Researchers at Scripps Research Institute identify structural changes in estrogen receptor binding molecules linked to regulating cancer growth. The study reveals predictive features of ligand-specific signaling through the receptor, moving closer to developing more effective treatments for breast cancer.
A recent study published in Science reveals that patent trolls are suing firms regardless of actual patent infringement, leading to a negative impact on research and development investment. The authors propose advance review procedures to screen out trolling and encourage legitimate infringement claims.
Researchers discovered that fungal spores can infect human immune cells, allowing them to transport themselves and cause systemic infections. The discovery sheds light on the ecological adaptation of Aspergillus terreus and its potential for detrimental effects in human infections.
Researchers found that snails choose seedlings based on dislike for naturally-omitted scents rather than taste. This discovery suggests harnessing these chemicals could provide an eco-friendly solution to protect crop seedlings from pests.
Researchers from SMU's Lyle School of Engineering are developing a computer-generated image of an object hidden from sight to create a hologram. The goal is to enable soldiers to 'see' around corners and behind walls, improving their situational awareness.
Researchers discovered TJP1's role in identifying patients most likely to benefit from proteasome inhibitors, with low TJP1 levels associated with resistance. The study provides a rationale for using TJP1 as a biomarker for personalized treatment approaches.
Research at University of Oxford found that individuals with more friends have a higher pain tolerance due to increased endorphin release, which promotes social bonding and pleasure. Additionally, the study discovered correlations between fitter people, those with higher stress levels, and smaller social networks.
A new assessment tool has been developed to gauge the risk of patients with mental illnesses committing crimes, improving upon the current evaluation system. The tool aims to strike a balance between patient rights and freedoms and public safety, facilitating quicker evaluations and hospitalizations for high-risk patients.
A recent study on Sci-Hub usage reveals that the site's millions of users are scattered across the globe, with significant activity detected in China, India, and Iran. The study also highlights the unintended consequences of Sci-Hub's illegal paper acquisition methods, including the impact on libraries and scientific communities.
A new study reveals that reptiles, like mammals and birds, experience REM and slow-wave sleep patterns. This discovery suggests a common ancestor for these sleep states, evolving over 300 million years ago in amniotes.
A team of scientists has linked a record-breaking neutrino detected by IceCube to an explosion in the galaxy PKS B1424-418, which was observed in 2012. The researchers calculated a 5-percent probability that the two events were unrelated.
A new study reveals that tropical ecosystems like the Amazon may be more sensitive to climate change than previously thought. The research found that the Amazon can experience large shifts in its carbon balance in response to extreme heat and drought, with these changes occurring surprisingly quickly.
Researchers have identified nine chemical compounds that can transform human fibroblasts into cardiomyocyte-like cells, which can then be used to partially heal damaged hearts. This breakthrough could lead to new avenues for cardiac regenerative therapies.
Scientists have discovered REM and slow-wave sleep in bearded dragons, a finding that suggests brain sleep dates back at least to the evolution of amniotes. The study's authors believe that this common origin is more plausible than convergent evolution, given the early branching out of reptiles.
Researchers modified an obesity drug to block brain penetration, reducing psychiatric side effects. The new version of the drug can work on cannabinoid receptors outside the brain.
A large-scale study has found that lifestyle factors significantly impact the diversity of intestinal bacteria, with a diverse microbiome associated with better health outcomes. The study analyzed DNA from over 1,100 participants and identified 60 dietary factors that influence gut bacteria diversity.
Researchers at Penn State have developed a nanowire array that can cool about 5.5 degrees Fahrenheit using 36 volts, an electric field level safe for humans. The material is flexible, can be powered by a 500g battery pack for two hours, and could potentially be incorporated into firefighting gear or athletic uniforms.
A study by Fatima Maia and her team found that modifying household utensils can increase autonomy and self-esteem among patients with leprosy. Patients reported feeling joyful using modified tools like toothbrushes, pens, and mugs, while also experiencing frustration with remaining limitations.
Researchers recommend increased subsidies and public funding to help Taiwanese solar producers develop advanced technology and compete globally. The study highlights the need for policymakers to encourage collaboration between academics and industry experts to drive innovation.
A new study has identified a long non-coding RNA that plays a crucial role in the repair of DNA breaks in triple-negative breast cancer cells. The research found that blocking this RNA significantly increases sensitivity to radiation therapy, providing new insight into the biology of this tough-to-treat breast cancer subtype.
