A study found that patients taking newer, targeted biologics for psoriasis have a decreased risk of serious infection compared to older medications. The researchers analyzed large insurance claims databases and found that certain biologics like apremilast, etanercept, and ustekinumab had a lower risk of infection.
Researchers mapped aluminum monoxide around a distant young star, clarifying details about our solar system's formation. The findings suggest that AlO gas rapidly condenses into solid grains, similar to calcium and aluminum-rich inclusions found in asteroids.
An expert panel recommends companies undergo third-party evaluations to certify probiotic quality and label accuracy. They suggest publicly available quality standards and methods to provide consumers with certainty about what's in their probiotic product.
A Kanazawa University study found Indonesian street vendors in Bandung are adapting to changing society by building networks, employing protection, and adopting new techniques. These efforts show that vendors can resist aggressive urbanization through subtle forms of resistance.
A study published in AJOB Neuroscience found that the general public views cognitive enhancers as acceptable in the workplace when positively framed and used by non-students and athletes. However, misuse continues to rise among adolescents and adults, with limited evidence supporting their cognitive benefits.
A study of over 4,500 participants found that those under 75 who closely followed the DASH diet had a significantly lower risk of developing heart failure. The research suggests that the DASH diet can reduce heart failure risk by almost half, making it a promising element in primary prevention.
Researchers found that tech-savvy people are more accepting of digital healthcare services, particularly when they have a strong belief in machine abilities and high levels of expertise. This suggests that designing interfaces to appeal to expert users can increase the adoption of automated healthcare providers.
A recent study from UT Southwestern Medical Center reveals that several species of bacteria can invade the bladder walls in postmenopausal women with urinary tract infections. The findings suggest that antibiotic treatment may not be effective due to high levels of bacterial resistance and a lack of targeted therapies.
Researchers at Princeton University developed a mouse model of hepatitis C by introducing human proteins that allow the virus entry to liver cells. The study found that small mutations in a liver cell protein significantly impact viral replication in mice and humans.
A study found that cancer screening rates decrease as the day goes on for patients seen later in the day. Decision fatigue and overwhelmed clinicians may contribute to this trend, leading to lower completion rates for screenings like mammograms and colonoscopies.
Scientists from the University of Würzburg and Harvard University successfully created quasi-particles called Majorana fermions in a two-dimensional system, paving the way for topological quantum computers. This breakthrough enables more powerful and efficient computing capabilities.
Researchers compared two cardiac resynchronization therapies in a pilot study, finding comparable rates of response between His bundle pacing and biventricular pacing. The study suggests that His bundle pacing may be a viable alternative for treating heart failure patients with electrical disturbances.
A trial remedy for racial disparities in early-stage lung and breast cancer treatment has shown nearly eliminating existing gaps. The intervention consisted of a real-time warning system, race-specific feedback, health equity training, and nurse navigators to reengage patients.
A team of researchers discovered polar skyrmions in an electric material, opening up a plethora of materials systems and physical phenomena to explore. The combination of polar skyrmions and electrical properties may allow for the development of novel devices with significant interest to the Army.
Researchers at University of Helsinki found that MDGI protein plays a key role in regulating lysosomal membrane stability. Inhibiting this protein causes glioblastoma cell death, particularly with antihistamine clemastine, which can cross the blood-brain barrier.
Researchers found that ghost forests supported a different group of bird species than the forests they replaced. Some bird species, like the northern bobwhite quail and woodpeckers, fared well with the changes in vegetation.
A study directly compares chondrogenic induction by hydrogels containing MSCs as either single cell suspensions or 100-500-cell micropellets. The results show that micropellet-encapsulated MSCs outperform single cells in cartilage regeneration, providing guidance for future cartilage engineering efforts.
Researchers at IST Austria identified PRC2 as a key protein regulating temporal maturation of stem cells, leading to correct neuron type production. Eliminating PRC2 activity resulted in incorrect neuronal cell type composition and reduced neuron numbers.
Researchers at SLU discovered a molecular pathway required for neuropathic pain and found blocking this signal can limit or stop pain. A new class of non-narcotic pain-killing therapies is being developed.
Researchers have uncovered details of microalgae's light-harvesting system, which is up to 95% efficient, using advanced mass spectrometry techniques. This breakthrough could lead to the development of more efficient organic solar panels, increasing energy efficiency and reducing environmental impact.
