Researchers propose a five-step decision-making framework to identify resistance risks early, refine promising drug candidates, and prevent costly failures. The framework groups antibiotic candidates into five main risk categories, helping developers decide which compounds to prioritize, redesign or pursue for more targeted applications.
A new method, MALVINA, connects bacterial entry into cells, host-cell responses, DNA damage, and genetic background at the single-cell level. This allows researchers to measure the efficiency of bacterial entry, accumulation, and DNA damage, separating distinct virulence profiles among different bacterial strains.
A new study suggests that HLA-II peptide-binding diversity influences antibody responses and susceptibility to infections. Individuals with broader peptide-binding repertoires were more likely to show antibody responses and had a lower risk of severe infections requiring hospital care.
Researchers developed AI-based methods to analyze microscopic tissue images and molecular information, revealing genetic and protein profiles of tumor clones. The approach enabled the identification of distinct cell populations within a tumor, which differ in gene activity and protein function.
A three-year project aims to create a new formulation that supports the targeted and less invasive regeneration of injuries affecting intimate tissues. The researchers focus on extracellular vesicles, tiny particles released by cells, to facilitate intercellular communication and tissue regeneration.
The CLEVER project aims to create a comprehensive fungal EV atlas, investigating the role of extracellular vesicles in communication between pathogenic fungi and the human body. The research may lead to more accurate diagnosis and improved treatment of fungal infections.
Scientists are conducting a European clinical trial aiming to reduce antibiotic use and lower recurrent urinary tract infection rates by targeting pathogenic E. coli strains with CRISPR-enhanced phage cocktails and microbiome restoration therapies.
A study identified molecular anchors on gut phages that enable them to attach to human cells and remain intact. The findings suggest that these proteins are evolutionarily advantageous strategies driven by modular phage surface proteins.
Researchers discovered five dominant patterns of protein-altering mutations that determine tumor visibility to the immune system. These 'fingerprints' help predict immunotherapy response and suggest a more personalized approach to cancer treatment.
Researchers at HUN-REN Szegedi Biológiai Kutatóközpont have developed an AI-powered platform for automated 3D cell culture analysis, enabling high-precision screening of cellular models. The technology removes the limitation of throughput in personalized medicine, allowing for fast and accurate analysis of clinical samples.
Researchers found that DMT reduces infarct volume and edema formation in rat stroke models by restoring blood-brain barrier function and reducing inflammatory cytokines. The compound's dual action may complement existing treatments, offering a novel approach to stroke therapy.
Actin research experts gathered to discuss latest discoveries and advancements in actin-related biology. Key topics covered included actin cytoskeleton dynamics and its role in cellular processes.
A groundbreaking study has identified a dual-target approach that significantly prevents the development of resistance in bacteria. This approach combines membrane disruption with an additional critical cellular pathway, offering a potential solution to mitigate the escalating threat of antimicrobial resistance.
The AAIF2025 conference will bring together experts in actin biology from around the world to present latest research and discuss directions. The meeting will feature 27 invited speakers, short presentations, poster sessions, and social events.
Recent studies have found that new antibiotics are prone to rapid development of resistance, even before they are widely used. This raises concerns about the effectiveness of these treatments in the long run. To address this issue, researchers call for a shift in antibiotic development prioritizing novel modes of action and responsible...