Researchers at UC San Diego are launching a project to improve communication and data-sharing among emergency officials during disasters. The new system aims to overcome obstacles such as unreliable wireless networks, staggering arrival times of responders, and rapidly changing infrastructure capabilities.
Research at the University of California, San Diego, reveals that obesity is a tumor-promoting factor for liver cancer, primarily through chronic inflammation caused by cytokines like IL-6 and TNF. This effect may be preventable with anti-TNF drugs, which also reduce liver fat accumulation.
Researchers at UC San Diego successfully synchronized bacterial genetic clocks to blink in unison and alter their blinking rates in response to environmental conditions. The achievement is a crucial step towards creating genetic sensors that can monitor temperature, poisons, and other hazards.
Scientists found that repeated exposure to tobacco smoke made lung cancer worse by causing inflammation in the lungs. The study provided definitive evidence for the role of lung inflammation in promoting lung cancer growth and suggested using anti-inflammatory agents to prevent or slow lung cancer progression.
Researchers discovered that gliomas can evade EGFR inhibitors by expressing alternative genes like KLHDC8, which halts tumor growth. This finding provides potential new targets and treatment strategies for brain tumors.
A team of scientists has discovered a new link between a common form of inherited blindness and the AHI1 gene. They found that patients carrying a specific genetic alteration were more likely to have retinal blindness, and some forms may be treatable with gene therapy.
A new study found that fluctuating water chemistry and temperature variations in freshwater lakes can actually increase biodiversity, while a stable but variable environment can also be detrimental. Zooplankton populations respond quickly to changes due to their fast reproduction rate.
A Scripps/LLNL team has won a grant to improve greenhouse gas emissions verification using continuous atmospheric measurements. The method will focus on industrially produced gases with limited sources, aiming to create reliable computer representations of emissions activity.
The discovery of Sox2, a protein that regulates stem cell formation, is crucial for spiral ganglion neuron development. The study's findings may lead to the regeneration of these nerve cells, potentially revolutionizing cochlear implant technology and biological treatments for hearing loss.
Researchers have developed a novel way to trace mutations in HIV that lead to drug resistance. By comparing sequences of HIV from treated and untreated patients, they identified clusters of mutations that help the virus escape treatment. This breakthrough could enable doctors to tailor drug cocktails to individual patient strains.
The study identified specific binding sites of microRNAs in C. elegans, providing a wealth of data for understanding miRNA regulation in development and disease. This breakthrough enables researchers to identify individual miRNA targets in various tissues and cell types.
Researchers have developed an efficient way to genetically modify human embryonic stem cells using bacterial artificial chromosomes, which can increase the yield by up to 20%. This approach enables the rapid development of stem cell lines that can serve as models for human genetic diseases and testbeds for potential treatments.
Researchers have made a breakthrough in engineering nanoscale materials, enabling the creation of large-scale arrays of individual structures with precise locations. This discovery could lead to advancements in sensing, transistors, and other applications.
A team of researchers developed a 'nano cocktail' consisting of two nanomaterials that work together to locate, adhere to, and kill cancerous tumors. The system uses gold nanorods to accumulate in tumors and then sends in a second nanoparticle type coated with a targeting molecule specific for the heat-treated tumor.
A study by researchers at the University of California - San Diego has found that amyloid beta reduces plasticity in dendritic spines, affecting synapse transmission and memory storage. Continuous release of Aβ is required to prevent this effect.
Researchers identified associations between genetic variations and brain surface area, suggesting a key role for microcephaly genes in human brain evolution. The study found significant links with regulatory regions of the CDK5RAP2 gene, indicating a need to focus on these processes for future research.
Researchers at UC San Diego's Englekirk Structural Engineering Center conducted comprehensive shake tests on semi-gravity reinforced concrete cantilever walls. The project aims to improve the seismic design of California's thousands of miles of retaining walls, ensuring safer transportation systems.
The San Diego Supercomputer Center (SDSC) at UC San Diego and Arizona State University will operate an internet-based national data facility for high-resolution topographic data acquired with LiDAR technology. The facility, funded by the NSF, will provide online processing tools and act as a community repository for information.
Researchers identified a protein switch that helps prevent liver damage and cancer, offering new insights into the development of liver disease and cancer. The study suggests that TAK1 could be a master regulator of liver function, and its role in liver disease and cancer may enable the development of new therapeutic strategies.
Biologists have discovered plant enzymes that enable plants to respond more efficiently to elevated carbon dioxide levels. This discovery could lead to the development of drought-resistant crops with improved water efficiency. The research found that specific proteins called carbonic anhydrases play a crucial role in this process.
Researchers used biosensors to study how anti-psychotic drugs, such as atypical neuroleptics, affect the brain. The study found that these drugs block a particular type of receptor, overriding the increase in acetylcholine they stimulate.
Renowned psychopharmacology expert Stephen M. Stahl, MD, PhD, highlights low confidence in army mental health care, excessive opiate prescribing, and understaffing of services at Ft. Hood. He proposes redeploying primary-care providers and nurse case managers to centralize mental health care delivery.
Scientists applied physics techniques to study bacteria's survival strategies, gaining insights into human decision making. The study found that bacteria's game theory decision making process is more advanced than the Prisoner's Dilemma, enabling them to weigh pros and cons in complex environments.
Scientists at UC San Diego discovered a downward curve in the pitch of blue whale songs across the globe. The decline may be due to an increase in population size, allowing males to sing lower frequency songs that don't need to travel as far.
Researchers at UC San Diego are developing new regenerative therapies for heart disease using adult stem cells and supportive materials. The study found that cells placed in these materials differentiate into cardiac muscle more effectively, offering a promising solution to treat cardiovascular diseases.
