The Cleveland Alzheimer's Disease Research Center will accelerate research for Alzheimer's disease and related dementias, supporting a wide range of studies and educating scientists and the public on dementia causes and treatment.
A new AI framework developed by Cleveland Clinic researchers can now use medical scans and health records to personalize the dose of radiation therapy used to treat cancer patients. The framework has been shown to reduce treatment failure probability to less than 5 percent.
A recent study found that including new clinical variables in the lung allocation score improved its accuracy for identifying the sickest cystic fibrosis patients. The updated scoring system also helped patients with chronic obstructive pulmonary disease (COPD) by re-evaluating their pulmonary function testing.
Researchers found that electronic inhaler monitoring, combined with a disease management program, reduced healthcare utilization in patients with COPD. The study showed a significant reduction in COPD-related hospitalizations and ER visits, from an average of 3.4 to 2.2 trips per year.
The National Institutes of Health has awarded a $3 million grant to the Cleveland Clinic to conduct a multi-site clinical trial investigating the long-term effects of aerobic exercise on slowing Parkinson's disease progression. The CYCLE trial aims to determine if high-intensity aerobic exercise can slow disease advancement.
The study analyzed data from 16,089 average-risk colonoscopies performed by 56 providers, finding that endoscopist characteristics do not impact adenoma detection rate. However, lower sessile serrated polyp detection rates were associated with endoscopists performing lower volumes of colonoscopies and those further from their medical t...
A Cleveland Clinic-led study found that an absorbable antibiotic envelope can significantly reduce major infections in cardiac device implantations. The envelope was shown to cut the rate of infections by 40% compared to standard care.
Researchers develop a new assay to measure the eco-evolutionary interactions between sensitive and resistant tumor cells in non-small cell lung cancer. The study finds that by applying drug or eliminating fibroblasts, it is possible to 'treat the game', allowing for coopting of evolution to help patients
Researchers found a diet rich in red meat increases TMAO levels, linked to heart disease. A study also revealed the kidneys can change how effectively they expel compounds depending on dietary choices.
A Cleveland Clinic-led study found that rivaroxaban significantly reduced venous thromboembolism (VTE) and VTE-related death in outpatient, at-risk cancer patients. The medication effectively prevented blood clots during the treatment period, but risk persisted after treatment was discontinued.
Dr. Nazha presents results of a personalized prediction model that surpassed current prediction models for Myelodysplastic Syndromes (MDS), predicting patient mortality and transformation risk with high accuracy.
A Cleveland Clinic genetic analysis found that excess fat itself is harmful to cardiovascular health, increasing the odds of Type 2 diabetes by 67% and coronary artery disease by 20%. The study used genetic data from over 880,000 participants, suggesting a significant association between obesity and these conditions.
A study published by Cleveland Clinic found that increased cardiorespiratory fitness is directly associated with reduced long-term mortality. Elite performers showed a significant survival benefit, particularly in older patients and those with hypertension.
The Cleveland Clinic-led research aims to improve outcomes for ACL tears by developing a new surgical technique called Bridge-Enhanced ACL Repair (BEAR). The BEAR procedure has shown promising results in preclinical and early clinical studies, and the five-year grant will coordinate a multicenter trial to evaluate its effectiveness.
A phase 2 trial conducted by Cleveland Clinic shows that ibudilast decreased progression of brain atrophy in progressive MS patients by 48 percent versus placebo. The study also demonstrated the utility of advanced imaging in clinical trials to measure the impact of therapies on brain health.
Researchers developed a novel imaging biomarker to quantify coronary artery inflammation, capturing changes in perivascular fat on CT angiography. This biomarker is associated with increased rates of death from any cause and cardiac causes.
Researchers have discovered a novel subtype of multiple sclerosis, called myelocortical MS (MCMS), which features neuronal loss but no demyelination in the brain's white matter. This new subtype is indistinguishable from traditional MS on MRI and has reduced neuronal density and cortical thickness.
Researchers will develop a risk calculator using biomarkers and statistical modeling to predict blood clot formation in cancer patients. The goal is to identify patients at high risk and treat them proactively with blood thinners.
Researchers have developed a potential new class of non-antibiotic compounds that target specific gut microbes to reduce cardiovascular risk. These compounds prevent the production of TMAO, a gut byproduct linked to heart disease, without killing beneficial gut bacteria.
The Cleveland Clinic has been awarded a $2.8 million grant to evaluate disparities in survival among heart failure patients before and after heart transplantation. The research will create tools to optimize outcomes, including identifying risk factors and developing dynamic models to predict patient conditions.
A new multi-center study found that patients receiving leadless pacemakers experience overall fewer short-term and mid-term complications than those receiving traditional transvenous pacemakers. Leadless pacemakers completely eliminated lead and pocket complications, including infection.
Researchers at Cleveland Clinic found that a common prostate cancer drug, abiraterone, yields high levels of a testosterone-like byproduct in men with advanced disease who have a specific genetic variant. This byproduct may trick androgen receptors into turning on pro-cancer pathways.
The American Heart Association awards Cleveland Clinic a $3.7 million grant for atrial fibrillation research, focusing on preventing disease progression and developing personalized therapies. The team will study the relationships between genes, aging, and metabolism to find new treatments.
Researchers from Cleveland Clinic Cancer Center presented data on a prospective clinical trial examining non-small cell lung cancer cells' response to immunotherapy. The study showed promising results with progression-free survival, and early data gathered from more than 20 sites has shown encouraging outcomes.
Ibrutinib, a drug approved for lymphoma and leukemia, shows potential in treating glioblastoma by slowing tumor growth and extending survival rates. Combining ibrutinib with radiation therapy overcomes resistance and extends lifespan more effectively than either treatment alone.