Using stem cells from six people, researchers recreated retinal cells in the lab and found a specific genetic variation that contributes to AMD. The study suggests that reducing VEGFA expression may be a key factor in the development of AMD.
A recent study found that targeting nitrogen oxides emitted by cars and power plants may increase harmful wintertime air pollution in the US West. Instead, limiting volatile organic compounds could be a more effective way to reduce particulate matter pollution.
A new minimally invasive procedure, endoscopic sleeve gastroplasty (ESG), has shown significant weight loss in a five-year study of over 200 obese patients. The procedure resulted in an average weight loss of up to 15-20% of total body weight, with less than 1% complications.
Scientists at the Francis Crick Institute and Imperial College London have identified novel compounds that target a different part of the malaria parasite's enzyme, evading the same resistance mechanism. This study aimed to prevent malaria treatment resistance by studying how it evolves during drug development.
A new tool connects environmental impact of shipping industry to geography, economics and policy choices. Policies such as carbon tax, maintenance regulations and compact urban development could save up to 4,000 lives per year by reducing warming contributions.
Researchers from UK and Malawi identify novel schistosome hybrids infecting children along Shire River Valley, with potential for abrupt genetic changes and increased disease transmission. A OneHealth approach is warranted to investigate inter-species combinations and zoonotic potential.
Researchers found that nitrogen-rich poop from penguins and seals creates biodiversity hotspots in Antarctica, supporting thriving communities of mosses and lichens. The extent of these hotspots is linked to the number of animals present, not climate or region dryness.
Research in southern Italy found that otters eat 12% of their prey items, including 28 species, with increased predation in Alpine regions during winter and spring. This suggests a previously underestimated threat to small amphibian populations.
Researchers have discovered a new moth family, Ustyurtiidae, in Eurasia, revealing the existence of previously unknown species. The newly described family is a sibling group of the false burnet moth family Urodidae, and its members are well adapted to hot desert conditions.
Researchers have identified 18 unique cell populations in RA joint tissue, including a fibroblast subset that produces pro-inflammatory cytokine interleukin-6. COX inhibitors like NSAIDs also alter these macrophages, but not TNF responses, suggesting new treatment approaches may be needed.
Researchers at Kobe University successfully grew precursors for human pigment cells, providing a stable supply of melanocytes for research on melanoma and other pigment cell-related illnesses. These precursor cells can be used to study the causes of albinism, freckles, and melanoma.
Researchers developed a new class of single-atom nanozymes with intrinsic enzyme-like active sites, overcoming conventional nanozyme drawbacks. The discovery provides a new perspective on catalytic mechanism and rational design of nanozymes.
A joint study reveals that plants utilize their root-derived chemicals to shape and maintain diverse microbial communities. The findings provide a gateway to engineering plant root microbiota in major crops, potentially leading to improved productivity and sustainability.
New trials suggest whole body MRI can diagnose cancer stage more quickly and accurately than standard imaging for colorectal and non-small cell lung cancers. This reduces treatment decision time from an average of 13 days to 8 days, while costs are lowered by nearly a quarter in some cases.
Researchers at NIST have developed a portable, stable standards-quality radiation thermometer capable of measuring temperatures to a precision of within a few thousandths of a degree Celsius. The instrument is suitable for applications such as clinical medicine, satellite measurement, and food processing.
Researchers at Temple University Health System found that the heart communicates with fat cells through a signaling enzyme, GRK2, regulating weight gain in patients with heart failure. The study's findings could lead to new ways to modulate weight gain.
Swiss and Belgian researchers decipher the genetic programmes of neurons in the cerebral cortex to understand how specific cell types are generated. They found temporal patterns of gene expression that control the developmental scenario, which may contribute to neurodevelopmental disorders.
A study published in ACS Central Science found that many DNA cage nanostructures are not taken up by cells, but rather degraded by enzymes outside the cell. The researchers' findings have significant implications for the use of DNA strands as a tool for delivering therapeutic agents into diseased cells.
A school-based survey study in Iceland found that bullied students were more likely to use pain medications, despite controlling for pain levels. The study suggests that interventions aimed at reducing bullying may help reduce analgesic use in adolescents.
A study at Boston Medical Center found that mothers of very low-birth-weight (VLBW) infants who expressed first milk within 8 hours had a higher probability of successful lactation. The research suggests prioritizing early milk expression to support long-term lactation success.
