A study published in Cell Chemical Biology highlights the need for new treatment approaches for treatment-resistant prostate cancer. Researchers found that effective steroidal anti-androgens share common metabolic activities, suggesting a potential strategy to improve efficacy.
Researchers at Cleveland Clinic conducted the first randomized controlled trial of DBS for neuropathic pain, targeting brain structures related to emotion and behavior. The study showed significant improvements in indices of depression, anxiety, and quality of life, suggesting a potential shift away from analgesia-based treatments.
The new Dementia with Lewy Bodies Consortium will centralize research efforts and create a national, coordinated registry for clinical data. Researchers aim to find DLB biomarkers to improve diagnosis and treatment of patients with this disease.
A new study by Cleveland Clinic researchers found that delays in initiating cancer therapy are associated with a substantially increased risk of death. Patients who wait more than six weeks for treatment have significantly worse survival rates, with some cancers experiencing declines of up to 40% in five-year survival rates.
A new study published in the New England Journal of Medicine shows that angiotensin II can safely improve blood pressure among critically ill patients experiencing life-threatening hypotension. Nearly 70% of patients treated with angiotensin II saw improved blood pressure, compared to 23% of those receiving a placebo.
Researchers have developed a new blood test called IsoPSA that detects prostate cancer more accurately than current tests. The study found that IsoPSA can distinguish cancer from benign conditions and identify patients with high-risk disease, potentially reducing the need for unnecessary biopsies.
A Cleveland Clinic survey found that individuals with healthier lifestyles, including regular exercise and a balanced diet, were less likely to have a personal history of colorectal cancer or colon polyps. However, less than 10% of respondents met daily fruit and vegetable intake recommendations.
A new study published in Inflammatory Bowel Diseases shows endoscopic needle knife therapy to be safe and effective for treating intestinal strictures in IBD patients. The procedure, pioneered by Cleveland Clinic doctors, offers advantages over traditional treatments like surgery and balloon dilation.
Researchers have proven that understanding and predicting tumor resistance can lead to additional treatment options in the clinical setting. By studying non-small cell lung cancer cells, the team found that some drugs are more susceptible to other drugs, even when resistant to a single drug.
Cleveland Clinic researchers found that dietary choline and TMAO levels are associated with increased blood clotting risk. Adding a low dose of aspirin may help mitigate this risk.
Researchers found obesity resulted in 47% more life-years lost than tobacco, with diabetes causing similar loss. The study highlights the importance of treating modifiable behavioral risk factors to prevent premature death.
Researchers aim to reduce body fat, improve glucose and lipid metabolism in overweight women planning pregnancy with the Lifestyle Intervention in Preparation for Pregnancy (LIPP) program. The goal is to prevent childhood obesity and related health issues in women and their children.
A new study by Cleveland Clinic researchers found that the rarely studied gene USF3 is associated with an increased risk of developing differentiated thyroid cancer. The team discovered a compound heterozygous deletion in USF3 linked to the disease, which may lead to a potential therapeutic strategy by removing glutamine.
A Cleveland Clinic study found that a whole grain diet significantly lowers the risk of cardiovascular disease in overweight and obese adults under 50. Participants saw a three-fold improvement in diastolic blood pressure, reducing heart disease risk by nearly one-third.
Researchers Jaroslaw Maciejewski and Richard Padgett will investigate the role of spliceosomal factor mutations and deletions in myelodysplastic syndromes. The study aims to clarify the pathogenesis of these diseases by identifying their effects on mRNA splicing.
The IsoPSA test detects prostate cancer by identifying molecular changes in the prostate specific antigen (PSA) protein. It also differentiates between high-risk and low-risk disease, as well as benign conditions.
Glycemic control and weight loss achieved through bariatric surgery persist for up to five years, with significant advantages over a medical therapy-only approach. The study found that gastric bypass and sleeve gastrectomy patients maintained healthy blood glucose levels without insulin use, while also experiencing greater weight loss.
