Genetic variations in metallothionein and zinc transporter genes impact zinc homeostasis and immune function. SNPs may influence the response to zinc supplementation in individuals with certain non-communicable diseases.
A new study reveals that incorporating genetic diversity into a mouse model of Alzheimer's disease improves translatability, enabling more accurate predictions and potential treatments. The Resilience-Alzheimer's Disease Consortium has created a genetically diverse panel of mice with Alzheimer's mutations.
The rose hip fruit contains a range of bioactive compounds, including flavonoids and tannins, with potential therapeutic effects on conditions such as arthritis, hypertension, and respiratory problems. Further research is needed to confirm its efficacy in treating various illnesses.
A study of 3003 African-American adults found that consuming a pattern of soda, sweetened fruit drinks, and water was associated with a higher risk of developing chronic kidney disease. The researchers were surprised to see that water as part of this beverage pattern was linked to a higher risk of CKD.
Researchers have discovered a previously unknown strain of bacteria in ancient Irish soil that effectively inhibits the growth of four top-six multi-resistant pathogens. The strain, Streptomyces sp. myrophorea, has shown promise against gram-positive and gram-negative bacteria, providing new hope for combating antibiotic resistance.
Scientists at Tokyo Institute of Technology propose a new mechanism to generate spin currents without energy loss, exploiting the Rashba effect in quasi-1D materials. The mechanism simplifies potential spintronic devices and allows for further miniaturization.
Recent advances in computational methods enhance the accuracy and reproducibility of label-free quantification (LFQ) in cancer proteomics, enabling discovery of anti-cancer targets and drugs. The study evaluates popular acquisition techniques and state-of-the-art quantification tools to improve LFQ performance.
A 12-week exercise intervention reduced visceral abdominal fat in obese adults, but tocilizumab treatment abolished this effect and increased cholesterol levels. Exercise promotes better health and reduces the risk of cardio-metabolic diseases by reducing abdominal fat mass.
A clinical trial tested the effectiveness of topical antibiotic mupirocin in eliminating Staphylococcus aureus colonization in hospitalized infants. The study found that mupirocin is safe and highly effective in reducing SA infection, with over 90% of treated infants testing negative for SA after treatment.
Research reveals that trypanosomes use gluconeogenesis and glycerol metabolism to produce ATP and synthesize glucose, challenging the long-held assumption of exclusive reliance on glycolysis. This metabolic flexibility is essential for adaptation to environmental conditions and survival in mammalian host tissues.
A new approach solves challenges in assessing student knowledge in online courses, considering multiple attempts and student experience. The expanded Rasch model provides a single scale for comparing students' proficiency even with changing test questions.
Historical genomes of eastern gorillas show significant decline in genetic diversity and increase in harmful mutations. This decline may make them less able to adapt to disease outbreaks and environmental changes.
A systematic review and meta-analysis found that CoQ10 supplementation significantly reduced total-cholesterol, malondialdehyde, and creatinine levels in patients with chronic kidney disease. The treatment did not affect other metabolic markers, suggesting a potential therapeutic benefit for CKD patients.
Aging endothelium displays reduced vasomotor functions and angiogenic capabilities due to increased oxidative stress. Lifestyle factors like exercise and omega-3 intake influence Endothelial Progenitor Cells (EPCs), which support endothelial health and function.
Recent studies have highlighted the significant role of Shp2, a phosphatase protein, in governing signaling response amplitude and regulating cell differentiation and growth. Dysregulation of Shp2 has been linked to various types of leukemia, including acute myeloid, juvenile myelomonocytic, and B-cell acute lymphoblastic leukemia.
Researchers from Tilburg University studied over 2000 YouTube vlogs and found that people mirror the emotions of those they see online. They also seek out others with similar outlooks and moods, a phenomenon known as homophily. This emotional contagion can be seen in both immediate and sustained reactions.
Scientists have elucidated the formation mechanism of amyloid-β substances, causative agents of Alzheimer's disease. They found that Aβ peptides tend to aggregate at hydrophilic/hydrophobic interfaces, forming β-hairpin structures that facilitate intermolecular hydrogen bonding.
Researchers analyzed global forest communities to understand how climate affects tree growth traits, revealing nine key changes that could impact forest productivity and composition. Temperature variability and vapor pressure emerged as major factors influencing these traits.
Researchers found that a simplified examination focusing on hands, feet, and lower legs can detect over 90% of scabies cases. This approach may be useful for public health assessments and guiding decisions on scabies control.
