Research finds that microglial dysfunction, neurovascular inflammation, and focal neuropathologies are associated with systemic inflammation in COVID-19. The study suggests that targeted inhibition of these changes could help alleviate neurological symptoms.
Studies using a rodent model found sustained increase in neural activity in the paraventricular thalamus (PVT) after exposure to a strongly stressful event. This persistent activity is linked to altered behavior, including restlessness and disturbed sleep patterns. The findings suggest a new therapeutic target for stress-related issues.
Research reveals that long-range projecting inhibitory neurons, particularly those expressing parvalbumin, play a key role in learning from aversive stimuli. These neurons are necessary for integrating multiple sources of aversive information and transmitting integrated data to the limbic system.
Researchers found that the medial septum, a brain area in the center of the forebrain, plays a key role in encoding and retrieval processes. It helps generate gamma oscillations, which are faster for storing and slower for recalling memories.
A new study reveals a novel cortico-thalamic connection that targets the thalamic reticular nucleus (TRN), which plays a crucial role in regulating inhibitory activity in the brain. The discovery provides insights into the neuronal basis of normal cognition and chronic neurological diseases linked to frontal cortex.
Researchers discovered specialized direct contact sites between microglial cells and developing neurons, regulating brain development. Inhibiting these interactions disrupts normal cerebral cortex structure, highlighting microglia's crucial regulatory role in brain development.