Researchers found that glucose levels sustain increased STAT3 activation in colorectal cancer cells. Targeting glucose metabolism could inhibit STAT3 and lead to novel therapeutic strategies.
Seq-Scope-eXpanded allows researchers to see even finer transcription detail, enabling discoveries that weren't possible with previous methods. The technology has been expanded to capture transcriptome from tissue with greater resolution.
A new poll finds that pets contribute to healthy aging benefits for older adults, including increased sense of purpose and reduced stress. However, 31% of pet owners aged 50+ report that owning a pet strains their budget, mainly due to financial costs.
A national poll found that nearly half of parents are aware of the risk of sudden cardiac arrest in teens, but only about half know their school has an automated external defibrillator (AED) on site. Parents support CPR and AED training, with four in 10 already trained to use an AED, and nearly nine in 10 willing to receive free training.
Researchers used AI to analyze RNA sequences from patients with antiphospholipid syndrome (APS), uncovering four distinct molecular patterns or 'endotypes' that drive disease. These patterns suggest different immune system behaviors and may require tailored treatments, offering a more personalized approach to APS care.
A new AI-powered model can read a brain MRI and diagnose neurological conditions with up to 97.5% accuracy, predicting treatment urgency and automating alerts for immediate medical attention. The technology has the potential to transform neuroimaging at health systems across the US, reducing workload and improving patient outcomes.
A machine learning model identified 17 environmental and social factors that contribute to out-of-hospital cardiac arrests. Mean ambient temperature and higher relative humidity are associated with an increase in OHCA incidents.
A recent poll found that 42% of people over 50 haven't gotten either flu or COVID-19 vaccines in the past six months. The leading reason for not getting vaccinated was a lack of perceived need, despite clear evidence showing vaccination reduces the risk of serious illness and death in older adults.
The Ann Arbor Guide provides two algorithms for triaging adults with suspected UTIs, one for non-pregnant women and the other for men. It also emphasizes the importance of accurate testing and treatment to prevent overuse of antibiotics and antibiotic resistance.
Researchers developed a novel tool, CytoTape, to record temporal cell activities in situ along a flexible intracellular protein fiber. This technology enables scientists to view interactions on a large scale and over long periods of time, breaking through the tradeoff between resolution and scale.
A pilot study found that long-term exposure to higher pollen levels leads to worse symptoms and quality of life for patients with chronic rhinosinusitis. Higher ragweed pollen exposure correlated with worse Sino-Nasal Outcome Test scores.
A new study finds that hospitals treating more patients with Medicare Advantage plans face higher readmission penalties despite taking similar actions to prevent repeat hospitalizations. The analysis highlights the need to incorporate Medicare Advantage data into the Hospital Readmissions Reduction Program.
A new study suggests that gaps in the nation's stroke transfer system reduce survivors' chances of receiving critical treatment and increase disability. Patients with longer delays in hospital transfer experienced worse disability after their stroke, highlighting missed opportunities for many stroke patients.
A statewide partnership in Michigan led to a significant increase in patients receiving follow-up imaging after aortic aneurysm repair. This resulted in a reduced likelihood of dying within one year of surgery and improved detection of early problems that can lead to device failure or future complications.
A national poll found that only half of parents believe children should never swear, with many acknowledging their own kids' occasional use of curse words. Peers are the top source of profanity, followed by popular media and home language.
Researchers developed a model that can predict long-term prostate cancer mortality risk using PSA scores, helping doctors and patients make informed decisions about further screening and treatment. The model was tested on over 200,000 patients and showed improved accuracy compared to existing risk calculators.
A recent University of Michigan study analyzed over 60 million Medicare participants and found that total visits remained stable or declined slightly through June 2024. Despite widespread adoption of telehealth, overall healthcare visits stayed steady or decreased, contradicting predictions of increased utilization.
A study analyzing 218.1 million notes from 1.6 million patients found 372 emojis in 4,162 notes between 2020 and 2025, with smileys/emoticons being the most common type used.
Researchers have uncovered the critical function of occludin in regulating cell barriers, particularly in diabetic retinopathy. The study revealed that occludin's alternative splicing produces a form of occludin that controls leaky blood vessels and excessive vessel growth.
Researchers found that over half of IVF cycles in the US were performed at clinics affiliated with private equity firms, sparking concerns about the impact on quality and accessibility. The study's authors emphasize the need for further research to understand the benefits and risks of this business model.
Researchers developed a microfluidic device to capture biomarkers released by tumor cells in glioblastoma patients. The device detected specific proteins associated with the disease and predicted patient responses to chemotherapy, improving treatment outcomes.
Researchers discovered a new protein target and developed a drug to treat non-small cell lung cancers with KRAS mutations. The molecular glue RPT04402 stabilizes the protein phosphatase 2A complex, leading to cancer cell death and delaying resistance to therapies.
Researchers developed an AI model that can detect coronary microvascular dysfunction using a common electrocardiogram, outperforming previous models in diagnostic tasks. The model can accurately identify a condition often missed in emergency department visits, providing a cost-effective and non-invasive way to diagnose serious heart co...
A national poll reveals that many parents struggle to provide guidance on healthy eating habits for their teens, particularly during the holiday season. The poll found that only half of parents report their teen eats three meals a day, and nearly a third report their teen snacks throughout the day.
A study published by Michigan Medicine suggests that AI can help increase the chance of people with risky drinking patterns or signs of alcohol use disorder getting outreach and help. The NLP tool analyzed full text of health records and identified over 47,500 patients with some sign of risky drinking.