A new study found that two common treatments for post-operative atrial fibrillation, rhythm control and rate control, are equally safe and effective. The study, conducted by the Cardiothoracic Surgical Trials Network, showed that both strategies were associated with low rates of complications and no difference in hospital days.
A new study by the Cleveland Clinic has identified statin intolerance objectively, showing that evolocumab is a more effective option for lowering cholesterol in patients who are intolerant to multiple statins. The PCSK9 inhibitor reduced cholesterol levels by 52.8%, while ezetimibe had a smaller reduction of 16.7%.
A phase 3 clinical trial showed evacetrapib reduced LDL cholesterol by 37% and HDL cholesterol by 130%, but failed to lower rates of major cardiovascular events. Researchers attribute the lack of benefits to the drug's inability to translate improved cholesterol levels into clinical outcomes.
Research reveals gut microbes produce compound TMAO, which encourages over-reactive platelet function, increasing thrombosis risk. Higher TMAO levels linked to heart attacks and strokes in humans.
Researchers discovered a significant link between pregnancy and higher risk of melanoma, including increased death rates, metastasis, and recurrence.
Researchers have identified a naturally occurring inhibitor that reduces TMAO levels and prevents atherosclerosis in mice, suggesting a potential new therapeutic approach for preventing heart disease and other metabolic diseases linked to gut microbes.
A study published in the American Journal of Transplantation shows that new policies could increase pediatric lung transplants by twice as much. The research team tested alternative allocation models to improve pediatric access to donor lungs and found two models resulted in significantly more transplants for pediatric patients.
Researchers have identified a new cancer-predisposing gene, SEC23B, associated with thyroid cancer and Cowden syndrome. This gene is involved in protein transport within cells and has been found to promote aggressive growth of thyroid cells.
Researchers at Cleveland Clinic have discovered a metabolite of the FDA-approved drug abiraterone that shows more anti-cancer properties than its precursor. The new compound, D4A, has been found to be more effective at killing aggressive prostate cancer cells, suggesting potential benefits for patients with metastatic prostate cancer.
Researchers found that TAVR improves survival rates and quality of life for elderly patients with severe aortic stenosis. The study compared five-year outcomes of TAVR with standard therapy, showing significant benefits in the TAVR group.
Women treated with goserelin during chemotherapy experienced an 8% ovarian failure rate compared to 22% for the control group. Goserelin also improved pregnancy rates by 21% within 5 years post-treatment.
A recent study by Cleveland Clinic found that a plant-based vegan diet can significantly improve cardiovascular risks in obese children, including lower BMI, blood pressure, and cholesterol levels. The study suggests that such diets may be more effective than the American Heart Association diet in reducing heart disease risk.
A research team led by Cleveland Clinic's Paul Marasco aims to develop a suite of outcome metrics for advanced prosthetic limbs, which could change the way these technologies are evaluated. The team plans to use bi-directional integrated systems and functional metrics to improve prosthetic devices.
Researchers at Cleveland Clinic have linked trimethylamine N-oxide (TMAO) to chronic kidney disease, finding higher levels in patients with the condition associated with greater mortality risk. Elevated TMAO levels are also linked to cardiovascular disease and kidney disease progression.
The Cleveland Clinic has received a $1 million grant to advance the treatment of lethal prostate cancer by identifying genetic biomarkers. The research aims to detect treatment-resistant prostate cancer at an early stage, improving treatment outcomes for patients.
A clinical study found that high levels of TMAO, a chemical byproduct of intestinal bacteria digestion, are linked to an increased risk of heart failure and poor long-term prognosis. Patients with low TMAO levels had a lower mortality rate despite advanced heart failure symptoms.
Researchers at Cleveland Clinic found that the immune system's response to protein S100B may contribute to memory impairment and cognitive dysfunction associated with conditions like chronic epilepsy and Alzheimer's disease. The study suggests that treatments targeting this autoimmune response could help alleviate symptoms.
