A new study by Osaka University researchers demonstrates that the endothelial cell-specific protein Robo4 plays a crucial role in reducing mortality in severe infection. By upregulating Robo4 expression, a drug treatment can decrease vascular permeability and increase survival rates.
A new study found that the antibody-drug conjugate STRO-001 showed nanomolar cytotoxicity in 88% of cancer cell lines tested, with potent efficacy against proliferating B cells. The research supports ongoing clinical studies for patients with B-cell non-Hodgkin lymphoma.
Patients with high fracture risk and complex medical conditions are less likely to receive osteoporosis treatment and have poorer health outcomes. The study highlights the need for a comprehensive treatment approach that considers the patient as a whole, rather than just focusing on individual diseases and treatments.
Researchers developed a novel acid-resistant nanofiltration membrane for efficient treatment of acidic wastewater. The membrane shows high permeation for H+ while maintaining high retention for organics, making it beneficial for 'zero discharge' in strongly acidic organic wastewater reclamation.
A team of researchers completed a comprehensive review study on functionalized copper current collectors for lithium metal anodes, revealing promising improvements in electrochemical performances. The study showed that planar modified copper foils and nanostructured 3D copper substrates can stabilize lithium nucleation and deposition, ...
Researchers from DePaul University studied small mammals in eastern Paraguay's Atlantic Forest remnants to understand biodiversity and its relation to forest edges. They found that species richness and abundance increase closer to the edge, while phylogenetic diversity is higher in interior sites.
A new behavioral model, TRIBE, explains why clinicians and family dynamics drive excessive end-of-life care. The model highlights the emotional pressures on doctors and complex family dynamics that provoke unnecessary treatment efforts.
Researchers found that island tiger snake skulls increase in length after feeding on large prey, while mainland counterparts show no change. This adaptation allows them to survive on islands where large seabird chicks are abundant.
A study found that mesopelagic fishes, including lanternfishes, shrink in size with climate warming. Body sizes decreased by 35% during the interglacial period, affecting the ocean's ability to reduce atmospheric carbon dioxide.
A searchable library of 1,600 chemically-diverse plant extracts has been established, providing valuable insights into plant metabolites' roles in drug development. The library shares both data and methods, making it an exceptional resource for advancing chemodiversity digitization.
Scientists have discovered that cuprates follow a charge distribution predicted in 2016, enhancing superconductivity under pressure. This finding brings researchers closer to achieving superconductors at room temperature, a goal long pursued by physicists.
A recent study found that the airline industry maintains feminine cabin crews through strict appearance standards and grooming guidelines. Researchers discovered that female flight attendants are expected to maintain a slim body and adhere to traditional gender norms, with subtle forms of resistance occasionally employed.
Researchers create a hydrogen plasma with known temperature anisotropy, demonstrating the Weibel instability and its potential to seed galactic dynamo magnetic fields. The study uses a novel experimental platform to measure the complex topology of generated magnetic fields.
A trapped mountaineer survived 16 frigid hours in a crevasse on Denali, highlighting the importance of expert rescue efforts and proper treatment. The case study emphasizes the need for responders to continue extrication and treatment efforts even when survival seems impossible.
Researchers have found a rare lead compound, lead formate, in Rembrandt's masterpiece The Night Watch, shedding light on the artist's painting techniques and conservation methods. This discovery is significant as it provides new clues about the possible use of lead-based oil paint by Rembrandt.
A new study modified the Hospital Elder Life Program (HELP) for remote use, enabling hospitals to continue support despite in-person interactions limitations. The adapted protocol achieved full implementation and high adherence, supporting improved delirium prevention and care for older adults.
Researchers at NREL developed a framework to compare the performance of various plastics recycling technologies. They examined technical metrics such as material quality and retention, as well as environmental metrics including energy use and greenhouse gas emissions.
A study by researchers at the Federal University of São Carlos found that 86% of health workers reported burnout and 81% suffered from stress. They also experienced depression, slept badly, and complained of aches and pains. The study aimed to assess the effects of long working hours and burden on physical and mental health.
A Phase 2 clinical trial found that a probiotic reduced S. aureus colonization by 96.8% in the stool and 65.4% in the nose. The probiotic Bacillus subtilis was administered orally, surviving passage through the stomach, and did not harm gut microbiota.
Scientists have identified a new class of 'bivalent' antibodies that can bind to two viral targets at once, neutralizing multiple Omicron variants. These potent antibodies retain efficacy against early SARS-CoV-2 variants and several later Omicron sub-lineages.
