IDRI and Medicago present data on their H5N1 Avian Influenza VLP vaccine candidate, combining IDRI's GLA adjuvant with Medicago's proprietary manufacturing technology. The trial shows promising results in evaluating the safety and immunogenicity of the vaccine.
Peter J. Stang has pioneered supramolecular chemistry, which could be used in drug delivery and oil refining. He is the first to receive the ACS Priestley Medal for his contributions to organic chemistry.
A new study suggests that medical therapy is a viable alternative to angioplasty in treating stable coronary artery disease, reducing the risk of complications and hospitalizations. The study proposes a targeted approach to shared decision-making, considering treatment options, risks, and outcomes for patients.
Researchers discovered that different wasp genotypes influence aphid behavior, including whether they die on the plant or elsewhere. The study sheds light on how genetic variation can manipulate host species.
A UC student researcher used satellite imagery to calculate ice flow velocity in Antarctica, predicting potential climate change impacts. The study aims to understand the process of ice motion and estimate influence on sea levels.
Using two therapies together has been shown to effectively restore vision in dogs with inherited blindness. The treatment approach may have implications for human patients as well. Researchers believe that combining gene therapy and selective photoreceptor cell destruction could lead to better therapeutic outcomes.
A team of healthcare professionals at Tufts University developed a list of 76 EPAs to structure competency-based assessment for family medicine residents. The EPAs cover key skills such as patient care, communication, and practice management.
A study found that the shingles vaccine halves the occurrence of this painful skin and nerve infection in people over 65. However, vaccination rates are low in the US, particularly among black people and those with low incomes.
A comprehensive study identifies multiple genes associated with schizophrenia risk, shedding light on brain function and immune response pathways. The findings pave the way for developing more efficacious drugs with fewer side effects.
Scientists at UC Irvine and the University of Kentucky have created synthetic materials that mimic the geometry of kidney bean leaves, trapping bedbugs in seconds. The technology has the potential to provide a non-toxic solution for bedbug infestations, which can cause significant discomfort and distress.
The 'Chemistry of the Bar' symposium delves into the scientific secrets of popular cocktails, including the Hurricane's key ingredients, their chemical compositions and sensory evaluations. The study highlights the importance of ingredient freshness and notes that using premium rum may not improve the taste.
Research at the University of Colorado Anschutz Medical Campus reveals that hsa-miR-146a is overexpressed in most metastatic bladder cancer tumors. This tiny miRNA molecule plays a crucial role in making bladder cancer more aggressive.
Researchers have identified a set of misregulated genes common to tobacco-related cancers, which are associated with poor patient outcomes in lung and bladder cancers. These genes relate to the regulation of the cell cycle and could serve as a new prognostic tool to predict survival rates for patients with tobacco-related cancers.
New models predict a massive 'greening' of the Arctic by mid-century, with up to 50% increase in wooded areas and acceleration of climate warming. This trend will have far-reaching impacts on global ecosystems and wildlife.
University of Michigan researchers create a new single-photon emitter that improves upon existing technology and is easier to make, paving the way for practical quantum cryptography. The device releases one photon at a time, allowing for secure communication by encoding messages in photons.
A new study by University of Missouri researcher Zhiqiang Hu has developed a cost-effective method for monitoring wetland health using microbial analysis. This approach can help identify healthy ecosystems and inform conservation efforts.
A new study found that placing copper objects in ICU hospital rooms reduced the number of healthcare-acquired infections (HAIs) by over half. The study showed significant reductions in HAI rates among patients in rooms with copper surfaces compared to traditional rooms.
Scientists have discovered several new species of hepaciviruses and pegiviruses closely related to human viruses in frozen stocks of wild mice. These rodent viruses have genes and proteins similar to human strains, suggesting their potential use in studying hepatitis C disease and developing vaccines.
Researchers found that prenatal stress increased obesity risk and associated conditions in adult rats. The study suggests that mothers' stress during pregnancy may alter the development of offspring, leading to a predisposition towards obesity and related health issues.
Researchers at Bonn University Hospital have achieved remarkable results using deep brain stimulation to treat treatment-resistant major depression. In six out of seven patients, symptoms improved considerably and rapidly, with significant improvements observed in anxiety, despondence, listlessness, and joylessness.
