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Mice flown on the International Space Station in microgravity experience bone loss mostly in weight-bearing bones, which might help inform human acclimation to spaceflight

03.26.25 | PLOS

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37-Day microgravity exposure in 16-Week female C57BL/6J mice is associated with bone loss specific to weight-bearing skeletal sites
MicroCT images of the femoral head bone and cartilage in ground control (GC) versus spaceflight (FLT), showing premature secondary ossification in microgravity. Credit: Eduardo Almeida, Rukmani Cahill and Elizabeth Blaber, CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/)

Article URL : https://plos.io/3FxPQEj

Article title: 37-Day microgravity exposure in 16-Week female C57BL/6J mice is associated with bone loss specific to weight-bearing skeletal sites

Author countries: US

Funding: Supported by NASA Space Biology Grant NNH14ZTT001N14-14SF to EACA. The funder did not play any role in the study design, data collection, analysis and manuscript preparation, or in the decision to submit for publication. https://science.nasa.gov/biological-physical/programs/space-biology/

PLOS One

10.1371/journal.pone.0317307

37-Day microgravity exposure in 16-Week female C57BL/6J mice is associated with bone loss specific to weight-bearing skeletal sites

26-Mar-2025

The authors have declared that no competing interests exist.

Keywords

Biomedical Research Funding Bones Human Biology Space Flight Space Stations

Article Information

Journal
PLOS One
DOI
10.1371/journal.pone.0317307
Article Publication Date
2025-03-26
Article Title
37-Day microgravity exposure in 16-Week female C57BL/6J mice is associated with bone loss specific to weight-bearing skeletal sites
COI Statement
The authors have declared that no competing interests exist.

Contact Information

Hanna Abdallah
PLOS
onepress@plos.org

How to Cite This Article

APA:
PLOS. (2025, March 26). Mice flown on the International Space Station in microgravity experience bone loss mostly in weight-bearing bones, which might help inform human acclimation to spaceflight. Brightsurf News. https://www.brightsurf.com/news/80ERQVQ8/mice-flown-on-the-international-space-station-in-microgravity-experience-bone-loss-mostly-in-weight-bearing-bones-which-might-help-inform-human-acclimation-to-spaceflight.html
MLA:
"Mice flown on the International Space Station in microgravity experience bone loss mostly in weight-bearing bones, which might help inform human acclimation to spaceflight." Brightsurf News, Mar. 26 2025, https://www.brightsurf.com/news/80ERQVQ8/mice-flown-on-the-international-space-station-in-microgravity-experience-bone-loss-mostly-in-weight-bearing-bones-which-might-help-inform-human-acclimation-to-spaceflight.html.