A Dartmouth study reveals that surface meltwater and subglacial discharge are driving the loss of ice mass in Greenland's coastal glaciers. The findings show that meltwater can exploit weaknesses in glaciers, fracturing and weakening them, and also increase calving and melting.
A new study finds HPV vaccination is expected to reduce cancer burden across all racial/ethnic groups, with some disparities persisting despite high vaccine uptake. The study suggests that efforts to improve vaccine uptake must be accompanied by efforts to address access issues for screening and timely diagnoses.
A new study suggests that neurons often co-express functionally distinct alternative products from the same gene, facilitating acquisition of complex shapes and functions. Co-expression of alternative variants is essential for proper development of axons and dendrites in mice.
Researchers at Aalto University propose a new theory explaining why touchscreens are less accurate for gaming due to finger movement and latency. By registering touch events at maximum contact area, performance can be improved significantly.
A nationwide study by Texas A&M University found that approximately 15% of people in residential care facilities suffer from injurious falls. The majority of these falls occurred among female residents who required assistance with daily activities and lived in larger facilities.
A randomized controlled trial found that black raspberry extract significantly lowers arterial stiffness, a key indicator of cardiovascular disease. The study also showed increased levels of endothelial progenitor cells, which help repair damaged arteries.
Cancer cells' ability to slide past obstacles and travel out of primary tumors is enabled by abnormal protein fiber scaffolding and the agility of cancer cells themselves. The researchers developed a model environment that mimics protein fibers, allowing them to observe and quantify the behavior of breast cancer cells.
A pioneering gene therapy has restored vision to patients with a rare form of genetic blindness for up to four years, providing sustained improvement and raising hopes for a cure. The treatment involves injecting a virus into the eye to deliver billions of healthy genes, replacing a key missing gene.
A new study found a statistically significant association between high levels of residential radon and the risk of hematologic cancer in women. The analysis included over 140,000 participants and showed a 63% higher risk of hematologic cancer in counties with the highest mean radon concentration.
A University of Wisconsin-Madison neuroscientist has successfully inserted a genetic switch into nerve cells to regulate dopamine production with designer drugs. This breakthrough could lead to the development of a new Parkinson's disease treatment and expand its application to other conditions.
Researchers at Lund University have found a promising new therapeutic target to treat bacterial infections, regulating the immune response and avoiding destructive inflammation. The discovery of IRF-7 as an immunotherapeutic target holds promise for non-antibiotic therapy.
Researchers have identified how low testosterone raises diabetes risk by impairing insulin regulation in the pancreas. Testosterone triggers key signaling mechanisms that produce insulin, and its absence leads to glucose intolerance.
Parents' attitudes toward failure, not their views on intelligence, influence children's mindset about intelligence growth. Children are attuned to parents' emotional responses to failure.
Researchers from Trinity College Dublin found that the oldest zircon crystals likely formed in massive asteroid impact craters rather than through plate tectonics. The discovery sheds new light on Earth's early history and suggests a more violent bombardment by asteroids in its nascent years.
A new device enables real-time monitoring of central venous and pulmonary artery pressures in patients with single ventricle Fontan anatomy, reducing the risk of heart failure. The first implantable hemodynamic monitor has been successfully placed in two patients, showing early safety and feasibility.
A study by Vrije Universiteit Amsterdam has identified two genetic variants that increase the chance of mothers having dizygotic twins. These variants are associated with fertility measures such as age of first menstruation and polycystic ovary syndrome, a major cause of infertility in women.
A new study examines human behavior's impact on wildfires in California, finding that it explains as much about their frequency and location as climate change. The researchers recommend considering both climate change and human variables for future models to accurately predict wildfire risks.
Researchers recreated high-pressure conditions to study iron isotope fractionation, shedding light on Earth's core composition and planetary history. The study identified potential light elements in the core, including oxygen, silicon, and sulfur, and provides a new understanding of the planet's geochemical evolution.
A team from McGill University Health Centre identified an outbreak of the intestinal parasite Cryptosporidium in Nunavik, Quebec. The strain was found to be Cryptosporidium hominis and had a significant impact on children under five years old, causing growth delays and difficulty at school.
Biologist Dr Aldemaro Romero Jr explores how major religions have influenced evolutionists and their scientific thinking over the centuries. He challenges notions of predetermination and linearity in evolutionary theory by highlighting the importance of considering philosophical baggage in research conclusions.
