boosting computing performance. The tool, called a compiler, can increase program execution speed by up to 30% compared to manual GPU optimization.
Researchers have identified a previously undiagnosed condition and treated it with a stem cell transplant, saving the patient's life. The key to unlocking the reason for the patient's symptoms was contracting a rare version of glandular fever.
A study of 600 subjects found that consuming 67 grams of nuts per day significantly lowered total and LDL-cholesterol levels, as well as triglycerides. Pistachios' unique nutrient profile provides significant heart health benefits.
A Johns Hopkins study found that nearly 40% of children with infantile spasms became seizure-free after being on the high-fat ketogenic diet for at least six months. The diet, which is rich in fat and low in carbohydrates, works by triggering biochemical changes that eliminate seizure-causing short circuits in the brain.
Researchers found that traditional aerobic fitness training improved systolic blood pressure, rating of perceived exertion, and peak VO2 levels compared to pedometer-based walking programs. Participants in the supervised fitness program also showed greater adherence rates.
The University of Cincinnati's School of Design contributed 22 new signage symbols to the 'Signs that Work' project, which aims to create a universal system for hospital signage. The new symbols will be integrated into a total of 50 symbols and tested at four national hospital sites.
A recent study by Brandeis researchers found that medicalizing human problems has led to substantial economic costs, with $77.1 billion spent on conditions like menopause and ADHD in 2005.
A study found that nurses in Belgium frequently act outside of the law by administering life-ending drugs without a patient's explicit request. In euthanasia cases, 48% of nurses helped prepare drugs and 56% were present during administration, mostly without physician co-administration.
Researchers discover a combination of drugs that effectively target stubborn leukemia stem cells, which often escape standard treatment and lead to disease relapse. The study supports clinical trials of HDACi in combination with tyrosine kinase inhibitors to eliminate leukemia stem cells in patients with CML.
A gene network controlling lung development has been identified as responsible for the failure of lungs to form due to vitamin A/retinoic acid deficiency. This network, which balances two opposing pathways, can be corrected, potentially preventing lung defects in animals.
Researchers found that genetic mutations affecting cilia function may predispose older individuals to pulmonary diseases. A simple nitric oxide testing can identify patients at risk of abnormal ciliary function.
A study comparing radiofrequency ablation (RFA) and endovenous laser ablation (EVLA) for varicose veins found that RFA caused less post-operative pain. Both groups showed similar improvements in clinical and quality of life scores at six weeks after surgery.
The American Cancer Society has awarded $50.7 million in new national research and training grants to 93 institutions across the US, with a focus on early career researchers and innovative ideas addressing various types of cancer, including prostate, endometrial, and liver cancers.
Food cravings are intense, specific desires to eat certain foods, which can pose serious health risks. Research suggests that mental imagery is a key component of food cravings, taking up brain power and making it hard to focus on other tasks.
The American Institute of Biological Sciences recognizes scientists, educators, and organizations for their leadership and contributions to science. The LTER Network receives the Distinguished Scientist Award, while Duke University Professor Kathleen K. Smith receives the Outstanding Service Award for her work at NESCent.
Researchers used PET probes to monitor immune cell function in mice with a retrovirus-induced sarcoma. The study found that two different PET probes detect distinct immune cell populations, primarily innate immune cells and active CD8+ T cells.
A new study found that altered brain blood flow due to high blood pressure may lead to an increased risk of falls in elderly people. The research, published in Neurology, suggests that daily exercise and treatments for high blood pressure could be a new strategy for preventing falls.
Researchers discovered an identical gene for antibiotic resistance in human and animal samples, suggesting its transfer between bacteria species. This finding poses a risk to the treatment of common human infections like UTIs, which are increasingly difficult to treat due to rising antibiotic resistance.
A team of scientists led by Caltech biologists found that cell-cycle length and chromosome duplication without division play key roles in determining sepal cell sizes in Arabidopsis thaliana. This probabilistic development process results in unique patterns and proportions among sepals.
Kudzu's chemical reaction contributes to surface ozone pollution, causing 50% more unhealthy ozone days. The invasive vine's production of isoprene and nitric oxide exacerbates air quality issues.
Researchers have isolated the ICR1 protein, which influences auxin distribution in plants, allowing breeders to manipulate plant cell wall composition and increase yields for biofuel production. This breakthrough has the potential to make fuel production more cost-effective by reducing lignin content and increasing cellulose levels.