A new study from the University of Wisconsin-Madison found that age at diagnosis for children with autism depends on specific behavioral symptoms. Children exhibiting impairments in nonverbal communication and repetitive behaviors were more likely to be diagnosed earlier.
Researchers at Rhode Island Hospital found that patients co-infected with H1N1 pandemic virus and a second respiratory virus experienced similar outcomes as those with single-virus infections. Despite increased risk of secondary bacterial pneumonia, co-infection was not linked to hospital admission or ICU treatment.
UCLA researchers found a potential link between exposure to traffic-related air pollution and several rare childhood cancers, including acute lymphoblastic leukemia, germ-cell tumors, and retinoblastoma. The study analyzed data from 3,950 children born in California between 1998 and 2007.
Researchers found that egg white protein peptide RVPSL reduces blood pressure in laboratory rats, comparable to a low dose of Captopril. The study suggests that egg white peptides could become useful as an adjunct to high-blood-pressure medication.
McGill researchers demonstrate ability to modulate light using laser-pulse inputs to manipulate quantum mechanical state of semiconductor nanocrystals. This breakthrough could lead to the development of optical transistors, which would enable faster and more efficient data processing in telecommunications networks.
A study found that patients with papillary thyroid cancer (PTC) who have the BRAF V600E genetic mutation are at higher risk of death. However, overall mortality rates for PTC are low, and the association between the mutation and mortality was not independent of tumor characteristics.
A phase 1 clinical trial of Rigosertib, a dual kinase inhibitor, demonstrated the drug's effectiveness in patients with head and neck cancer who have failed platinum-based therapies. The results led to an 80-patient multi-institutional Phase II trial to explore biomarkers for accurate patient matching.
A new study in the Journal of Consumer Research found that subtle physical acts of closure can trigger choice closure and increase consumer satisfaction. Consumers who closed lids or menus on their selected items liked what they ate more than those who didn't perform an act of closure.
A new study has characterized cells responsible for driving calcium build-up in vessel walls, providing a potential therapeutic target. The researchers found that certain cells can differentiate into osteoclasts, leading to softening of the blood vessels, and that manipulating these cells could lead to a reduction in heart disease risk.
A study found a significant association between the ABCA7 gene variation and increased late-onset Alzheimer disease risk among African Americans, with a twofold increase in risk compared to European American populations. The research also highlights unique genetic risk levels for African Americans.
Researchers found short-term improvements in 68% of patients with FHD after low-frequency rTMS sessions, with reduced axial pen force and enhanced intracortical inhibition. However, clinical benefits were not sustained at longer follow-ups.
Researchers at Fox Chase Cancer Center have identified a naturally occurring agent that targets a gene important for the growth of leukoplakia cells, which can lead to head and neck cancer. Pharmacological inhibition of this gene reduced cell movement and proliferation in leukoplakia cells.
A study published in the BMJ found that a 5kg population-wide weight loss resulted in a significant reduction in Type 2 diabetes and cardiovascular disease mortality. The Cuban experience of rapid weight loss during economic crisis demonstrates the potential health benefits of reversing the global obesity epidemic.
Research by UC assistant professor Amy Townsend-Small found that intensive lawn care can negate soil's natural ability to store atmospheric toxins, despite improving its carbon-quelling capacity. The study compared urban lawns in Los Angeles and Cincinnati, revealing stark differences in their ecological impact.
A study of 91 unexplained fetal deaths found genetic mutations associated with long QT syndrome, a heart condition that can cause sudden death. The discovery sheds light on a potential cause of stillbirths and highlights the need for further research.
Researchers found that excess estrogen levels during pregnancy can silence the BRCA1 tumor suppressor gene, increasing breast cancer risk in daughters. Additionally, molecular abnormalities in the unfolded protein response pathway were also found to contribute to breast cancer risk.
A new study by Fox Chase researchers finds that heterogeneity is prevalent even in early-stage ductal carcinoma in situ (DCIS) breast cancer, making it challenging for pathologists to accurately diagnose and treat the disease. The results suggest that a multiple-target approach may be necessary to effectively combat breast cancer.
Beneforté broccoli consistently produces 2-3 times the amount of glucoraphanin as other varieties without affecting yield or nutrient levels. Genetic analysis identified a single gene responsible for increased glucoraphanin production, which channels more sulphur from the soil into this compound.