A new study by an international team has used seafloor seismometers to image the Hawaiian mantle, revealing a high-temperature plume from the lower mantle. The findings suggest that the Hawaiian hot spot is the result of this upwelling plume, which tilts southeastward as it extends downward.
Computer scientists at UC San Diego are creating a network of environmental sensors attached to people's clothing, which will provide up-to-the-minute information on outdoor and indoor air quality. The system, called CitiSense, aims to empower individuals to make healthier choices by giving them real-time data on polluted areas.
Chromosomal translocations, a hallmark of leukemias and lymphomas, may be more systematically driven than previously thought. The study identifies the male sex hormone (androgen) receptor as a key player in driving specific translocations in prostate cancer.
A study by researchers at the University of California, San Diego reveals that normal skin bacteria trigger a pathway preventing excessive inflammation after injury. This mechanism involves staphylococcal lipoteichoic acid and Toll-like receptor 3 activation, providing new therapeutic approaches for inflammatory skin diseases.
Researchers from UC San Diego used a systems biology approach to determine how core biochemical pathways are altered in skeletal muscle cells and fat cells in people with insulin resistance. The study found that common drugs for treating insulin resistance, such as TZDs, alter these pathways, leading to improved drug therapies.
Artificially introducing defects in nanotubes can enhance the development of supercapacitors, which combine the advantages of batteries and electrostatic capacitors. The researchers found that defects create additional charge sites, increasing stored charge capacity and power density.
A study by neuroscientist William C. Mobley demonstrated a possible new approach to slowing cognitive decline in Down's syndrome using a pro-drug for norepinephrine, rescuing cognition in mice.
Researchers developed a fast and accurate method to quantify subtle brain volume loss in Alzheimer's patients, outperforming existing measures. The new technique identifies changes in memory regions, particularly the entorhinal cortex, as sensitive markers for early disease stages.
UC San Diego engineers develop algorithms for swarms of ocean robots to track ocean currents, predict oil spill movement, and improve models. The system will enable local agencies to deploy robots quickly to monitor spills and aid in the development of marine protected areas.
Researchers at Scripps Institution of Oceanography are developing autonomous underwater explorers, or AUEs, to trace small-scale ocean processes vital to tiny marine inhabitants. The miniature robots will provide new information about marine protected areas, harmful algal blooms, and oil spills.
Researchers at UCSD have made a breakthrough discovery that enables the experimental annotation of genomes. By combining multiple genome-scale measurements, they can identify the location and use of genomic elements with precision. This innovation has significant implications for metabolic engineering, disease research, and drug design.
Researchers developed a tool to visualize bacterial communication, revealing that chemical signals function simultaneously in interspecies interactions. This approach may aid in understanding microbial interactions with human cells, leading to novel immune system modulators and anti-infectives.
Gordon is a powerful supercomputer that will use flash memory to speed solutions to critical science and societal problems overwhelmed by the growing amount of data generated by digital devices. The system will feature 245 teraflops of compute power, 256 TB of flash memory, and four petabytes of disk storage.
Engineering students at UC San Diego helped streamline the application process for federal Clean Renewable Energy Bonds, securing $154 million for 192 solar projects. The students developed an analytical tool to calculate energy output and payback time, allowing applications to be completed in 10 minutes.
Scientists at the University of California, San Diego School of Medicine report that regeneration of central nervous system axons can be achieved in rats even when treatment is delayed by more than a year after the original spinal cord injury. The team used a combination of treatments to coax chronically injured axons to regenerate and...
Researchers created a music recommender system that generates playlists as good as or better than Genius, but with less user data required. The system uses auto-tagging algorithms to label songs based on their acoustic content, leading to high-quality playlists including lesser-known songs.
Researchers at UC San Diego have identified a key protein promoting pulmonary arterial hypertension and developed a drug therapy to block its effects. The treatment, using γ-secretase inhibitor, reversed the disease in mice, offering new hope for patients with this debilitating condition.
Researchers at UC San Diego discover that a protein interaction generates force that shapes the Golgi apparatus, revealing a link between form and function. The discovery sheds light on the mechanism of the Golgi apparatus, a processing center for protein export.
Researchers used a rare brain procedure to document how the human brain computes grammar and produces words. The study found that distinct linguistic processes are computed within small regions of Broca's area, separated in time and partially overlapping in space.
Researchers at the University of California, San Diego, have developed a new high-throughput cellular array technology that can identify the biological components leading to or alleviating liver disease. By controlling the environment surrounding star-shaped liver cells, they found critical proteins regulating HSC activation.
The San Diego Supercomputer Center (SDSC) is part of a four-year project called 'FutureGrid' that aims to develop and test new approaches to parallel, grid, and cloud computing. Researchers will collaborate to create an experimental high-performance grid test-bed, enabling the detection of bugs in software before production.
Scientists at UCSD have successfully built an integrated circuit that operates at 125 degrees Kelvin, a temperature easily attainable commercially with liquid nitrogen. This breakthrough enables faster and more efficient computation and communication devices.
Researchers created a complete model of the bacterium Thermotoga maritima's central metabolic network, including three-dimensional protein structures. This breakthrough could help identify positive and adverse drug reactions and engineer bacteria to produce clean energy.
The Siebel Foundation has awarded UC San Diego's top bioengineering graduate students with a $2 million endowment to fund fellowships. The fellowships will be administered by the UCSD Institute for Engineering in Medicine, recognizing the Jacobs School's pioneering efforts in medicine and health.
A new study by University of California - San Diego researchers found that parents regularly lie to their children to promote good behavior and make them happy. The practice, known as 'parenting by lying,' is more common among Asian-American parents.