A mass extinction of fish 360 million years ago led to the demise of dominant species and created a new world. The Hangenberg event marked a critical shift in vertebrate diversity, with few surviving species giving rise to modern vertebrates, including humans.
Researchers found warning young women about the effects on their appearance caused a 35% drop in indoor tanning visits. The study suggested that focusing on appearance is more effective than just skin cancer warnings, and offering alternative options can help individuals change their behavior.
Adult patients without health insurance admitted to ICUs in Pennsylvania hospitals face a 21 percent increased risk of death compared to similar patients with private insurance. Uninsured ICU patients were also less likely to receive certain critical care procedures, including placement of central venous catheters and tracheostomies.
The LungPoint System enables accurate and efficient biopsy procedures for diagnosing and treating lung cancer by providing pre-procedure mapping and visual guidance during bronchoscopy. This technology allows physicians to plan their path ahead of time, reducing the need for invasive procedures.
A large population-based study found that individuals treated with vitamin A analogues do not have an increased risk of fractures. The research, published in Archives of Dermatology, analyzed data from two nationwide registers and found no association between retinoid use and fracture risk at any skeletal site.
Physicists have made significant progress in understanding the properties of helium, a key element used in lasers, nuclear reactors, and space exploration. The new findings may enable more accurate measurements of temperature and pressure, benefiting fields such as low-temperature condensed matter physics and metrology.
Researchers discovered that newborns can learn and respond to tones while asleep, a finding that could lead to early identification of infants at risk for developmental disorders such as autism and dyslexia. The study used EEG recordings to measure brain waves and found that 24 of 26 babies showed neural activity during sleep.
A previously-unknown ion channel in human blood vessels has been identified as a natural defence mechanism against heart disease. Pregnenolone sulphate, a 'fountain of youth' steroid, can trigger this protective effect in diseased and healthy blood vessels alike.
The lake's surface waters have reached the warmest temperature on record, affecting fish productivity and ecosystem. Climate change models predict further warming, exacerbating the decline of fish stocks and impacting the region's food security.
Researchers identified GRP78 as a key protein facilitating fungal invasion of blood vessels in diabetes-related infections. Mice treated with GRP78-specific immune serum showed protection from mucormycosis.
Children requiring home mechanical ventilation often receive frequent chest x-rays, but research suggests these may not be necessary to change treatment plans. Researchers analyzed records of 28 patients and found that two-thirds of repeat x-rays did not prompt changes within 24 hours.
Scientists have found evidence of neotectonic activity in the Alps using speleothems, a type of cave formation. The study also presents new constraints for dating shallow faults at the AlpTransit tunnel site in Switzerland.
Researchers at Thomas Jefferson University found that hypofractionated stereotactic radiotherapy significantly improves survival rates for patients with recurrent brain cancers, while minimizing side effects. The treatment provides longer survival without experiencing common chemotherapy and targeted therapy side effects.
The American Association of Pharmaceutical Scientists (AAPS) honored outstanding researchers with awards for their contributions to biotechnology. The Excellence in Ligand-Binding Assay Award and Innovation in Biotechnology Awards recognized achievements in fields such as drug detection, vaccine development, and cancer treatment.
Researchers found fossil teeth of Carcharocles megalodon, the world's largest shark species, in an ancient nursery in Panama. The teeth suggest young sharks spent their early years near the coast among mangroves.
Good oral health during pregnancy combats adverse effects of oral disease, preventing pain, infections, and nutrient deficiencies. Regular dental treatment can be safely performed at any time during pregnancy.
ARS scientists have developed a biocontrol agent that uses neuropeptide mimics to kill aphids, potentially reducing pesticide use and environmental harm. The treatment was found to be highly effective in killing 90-100% of aphids within three days, comparable to insecticides on the market.
Research reveals that intermittent hypoxia associated with sleep apnea can cause distinct drops in insulin sensitivity in mice. This finding suggests that sleep apnea may increase the risk of developing metabolic disorders such as type 2 diabetes.
The Asian shore crab has found a hospitable niche in its new environment, coexisting with native species in the cobbled beach ecosystem. The cordgrass-ribbed mussel environment provides a stable habitat for the crabs, allowing them to thrive without crowding out native species.
