Researchers have found that CD163 can predict mortality in blood samples from patients with acute on chronic liver failure, a condition with a high four-week mortality rate of 20-30%. Measuring this biomarker may lead to improved diagnostics and treatment towards macrophages via CD163.
Luis Martinez, a PhD candidate at the University of Houston College of Pharmacy, has made significant breakthroughs in understanding Fragile X Syndrome. His research suggests that pharmacologically inhibiting Rac1 can rescue cognitive deficits and improve learning and memory skills in FXS models.
Researchers developed a gene therapy that programs T regulatory cells to protect transplanted tissues from rejection by the patient's immune system. This breakthrough could lead to new treatments for autoimmune diseases and open up possibilities for building genes for any disease where the immune system is overactive.
A global study found that people living in densely populated and walkable neighborhoods with interconnected streets got up to 90 minutes of physical activity weekly. Four environmental attributes stood out as having the most impact on physical activity: net residential density, intersection density, number of parks and public transit d...
A team of chemists has developed a new method to make metal nanoframe catalysts, which could lead to improved hydrogen fuel production and reduced usage of precious materials. The breakthrough involves creating ruthenium nanocrystals with a unique crystal structure, increasing their surface area and catalytic activity.
The study found that agricultural land has doubled within the Cerrado region, replacing native vegetation and altering the water cycle. Continued agricultural growth could reduce rainfall or delay critical rainy periods, threatening both natural vegetation and agricultural production.
A new evidence-based toolkit will help family health teams in Ontario provide more proactive care for adults with intellectual and developmental disabilities. The toolkit includes a four-step process to implement health checks, resources for clinicians and patients, and examples of how to embed the tools into Electronic Medical Records.
A recent study published in Science Advances found a striking absence of pre-Columbian genetic lineages in modern Indigenous Americans, suggesting extinction with the arrival of Europeans. The research reconstructed ancient DNA from 92 pre-Columbian mummies and skeletons, revealing a separation that appeared as early as 9000 years ago.
Scientists at ETH Zurich and IBM Research have developed a new method to manufacture micro-objects with precisely defined magnetic, non-magnetic and differently charged areas. The technique enables the creation of small rods, tiny triangles and basic three-dimensional objects.
Recent decades have seen increased frequency of large-scale atmospheric circulation patterns associated with California's precipitation and temperature extremes. The researchers found that the 'Ridiculously Resilient Ridge' pattern, which diverts winter storms northward, has become more common, leading to increased dry conditions.
A systematic review of studies found associations between poor oral health and increased risk of cognitive decline, particularly among those with dementia. However, more research is needed to confirm these findings and explore the potential causal link between oral health and cognitive status.
A study found that autism diagnoses are still being made at an average age of 4.5 years, with some children not diagnosed until 30 months old. Early intervention can improve social and communication skills in children with autism spectrum disorder.
Chronic diseases like hypertension and heart disease are rising in Africa due to infectious disease spread, healthcare worker shortage, and lack of investment. A multidisciplinary approach is needed to address the growing epidemic and promote health equity.
Researchers at Northwestern University developed a prosthetic ovary implant using 3D printing technology that restored fertility in mice. The bioprosthesis was made from gelatin and supported hormone-producing cells and immature egg cells, enabling oocyte growth and ovulation.
A new study suggests that sleeve-IT surgery is an effective treatment for mild obesity-related Type 2 diabetes, with improved glycemic control and significant weight loss. The procedure resulted in 100% of patients achieving glycemic control compared to 8% of those treated clinically.
The American Cancer Society has awarded nearly $44 million in grants to 103 researchers across the US. New grants focus on immunotherapy, DNA repair pathways, and metastasis, while existing grants support programs for adolescents and young adults with cancer.
Researchers have engineered a novel variant of streptavidin that forms a stable monomer and binds biotin without crosslinking, allowing for efficient biotinylation of targets. The optimized monomeric streptavidin (mSA) can be fused to proteins to create a bi-functional molecule, enabling proximity-dependent biotinylation techniques.
A new method has been proposed to detect bacterial infections in preterm infants by monitoring serum procalcitonin levels. The study found that PCT levels take longer to return to normal in preterm infants, providing a potential early detection criterion.
A new study predicts severe obesity can be identified at 6 months of age using a simple BMI measurement. Pediatricians are advised to measure BMI during infant well-child visits to identify high-risk children and provide targeted education on healthy lifestyles.
A study by The Endocrine Society found that exposure to phthalates in medical devices used for children with critical illnesses was strongly associated with attention deficit disorders later in life. Researchers measured blood levels of DEHP metabolites in healthy and critically ill children, finding high levels in the latter group.
Researchers have developed a new technology to examine gene expression in single cells, shedding light on the molecular causes of rare diseases. The study found highly variable and different gene expression patterns in single cells, even in the same organ.
A Mayo Clinic study found a strong association between physician burnout and reducing clinical practice hours, particularly among primary care specialties. The research suggests that increased emotional exhaustion predicts physicians cutting back on work hours, exacerbating the existing US physician shortage.
A new study found that measuring anti-Mullerian hormone in blood can help predict the rate of future bone loss during menopause transition. Women with lower hormone levels are more likely to experience faster-than-average bone loss.
