Long-term follow-up of BCG vaccine trial participants shows significant clinical benefits, including near-normal blood sugar levels, which persist for up to five years. The study reveals a novel metabolic mechanism that increases cellular glucose consumption, leading to improved insulin sensitivity.
Researchers developed a new data processing technique to monitor brain state using heart rate variability, revealing that yoga is more effective than Chi meditation in reducing stress. The study also found that long-term meditation practice can make permanent changes and improve executive control.
A regional climate model found that deforestation could lead to a slight annual cooling overall, but with big differences locally. Northern and eastern Europe cooled while western and central Europe warmed. Deforestation also increased summer temperature extremes.
Researchers found that combining antibiotics with synthetic peptides can significantly reduce the number of infecting bacteria and the size of abscesses in mouse models. The peptides disrupt the bacterial response to stressors like antibiotics, amplifying their uptake and increasing treatment efficacy.
Researchers created a synthetic DNA enzyme that outperforms naturally occurring enzymes by three orders of magnitude, flipping lipids in cell membranes and inducing cell death in cancer cells. The new enzyme is poised to be used for personalized therapeutics and treatments.
Fragment-based lead discovery (FBLD) increases the chances of finding hit compounds and delivers results without high-throughput screening investment. FBLD starts by identifying low molecular weight fragments that bind to protein targets, then grows them into potent drug candidates.
Researchers at Princeton University have found a way to make a naturally occurring enzyme take on a new role, enabling the catalysis of non-natural reactions. This breakthrough could lead to the development of new enzymatic reactions and potentially more cost-effective chemical catalysis.
A recent study published in the American Journal of Human Biology found that healthy gaming experiences are linked to favorable gene expression profiles. The research, led by Dr. Jeffrey Snodgrass, highlights the importance of social connectedness in mitigating negative effects of online gaming.
Researchers found that rats who chose alcohol showed similarities to human alcohol addiction diagnostic criteria, including continued use despite negative consequences. The study identified a gene expression change in the amygdala region of the brain as key to understanding this behavior.
Researchers at NYU School of Medicine discovered that mTORC1 regulates cell crowding, which can cause proteins to solidify and interfere with cellular functions. The study suggests that malfunctioning mTORC1 may contribute to the development of aging diseases.
Professor Maurizio Pellecchia has received $2.5 million in funding from the National Academy of Sciences and the National Institute of Neurological Disorders and Stroke to study the EphA3 receptor's role in cancer and ALS. His research aims to develop therapeutic agents that target this receptor, which is overexpressed in cancer cells.
Research suggests that standardized online and in-person courses are falling short and need improvement to optimize retention and mastery. The American Heart Association recommends adopting best practices in education, such as mastery learning, spaced practice, and feedback, to enhance CPR skills.
A team from Osaka University invents a pseudo-rotaxane with unidirectional movement, enabling the observation of simultaneous motion and chemical reactivity. This innovation demonstrates 'face-selective translation,' where α-cyclodextrin interacts with the molecular machine to catalyze a reaction.
Researchers discovered that mice can learn to plan ahead and avoid future regret by skipping bad deals and taking extra time to make informed decisions. Over time, the mice's strategies changed from immediately going for the best option to planning ahead to prevent regret.
Dr. Daniel J. Rader, a renowned expert in heart disease prevention and treatment, has received the 2018 Gotto Prize for his pioneering work on lipoprotein metabolism. His research has significantly impacted current strategies to prevent and treat cardiovascular disease.
Researchers have recovered ancient syphilis genomes from skeletal remains in Mexico, distinguishing between the subspecies that cause syphilis and yaws. The findings shed new light on the evolutionary history of syphilis, suggesting a complex history that challenges previous hypotheses.
A new study found that psychiatric disorders such as schizophrenia and bipolar disorder have similar genetic patterns, which may not be reflected in current diagnostic categories. The research suggests that a single mechanism regulating concentration could drive both ADHD and schizophrenia.
Two Phase I/II clinical studies, PROter and PROfind, evaluate the safety and efficacy of radiolabeled PSMA-R2 for prostate cancer treatment. The trials assess tumor activity and patient response to treatment.
A new assessment called Exam Roulette uses a game of chance to increase student preparation and motivation for essay tests. Students can preview potential questions, ask clarifying questions, but not receive specific content information, reducing anxiety and stress.
Researchers found that exposure to fracking chemicals and wastewater at diluted concentrations spurred fat cell development, with effects seen even when samples were diluted 1,000-fold. The study used laboratory models and observed significant increases in fat cell proliferation and lipid accumulation.