A study from Michigan Medicine found that only 24% of public insurance patients and 30% of private insurance patients received primary care follow-up within one week of ICU discharge. Younger, healthier children were more likely to receive timely care. The lack of guidance led researchers to investigate this issue.
Scientists at Michigan Medicine have developed machine learning models that can analyze blood samples for biomarkers to detect ALS earlier and predict disease severity. The models show promising results, with predictions accurate up to 91% in some cases, and could lead to improved diagnostic accuracy and treatment options.
A new study suggests that prevention campaigns for cannabis-related vehicle crashes should target middle-aged and older adults, who are at risk of driving after using the drug. Adults over 50 who use cannabis daily or have mental health reasons are most likely to drive after using THC-containing products.
The new guideline recommends full-time infection prevention staff, comprehensive training, and support for all staff, as well as partnerships with hospitals and public health agencies. This guidance aims to reduce the risk of infections in nursing homes, saving lives and money.
A new study from Michigan Medicine found that its data-driven command center increased hospital bed use efficiency by 63%, reducing emergency department boarding time by 33% and patient transfers by 13%. The initiative also streamlined discharge processes, resulting in a 12% drop in waiting times for patients ready to leave the hospital.
A new poll suggests that more than 80% of people over 65 drive at least weekly, but less than half have made a plan for when they can no longer drive safely due to health changes. Only 6% of older drivers have discussed their driving with a healthcare provider.
A recent University of Michigan study sheds light on the critical protein Sarm1, which controls both nerve breakdown and regeneration. The research found that blocking Sarm1 boosts nerve regeneration but only if it preserves a delicate balance between protection and repair.
A newly developed tool called the DILI-Inpt prognostic score can predict which hospitalized patients with severe idiosyncratic drug-induced liver injury are unlikely to recover on their own. The scoring system outperformed existing systems in identifying patients at high risk of death and liver transplant need.
Leading experts urge universal hepatitis B vaccination for all newborns in the US, citing a 95% decline in infant infections since 1991. The policy has prevented an estimated one million hospitalizations and 90,000 deaths.
A two-stage, 24-week controlled trial found that patients who received lactulose therapy followed by tai-chi experienced fewer falls compared to a control group. The rate of injurious and non-injurious falls was significantly improved for those receiving both treatments.
A new poll found large gaps in knowledge about palliative care and hospice among older adults, with many unaware of the options despite interest expressed once explained. The poll highlights racial and demographic differences in understanding and interest, with some groups more likely to know about these types of care.
Research from Michigan Medicine uncovers connections between a longevity gene, behavior, and environment, suggesting that manipulating stress responses could extend life without downsides. Touch activates a circuit modulating signals to reduce the longevity effect of dietary restriction.
Two new studies found that 75% of adults prefer non-colonoscopy screening options like stool tests, while physicians prefer colonoscopy. Additionally, follow-up colonoscopies rose 41% after a policy change eliminated patient cost sharing for abnormal home-based stool tests.
Cardiac rehabilitation significantly improves short and long-term recovery for heart surgery patients, but women participate less than men due to barriers such as lower referral rates, clinician bias, and caregiving responsibilities. The American Heart Association scientific statement calls for targeted interventions to improve enrollm...
Researchers discovered that brains and economies follow similar rules in crisis, using physics principles to predict collapse and recovery. The study found that networks closer to first-order transition show faster collapse and slower recovery after a crisis.
A University of Michigan study found that Medicaid coverage is linked to employment gains among low-income adults with serious health problems. Employment nearly doubled among enrollees who experienced improved health, from 26% to 47%. This suggests that Medicaid expansion may actually help individuals participate in the workforce.
A study found that further testing in renal cell carcinoma with an overexpression of gene TRIM63 could uncover a mutation otherwise undetected, leading to more treatment options. In cases where tumors were positive for TRIM63 on a biomarker level but FISH negative, 70% ended up having MiTF gene rearrangement.
Researchers found that RNA modifications regulated Six3 RNA stability and inhibited stem cells-to-retina formation. The study also discovered a surprising effect of METTL3 on DNA without affecting its shape.
Rates of medications for opioid use disorder (MOUD) use increased among surgical patients from 2016 to 2022, with buprenorphine being the primary driver. MOUD use was highest in debridement and orthopedic procedures, highlighting the need for clinical practice guidelines to coordinate care and pain management.
A new poll reveals that 19% of people age 50 and over identify as a person with a disability, while half may be entitled to protections and accommodations due to physical or mental conditions. Despite this, only 18% receive accommodations for healthcare visits.
Researchers have discovered a novel compound that degrades key proteins found in prostate cancer cells, blocking oncogenic androgen receptor signaling. The study found that levels of H2BNTac, p300 and CBP are elevated in prostate cancer compared to normal tissue.
A national poll found that 1 in 10 young children play outdoors as infrequently as once a week, while nearly all engage in screen time daily. Parents are encouraged to create space for active, imaginative, and social play to support healthy development.
Physician Organization of Michigan ACO (POM ACO) has achieved significant savings for Medicare by reducing unnecessary spending and focusing on preventive care. The organization's efforts saved Medicare nearly $35 million in 2024, with members sharing in the $17 million incentive.
A recent study by the University of Michigan highlights the issue of limited language accessibility in patient portals, which can prevent vulnerable patients from accessing vital healthcare services. The study found that 29% of hospitals only offer access to their patient portal in English, and fewer than 5% offer it in the most common...
A new study finds that benzodiazepines and antipsychotics prescribed to patients with dementia receiving hospice care may carry major unintended risks, including increased mortality. The study highlights two policy issues: lack of oversight of medication use in hospice and a mismatch between hospice policy and dementia care.