Experts warn of disappearing artisanal Mexican cheese varieties due to lack of documentation and standardized production processes. Standardization and preservation efforts aim to protect these unique cheeses and secure protected designation of origin (PDO) status.
A study by the Endocrine Society found that transgender veterans have a fourfold higher rate of gender dysphoria compared to the general population. The study also showed high rates of depression, anxiety, PTSD, and substance abuse among these patients.
A new study published in Frontiers in Psychology suggests that watching online tutorials with prior knowledge of the demonstrator's skill level can lead to improved performance. The researchers found that this approach enables students to better detect technical errors and imitate expert-level shots.
Researchers used X-rays to observe exactly how silver electrical contacts form during manufacturing, shedding light on the complex process. The results show that lead oxide plays a key role in forming the contact, etching away the solar cell's antireflective coating and allowing silver to move through and harden.
A University at Buffalo researcher has developed a comprehensive model to explain why people fall for spear phishing attacks, accounting for user vulnerabilities and behavior patterns. The model proposes a new approach to training and education, using individual profiles to identify specific weaknesses, and enables organizations to dev...
A critical regulator of EUI1 gene expression in rice, HOX12, has been identified as a central regulator of panicle extension. This discovery holds promise for fine-tuning panicle extension and improving hybrid rice seed production.
The supplement tackles childhood poverty from various angles, including its impact on cognition, health, and socioeconomic outcomes. Experts offer insights on defining poverty, international comparisons, and interventions in the US to address child poverty.
Researchers have discovered a complex 4-step process for gypsum formation, opening the way to more energy-efficient production of Plaster of Paris. This breakthrough could also aid in understanding past water availability on Mars and other planets.
Julie Rovner received the Endocrine Society's Award for Excellence in Science and Medical Journalism for her article on ensuring more women are included in clinical trials. Her coverage highlights efforts to balance research on both sexes, as women have a higher rate of adverse effects from approved medications.
The GPM core observatory satellite measured heavy rainfall rates of over 3.6 inches per hour in a powerful storm east of Chattanooga, Tennessee. The satellite also revealed the three-dimensional structure of precipitation in storms beneath it, showing storm tops reaching heights above 7.4 miles.
A study at Hospital for Special Surgery found that peripheral nerve blocks significantly reduce cardiac and wound complications in hip and knee replacement patients. The use of PNBs was associated with lower odds for almost all complications, particularly in resource utilization.
A new study found that higher levels of cord-blood leptin and adiponectin at birth were associated with greater fat in the child at ages 9 and 17. This suggests that fetal overnutrition may program greater adiposity in the child, extending into childhood and adolescence.
A new meta-analysis reveals a clear correlation between higher BMI, waist circumference, and the risk of heart failure. Overweight individuals had a 35% increased risk of heart failure compared to normal weight individuals.
A new study found that exceptionally warm weather episodes, rather than radiant energy, cause significant melting of the Greenland ice sheet. The research revealed that climate models tend to underestimate the impact of these events, which are expected to occur more frequently in the future due to climate change.
Researchers successfully grew skin tissue with hair follicles and sebaceous glands in the laboratory using reprogrammed iPS cells. The tissues formed normal connections with surrounding nerves and muscle fibers, paving the way for potential functional skin transplants.
Researchers at Lund University have developed a method to control the movement of active particles using light, which can be used to create programmable materials. This technology has potential applications in environmental science, such as locating oil spills, and medicine, including delivering pharmaceutical substances.
A new study in veterans with PTSD finds that mindfulness training can enhance the ability to manage thoughts and emotions, leading to reduced symptoms. Brain scans reveal stronger connections between brain networks involved in attention and inner thoughts, suggesting a potential tool for emotional regulation and trauma processing.
The April issue of Neurosurgical Focus presents 12 articles on sports-related concussion, sequelae such as CTE, and prevention strategies. Key findings include diagnostic assessment tools and treatment strategies for concussions.
A new animal study finds that exposure to triclocarban, a common ingredient in antibacterial soap, can alter the composition of intestinal bacteria and other micro-organisms in offspring. The study suggests that this disruption may have unintended health consequences, including changes in obesity, diabetes, and asthma.
Researchers at PNNL have developed a stronger titanium alloy using a novel nanostructure, with potential applications in lightweight vehicle parts. The alloy achieved a 10-15% increase in strength, making it suitable for high-strength-to-cost ratio and greater fuel economy.
The University of Akron researcher is designing a new class of tough double-network hydrogels with unique mechanical toughness and self-healing properties. These hydrogels can be used in various applications such as wastewater treatment, tissue engineering, and drug delivery.
Monophosphoryl lipid A (MPLA) has shown protective effects in mice with burn injuries, stimulating G-CSF production to bolster immune cells' ability to fight bacteria. Increased neutrophil levels mediate this protection.
Researchers identify two distinct HSV-1 virus strains in an individual, revealing their European/North American and Asian origins. The discovery opens doors to tracing a person's life history using genetic fingerprinting of viral genomes.
Scientists at NIST have made significant advances in creating safe and efficient solid-state rechargeable batteries. By modifying the chemical makeup of promising compounds, they increased their current-carrying capacity and enabled them to operate within a wider temperature range.