A new review suggests that vitamin D may play an integral part in the induction and regulation of critical immune tolerance in early pregnancy. Vitamin D deficiency has been linked to increased risk of recurrent pregnancy loss.
The new guidelines emphasize the importance of involving patients with diabetes in their care plans and provide guidance on how to implement effective self-management strategies. By empowering patients to take an active role in their treatment, these guidelines aim to improve safety and outcomes for hospitalized diabetes patients.
In water-limited landscapes, sick animals may have more contact with others due to lethargy, leading to faster pathogen transmission. The study suggests that understanding sickness behavior can help predict and control disease transmission in wildlife and domestic animals.
Researchers developed a portable keyboard using soft Ecoflex silicone rubber with conductive carbon nanotubes that can withstand bending and crumpling. The device is thin, flexible, and inexpensive, costing only $1, making it suitable for everyday life.
A University of Guelph study found residues of neonicotinoids in the livers of nearly 10% of wild turkey carcasses, suggesting that free-ranging animals are ingesting these insecticides. The researchers also discovered corn and soybean seeds coated with neonicotinoids in some birds' digestive systems.
A team of researchers from the Santa Fe Institute has published a paper on the thermodynamics of computation, which involves elements of statistical physics, computer science, cellular biology, and neurobiology. The study aims to understand how computers process information and reduce energy waste by optimizing computational processes.
Researchers at EPFL Sion found that adding specific functional groups, known as chemical caryatids, can enhance the mechanical stability of metal-organic frameworks (MOFs). This is crucial for MOF applications in carbon capture and water filtering.
A tumor suppressor protein called Arl11 has been found to play a crucial role in the functioning of the immune system, particularly in detecting and destroying pathogens. By initiating a signaling cascade, Arl11 helps macrophages to engulf bacteria and release signaling molecules that activate other immune cells.
Researchers developed a metric called the Facebook Gender Divide based on aggregate statistics from 1.5 billion users across 217 countries. The study found that countries with lower Facebook Gender Divide are rapidly approaching economic gender equality.
Researchers found that American swamp sparrows accurately learn their songs 98% of the time, with a conformist bias strategy that filters out new song types. This leads to stable cultural traditions that can rival human customs in stability and longevity.
Researchers have successfully measured participants' risk behavior while observing their brain activity using electroencephalography (EEG), revealing a key link between anxiety and decision-making. High anxious participants chose the low-risk option more often, and specific brain activity was associated with heightened cognitive control.
Researchers have developed a rhesus macaque model to study Zika brain pathology, revealing similar brain lesions as in human infants with congenital Zika syndrome. The findings suggest that therapies can be tested using fewer animals, providing hope for the development of new treatments.
Researchers at the University of Bonn found that coconut oil diet significantly increases vitality and lifespan of fruit flies with peroxisomal disorder. The diet dampened cell damage caused by lipase 3 activity.
A new study found that measuring ethyl sulphate in hair can assess alcohol consumption and detect a wider time frame of drinking behavior. Researchers successfully applied this method to patients with alcohol use disorders, highlighting the potential of hair as a non-invasive testing matrix.
Researchers have found that giving sodium thiosulphate after chemotherapy reduces hearing loss in children treated for hepatoblastoma, a childhood liver cancer, by nearly 50%. The treatment is a major step forward in minimizing long-term side effects and offers hope to families affected by the debilitating condition.
People with severe obesity report using various weight loss methods, but none prove more effective than maintaining lower caloric intake. Weight loss surgery is a proven method for reducing weight in the long term and lowering disease risk, but not suitable for everyone.
A study published in Academic Emergency Medicine found that most emergency department patients want some degree of involvement in decision making, but will wait for a clinician's invitation. The study recommends clear explanations and avoiding misdiagnosis of patient preferences based on verbal cues.
Researchers used super-resolution microscopy to study GLUT1 distribution on cell membranes, revealing clusters with an average diameter of ~250 nm. The transporter's clustering is linked to lipid rafts, actin cytoskeleton, and N-glycosylation.
A new study from the University of Washington found that consistent hours, regardless of time of day, can give families flexibility and in some cases, improve children's behavior. The study examined two-parent households with one parent working nonstandard shifts and found that rotating or split shifts were associated with more behavio...
A study by Philipp Maass and Anja Weise found that chromosomes 12 and 17 frequently interact with each other across different individuals, resulting in recurrent patterns. This interaction is linked to a human genetic condition, brachydactyly, where the deletion of a specific gene alters chromosomal arrangements and disturbs interactions.
