The HCS-3DX platform performs automated analysis of three-dimensional cell cultures, known as spheroids. Using AI-based image processing and sample selection, the system enables large-scale, high-precision screening of cellular models within a fraction of the usual time.
“ Our goal was to create a unified platform that integrates the strengths of existing technologies and can be easily implemented in research and industry ” said Ákos Diósdi, first author of the study.
According to Dr. Péter Horváth, director of the Institute of Biochemistry at the HUN-REN Biological Research Centre, Szeged and senior author of the paper:
“ One of the main bottlenecks in personalized medicine has been the limited throughput of cell-based assays. The HCS-3DX system removes this limitation, allowing for fast, large-scale, and highly accurate analysis. ”
The technology is already being tested on clinical samples through a collaboration with the Heidelberg Children’s Hospital, where miniature tumor models derived from pediatric brain cancer patients are used to identify the most effective therapeutic options.
Official website: https://hcs-3dx.com/
Publication:
DOI: https://www.nature.com/articles/s41467-025-63955-5
Nature Communications
Cells
HCS-3DX, a next-generation AI-driven automated 3D-oid high-content screening system
7-Oct-2025