A global clinical trial has shown that chimeric antigen receptor (CAR) T cell therapy can lead to long-lasting remissions in patients with relapsed/refractory diffuse large B-cell lymphoma. The treatment, known as Kymriah, modified patients' own immune T cells to target cancer cells and achieved high remission rates.
SourceUniversity of Pennsylvania School of Medicine·JournalNew England Journal of Medicine·DateDec 1, 2018
The phase-2 JULIET trial found that CAR-T cell therapy achieved a 52% favorable response rate in patients with relapsed or refractory diffuse large B-cell lymphoma, with 40% experiencing complete responses. Sixty-five percent of patients remained relapse-free after one year.
SourceUniversity of Chicago Medical Center·JournalNew England Journal of Medicine·DateDec 1, 2018
Researchers found that checkpoint blockade therapy can sensitize patients to better respond to future use of drugs, even when initial attempts failed. This breakthrough has significant implications for treating relapsing non-Hodgkin lymphoma and Hodgkin lymphoma patients.
SourceNYU Langone Health / NYU Grossman School of Medicine·DateDec 1, 2018
A daily hydroxyurea pill has been shown to improve health outcomes for young children with sickle cell anemia in resource-challenged sub-Saharan Africa. The treatment reduced rates of pain episodes, infections, malaria, transfusions, and death by significant margins.
SourceCincinnati Children's Hospital Medical Center·JournalNew England Journal of Medicine·DateDec 1, 2018
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A new study highlights the effectiveness of CAR T-cell therapy in treating diffuse large B cell lymphoma patients. The real-world outcomes show that 81% of patients responded to the therapy with 58% having no detectable cancer after four months.
SourceH. Lee Moffitt Cancer Center & Research Institute·DateDec 1, 2018
A 5-year study finds that deep-insulating snowpack loss could reduce forest carbon storage and filter pollutants by 95% in the northeastern US. This decline affects sugar maple trees, impacting industries like timber, maple syrup production, and tourism.
SourceAdvanced Science Research Center, GC/CUNY·JournalGlobal Change Biology·DateDec 1, 2018
Preliterate 6-year-olds outperformed their peers on grammatical relations, but struggled with novel words. After six months of reading instruction, the advantage disappeared, suggesting that literacy may come at a cost.
SourceMax Planck Institute for Psycholinguistics·JournalJournal of Cultural Cognitive Science·DateDec 1, 2018