Researchers at MUSC are developing a gene-modifying treatment for sickle cell disease by targeting the LSD 1 enzyme. The potential breakthrough could lead to a disease-modifying treatment and fast-track human clinical trials in as few as three years.
The 2017 Kessler Foundation National Employment and Disability Survey: Supervisor Perspectives shows that most employers have processes and practices in place for the inclusion of employees with and without disabilities. Effective practices like centralized accommodation funds are highly effective, but underutilized by many organizations.
International experts have identified a new protein called ZATT that can directly clean DNA breaks without degradation, allowing for more efficient repair and potentially increasing chemotherapy sensitivity. This breakthrough has the potential to improve treatment outcomes and enable personalized therapies.
Researchers found that users struggle to use drone images to locate objects on the ground, posing challenges for emergency operations and applications. Switching from an aerial view to a ground view slows down estimates of object location, with incorrect placements four times farther away.
The proteasome complex has been found to regulate DNA packing in the nucleus, influencing gene expression. In yeast cells, the proteasome can induce heterochromatin formation but prevent its spread, suggesting an alternative mechanism of action beyond proteolysis.
Scientists have discovered that weak binding between antibodies and biological gels like mucus is more effective in trapping pathogens, making it a stronger first line of defense. This finding has the potential to revolutionize the treatment and prevention of various diseases by providing new targets for engineered antibodies.
TBA-7371 and sutezolid have entered phase 1 clinical trials after early preclinical development. These novel drugs show promise in treating TB with no pre-existing resistance, addressing a growing concern in the disease's increasing resistance to older treatments.
Web-based treatments have been found to significantly increase employment rates among individuals with severe mental illness. The studies show that participants worked for three times the number of hours and earned almost $2000 more than the control group.
Researchers at Michigan State University have identified the PNLDC1 gene as a key player in regulating sperm production, providing a genetic foundation for male birth control. The study's findings suggest that silencing this gene can lead to infertility in mice, making it a promising approach for human male contraception.
A new species of ichthyosaur, Protoichthyosaurus applebyi, has been identified from a fossil at the University of Nottingham. The specimen is significant due to its rarity and uniqueness, providing valuable insights into Britain's early fossil past and ichthyosaur evolution.
A new study reveals how rabies induces frenzied behavior in animals by binding to and inhibiting brain receptors, leading to the transmission of the disease. The research provides a molecular mechanism for this behavior change, shedding light on why rabies is devastating in poor, rural regions.
PharmaMar's Phase I/II trial combining PM1183 with doxorubicin shows a progression-free survival of 5.3 months, surpassing historical data for topotecan. The study also reveals manageable adverse events with no mucositis or neuropathy, paving the way for the pivotal Phase III Atlantis trial.
Researchers at MPFI discovered significant regional differences among chandelier cells in the hippocampus and neocortex. Chandelier cells exhibit distinct characteristics, including expanded axonal arbors, increased connections, and differential gene expression.
A study published in PLOS Medicine found that law enforcement-related deaths in the US are significantly undercounted in official government data. The study used capture-recapture analysis and multilevel logistic regression to estimate the number of such deaths, finding that only 44.9% were documented by state death certificates compar...
Sandia scientists develop a system to convert surplus solar flux into additional electricity at tower CSP plants, increasing capacity by up to 10 MW and reducing costs. The concept involves cladding the tower with photovoltaic panels, generating over 10% of total capacity.
The global prevalence of child and adolescent obesity has increased significantly over the past four decades, from 0.7% to 5.6% for girls and 0.9% to 7.8% for boys. Despite this rise, more children remain moderately or severely underweight than obese globally, highlighting the need to improve food security.
Researchers at FAU successfully developed a new technique to generate an optical field that can be influenced with great precision, enabling light and electrons to coincide within 'attoseconds'. This allows for high-energy acceleration of electrons, promising applications in materials science, biology, and medicine.
A study by Queensland University of Technology found that 50% of drivers tailgate, with most leaving less than a two-second gap between vehicles. The researchers identified confusion among drivers over what is deemed a safe following distance, which can lead to rear-end crashes.
A study published by the American Psychological Association found that listening without visual cues improves emotion recognition. Researchers conducted five experiments with over 1,800 participants and discovered that voice-only communication yields more accurate results than combined visual and auditory cues.
A new study has re-examined a 1970s-discovered ichthyosaur, Protoichthyosaurus, and found major differences in its forefin structure compared to Ichthyosaurus. The discovery of fake fins added to some specimens led to the recognition of a new species, Protoichthyosaurus applebyi.