Scientists use AwakeSPECT to study Alzheimer's, dementia, and Parkinson's disease by acquiring functional images of conscious mouse brains. The system, developed at Jefferson Lab, tracks movement and removes motion artifacts, providing detailed brain chemistry changes.
Researchers identified genetic variants associated with long QT syndrome in a small number of cases of intrauterine fetal death, including stillbirths. The study found that these variants were more common in late miscarriages and stillbirths than expected, suggesting a potential link between LQTS and intrauterine fetal deaths.
Research reveals Six2 homeoprotein promotes detachment of breast cancer cells from tissues, enabling their survival through the bloodstream and colonization at distant sites. Higher Six2 expression in human breast cancer tissues is associated with aggressive metastasis.
Dartmouth researchers found significant geographic differences in male and female chin shapes, contradicting the notion of a single 'sexy' chin. The study tested the universal facial attractiveness hypothesis across nine regions, challenging Darwin's theory on the evolution of physical characteristics.
A study by Helga Tinnesand and her colleagues found that beavers use anal gland secretions to assess their foes, with older sons detected as a greater threat. This allows established territory owners to accurately gauge the level of response required.
Researchers found that Mer receptor overexpression correlates with melanoma progression and aggressiveness, driving disease severity. Investigational drug UNC1062 blocks Mer survival signaling, killing melanoma cells in dishes and mouse models.
A new study published in the Journal of Neuroscience reports that Riluzole, an ALS drug, has pinpointed a mechanism for spinal muscular atrophy (SMA) and restored neuromuscular function in worm models. The researchers suggest targeting SK2 potassium channels could lead to a more effective therapy for SMA patients.
Researchers have found that chlorogenic acids extracted from unroasted coffee beans can significantly reduce blood sugar levels and improve glucose control. The study involved 56 men and women who took different doses of a commercial green coffee extract, with results showing a dose-response effect and no gastrointestinal side effects.
An international team of scientists has created the first digital map of the entire Antarctic seafloor, revealing detailed topography with resolutions as low as 500x500 metres. This new bathymetric chart will help researchers predict sea currents, model geological processes, and understand marine life.
Researchers found that blocking phosphodiesterase 4B suppresses inflammation by affecting the CLYD gene, which acts as a brake on inflammation. This new strategy offers a safer alternative to current treatments that come with serious side effects.
A recent study found that Antimicrobial Copper surfaces can continuously kill 83% of bacteria causing HAIs within two hours, reducing the risk of infection. The use of copper alloy surfaces has been shown to significantly lower the proportion of patients developing HAIs in Intensive Care Units.
Researchers at Helmholtz Institute for Pharmaceutical Research Saarland have discovered a new peptide that inhibits bacterial RNA polymerase, preventing DNA-to-RNA transcription. The peptide, P07, shows promise as a potential new antibiotic with a unique mechanism of action that does not lead to cross-resistance.
A recent study suggests that people with low self-control prefer and depend on individuals with high self-control, which can aid in overcoming temptation. The findings also indicate that these individuals may be more likely to form adaptive relationships by surrounding themselves with others who possess strong self-control.
A new study found that consumers from less individualistic cultures are more likely to use price as a signal for product quality, whereas individualists focus on separate attributes. This insight can help companies target higher-priced brands towards collectivistic markets.
Researchers found that cosmic radiation impairs the ability of cells in the intestines of mice to eliminate oncogenic proteins, substantially increasing development of colorectal tumors. The study suggests that space travelers may be at increased risk of developing colorectal cancer due to prolonged exposure to cosmic radiation.
Scientists have discovered two new species of earthworms in the Mongolian Gobi Desert that possess extreme temperature tolerances and can partially regrow body parts when cut in half. The discovery sheds light on the fascinating world of earthworms, which play a crucial role in soil fertility and food chains.
The Johns Hopkins researchers developed a Web-based mathematical model to predict which patients would benefit from taking a possibly infected organ. The tool considers factors such as waiting list duration, previous transplants, age, and diabetes status.
BIND-014, a PSMA-targeted nanoparticle containing docetaxel, demonstrated anti-tumor activity in 28 patients with advanced or metastatic solid tumors. The Phase 1 trial showed encouraging signs of effectiveness, including one complete response and five patients with stable disease.