A study by Dr Carolyn Mair and Soljana Cili found that 62% of women aged 40-89 use make-up daily for confidence, not to look younger. The results highlight the need for advertisers to focus on making products feel good about themselves, rather than just looking younger.
Researchers in China created a portable and high-performance device to detect glucose levels using fiber optic biosensors integrated with microfluidic chips. The device can detect glucose concentrations as low as 1 nM, making it an appealing technology for early diagnosis of diabetes via monitoring glucose content within sweat.
A new University of Illinois study reveals that the shape of a tumor may play a significant role in determining whether cells can metastasize. The research found that curved edges and corners activate cancer stem cells, which are responsible for spreading cancer to other tissues.
A clinical trial found narrow band imaging (NBI) significantly reduces bladder tumor recurrence in low-risk patients compared to conventional TURBT surgery. NBI detected small tumors that might be overlooked by white light cystoscopy, leading to a 5.6% recurrence rate versus 27.3% with traditional methods.
Scientists have discovered that cells can perceive their own shapes, specifically curvature of the cell membrane, through a protein-based mechanism. This ability allows cells to organize themselves in response to changes in their environment.
Researchers have identified a key action of a watershed gene crucial to bone formation and the evolution of vertebrates. The Sp7 gene emerged about 400 million years ago, expanding life diversity and programming bone-secreting cells.
Researchers at Cornell University found that consumers who have poor eating habits benefit most from long-term reward incentives for healthy food choices. In contrast, healthy eaters are more likely to purchase less healthy items when offered price breaks.
A new method for exhaustively isolating olfactory receptors responding to specific odorants has been developed by Osaka University and Panasonic Corporation. This breakthrough enables quick and easy analysis of ORs responding to desired odorants, with potential applications in biosensors.
Researchers found that altering the balance of ions in the fluid surrounding brain cells can stimulate or dampen nerve cell activity and cause brain cells to shrink while we sleep. This process facilitates waste removal and may lead to new ways to regulate the sleep-wake cycle.
Researchers developed a noninvasive data analysis technique to distinguish between actively driven and thermally induced motions inside cells. The method, based on statistical physics, tracks particle transitions between states and identifies imbalances that indicate active processes.
A University of Vermont-led study finds that insect outbreaks, such as mountain pine beetle and western spruce budworm infestations, significantly reduce wildfire severity. This contrasts with popular attitudes linking the two, and provides new insights for forest management and policy applications.
Researchers from KU Leuven measured individual brain cell responses to animal and human body images, finding that each cell specializes in recognizing specific features. The findings suggest a collaborative process where different cells work together to recognize bodies.
A study by Northumbria University researchers found that peppermint tea significantly improved long-term memory and working memory, while chamomile tea slowed these functions. The study suggests beneficial effects of peppermint's enhancing and arousing properties on cognition.
A team of researchers led by Robert W. Boyd has demonstrated up to 100 times greater nonlinearity in indium tin oxide than other known materials, revolutionizing photonics applications. This breakthrough opens the door for more careful study of the material's unique properties and potential applications.
Researchers at Aalto University developed an augmented climbing wall, combining body tracking and custom software to empower users as content creators. The system offers diverse movements, challenges, and endless gaming experiences, increasing the sport's appeal to new audiences.
Researchers at RIKEN Brain Science Institute discovered myosin-Va's role in directing neuron growth. The protein complex acts as a calcium sensor that tells new axon pieces where to go.
Researchers at Gladstone Institutes successfully reprogrammed human skin cells into beating heart cells and neural stem cells using chemical cocktails. This breakthrough could lead to new treatments for heart failure and neurodegenerative diseases.
A recent cancer diagnosis was associated with an increased risk of mental health disorders, including depression and anxiety, peaking in the first week after diagnosis. The study also found increased use of psychiatric medications among patients with cancer, remaining elevated two years post-diagnosis.
Researchers from KU Leuven have developed machines that can learn to tell the difference between familiar and unfamiliar objects, such as a blurred shape on the road. This technology has the potential to improve self-driving car safety by allowing machines to make more reasonable decisions in new situations.
A new study has found a link between rosacea and an increased risk of dementia, with the highest risks seen in older patients. The study published in Annals of Neurology suggests that treating rosacea may also modify patients' risk of developing dementia.