The Art of Science 2010 exhibition features breathtaking images created by Princeton researchers, exploring the beauty in scientific inquiry. The competition attracted top talent, with cash prizes awarded to first, second, and third place winners for their visually stunning entries.
A study found cochlear implants slightly benefit older adults, but not as much as younger patients. The results suggest that older patients may experience a prolonged adaptation phase and have inherent limitations in processing high-rate stimulation paradigms.
A national survey of surgical residents found that those who are single or do not have children are more likely to pursue specialty fellowships. The study also highlights the growing trend of specialization among surgery residents, which may impact the future of general surgery.
A new study challenges the long-held assumption that children adopt an anthropocentric perspective on human-animal relationships from birth. Instead, research suggests that human-centered reasoning emerges around age 3 in urban children, reflecting their community's perspectives.
Researchers are developing methods to protect cacao crops from devastating plant pathogens, targeting two mechanisms critical for pathogen attack. The project aims to improve crop resilience and provide nutrition and income options for smallholder farmers in developing countries.
The Interphone International Study Group found no increase in brain cancer among users, but heavy users appeared at a higher risk. The study's inconclusive results were attributed to restricted access to participants and flawed ethics reviews.
Neuromuscular electrical stimulation (NMES) may reduce muscle atrophy in patients with severe chronic obstructive pulmonary disease (COPD). NMES improved quadriceps and calf muscle mass, increasing the anabolism to catabolism ratio in muscle proteins.
Researchers at Argonne National Laboratory discovered that nanoparticles can self-assemble into a crystal lattice with low defects when floating at a liquid-air interface. This process allows for two-dimensional crystallization over a longer time scale, enabling the formation of highly ordered phases.
Researchers used clinical-grade human mesenchymal stem cells (hMSCs) to treat ALI, restoring normal function of alveolar epithelial cells and reducing inflammatory cytokines. The study found that intravenous delivery of hMSCs was as effective as intrabronchial administration in repairing damaged lung tissue.
A recent study found that most patients with localized papillary thyroid cancer can expect favorable outcomes without treatment. The 20-year survival rate for these patients is estimated to be around 97%, similar to those who received treatment. Clinicians and patients can feel comfortable considering observation as an option.
Researchers identify GRP78 as key factor in mucormycosis pathogenesis, providing new avenue for therapeutics development. PET probes detect distinct immune cell populations, suggesting wider use for immune modulating therapies.
A new study published in The Lancet found that common blood tests for kidney function and urine protein levels can predict mortality risk. People with high levels of albumin in their urine were at a higher risk of mortality, with an increased risk of nearly 50% at certain thresholds.
A study found that focusing on the negative effects of indoor tanning on appearance can reduce tanning behavior in young women, even those motivated by health concerns. The appearance-focused booklet also showed promise in reducing tanning behaviors among those with pathological motives for tanning.
Endoscopic sinus surgery rates increased by 20% among Medicare beneficiaries from 1998 to 2006, while open sinus surgery rates declined 40%. This trend suggests a shift towards minimally invasive procedures for managing chronic rhinosinusitis in the elderly population.
A Purdue University researcher used NASA satellite data and Google Earth to detect changes in North Korea's Mount Paekdu Biosphere Reserve, finding that up to 75% of the forest had been removed through extensive logging. This has raised concerns over biodiversity loss and habitat destruction in the region.
The discovery of three new Philippine monitor lizard species and a new subspecies sheds light on the immense biodiversity of these giant reptiles in the region. The study highlights the importance of museum collections and the need for continued research to recognize and name all species, emphasizing the global taxonomy crisis.
A Belgian-Dutch study found that the use of life-ending drugs without explicit patient request occurred in 1.8% of deaths in Flemish Belgium. The majority of these cases involved elderly patients or those in irreversible comas, with discussion with families and healthcare professionals often present.
A study led by St. Jude Children's Research Hospital identified a cancer gene unusually active in some childhood brain tumors, providing a new treatment target for high-grade gliomas (HGGs). The research found significant differences between genetic defects in children and adults with HGG.
A recent study at the University of Illinois found that some impatiens plant varieties are more attractive to Western flower thrips than others. The researchers discovered that the Dazzler White variety emits volatile compounds that attract thrips, while the Cajun Carmine variety does not.