Researchers at Hiroshima University discovered a new role for the gene Rab6 in cell polarity, which directs proteins to specific sides of cells. The study found that Rab6 distinguishes between proteins destined for different parts of the cell, shedding light on how cells maintain their orientation.
Researchers at Disney Research and Carnegie Mellon University have developed a system to debug intermittent systems, such as those that harvest energy from the environment. The Energy-interference-free Debugger (EDB) can monitor and debug these systems without interfering with their power state.
A team of scientists has turned off a key protein that fuels the growth of aggressive breast cancer cells, making them more vulnerable to chemotherapy. The study reveals a pivotal catalyst in the development of triple-negative breast cancer and paves the way for new therapies.
A new study from Harvard T.H. Chan School of Public Health identifies a sugar variant on the surface of human red blood cells that limits the ability of P. knowlesi to invade. The parasite has been shown to evolve and overcome this barrier, potentially leading to enhanced transmission between humans.
A new University of Cambridge research project explores the history of writing and its connection to modern culture. The CREWS project reveals surprising links between ancient societies and their use of alphabetical order.
A new study finds that end-stage heart failure patients who received stem cell therapy experienced a 37 percent reduction in cardiac events, including deaths and hospital admissions. The treatment showed fewer side effects and complications compared to the placebo group.
Researchers developed a new Liver-on-Chip device with glucose and lactate micro-sensors to track metabolic function in real-time, enabling detection of chemical toxicity before cellular damage. The technology has the potential to redefine studies on neurodegenerative diseases, cancer, and drug discovery.
A recent study found that six commonly used insecticides kill amphibian parasites, potentially decreasing the number of parasites an amphibian must defend against. The study also showed population-specific differences in pesticide resistance, highlighting the importance of considering multiple populations when assessing toxicity.
A new study published in Diabetologia found that the GLP-1 analog drug liraglutide decreases activation in the brain's cortex when individuals are shown images of desirable foods, making these foods less appealing. This suggests that liraglutide may be an effective weight loss therapy for people who tend to eat as a reward.
A team of researchers has found evidence of a mysterious new state of matter, known as a quantum spin liquid, in a real two-dimensional material. The discovery matches theoretical models and could lead to the development of faster quantum computers.
A new biomarker-based tool, 'ABC risk score,' allows for personalized treatment to prevent strokes with minimal bleeding complications. The app is available as a web-based instrument and will soon be available as an app.
Researchers have successfully observed raft domains in live cells using new fluorescent probes, revealing dynamic interactions between gangliosides and cholesterol. The findings open up new avenues for investigating how toxins, bacteria, and viruses invade cells through these membrane structures.
Researchers from the Icahn School of Medicine at Mount Sinai present new findings on CABG alone or with mitral valve repair for moderate ischemic MR, as well as rate versus rhythm control in patients with postoperative atrial fibrillation after cardiac surgery.
A treatment called prostatic artery embolization (PAE) decreases nocturnal urination frequency and improves quality of life in men with enlarged prostates. PAE is a less invasive option compared to surgery, performed on an outpatient basis.
A recent study found that CEOs who experience an independent director's death engage in significantly fewer acquisitions, with a decrease of nearly 4% and lower acquisition values. This may be due to increased mortality awareness, prompting CEOs to pursue a quieter life and scale back on extrinsic goals.
Researchers used microbial metagenome analysis and environmental chemistry to find the most likely transit route Hannibal's forces took across the Alps, pinpointing the Col de Traversette pass as a key crossing point. The study, published in Archaeometry, provides solid evidence for Hannibal's route, dating back to 218 BC.
A recent study found that 74% of fentanyl patch prescriptions were not safe due to insufficient prior opioid exposure. The prescribing guidelines for the 50 µg/h dose are often not followed, especially among patients over 65, who are at a higher risk of adverse outcomes.
Researchers have synthesized micrometer length-scale carbon chains, surpassing previous records by more than one order of magnitude. The discovery confirms the existence of ultra-long linear carbon chains, also known as carbyne, using various advanced spectroscopic and microscopic techniques.
A national study found that a shorter, intensive radiation therapy schedule of about 5.5 weeks was comparable to the standard 8-week regimen in terms of controlling cancer, while also reducing treatment duration and costs. The researchers reported slightly more mild side effects in patients receiving the shorter schedule.
Carbon nanotubes as small as eight-tenths of a nanometer in diameter can transport protons faster than bulk water. Researchers validated a 200-year-old mechanism by creating one-dimensional water wires that allow for enhanced proton conductivity.
A University of Virginia study found that false beliefs about biological differences between black and white people contribute to undertreated pain among black patients. White medical students and residents who held these false beliefs showed lower pain ratings and less accurate treatment recommendations for black patients.