Researchers at Rockefeller University have developed new smell tests that can detect olfactory disorders more reliably than conventional options. The tests aim to identify underlying causes of neurological disorders like Alzheimer's and Parkinson's diseases early on, potentially improving treatment outcomes.
A team of researchers at KAUST discovered the origin of strong photoluminescence in Cs4PbBr6, a perovskite material. Heating the crystal to 180°C irreversibly destroys its photoluminescence, but creates CsPbBr3 nanocrystals that act as traps for excitons, leading to efficient re-emission of light.
Scientists at the U.S. Army Research Laboratory have discovered poly(urethane urea) elastomers that exhibit hyperelastic behavior, becoming extremely stiff and bouncing back after high-speed impacts. This could lead to new designs for military armor, such as enhanced combat helmets.
A team of researchers from Sydney's Westmead Institute for Medical Research has discovered a new drug target, Arg1, to combat life-threatening fungal infections. The protein enables Cryptococcus neoformans fungus to establish fatal infections in patients with weakened immune systems.
Researchers have developed a new, simplified technique to produce homogeneous human brain cells in the lab, accelerating drug screening and disease study. This breakthrough allows for cost-effective production of large quantities of brain cells within weeks, enabling wider adoption in basic science and industry.
Patients with bipolar disorder who received bright light therapy at midday experienced a higher remission rate of 68% compared to 22.2% on placebo, with significant reductions in depression scores and improvements in daily functioning.
Researchers aim to reduce comorbid illness in people living with HIV by developing personalized prebiotic and probiotic therapies, targeting gut bacteria balance. The study seeks to attenuate metabolic health issues associated with harmful alcohol use and heart disease.
A recent study published in Geoderma suggests that high-intensity forest land use like grazing can counteract the positive effect of tree planting on reducing flood risk. Researchers found that infiltration rates were higher under trees when the forest was undisturbed, but decreased when sheep grazed underneath
Researchers discovered that stomach acid suppression alters specific gut bacteria in a way that promotes liver injury and progression of three types of chronic liver disease. This association was found in both mouse models and human patients with chronic alcohol abuse, highlighting the potential risks of common acid reflux medications.
A new NIH-funded study finds that biomarkers for ovarian reserve do not predict fertility in older women attempting to conceive. Hormone levels linked to menopause onset were also found to have no association with conception rates.
A randomized controlled trial found ibuprofen to be a better choice for postoperative pain relief in children aged 5-17 after minor orthopedic surgery. The study showed that ibuprofen had fewer adverse effects compared to oral morphine, which was associated with significant side effects such as nausea and drowsiness.
Researchers are exploring the role of microRNAs in brain structure changes associated with neuropsychiatric disorders. The study aims to identify biomarkers in blood and cerebrospinal fluid that correlate with brain variations.
Researchers analyzed how water molecules interact with one another in three types of ice, finding that interactions depend strongly on molecule orientation and ice structure. Insights from this analysis will help understand liquid water and its behavior surrounding biomolecules.
Researchers developed a growth-accommodating implant that can expand in tune with a child's natural growth, decreasing the number of heart surgeries a child must endure. The novel design, inspired by nature, could also be adapted for other growth-accommodating implants throughout the body.
A multi-disciplinary team developed flexible sensors that can sense movement and ingestion in the stomach for at least two days. These devices can harvest energy from the gastrointestinal tract movement and potentially power novel ingestible electronic systems.
A study of 220 Australian children found that a maternal immune-mediated subtype of autism is linked to poorer social outcomes. The researchers identified associations between maternal allergies or asthma and increased severity of social symptoms in children with ASD.
Researchers at NASA and Binghamton University developed a new material, boron nitride nanotubes (BNNTs), which can withstand extreme temperatures and stresses, paving the way for faster planes. The study found BNNTs could handle high amounts of stress and were extremely lightweight.
A new study found that state laws mandating autism coverage by private insurers resulted in a large jump in spending on care for children with autism. Children in states with mandates were more likely to receive treatment, with increased spending on outpatient services and a significant impact on their lives.
Researchers found that neratinib can block the function of Ras oncogenes through an unexpected process, killing non-small cell lung cancer cells resistant to afatinib. The study also discovered that neratinib triggers a seismic event in the plasma membrane, rapidly reducing expression of mutated K- and N-Ras genes.
Andrea Deaton, University of Oklahoma administrator, has been designated as a Society of Research Administrators International Distinguished Faculty. She is recognized for her exemplary teaching, scholarship, and practice in research management and administration.
