A large-scale study identified seven new gene loci linked to obesity, showing a significant overlap with genetic mechanisms causing milder forms of overweight. The research included over 260,000 participants and demonstrated that extreme obesity shares similar genetic factors as normal or slightly elevated BMI.
Researchers developed a dual CAR approach that allows engineered T cells to selectively target tumor cells while sparing normal tissue. This innovative approach uses two separate antigen-specificity proteins, one for starting and another for boosting the immune response.
A researcher debunks the myth that temperature alone determines perfect eggs, highlighting the importance of cooking time. He also discusses how scientific misconceptions in cooking can be clarified through research, promoting a better understanding of chemistry and its applications.
Researchers found that Paragazole increases the sensitivity of triple-negative breast cancer cells to chemotherapy by inducing expression of estrogen receptors. The drug outperforms chemotherapy alone in a range of breast cancer cell lines, offering new hope for treatment options.
Scientists have developed a method to infuse fruit juice into chocolate, reducing its fat content by up to 50%. The process creates a smooth texture and prevents 'sugar bloom' on the surface of the chocolate.
Researchers found that fine particles in air pollution shade corals from sunlight, cooling surrounding waters and reducing growth rates. The study, published in Nature Geoscience, links coral growth to particulate pollution in the atmosphere.
Research from Nobel laureates presented at the American Chemical Society meeting includes advances in green chemistry and understanding of molecular structures. The work has significant implications for industries such as medicine and energy production.
Researchers discovered a genetic deletion in the SMIM1 gene responsible for the Vel blood group, allowing for more accurate DNA testing and reducing the risk of severe reactions during blood transfusions. The study also sheds light on how this gene influences red blood cell traits and haemoglobin levels.
Stress circuits in the brain can self-tune following a single stress, preparing for subsequent challenges. Unique time windows exist after brief stress challenges, where learning is increased or decreased.
Researchers have made significant progress in engineering blue-green algae to produce nanocellulose, a 'wonder material' with great strength and potential applications in biofuels, biomaterials, and more. The team successfully engineered the algae to produce fully functional nanocellulose.
Researchers use PALM microscopy technique to analyze enzyme cocktails and find specific targets for cellulase synergy. This reveals how different combinations of enzymes can generate synergistic activity, increasing saccharification efficiencies and reducing biofuel production costs.
Researchers found that kieselguhr, a common filtering material in beer production, releases arsenic into the beverage. The levels of arsenic are considered low and unlikely to cause illness, but the study highlights the need for breweries to take precautions when using this substance.
Researchers have identified four genes newly associated with severe childhood obesity and found an increased burden of rare structural variations in severely obese children. These variations can delete sections of DNA that help maintain protein receptors involved in weight regulation, promising new drug targets against obesity.
Researchers discovered that cells beyond the nose have receptors for sensing odors, raising questions about whether organs 'smell' food. The study's findings could revolutionize our understanding of how we experience flavors and aromas.
A physician-researcher from The Children's Hospital of Philadelphia will lead the first-ever pediatric Dream Team to combine genomics and immunotherapy to increase cure rates in difficult childhood cancers. The team aims to develop more precise and effective treatments based on unique genetic characteristics of each child's tumor.
A new study by Cleveland Clinic researchers reveals a connection between red meat consumption and an increased risk of heart disease. The research found that a diet high in carnitine promotes the growth of bacteria that metabolize the compound, leading to the production of TMAO, which is associated with atherosclerosis.
Scientists analyzed patent medicines from the Henry Ford Museum collection to identify potentially toxic substances like arsenic, mercury and lead. The study found that some ingredients were actually healthy and mainstays in modern dietary supplements, while others posed significant health risks.
Researchers developed a tunable process that separates human induced pluripotent stem cells (hiPSCs) based on their adhesive properties. The method allows for high-throughput separation and produces pure cultures with up to 99% hiPSC purity, enabling improvements in cell reprogramming and disease modeling.
Researchers found that combining non-steroidal anti-inflammatory drugs with cholesterol-lowering medication Lipitor can effectively prevent colorectal adenomas in mice. In contrast, the same combination was only effective when administered to mice with existing tumors.
Researchers found that women with HIV are at risk of acquiring cancer-causing forms of HPV, including types 52 and 58, which are not covered by current vaccines. Treating HIV may also protect women from HPV-related cancers.
Reducing food waste is vital to feed a global population of 9 billion by 2050. Scientists estimate that up to half of the food harvested from farmers' fields in developing countries is lost due to spoilage and pests. In developed countries, households throw away about 4 out of every 10 pounds of food produced each year.
Researchers at CSHL found that transposons increase in abundance and activity in the brains of fruit flies as they age, correlating with neurological degeneration. This 'transposon storm' may contribute to age-related brain defects in humans.
A phase 1 clinical trial found that a combination of sapacitabine and seliciclib showed anti-cancer activity in patients with incurable solid tumors and inherited BRCA mutations. The treatment demonstrated partial responses in four patients, stable disease for over a year in three others.
Researchers found that resistance training promotes the growth of white muscle, which helps regulate blood glucose levels. The study also identified potential drug targets for obesity and metabolic disease.
Scientists have developed a technology that enables microalgae to produce multiple types of renewable oils for fuels, chemicals, foods, and personal-care products within days. Solazyme's biotechnology platform unlocks the power of microalgae, producing tailored oils with optimized properties for various applications.
A recent study found that male smokers with low levels of serum bilirubin are at a higher risk of developing lung cancer and dying from the disease. The researchers analyzed data from over 435,000 people in Taiwan and found that lower bilirubin levels were associated with significantly higher rates of lung cancer incidence and mortality.
Researchers visualize retinoic acid distribution for the first time in a live zebrafish embryo, observing two opposing concentration gradients along the head-to-tail axis. This discovery confirms retinoic acid as a morphogen, essential for understanding tissue development and regenerative medicine.
A multinational study reveals that dengue is more prevalent globally than previously estimated, with 390 million infections annually, and Asia accounting for 70% of the burden.
The American Chemical Society has awarded $3,000 grants to 11 local sections to promote the use of the ACS Climate Science Toolkit in engaging diverse audiences. This initiative aims to increase understanding of global climate change among thousands of people across the country.
At the ACS meeting, scientists will discuss new discoveries related to energy and food, including sustainable sources of renewable oil. The event is expected to generate at least $16 million for the local economy.