A new study by George Mason University researchers found that meditating before a lecture leads to better grades, with the effect being stronger in classes with more freshmen students. The study suggests that meditation may help students who struggle with focus and attention, particularly those in high-risk freshman courses.
Researchers developed a high-speed camera system to photograph snowflakes in 3D as they fall, capturing their true complexity and size. The Multi-Angle Snowflake Camera collects vast amounts of data to improve weather forecasting models and simulate precipitation.
Triplet-negative breast cancer lacks receptors for progesterone, estrogen, and HER2/neu, making it difficult to treat. Researchers identified key metabolites that could help differentiate among subtypes and point to new treatment targets.
Researchers used metagenomics to reconstruct genome sequence of Shiga-toxigenic E. coli outbreak strain, identifying pathogens without laboratory culture. The approach showed potential for rapid identification and characterization of bacterial pathogens in clinical specimens.
A new study by the American College of Radiology found that any potential work efficiencies gained when different providers interpret different medical imaging scans on the same patient are minimal and vary by procedure. The study suggests that Medicare's estimates of potential work savings were greatly exaggerated, with a maximum redu...
A new study found that one-quarter of women who need hormone-blocking therapies as part of their breast cancer treatment either do not start or do not complete the five-year course. Side effects were cited as the most common reason for skipping treatment.
Researchers found that Ranibizumab reduced the bioactivity of vitreous from patients and experimental animals with PVR, protecting rabbits from developing this disease. The study suggests a novel prophylactic approach to neutralize VEGF-A for managing diseases.
A study published in JAMA Network identifies genetic variants associated with Alzheimer's disease in African Americans, including ABCA7 and APOE genes. The findings suggest that these variants may also be relevant for individuals of European ancestry.
Researchers found that human hematopoietic stem cells can survive for longer periods when cultured with a feeder layer of adipocytes, or fat cells. The study demonstrates the potential for using fat cells to extend the lifespan of hHSCs in vitro, which could be crucial for developing advanced cell therapies.
Researchers have identified a protein called E2F3 that activates the IGF2 gene in normal development and cancer, shedding light on the genetic underpinnings of common cancers. This discovery may help understand the complex genetic choreography responsible for normal growth and diseases.
In a competitive context, consumers bid more when unknown bidders are involved. However, mixing eBay and Facebook reduces bidding prices by assuming competitors' traits, leading to lower aggressiveness. This study reveals the impact of interpersonal ambiguity on bidding behavior in auctions.
Researchers found that the drug combination resulted in a 70% decrease in tumor volume compared to single-drug treatment. The study suggests that MK-1775 and gemcitabine may represent a novel approach in treating sarcomas, offering new hope for rare cancer patients.
Researchers study Carboniferous collision in central Asia, crystal xenoliths in Bolivia, and the Tsakhir Event in southern Mongolia. The GSA Bulletin also examines iron oxide deposits in Brazil, paleotopography of Norway, and the Cheyenne belt suture zone.
Researchers identified BRCA2 gene mutation as first genetic factor for prostate cancer prognosis, associated with advanced disease and higher mortality rates. The study suggests a need for new treatment strategies for patients carrying these mutations.
Unused medical supplies can become contaminated with multidrug-resistant organisms, leading to increased healthcare costs. Hydrogen peroxide vapor disinfection has been shown to effectively sanitize the outside of packages, reducing contamination rates and associated costs.
Researchers from the University of Akron discovered that wet, water-repellent surfaces secure geckos' grip similarly to dry surfaces. The study may inform future bio-inspired gecko-like adhesives for underwater applications.
A new study found that Google searches for information on all major mental illnesses followed seasonal patterns, with winter queries consistently higher than summer ones. This suggests that mental illness may be more strongly linked to seasonal patterns than previously thought.
NREL employees Debbie Lew, Greg Brinkman, Maureen Hand, Trieu Mai, and Brian Parsons were awarded for their contributions to wind and solar integration studies. The Utility Variable-Generation Integration Group recognized their work on grid operations with high renewable power shares.
A new chemotherapy regimen combining Tarceva and Alisertib appears safe in patients with non-small cell lung cancer that has not responded to previous treatments. The study found minimal side effects and stabilization of tumors in some patients, paving the way for further research.