A global assessment reveals that genetically engineered crops producing insect-killing proteins from Bacillus thuringiensis have led to a fivefold increase in pest resistance cases over the past decade. However, some pests remain suppressed due to factors such as recessive inheritance of resistance and abundant refuges.
Scientists have discovered that the moon's mantle is composed of orthopyroxene, not olivine, contrary to previous assumptions. This finding challenges models for the formation and evolution of the Moon and its differences from Earth.
High levels of inflammation in the brain can reduce neurogenesis and increase cell death, potentially increasing depression risk. Researchers found that a protein called interferon-alpha accelerates these processes.
Scientists at ETH Zurich have developed a method to monitor lipolysis in real-time by analyzing exhaled acetone during exercise. The new breath test can detect when the body starts burning fat, allowing athletes to optimize their training regimen.
A study published in JAMA found that insulin pump therapy among young patients with type 1 diabetes was associated with lower rates of severe hypoglycemia and diabetic ketoacidosis compared to traditional injections. This innovative treatment approach offers improved clinical outcomes for this vulnerable population.
A three-year trial will examine a new transplantation approach to cure patients with sickle cell disease using a matched related donor. The goal is to find a well-tolerated and safe cure for children with the disease.
A recent study by the University of Bristol found that India's methane emissions have shown little growth over the last few years, with accurate reporting by the country's authorities. The research used a combination of observations from the surface, an aircraft, and a satellite to quantify India's methane emissions.
A recent study published in Scientific Reports found that male scientists are more likely to share their research than female scientists. The researchers discovered a significant gender gap in scientific collaboration, with males being over 15% more likely to respond positively to requests for shared work.
The University of Illinois Chicago has established a Center of Excellence in minority health and health disparities research, funded by a $6.75 million NIH grant. The center will investigate social determinants contributing to health disparities in marginalized groups.
Researchers at the University of Edinburgh have made a significant discovery on how a harmful parasite harnesses energy, which could lead to new treatments. The study reveals that targeting a key enzyme linked to metabolism could be an effective way to kill the parasite without harming humans.
A study found that Quebec's system increased access to medicines for working population but came at a cost of $200 more per person than the rest of Canada. The private-public model disproportionately affects low-income individuals and families, with premiums exceeding three percent of household income.
Researchers have discovered that quinoa plants can absorb and store salt in bladder cells, allowing them to thrive on saline soils. This unique adaptation enables the plant to recycle energy from sugar molecules to neutralize toxic salt.
Global childhood obesity rates have increased ten-fold over four decades, with 12-16 million overweight youth in Europe. Early intervention and comprehensive policies are crucial to address this complex disease, which has strong associations with adult mortality and morbidity.
Scientists studying cone snail venom aim to develop new medicines by understanding how the poison works. Researchers have discovered that cone snail toxins can overlap between the immune and central nervous systems in humans, potentially leading to breakthroughs in treatments for neurological diseases like Alzheimer's.
The University of Illinois Chicago is conducting a $3 million study on inflammation's role in polycystic ovary syndrome (PCOS), which affects one in seven women. The research aims to test whether nonsteroidal anti-inflammatory drug salsalate can improve ovarian function and reduce inflammation.
A University of Houston psychologist explores how social media influences alcohol consumption among college students, finding that heavy drinkers overestimate others' drinking and misperceive what's normal. A new intervention uses social media to provide personalized feedback and reduce excessive drinking.
Atrial fibrillation patients can use My AF app to access condition information, treatment options, and lifestyle tips. The app also enables face-to-face consultations with healthcare professionals. Meanwhile, AF Manager app helps healthcare providers import patient data, suggest personalized treatment plans, and share notes with patients.
A new study by Imperial College London and the World Health Organization found that childhood and adolescent obesity rates increased tenfold over four decades, from less than 1% in 1975 to nearly 6% in girls and 8% in boys in 2016. The number of obese children and adolescents is expected to surpass those who are underweight by 2022. He...
A large-scale study found that patients who receive antibiotics before certain types of low-risk operations have the same risk for developing antibiotic-resistant infections as those who don't. The study analyzed data from over 22,000 patients and found no association between prophylactic antibiotic use and postoperative antibiotic res...
Researchers found that ceritinib, an FDA-approved drug for ALK-rearranged non-small cell lung cancer, also inhibits previously unknown targets. The study shows promise for repurposing the drug to target other cancers with networked alterations.