Researchers discovered a naturally occurring enzyme called viperin that produces the molecule ddhCTP, which prevents viruses from copying their genetic material. The compound shows promising antiviral effects against flaviviruses, including Zika and West Nile viruses, but not picornaviruses.
New archaeological findings at Lund University confirm that Swedes produced malt for beer brewing during the Iron Age. The discovery was made in Uppåkra, southern Sweden, and dates back to the 400-600s.
A recent in-vivo study published in Nature Communications found that the nucleus accumbens, a part of the brain with weak connections, plays an unexpectedly influential role in enhancing the memory network. This research has implications for understanding diseases like Alzheimer's and brain cancer affecting cognitive functions.
Researchers created computer models to understand how wheat responds to heat stress, including timing, intensity, and duration. The models predict the impact of heat waves on wheat yields and grain size, providing valuable insights for farmers to mitigate losses.
Scientists have created gene-edited pigs that resist Porcine Reproductive and Respiratory Syndrome (PRRS) by removing a section of the CD163 receptor. The research shows that these pigs do not become infected with the virus, which causes significant economic losses in the pig industry.
Economists estimate that asylum seekers have a positive impact on the economy of host countries after becoming permanent residents. The study analyzed 30 years of data from 15 Western European countries and found that an increase in migration flows produces positive effects on GDP per capita, unemployment rate, and public finances.
Researchers developed a new blood test that uses Raman spectroscopy to estimate the age of victims and suspects. The test was able to distinguish between different age groups with high accuracy, making it a potentially useful addition to current forensic science techniques.
A team of researchers has identified a new family of enzymes that modify transfer RNAs in malignant melanoma, leading to addiction and resistance. Inhibiting these enzymes synergizes with targeted therapies to produce a strong anti-tumoral effect.
A blended course format that combines online content presentation with weekly interactive class meetings can improve academic achievement and reduce student withdrawal rates. Students who chose the blended format reported less end-of-semester anxiety compared to those studying solely online.
A new microscope system can image living tissue in real time and molecular detail, allowing for the study of concurrent processes within cells and tissue. This technology has the potential to track tumor progression and improve cancer diagnosis.
A study found that adults who survive nonfatal opioid overdoses are at high risk of dying from substance use-associated diseases, cancer, and circulatory system diseases. The study also revealed that women are more likely to die by suicide after surviving an overdose
Researchers discovered that trehalose increases cellular waste disposal and improves neurological symptoms in MPS IIIB mice. The study found that trehalose delayed retinal degeneration, vision loss, and improved lifespan by activating a master regulator of the lysosomal system.
Adults who survive opioid overdoses have exceptionally high risks of dying from respiratory diseases, viral hepatitis, and suicide. The study analyzed Medicaid records to find that survivors are substantially more likely to die of these causes than the general population.
Researchers at MIT's CSAIL have developed a system that allows people to control robots using brainwaves and hand gestures. The system uses EEG and EMG feedback to detect errors and correct robot mistakes on multi-choice problems, enabling more natural human-robot interactions.
University of Alberta researchers discovered 11 genes that play essential roles in cancer cell metastasis, enabling the blockage of over 99.5% of cancer metastasis in living cells. The study suggests potential therapeutic targets for preventing cancer spread.
A team of researchers has discovered the last reservoir of ordinary matter hiding in the universe, located in the space between galaxies. The finding is significant as it fills in the gap of about 30% of missing baryons predicted by theorists.
New fossil evidence suggests that ancient primates, including Teilhardina brandti, had specialized grooming claws as well as nails. This finding overturns the prevailing assumption that the earliest primates had nails on all their digits and provides crucial insights into their daily behavior and evolutionary story.
A study by a Danish-German research team reveals that modified RNA bases play a crucial role in controlling gene expression from DNA to functional RNA. The researchers used a newly developed technique to label newly made RNA with the m6A modification, demonstrating its impact on RNA maturation and splicing efficiency.
A new study found that 24 countries, including the USA and India, experienced a decline in democratic qualities between 2017 and 2023. Non-electoral aspects of democracy, such as media freedom and freedom of expression, are under increasing threat.
Scientists use AI-powered tool to track songbirds' arrival patterns in Alaska's North Slope, providing insights into their adaptation to hotter temperatures and more erratic weather. The study's findings suggest that birds may time their migrations to local conditions, including day length, rather than just temperature.