Researchers at UC Davis found that turbulence in waves signals purple sea urchin larvae to start searching for suitable habitat. The two-step process involves an initial response to turbulence, followed by a chemical signal triggering settlement and transformation into juvenile sea urchins.
A new study reveals how social class influences men's attitudes towards DIY home improvement. Upper-class men use DIY to experience physical labor and feel fulfilled, while lower-class men treat it as a chore to assert their masculinity and provide for their families.
The American Chemical Society presents a report outlining changes needed in graduate education in chemistry, aiming to prepare scientists for addressing global challenges like climate change and sustainable development.
A genetic biomarker, MYCN amplification, has been identified as a potential target for a new class of anti-cancer drugs in neuroblastoma patients. The study found that tumors with excess copies of the gene were highly sensitive to BET bromodomain inhibitors, leading to impaired cell growth and induction of cell death.
A novel protein governing metastasis and chemoresistance in pediatric osteosarcoma has been discovered using K9 osteosarcoma samples. The IGF2BP1 protein's overexpression is linked to aggressive disease progression, offering a potential target for treatment.
A Mayo Clinic study found gene variations that can predict chemotherapy-induced peripheral neuropathy, a debilitating condition affecting 20-30% of cancer patients. The study implicates genes EPHA5, ARHGEF10, and PRX, enabling clinicians to individualize treatment and improve patient outcomes.
Researchers developed a technique to measure the structure of gold nanocrystals under extremely high pressures, resolving distortion issues with X-ray beams. This breakthrough could lead to improvements in nanomaterials and a better understanding of planetary interiors.
University of Cincinnati student researcher Bo Yang develops method to combine thermal data from separate satellite systems, creating detailed maps of regional temperature fluctuations. This technique simplifies the process of analyzing parallel data, allowing geographers to derive daily surface temperature and emissivity information.
BIND-014, a targeted docetaxel Accurin candidate, demonstrated encouraging anti-tumor activity and was well-tolerated in 28 heavily-pretreated patients with advanced or metastatic solid tumors. The Phase 1 results established the maximum tolerated dose of 60 mg/m2 and showed signs of stable disease lasting at least four cycles.
A new class of tumor-fighting drugs using RNA interference has shown promising safety and efficacy in a clinical trial. The study found that the drug acts by silencing the PLK1 gene involved in tumor growth and can be safely administered in humans, with most patients tolerating it well and some showing therapeutic benefit.
A Johns Hopkins study found that official guidelines leave room for interpretation, leading to variable treatment choices and outcomes. Clinicians expressed ambivalence about hospitalizing patients, particularly those with recent abortions or social circumstances making inpatient care challenging.
The Gulf of Mexico's 'Dead Zone' grows larger due to increased fertilizer runoff from Midwestern fields, depleting oxygen levels and harming fish and shellfish populations. Advanced solutions like soil-staying fertilizers and genetically modified crops could mitigate the problem.
African-Americans with a variant of the ABCA7 gene have nearly double the risk of developing late-onset Alzheimer's disease compared to those without the variant. The study, led by Columbia University Medical Center, suggests that lipid metabolism may play a more important role in Alzheimer's disease among African-Americans.
Teenagers who increased daily exercise to at least 20 minutes were able to cut back on their smoking habit. The study found that this short walk helped teens resist lighting up a cigarette and increase their chances of quitting altogether.
Researchers have developed a new preclinical technology that enables quick determination of a treatment's effectiveness against gastrointestinal stromal tumors (GISTs) as early as 24 hours after administering the compound. This tool can help identify new drugs or drug combinations and quickly identify the most effective treatments for ...
A £670,000 project led by Professor Ian Glover aims to transform fault detection techniques, predicting and diagnosing imminent system failures. The technology enables quicker diagnosis, reducing maintenance needs and associated costs.
Researchers have created a new genetically engineered rat model that closely represents the brain changes associated with Alzheimer's disease, including tau pathology and extensive neuronal cell death. The rats developed memory and learning problems with age, supporting the idea that increases in beta-amyloid causes the disease.
A recent study found that people with HIV who start treatment before their CD4 count drops below 200 cells per microliter have life expectancies around 80% of the general population. Long-term treatment can manage HIV as a chronic illness, suggesting revised estimates for life insurance companies and epidemiological models.