A study using PET technology found that dopamine release in the brain happens twice during a meal: first when eating and second when food reaches the stomach. This release is linked to brain regions involved in reward, sensory perception, and higher cognitive functions.
The Madden-Julian Oscillation is likely to experience increased precipitation intensity under a warmer climate, while wind variations may slow or even decrease, according to a new study published in Nature Climate Change. This change could impact weather prediction for extreme events like hurricanes and droughts.
A new study by Nicolas Davidenko and colleagues reveals that a small tilt of the head can reduce the left-gaze bias and increase the upper-eye bias when viewing faces, making people more approachable. This finding has potential implications for individuals with autism and amblyopia.
A new study found that the proportion of cancers related to excess body weight varies greatly among US states, ranging from 5.9% in Hawaii to 8.3% in the District of Columbia. The study highlights the need for targeted interventions to reduce obesity and its associated cancer risks.
Researchers developed a simple method to create silver nanowire-coated fibers with high conductivity, flexibility, and mechanical strength. The fibers have promising applications in wearable devices, addressing the need for comfortable and functional smart textiles.
A psycho-educational team was found to have a positive impact on early breast cancer patients' coping strategies, particularly in reducing depression. The study evaluated the effects of group action on women's anxiety and body image.
A recent study by WiKim has identified five yeast strains responsible for forming white colonies on the surface of kimchi. The research uses whole-genome sequencing and NGS technology to confirm that these yeasts do not produce toxin-related genes, making them safe for consumption.
Researchers from KAIST have identified novel pathways involving T immune cell exhaustion in liver cancer patients. The study provides evidence for designing optimal strategies for immune checkpoint blockades and offers a new path for customized medicine.
This study investigates the role of miRNAs in cardio-protective effects of halogenated anesthetics, a widely used cardiac surgery agent. The expression profile of miRNAs is modulated by perioperative administration of these anesthetics.
Research reveals flavonoids as potent P-gp modulators with high binding affinity and low toxicity, offering a new generation of drug candidates to reverse multidrug resistance. Synthetic flavonoid dimer FD18 specifically targets the pseudodimeric structure of the drug transporter.
Kinetoplastid and apicomplexan parasites are targeted by inhibiting thymidylate biosynthesis, leading to decreased dTTP levels and cell death. Novel inhibitors with anti-parasitic activity have been identified in the review.
Neuronal cell death in Alzheimer's disease may be beneficial as it removes dysfunctional neurons, according to new research published in Cell Reports. The study suggests that the anti-aging mechanism of 'cell competition' plays a crucial role in protecting the brain from damage.
Researchers at NIMS developed topological LC circuits with a honeycomb pattern that transport electromagnetic waves without backscattering. This discovery enables the miniaturization of high-frequency electromagnetic waveguides for various electronics devices.
A class of breast cancer drugs could potentially benefit patients with EGFR-mutant lung cancers that have become resistant to treatment. Lung tumours in mice caused by mutations in a gene called EGFR shrunk significantly when a protein called p110α was blocked.
A new study found that genes cause about 1 in 10 cases of chronic kidney disease in adults, and identifying the responsible gene has a direct impact on treatment. DNA testing reclassified the cause of kidney disease in 1 out of 5 individuals with a genetic diagnosis.
Recent advancements in Parkinson's disease treatment hold promise for patients, with gene therapy approaches showing potential, and brain stimulation techniques also being explored. Despite progress, hurdles persist, and understanding the reasons for treatment failure is crucial to overcoming the disease.
Researchers discovered the pathway that causes dermal fibroblasts to lose their ability to convert into fat cells as people age. This process affects the skin's ability to fight infections, particularly bacterial ones like MRSA. The study may lead to new treatments for obesity, diabetes, and autoimmune diseases.
Researchers at Duke University have discovered that fish ear bones can serve as a fingerprint for identifying and tracking coal ash contamination in aquatic ecosystems. The study used strontium isotope ratios in otoliths to connect high levels of toxic elements back to the contamination source.
Researchers developed a new catalyst composed of platinum and nickel, which is more efficient than pure platinum. The study used ultrabright x-rays to reveal the growth pathway and chemical characterization of the nanoparticles in real time.
Researchers at Scripps Research Institute have identified an important intermediate step in how alcohol intoxication occurs. The enzyme phospholipase D2 links ethanol molecules to lipid membranes, triggering a metabolite called phosphatidylethanol that causes nerves to fire more easily, leading to hyperactivity in flies.
Essential oils and aqueous plant extracts inhibit Aspergillus growth and aflatoxin biosynthesis, offering potential solutions to prevent food contamination. Standardization of extraction procedures and further study on active compounds are necessary to ensure safe use in food products.