A new blood test called IsoPSA has been shown to be more accurate in predicting overall risk of prostate cancer than standard PSA tests. The study found that nearly 40 percent of biopsies could have been avoided with the use of IsoPSA, potentially lowering overtreatment rates and reducing unnecessary procedures.
Cleveland Clinic researchers found that lowering cholesterol levels can activate anti-tumor pathways in T-cells, leading to improved cancer-killing success. By reducing intracellular cholesterol, the cells' anti-cancer properties were enhanced.
Researchers aim to identify genetic markers that can predict tumor response to radiation therapy, leading to more personalized treatment approaches. The goal is to improve treatment responses, reduce toxicity, and enhance quality of life for cancer survivors.
A substudy of the PRECISION trial found that adding aspirin to celecoxib reduced its cardiovascular safety advantage, while maintaining fewer GI problems and kidney issues compared to ibuprofen. Celecoxib remained associated with better overall outcomes in patients taking aspirin.
A team of researchers has developed a method to restore natural movement sensation in patients with prosthetic arms, enhancing control and independence. The breakthrough uses small robots to vibrate muscles, allowing patients to feel their missing limbs move and manipulate their prostheses with improved fine motor control.
Cleveland Clinic researchers developed a four-step protocol to improve STEMI patient outcomes, reducing mortality rates for both men and women. The protocol eliminated gender disparities in care and outcomes, with significant reductions in door-to-balloon times and complications.
Researchers identified a new survival pathway in cancer stem cells that fuels the growth and spread of triple-negative breast cancer. The study suggests targeting this pathway may lead to new treatments for women with this aggressive subtype of breast cancer.
Researchers confirmed a mechanistic link between HSD17B4 and treatment-resistant prostate cancer. The study found that men lacking a specific isoform of the gene are more susceptible to aggressive prostate cancer.
Researchers will examine patients' and family members' perspectives on personality changes before and after Parkinson's disease treatment. The study aims to develop personalized measures of personality and inform public discussions of identity and autonomy in the context of deep brain stimulation.
The Cleveland Clinic has been awarded a 5-year, $2.6 million grant from the National Cancer Institute to create innovative models of colorectal cancer. The project aims to better understand how the disease develops and spreads.
The Cleveland Clinic has developed updated guidelines for accelerated partial-breast irradiation (APBI), a technique that targets radiation to the tumor site only. The new guidelines recommend APBI for a broader range of patients, including younger individuals and those with ductal carcinoma in situ.
A new Cleveland Clinic study emphasizes the significance of prompt treatment in stage I melanoma, with patients treated within 30 days showing better survival rates. Delayed treatment beyond 90 days led to significantly worse outcomes, especially among older patients and those with comorbidities.
Researchers discovered a testosterone-related genetic variant that can predict individual patient responses to specific prostate cancer therapies. The studies suggest that men with this variant would benefit from personalized treatment plans targeting hormonal pathways.
A new study by Cleveland Clinic researchers has found a significant link between bacterial imbalances and breast cancer, with healthy breast tissue containing more of the bacterial species Methylobacterium. The study's findings could lead to new perspectives in the battle against breast cancer.
Researchers at Cleveland Clinic found that TRPV1 protein plays a critical role in airway disease through mucus production, cough reflex stimulation and airway narrowing. The study suggests that targeting this protein may lead to new strategies to reduce the impact of RSV infections in both asthmatic and non-asthmatic children.
Researchers aim to develop a new model incorporating environmental and neighborhood-level characteristics to better predict major cardiovascular disease. The project will include over 200,000 patients' electronic health records and neighborhood-level information.
The Cleveland Clinic research team will conduct the first head-to-head trial comparing two treatment approaches for relapsing-remitting MS. The study aims to determine which approach is better at slowing brain volume loss, is safer, and more effective.
A study by Cleveland Clinic researchers found that beta blockers can help treat pulmonary arterial hypertension, a debilitating lung disease. The treatment improved heart rate and efficiency, reducing the risk of right-sided heart failure.
A team of Cleveland Clinic researchers have discovered a key pathway that leads to recurrence and treatment resistance in endometrial cancer. High levels of CD55 cause cancer stem cells to be more aggressive and resistant to cisplatin than non-stem cell cancer cells.
Researchers analyzed years of life lost due to top causes of death in the US from 1995 to 2015, revealing disparities and successes. Life-years lost showed that cancer caused more life-years lost than heart disease, despite heart disease being the leading cause of death.
A Cleveland Clinic study found that price increases for nitroprusside and isoproterenol led to a significant decrease in their use between 2012 and 2015. The medications, used primarily in hospitals with no direct-to-consumer advertising, saw a 53% and 35% drop in patient treatment respectively.
A multicenter trial will assess the effectiveness of bariatric surgery compared to medical and lifestyle therapy for treating Type 2 diabetes. The study aims to identify clinical predictors of diabetes remission and relapse, with data collected from 302 patients over seven years.
Researchers identify JAK2-STAT3 cellular signaling pathway as key link between high-fat diet and tumor growth in the colon. The study provides insight into how diet influences cancer stem cell populations, potentially leading to new therapeutics.
Researchers discovered that blocking a specific intestinal microbial pathway can prevent obesity, insulin resistance, and promote active fat tissue. High levels of TMAO are linked to Type 2 diabetes and cardiovascular disease.
A comprehensive tool to predict individual outcomes in epilepsy surgery will be developed using diagnostic technology and predictive modeling. The project aims to improve patient counseling and benefit public health by providing an objective, validated, user-friendly risk calculator.