Researchers at University of Galway outline a potential new treatment option for MRSA infections using purine nucleosides. The study shows that these sugar versions of DNA building blocks can interfere with bacterial signaling systems, making bacteria more susceptible to penicillin-type antibiotics.
A new study finds that dietary choline deficiency can cause profound negative effects on the body, including organ damage and changes in brain pathology associated with Alzheimer's disease. The research highlights the importance of adequate choline intake to protect against neurodegeneration and improve overall health.
A recent study found that soil microbes are releasing less CO2 in the summer due to decreased food availability, threatening their viability. However, autumn leaves mitigate this effect, but fewer dead leaves lead to a reduction in microbial biomass during the summer.
A new study standardizes the use of optical genome mapping (OGM) for patients with blood cancers, demonstrating its potential as a frontline test for diagnosing hematologic malignancies. OGM outperforms existing tests in detecting cancer-causing gene variants and identifying additional information that can improve patient outcomes.
A systematic review and meta-analysis found common risk factors for primary dysmenorrhea and premenstrual syndrome, including physical characteristics, menstrual characteristics, and lifestyle factors. Lifestyle changes such as maintaining regular sleep patterns, a healthy BMI, and stress management may help alleviate symptoms.
A new study found that children with persistent speech disorder are more likely to experience peer problems and emotional difficulties in school. The researchers analyzed data from over 7,300 participants and found no significant associations between speech disorders and depressive symptoms or antisocial behavior.
A comparative study of over 1,000 bird species found that parental care is the key factor influencing brain size. The researchers concluded that parental energy input, via egg size and active feeding after hatching, drives brain growth. This finding has implications for understanding differences in brain size across various animal groups.
Researchers at Linköping University found that climate fluctuations and agriculture coincided with the rise and fall of Persian Empires in southeastern Iran. The study suggests that climate played a crucial role in shaping these civilizations.
A new study by University of California, Davis researchers reveals that the internal circadian clock in sunflowers coordinates florets to open in concentric rings, attracting more pollinators. The study found that continuous light disrupts this pattern, leading to fewer pollinator visits.
A study found that individuals with the HLA-A*01:01 allele have developed robust T-cell immunity to COVID-19, suggesting a genetic predisposition to severe forms of the disease. The allele is more common in patients with mild or asymptomatic COVID-19.
A new framework identifies barriers and context-specific measures for plastic use and disposal, guiding policymakers in selecting effective intervention measures. The framework has been tested in Kyoto City, revealing potential desirable behavioral changes, critical barriers, and corresponding intervention measures.
A study at the University of Turku found that residential green environments increase oligosaccharide diversity and alter individual sugar molecule compositions in breastmilk. This suggests a potential mediating role for breastfeeding in mitigating disease risks in infancy.
People surveyed during the pandemic reported using fewer personal care products, more household cleaners, and eating less fast food. However, these changes may worsen health outcomes due to increased exposure to environmental chemicals linked to poor health.
Scientists from Nagoya Institute of Technology have discovered that Auger recombination rate decreases with increasing excited carrier concentration under high injection conditions. This finding has significant implications for optimizing SiC bipolar device efficiency and development of next-generation high-power devices.
Muscle mass and blood pressure are key factors in maintaining healthy arteries, with higher muscle mass and lower blood pressure linked to reduced arterial stiffness. The study found that these associations remain significant even after accounting for age.
Researchers have designed an algorithm based on insect neural circuitry to create a power-saving collision detector that can detect vehicles in real-life nighttime scenarios. The novel detector uses atomically thin and light-sensitive memtransistors, resulting in significant energy savings compared to existing systems.
Researchers develop a new optical method to detect topological phases in magnetic materials using Raman scattering. The technique shows promise for validating magnon topology and could lead to more sustainable technological devices with lower energy consumption.
Researchers have identified a new genetic risk factor for adult-onset macular degeneration by combining multiple maps. The study reveals that variations in the TRPM1 gene promoter alter LHX2 transcription factor binding, reducing gene activity and increasing disease risk. This finding advances our understanding of AMD's complex pathology.
In an emergency situation like infections or blood loss, the body needs to quickly compensate for the loss of blood cells. Scientists have found that progenitor cells in mice are responsible for regenerating mature blood cells, not hematopoietic stem cells.
A large clinical trial supported by the National Institutes of Health found that two widely used diuretics, furosemide and torsemide, did not differ in improving patient survival when compared. The study suggests a need for better treatments for heart failure patients and highlights the importance of optimizing diuretic doses to improv...
A new prostate cancer therapy is being tested in clinical trials, targeting the treatment-resistant form of the disease. The therapy uses a drug called Abivertinib to block a specific protein that allows tumors to produce androgens, a goal of using more targeted treatments like TKIs.