A novel imaging technique using scorpion venom-derived protein BLZ-100 has shown promise in detecting and removing brain tumors. The agent binds to tumor cells and glows under near-infrared laser stimulation, enhancing surgical visualization. Clinical trials demonstrate the imaging system's safety and effectiveness.
A Boston College researcher found that when paired with a selfish partner, it is better to behave altruistically rather than selfishly. When paired with an altruistic partner, it is better to behave selfishly to achieve a desired outcome.
Researchers successfully changed some of the composition of the gut microbiota of patients with obesity using fecal matter from a lean donor. The study found alterations in stool samples and decreased levels of a specific bile acid, suggesting potential new weight-loss therapy.
LaViers' paper presents a simplified counting model that compares the expressive capabilities of robots and natural beings, revealing trends in robotic capacity. The research shows that robots perform similarly to a microscopic worm, highlighting the need for improvement in mimicking nature in robotics.
Researchers have discovered that graphene flakes can selectively and reversibly affect specific neurons in the brain, offering a promising approach for treating conditions like epilepsy. The study's findings suggest that the particles' size is key to their selectivity, with effects observed only at specific synapse sites.
A 330-million-year-old fossil discovered in Scotland reveals a unique dental pattern and deep lower jaw, allowing it to pierce and grind crustaceans. The discovery challenges the understanding of early tetrapods' dental evolution, showing an unprecedented level of adaptation.
A 14-year investigation in Bangladesh found that older male patients and those with respiratory issues are at higher risk of transmitting the Nipah virus. The study analyzed 248 cases and identified key factors associated with transmission, recommending public health measures to prevent outbreaks.
Penn State researchers have discovered a way to control substrate defects to improve the quality of 2D materials, enabling wafer-scale growth. The new method uses hexagonal boron nitride as a surface to orient transition metal dichalcogenides in a preferred direction.
A recent survey of 5000 adults in England found that nearly one in five people experienced harm due to others' drinking, including physical violence and emotional neglect. The study also revealed that younger age, certain ethnicities, and hazardous drinking habits were associated with a higher risk of experiencing harm.
Researchers argue that Spain's current regulations on light pollution are inadequate and propose a change in approach to minimize the problem. Using white light instead of yellow light can provide significant energy savings while maintaining user safety, with potential benefits for environmental and economic aspects as well.
A new study led by the University of Birmingham found that athletes are more likely to dope if they can justify their actions morally. Athletes with strong moral identities were less likely to cheat, while coaches' behavior and performance climate also played a significant role. The research aims to develop anti-doping interventions fo...
A new study finds that routine sickle cell disease screening among migrants can help prevent severe complications and death. Researchers estimate that up to 80% of newborns with SCD are born in sub-Saharan countries, where the condition is highly prevalent.
A study of gay and bisexual men in Melbourne found that kissing, with or without sex, was associated with a higher risk of throat gonorrhoea. The researchers suggest that this may be an important route of transmission, potentially leading to new preventive options.
Researchers discovered that low levels of syntaphilin at the central core of prostate tumors correlate with increased risk of metastasis. The biomarker may identify patients who require more aggressive management and treatment.
A new study found a significant association between digital media use and depression among Chinese adolescents. The research suggests that excessive screen time, particularly online activities, is a major risk factor for depression, while spending more time on non-screen activities can reduce symptoms.
A new computational framework has compared four rheumatoid arthritis medications' impact on biological pathways in mice, revealing previously unknown differences in gene expression. The study suggests that some treatments may affect non-arthritis-related genes, providing new insights into arthritis pathology mechanisms.
Researchers found that deep-sea fish have expanded rhodopsin genes to detect bioluminescent signals, giving them an evolutionary advantage. The silver spinyfin has the most photopigment genes of any vertebrate, allowing it to detect specific wavelengths of light produced by bioluminescent organisms.
A computer simulation found that health care facilities using a patient registry could reduce CRE spread by 15.5% over three years, even with modest participation rates. The study suggests that maintaining a registry can help contain the enemy of antibiotic-resistant bacteria.
Researchers found that using high UVA protection factor sunscreen allows for better vitamin D synthesis due to increased UVB transmission. Despite concerns, optimal sunscreen use does not harm vitamin D production, according to a new study published in the British Journal of Dermatology.
Research from Göttingen reveals that wild red deer grazing in open landscapes can contribute to the conservation of protected habitats. The proportion of plant growth eaten by wild red deer is comparable to extensive grazing by farm livestock.