New research from UEA's Centre for Ocean and Atmospheric Sciences found that oceans on distant Earth-like planets with varying salinity levels can significantly impact their climates. The study discovered that extreme salinity levels could lead to dramatic warming in polar regions, potentially extending a planet's habitability.
Investigational stem cell therapy derived from a patient's own blood marrow significantly improved outcomes in patients with severe heart failure. The study found that the treatment reduced deaths by 37% and hospitalizations by 49% compared to placebo.
Researchers have created a new metallic glass with an unusual chemical structure that makes it incredibly hard and yet elastic. The material can withstand heavy impacts without deforming and retains most of its original strength.
Researchers at the University of Copenhagen have discovered a method to break down plant biomass using sunlight, potentially producing biofuels and biochemicals. The process, known as reverse photosynthesis, uses enzymes and chlorophyll to accelerate chemical reactions, reducing pollution and increasing production speed.
A tool called Chest Pain Choice facilitates shared decision-making between physicians and patients with chest pain, improving patient knowledge and follow-up care options. The intervention reduced unnecessary testing and hospital admissions without adverse effects.
A recent clinical trial provides objective evidence of muscle-related side effects associated with statins. Evolocumab was found to be superior to ezetimibe in reducing low-density lipoprotein cholesterol levels. The study's findings have significant implications for treating patients with statin intolerance.
A new study by the Endocrine Society finds that children and teenagers taking ADHD stimulant medications may have lower bone density, a condition that can increase fracture risk or osteoporosis later in adulthood. The study suggests that these patients may need monitoring of their bone health during treatment.
A new study suggests that a combined vaccine therapy using live Salmonella is safe and effective in preventing diabetes in mice. The vaccine works by rebalancing the immune system and preventing the attack on insulin-producing cells. Researchers believe this targeted immunotherapy has great potential for treating type 1 diabetes.
Research discovered that individuals with coronary artery disease exhibit higher baseline troponin levels independently of stress or chest pain, indicating repeated ischemic events. Mental stress tests revealed a significant increase in troponin levels, even after the event, suggesting psychological triggers play a role
A large clinical trial of evacetrapib, a CETP inhibitor, showed no reduction in major adverse cardiovascular events, despite significant increases in HDL and decreases in LDL cholesterol levels. The study's findings challenge conventional thinking on the benefits of high-density lipoprotein (HDL) cholesterol.
A new study from Intermountain Medical Center Heart Institute shows that testosterone supplementation reduced major adverse cardiovascular events in elderly men with low testosterone levels and pre-existing coronary artery disease. The study found that patients receiving testosterone therapy had a lower risk of heart attacks, strokes, ...
Research suggests that combining aromatase inhibitors with growth hormone can effectively and safely increase height in very short adolescent boys. The study found significant gains in height and lean body mass when using this combination therapy.
A new study reveals that only 1.02% of eligible patients receive weight loss medications, highlighting a significant gap between guidelines and treatment practices.
A technology-based competition increased daily physical activity levels by over 3,500 steps per day and led to significant weight loss. The study, which involved over 68,000 participants from 64 countries, found improvements in exercise frequency, sitting time reduction, and overall health.
The Society of Interventional Radiology honored two research papers for their impact on patient care. Dong Il Gwon's study validated a rapid PARTO procedure for treating gastric varices, while Ron C. Gaba's research explored gene expression in hepatocellular carcinoma for improved treatment outcomes.
Researchers compared one-year outcomes of SAPIEN 3 TAVR and open-heart surgery in patients with severe, symptomatic aortic stenosis. Patients who underwent TAVR had better mortality and stroke rates compared to those who received open-heart surgery.
A large clinical trial found that ischemic postconditioning did not reduce death from any cause or hospitalization for heart failure in STEMI patients, but improved left ventricular ejection fraction in a specific subgroup.
A study found that only 2% of people with very high cholesterol have a familial hypercholesterolemia mutation, but those with the mutation face a six times higher risk of early-onset coronary artery disease. Genetic screening could help identify and ward off cardiovascular disease in affected individuals.
A new minimally invasive weight loss treatment called bariatric arterial embolization has shown safety and efficacy in a clinical trial, initiating weight loss and reducing hunger levels. The procedure targets the production of ghrelin, a hormone controlling hunger, with promising results in sustaining weight loss.
Researchers identified ezetimibe and evolocumab as effective alternatives for patients with muscle-related statin intolerance, demonstrating significant reductions in LDL-C levels. The study suggests that both drugs can be administered successfully in such patients, although with varying efficacy.