An international team of scientists suggests that an outward, fast migration of Jupiter can distort the configuration of Trojan swarms, resulting in more stable orbits in one swarm than the other. This new mechanism provides a natural explanation for the observed asymmetry in the number of asteroids in the L4 and L5 swarms.
Researchers at Kyoto University found that a poor, low-yeast diet causes fruit flies' larvae to grow dendrites in an unexpected way. The hyperarborization phenotype is triggered by a simultaneous deficiency in vitamins, metal ions, and cholesterol, which increases the production of Wingless signaling molecules from body wall muscle.
A new species record of mesophotic kelp was discovered in the Galapagos Islands, characterized by its extensive and dense kelp forest at depths of ~50m. The research highlights the importance of these forests as ecosystem engineers and supports for marine life, with potential implications for carbon sequestration.
Swansea University scientists developed a smart patch that can detect proinflammatory biomarkers of neurodegenerative diseases, including Alzheimer's, using microneedle technology. The patches can be self-administered for point-of-care diagnosis and have the potential to change the landscape of early disease detection.
A new study finds that exposure to salmonella bacteria increases colon cancer risk, with tumors developing earlier and growing larger in infected mice. The research highlights the potential for salmonella as an environmental risk factor for chronic diseases like colon cancer.
Researchers developed a cellphone-based colorimetric multi-channel sensor for simultaneous detection of various environmental contaminants. The compact sensor achieved high sensitivity, specificity, and reliability, with improved sensitivity by over six folds compared to direct photography.
Researchers developed a flexible genetic hacking system to convert split gene drives into full gene drives, enabling safe testing and potential real-world applications. The new system revealed surprising fitness costs of full drive systems, with slower-than-predicted spread rates in cage experiments.
Researchers from Kanazawa University have developed a nanoscopic tool using high-speed atomic force microscopy to assess alternative COVID-19 prevention methods. They found that viral surface roughness can enhance the infectivity of SARS-CoV-2 variants, but spike-neutralizing antibodies neutralize the Delta variant spike protein.
Researchers developed a novel approach to ionizable lipid synthesis for RNA therapy, targeting activated liver-resident fibroblasts with selective siRNA delivery. The treatment, shown to be successful in mice, stops fibrosis in its tracks by silencing Heat Shock Protein 47 and inhibiting collagen production.
Researchers found that UV nail polish dryers cause cell death, mitochondrial damage, and DNA mutations, leading to cancer-causing effects. Chronic use of these devices poses a significant public health risk.
A new study published in the Journal of Psychiatric Research found that even frontline healthcare workers without a formal PTSD diagnosis experience critical health symptoms. Subthreshold PTSD symptoms, not severe enough for a clinical diagnosis, were reported by over half of the surveyed healthcare workers.
This study found that advanced colorectal neoplasia prevalence is low 10 or more years after a negative screening colonoscopy. Extended screening intervals may be recommended for female and younger participants without gastrointestinal symptoms.
A new study published in Evolution, Medicine, and Public Health found that proper hand hygiene in clinical work can reduce the spread of antibiotic-resistant bacteria. The researchers developed a mathematical model to predict how good or poor hygiene affects resistance evolution, and tested it against data from 691 long-term care facil...
Researchers at Rice University have developed a new fluorescent dye that can cross the blood-brain barrier, allowing for noninvasive brain imaging and differentiation between healthy tissue and tumor cells. The dye's long-lasting fluorescence enables stable imaging over extended periods.
A study found that climate change threatens reproductive success of songbirds in California's Central Valley due to increasing rainfall and extreme heat. The researchers analyzed data from the Nestbox Highway project, which showed a decline in bird fitness amidst extreme precipitation or temperatures.
Researchers found women's immune responses to herpes simplex virus (HSV) vaccine are stronger, while those with prior exposure have different type I IFN signatures. This interaction may affect vaccine effectiveness.
A new study suggests that acupressure before surgery can reduce anxiety, while acupuncture during surgery may provide additional relief from severe pain. The research found that patients who received these treatments had better recovery scores and lower levels of pain and anxiety compared to those who received standard care.
Researchers found that echidnas blow bubbles from their nose to cool down, using the evaporation of moisture as an evaporative window. They also utilize flexible spines for insulation and lose heat through the spineless areas on their underside and legs, acting as thermal windows.
A new study published in The Lancet Child & Adolescent Health journal suggests that newborn screening for spinal muscular atrophy (SMA) can lead to better movement ability and independence in affected children. At two years post diagnosis, 11/14 children diagnosed by NBS were walking independently or with assistance.