Researchers have developed a Mouse Grimace Scale to measure spontaneous responses in mice resembling human pain expressions. The scale accelerates the development of new analgesics for humans while eliminating unnecessary suffering in lab animals.
Scientists at the University of Gothenburg have successfully photographed the movement of atoms during photosynthesis, revealing a temporary storage of light energy before chemical bonds form. The breakthrough could lead to more efficient solar panels by mimicking photosynthesis' sophisticated energy conversion process.
A new study from the University of Gothenburg found that 23% of bus and tram drivers in Sweden experience pronounced daytime sleepiness, while 28% struggle with getting to sleep. Treatment with a CPAP machine improved symptoms and reduced daytime sleepiness among drivers with obstructive sleep apnoea.
Warren Piers, a University of Calgary chemist, has developed a faster catalyst for olefin metathesis reactions. This breakthrough enables more efficient production of chemicals, pharmaceuticals, and biofuels while reducing energy costs and waste. The discovery opens up new applications and markets.
A randomized trial found that pramipexole significantly improved depressive symptoms and functioning in patients with mild-to-moderate Parkinson's disease. The study also showed that the antidepressant effect of pramipexole was largely independent of its effect on motor symptoms.
Scientists at the University of Gothenburg have created a method to develop safer drugs by simulating metabolism and identifying potentially toxic metabolites. This approach has been successfully applied to the antimalarial drug amodiaquine, which was withdrawn due to liver damage and immune system impairment.
Research finds common intestinal bacteria promote tumor growth in genetically susceptible mice, but an inhibiting protein enzyme suppresses growth, increasing survival time. The study's findings could lead to a new form of treatment for familial adenomatous polyposis, a genetic condition that increases the risk of colon cancer.
Research from neuroscientist Samuel Weiss shows that paternal mice physically interact with their babies grow new brain cells and form lasting memories of their babies. The study demonstrates a positive feedback loop between social interactions and healthy brains.
Researchers discovered insulin's properties reduce inflammation in fat tissue, a key factor in developing insulin resistance and type 2 diabetes. Identifying the inflammatory molecule IL-6 and protein PKCdelta improved understanding of signalling mechanisms that can lead to medicines to reduce inflammation and related disorders.
A Scripps Research Institute team has discovered a mechanism to enhance the cellular folding and function of mutated lysosomal enzymes, which are linked to Gaucher's disease. The researchers used FDA-approved drugs to increase calcium levels in cells from patients with Gaucher's disease, potentially paving the way for clinical trials.
A new antifouling substance, medetomidine, has been shown to cause paler fish by affecting their skin cells containing dark pigment. The research also found that the substance can impair a fish's ability to break down environmental toxins and affect its liver function.
A joint clinical trial found that administering fibrinogen before heart surgery reduces bleeding risk. The study suggests fibrinogen concentrate could be used as a preventive therapy for patients undergoing cardiac surgery.