About The Study: In the PREDIMED-Plus trial, an energy-reduced Mediterranean diet and physical activity lifestyle intervention mitigated weight loss– and age-related bone mineral density decline among older women with metabolic syndrome compared with conventional ad libitum Mediterranean diet recommendations. Weight-loss lifestyle interventions with longer follow-up are warranted in the future to confirm these results in relation to bone health.
Corresponding author: To contact the corresponding authors, email Jesús F. García-Gavilán, Ph.D. ( jesusfrancisco.garcia@urv.cat ), and Jordi Salas-Salvadó, M.D., Ph.D. ( jordi.salas@urv.cat ).
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(doi: 10.1001/jamanetworkopen.2025.3710)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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