Researchers at WSU will develop climate-resilient wheat varieties to tackle rising temperatures and limited water in growing regions. The project aims to identify genes associated with heat tolerance, benefiting all wheat-growing regions worldwide.
Research shows that diseases traditionally associated with wealth are now prevalent in middle-income countries, while obesity and high blood pressure are rising in poorer nations. The study suggests improved diagnosis and lifestyle changes in wealthy countries may be driving the shift.
Researchers found that high levels of cytokine TGFβ cause neural stem cells to become dormant, leading to reduced neurogenesis in aging and irradiation. Targeted therapies targeting TGFβ may improve cognitive function in elderly individuals.
Researchers found that omega-3 fatty acids and their metabolites slow or stop the proliferation of triple-negative breast cancer cells, reducing growth by up to 90 percent. The effect was stronger in triple-negative cell lines, with reduced motility and apoptosis rates.
A study published in Infection Control and Hospital Epidemiology found that a dedicated daily cleaning crew can effectively reduce C. difficile contamination in hospital rooms. The intervention included a standardized disinfection process, which significantly improved disinfection rates compared to traditional cleaning practices.
Researchers have successfully imaged the changes in morphology of gold nanocrystals under pressures of up to 6.5 gigapascals, solving a long-standing problem in measuring nanomaterial structures. The study shows that the nanocrystals undergo plastic flow, becoming more fluid-like at high pressure, and reveals new insights into the beha...
A study published in the Journal of Consumer Research found that sellers tend to focus on a product's desirability, while buyers consider both its desirability and usability. This difference in focus leads to price discrepancies between what sellers ask for tickets and what buyers are willing to pay.
The US Department of Energy's National Renewable Energy Laboratory (NREL) has launched an initiative to build an open-source database of real-world performance from solar facilities. The Open Solar Performance and Reliability Clearinghouse (O-SPaRC) aims to provide critical data on the long-term performance of residential and commercia...
A meta-analysis of 161 studies on prey diversity found that mixed diets enhance animal fitness, but not as well as specialized diets. Generalized diets may offer flexibility and less risk of predation, rather than nutritional benefits.
Researchers studied the teeth of the Neolithic mummy Ötzi, finding severe oral diseases such as advanced periodontitis and tooth decay. The Iceman's diet, which included starchy foods like bread and cereal porridge, contributed to his dental problems.
A new set of guidelines for abstracts in systematic reviews and meta-analyses aims to provide a robust summary of research. The PRISMA for Abstracts checklist helps authors present an explicit summary of results, facilitating quick assessment and efficient perusal.
A new genus of bat, Niumbaha superba, has been identified in South Sudan with a unique pattern of spots and stripes. The discovery highlights the country's rich biodiversity and underscores the need for conservation efforts.
A new study finds that sea level rise will lead to significant habitat loss and threaten the survival of endemic species in Southeast Asian and Pacific islands. The researchers predict that even a one-meter sea level rise could result in the loss of up to 14.7% of all islands in the region.
A study at Ohio State University found that 'grit' is a key factor in predicting college success for black men. Grit refers to the dedication to pursuing and achieving a goal despite obstacles and failures. This factor affects college grades almost as much as high school GPA and ACT scores, highlighting its importance.
Researchers found rapid genetic changes in laboratory soil mites leading to population growth and increased fertility, rescuing populations from extinction. The study demonstrates the intertwined nature of ecology and evolution.
A study using neutrons has explained how ozone causes severe respiratory problems by attacking the fatty lining of lungs. The attack leads to increased surface tension, impairing oxygen and carbon dioxide exchange.
Researchers at the University of Cincinnati have discovered how ancient Maya populations in remote areas built reservoirs to conserve water and used natural methods to purify their water supply. The findings, presented by doctoral student Jeffrey Brewer, show that these techniques were crucial for survival during extreme dry spells and...
The Myc oncogene can disrupt the 24-hour internal rhythm in cancer cells, suggesting potential for improved cancer treatments. By promoting the expression of Rev-erbα and NAMPT, Myc upregulates genes that suppress circadian oscillations, leading to altered metabolism and potentially increased replication rates in cancer cells.
Researchers have found that Yak-a-mein soup, a traditional Korean dish, contains ingredients like cysteine and salts that can help alleviate hangover symptoms. The soup's nutrients can also aid in replenishing lost sodium, potassium, and other essential minerals.