A leading paediatric expert emphasizes the importance of including children in research programmes to develop targeted therapies. This approach acknowledges key differences between children's and adults' metabolisms, organs, and disease behaviors.
Scientists at Wake Forest University School of Medicine have discovered that an obesity drug, orlistat, can be repurposed to target and kill cancer cells. The breakthrough, published in Nature Structural and Molecular Biology, provides a promising new avenue for the development of more potent cancer treatments.
The new criteria focus on a clinical core of early and significant episodic memory impairment, incorporating biomarker-based tests. Validation studies are necessary to optimize sensitivity, specificity, and accuracy.
A new drug candidate, abiraterone, has shown significant anti-tumor activity in early trials for patients with advanced prostate cancer whose tumors have continued to grow despite medical or surgical castration. The drug reduced PSA levels and shrunk tumors in both pre- and post-chemotherapy patients.
Researchers found a significant link between genetic variation on chromosome 8 and the risk of colorectal cancer, with individuals carrying the specific marker being 23% more likely to develop the disease. The study suggests that this single genetic variation might account for 14% of colorectal cancer cases in Israel.
Researchers found that pumpkin extract promotes regeneration of damaged pancreatic cells in diabetic rats, boosting insulin levels and reducing the need for daily insulin injections. The extract's protective effect is attributed to antioxidants and D-chiro-inositol, which may provide a new source of medication for diabetics.
Scientists at the University of Cape Town have developed a genetically engineered (GE) maize variety that is resistant to maize streak virus (MSV), a destructive pathogen that can wipe out entire maize crops. The transgenic maize variety has proven consistently resistant and can be reliably passed on to future generations.
The sizes and positions of floral anthers facilitate pollen collection by buzz-pollinating bees, according to Dr. Endress's work. Slight genetic changes can affect flower morphology and pollinator compatibility, highlighting the importance of understanding these interactions.
Researchers identified an essential protein that plays a key role in myelination and remyelination, processes vital for healthy brain development and repair. The discovery has major implications for treating brain damage in newborns and may lead to treatments or interventions to enhance brain health.
Scientists identify rapid evolution of plant defense genes as a cause of hybrid incompatibility, leading to sterility and defective offspring. This phenomenon may contribute to the formation of new species through gradual genetic incompatibilities.
Researchers at the University of Southern California have identified a common genetic risk factor for colorectal and prostate cancer. The study found that one variant previously associated with prostate cancer also increases the risk of developing colorectal cancer.
A new study reveals an alternative distribution mechanism in female sex cells that cause chromosome disorders, leading to infertility and irregular numbers of chromosomes. This fundamental mechanism may help explain the common occurrence of such disorders in females.
A successful bioeradication program in Lake Victoria reduced fish populations, improved hydroelectric power generation, and decreased malaria and schistosomiasis cases. The program used natural enemies of the invasive water hyacinth to control its spread, eliminating the need for pesticides.
Researchers have identified a gene, GLIS2, that protects against a serious kidney disease called nephronopthisis. Mutations in this gene cause the disease, which leads to kidney degeneration and failure.