A new study reveals that microglia can increase neuronal firing and enhance brain cell survival after traumatic brain injury, potentially slowing the progression of neurodegenerative diseases. The research found that activated microglia dislodge inhibitory synapses, leading to increased firing and enhanced survival.
A new protein variant called VEGF-Ax discovered by Cleveland Clinic researchers slows the development of new blood vessels necessary for tumors to expand and metastasize. This discovery could lead to new diagnostic tools and improved treatments to reduce cancer spread, according to Dr. Paul Fox.
Bariatric surgery patients report better quality of life, reduced need for cardiovascular medications, and improved blood sugar control without insulin or most diabetic medications. The STAMPEDE trial shows gastric bypass surgery is more effective than medical therapy in treating type 2 diabetes in obese patients.
Researchers from Cleveland Clinic and six other institutions present findings on surgical reconstruction of anterior cruciate ligaments. They found that using auto-graft tissue resulted in lower failure rates for high school, college, and competitive athletes. The study aimed to improve ACLR outcomes and highlight changes in practice.
Researchers at Cleveland Clinic have discovered a process by which high-density lipoprotein (HDL) loses its cardio-protective properties and promotes inflammation. The study identified the structure of dysfunctional apoA1/HDL and found that higher levels raise cardiovascular disease risk in patients.
Researchers at Cleveland Clinic have identified a critical role for the Neuroligin-1 protein in Alzheimer's-related memory loss, disrupting synaptic networks and leading to memory decline. The discovery may provide new approaches for preventing and treating Alzheimer's disease.
A new tool called CRC-PRO predicts an individual's risk of colorectal cancer, providing a more accurate estimate than current guidelines. The calculator includes gender, race, and family history as calculable risk factors, enabling physicians to identify high-risk patients for earlier screenings.
Researchers will investigate racial and ethnic differences in IRDS-positive tumors prevalent in African-Americans to improve outcomes for patients with treatment-resistant prostate cancer. The study aims to identify new management and treatment options for this aggressive disease.
Two Cleveland Clinic researchers, Dr. Richard A. Padgett and Dr. Edward F. Plow, have been named AAAS Fellows for their distinguished contributions to the field of RNA processing and vascular biology. Their research aims to understand how errors in RNA splicing lead to disease, such as cancer, and develop new treatments.
A trial testing varespladib to reduce cardiovascular events showed the drug actually increased the risk of heart attacks and other events. Researchers found that patients treated with varespladib were more likely to experience sudden death, heart attacks, strokes, and unstable angina than those on placebo.
A new study by Cleveland Clinic found that bariatric surgery significantly improves and reverses Type 2 diabetes in obese patients. Long-term weight loss and gastric bypass surgery are key predictors of sustained remission, with nearly one-third of patients achieving normal blood glucose levels off medication.
A 15-year study at Cleveland Clinic found that 72.5% of previously statin-intolerant patients could take statins on subsequent trials. Even those who couldn't tolerate daily dosing benefited from taking the drug less often.
The AQUARIUS trial found that Aliskiren reduced major cardiovascular events and slowed atherosclerosis progression in patients with prehypertension. The study suggests these patients may benefit from more aggressive treatment of their blood pressure to reduce risk of death, stroke, and heart attack.
A recent trial by Cleveland Clinic found that the drug RVX-208 failed to improve coronary health in patients with low HDL cholesterol, contradicting previous hopes for an 'HDL-raising' treatment. The study used intravascular ultrasonography to assess plaque buildup and found no significant difference between RVX-208 and placebo.
A genetic mutation in the androgen-synthesizing enzyme 3βHSD1 enables tumors to produce their own supply of androgens, leading to the growth of castration-resistant prostate cancer. This discovery could lead to the development of biomarkers and targeted therapies for personalized medicine.
A retrospective study from Cleveland Clinic found that patients who underwent stenting of the carotid artery followed by open heart surgery had the best outcomes. The researchers compared three common treatment approaches and found that this combination had significantly lower risks of serious events after one year.