Researchers found that post-natal depression in fathers is linked to increased risk of depression in their teenage daughters. Girls whose fathers experienced depression after birth were more likely to develop depression at age 18.
Researchers found that age and sex play a greater role in forming psychological boundaries than culture. In the study, youth had a higher level of personal sovereignty than adolescents, with men being more concerned with territory sovereignty and women with time habits sovereignty.
Researchers found that aromatase inhibitors suppress estrogen synthesis, but paradoxically increase estrogen levels in the brain, leading to memory and thermal regulation deficits. The study calls for new therapies to prevent breast cancer recurrence while minimizing side effects.
Researchers found that HIV-infected cells can only reactivate in larger host cells, while smaller cells remain latent or silent. The study suggests a natural mechanism for viral reactivation and offers potential strategies for biasing viral decision-making through drug treatments.
A study found that people taking antidepressants, having post-traumatic stress disorder or anxiety are at risk of developing REM sleep behavior disorder. Men are also more likely to have the condition. Lifestyle factors such as education level, income, smoking status and moderate to heavy drinking habits were also linked to the disorder.
Researchers at Ohio State University have discovered ways to gather water from nighttime fog and condensation using surfaces with conical shapes and grooved patterns. These designs can efficiently collect water droplets, similar to how cacti and desert grasses do in nature.
Researchers at Far Eastern Federal University propose using stem cell activation to target glioma tumors. The approach aims to bring cancerous stem cells into an active state, making them vulnerable to chemotherapy. This method has been approved for publishing and is considered promising despite its risks.
A study of 2,800 hectares of mixed-conifer forest found that increasing tree density due to fire suppression leads to increased drought stress and reduced resilience to wildfires. Rising carbon dioxide levels exacerbate this effect, suggesting that denser forests will be more vulnerable to drought in the future.
A new study reveals biases against immigrants with non-anglicized names in the US, particularly in moral dilemmas. The research suggests that anglicizing ethnic names may reduce bias towards immigrants, but cautioning against promoting equity through name changes.
Researchers successfully treated a patient with disfiguring sarcoidosis using a drug approved for rheumatoid arthritis. The treatment showed promising results in reducing skin lesions and halting the activation of the Jak-STAT pathway.
Research suggests that autophagy on neuronal cells can lead to neurodegeneration, highlighting the importance of targeting mitochondria and autophagy-related proteins in disease treatment. Mitochondrial dysfunction is a significant contributor to neurodegenerative diseases, such as Alzheimer
Researchers at Osaka University have developed a method to make industrial polymers adhesive without the need for adhesives or corrosive chemical treatments. This breakthrough enables vulcanized rubber and plastic PTFE to adhere strongly to each other, or to glass and copper, using surface chemistry.
Researchers found that mice exposed to secondhand smoke developed cardiac alternans, a precursor to arrhythmias and sudden cardiac death. The study expands knowledge of tobacco smoke's effects on cardiac function in nonsmokers.
Researchers discovered a key brain mechanism that underlies our ability to rapidly focus attention. The cholinergic system plays a crucial role in triggering desynchronization of neurons, allowing individual neurons to respond to sensory information differently. This allows us to focus on specific stimuli while ignoring distractions.
Researchers discover that conscious knowledge is key to declarative memory, a type of memory linked to facts and events. The study, using amnesic patients with MTL lesions, found impaired performance in recognizing changes in images, highlighting the role of the hippocampus in memory acquisition.
Researchers at Aarhus University found that current breeding programs for European wheat do not provide sufficient climate resilience. This lack of response diversity can lead to reduced yields, increased yield variability, and market volatility.
Researchers developed a modified CRISPR/Cas9 system to efficiently edit the malarial parasite Plasmodium falciparum's gene expression. By altering histone acetylation near invasion-related genes, they increased or decreased erythrocyte invasion efficiency.
Researchers have developed a novel way to streamline genetic analysis by utilizing the blacklist computing concept. This method has shown promise as a key to faster therapeutic innovation, enabling clinicians and researchers to focus on true disease-causing mutations., By removing non-pathogenic genetic variants from consideration, thi...
A decline in European wheat's climate resilience is reported, as analyzed from farmers' field data and trials. Wheat cultivar diversity hotspot exists in Slovakia, but deserts are found in Czechia, Germany, Italy, and Spain
Researchers surveyed 226 engineering students finding that socially isolated students received lower grades compared to those developing more friendships and collaborations. Friendships can evolve into collaborative academic relationships, improving academic success.