Researchers found that SSRI antidepressants cause decreased bone density in mothers during lactation, leading to higher risks of fractures. Folic acid supplementation may mitigate this effect, suggesting women may need more folic acid while breast-feeding.
A safe, minimally invasive treatment called bariatric arterial embolization (BAE) has been shown to lead to sustained weight loss in severely obese people. BAE targets the stomach's hunger hormone production, reducing appetite and resulting in significant weight loss.
Intermediate-risk patients who received TAVR with SAPIEN 3 had improved outcomes compared to surgical aortic valve replacement after one year. The trial showed reduced rates of death, stroke, and moderate or severe aortic insufficiency in TAVR patients.
The DANAMI-3-DEFER trial found that delayed stent implantation in STEMI patients did not reduce death from any cause, hospitalization for heart failure, or subsequent heart attacks. The study's findings contradict previous promising preliminary studies and may be due to the trial's limited sample size and patient selection.
A new study found that abaloparatide-SC increased bone mineral density in the spine and hip, reducing the risk of vertebral and nonvertebral fractures. The treatment also showed promise in a broad range of postmenopausal women with osteoporosis, regardless of baseline patient characteristics.
Researchers found that intravenous beta blockers before angioplasty in STEMI patients did not reduce heart attack severity or improve blood flow, according to the EARLY-BAMI trial. The study showed a slight decrease in ventricular arrhythmias but no significant differences in other endpoints.
A new study suggests that taking antibiotics in early childhood may disrupt the gut's microbial ecosystem and increase the risk of developing prediabetes in adolescence. The researchers found that a depletion of beneficial bacteria, such as Ruminococcus species, was associated with higher rates of antibiotic use.
A study found that familial hypercholesterolemia mutations account for less than 2% of cases with severely elevated LDL levels, but significantly increase the risk of coronary artery disease. Gene sequencing identified individuals at high risk who may benefit from additional preventive therapies.
Renan Uflacker received the Society of Interventional Radiology Foundation's Leaders in Innovation Award for his pioneering work in interventional radiology. The award recognized his contributions to transforming the field through innovative treatments for liver disease, peripheral vascular disease and aneurysms.
A new study by the Cleveland Clinic has identified statin intolerance objectively, showing that evolocumab is a more effective option for lowering cholesterol in patients who are intolerant to multiple statins. The PCSK9 inhibitor reduced cholesterol levels by 52.8%, while ezetimibe had a smaller reduction of 16.7%.
In a clinical trial of 100 obese men, researchers found that adding testosterone treatment to calorie restriction resulted in increased fat loss and preserved muscle mass. The study suggests that testosterone treatment may be a useful adjunct to weight loss in obese men with low testosterone levels.
A phase 3 clinical trial showed evacetrapib reduced LDL cholesterol by 37% and HDL cholesterol by 130%, but failed to lower rates of major cardiovascular events. Researchers attribute the lack of benefits to the drug's inability to translate improved cholesterol levels into clinical outcomes.
Researchers from the University of Pennsylvania found that heart transplants can be performed in adult patients with prior corrective surgery for congenital heart disease with excellent outcomes. The study, which included 17 consecutive patients, showed a 100% survival rate at both 30 days and one year.
Women who underwent uterine fibroid embolization reported improved sexual function, including pain, desire, arousal, and satisfaction. About nine in 10 women also experienced a better overall quality of life, with average scores increasing from 45 to 71 one year after treatment.
Patients who received a physician discussion using Chest Pain Choice increased their knowledge about their risk and options, answering 53% of questions correctly. The study also found that patients who used the tool were more likely to recommend discussing their care with their physicians, 68.9% compared to 61.2%.
A higher volume of TAVR procedures is associated with improved patient outcomes, including lower death rates and vascular complications. The study, which analyzed data from nearly 50,000 patients, found that even hospitals performing fewer than 100 cases showed significant improvements in patient outcomes with higher procedure volumes.
A new study found that AMH levels are related to high testosterone secretion and abdominal adiposity, making it a possible surrogate for ovarian antral follicle number. Additionally, AMH levels were correlated with age and body mass index, indicating its potential as a biomarker for PCOS diagnosis in obese adolescent girls.
New research from South Korea suggests that higher dietary calcium intake may lower the risk of cardiovascular disease in older people, but not stroke and fracture risk. In a population with low calcium intake, higher dietary calcium was significantly associated with decreased risk of CVD.
Researchers have discovered a new potential therapy that can protect transplanted human pancreatic islets from dying. The study suggests that pretreating cells with a peptide hormone called cholecystokinin (CCK) may enhance the curative potential of islet transplant for Type 1 diabetes.