The International Society for Heart and Lung Transplantation releases comprehensive global guidelines for managing heart failure patients prior to transplantation. The guidelines aim to enhance patient care, optimize outcomes, and improve resource allocation.
Researchers enhanced donor lungs using clinical maneuvers, increasing transplant procedures without compromising recipient function. The San Antonio Lung Transplant protocol improved lung procurement rates by up to 50%, reducing lengthy wait times and potentially eliminating deaths among patients awaiting lung transplantation.
Researchers developed uniform tungsten trimers on titanium dioxide, offering insights into metal oxide catalysts. The nanostructures reveal consistent alignment and uniform size, making them ideal for fundamental reactivity studies.
Half of registered nurses report chronic interference of work with their home lives, impacting personal health and ability to provide quality care. Work-family conflict can exacerbate the nursing shortage and lower job satisfaction.
A Northwestern University study finds that the kouprey, Southeast Asia's 'forest ox,' is unlikely to be a wild species due to its genetic similarity to a domesticated breed. The researchers believe it may have originated from a domestic hybrid between banteng and zebu cattle.
Researchers at The Wistar Institute have identified a single molecule required for genome compaction in spores and sperm, a process critical for passing genetic information to offspring. Compaction helps protect the genome from damage and is essential for maintaining fertility in higher organisms.
A new study suggests that taking rosiglitazone, a medication for type 2 diabetes, can prevent the disease in people at high risk. The three-year trial found that this combination reduced the risk by about two-thirds, preventing around 144 cases of diabetes per 1000 people.
Researchers at Thomas Jefferson University have discovered a new way to sidestep gleevec resistance in leukemia cells. By reactivating the protein C/EBP-alpha, they found that leukemia development is halted. This discovery could lead to new treatment strategies for leukemias resistant to gleevec and other cancers.
Patients can self-report muscle weakness, fatigue, cognitive problems, and mood changes associated with statin use on a new web site. The site aims to gather information on side effects and provide education on minimizing health risks.
The University of Miami Rosenstiel School has received a total of $1 million in NOAA grants to improve hatchery and offshore aquaculture technology. The program aims to develop ecologically sustainable aquaculture practices with minimal environmental impact.
Newly discovered behavior in cancer cells reveals a toggle switch that enables them to morph into highly mobile cells, invade other tissues, and adapt comfortably. This understanding could lead to finding ways to stop metastasis, the most deadly trait of cancer.
A University of Pittsburgh study reveals that weight concerns can decrease a woman's motivation to remain smoke-free postpartum. Women who were confident in their ability to control their weight without smoking were more motivated to stay abstinent.
A new test, OncoPlan, has been developed to predict which breast cancer patients are likely to benefit from chemotherapy. The test measures the levels of two proteins that play a role in cancer growth and survival.
A potential diagnostic marker indicates anti-angiogenic drugs' effectiveness by measuring a decrease in circulating endothelial cells. Anti-angiogenic drugs target tumor blood vessels, starving them of oxygen and nutrients.
Researchers at NIST and NC State University found that Prozac can interfere with freshwater mussels' reproductive cycle. The study, which examined fluoxetine's effect on native mussels, raises concerns about potential health impacts for humans and animals due to continuous exposure to pharmaceuticals in waterways.
A new study found that IPF patients who can cover less than 680 feet during the six-minute walk test are four times more likely to die. The test's accuracy was found to be superior to other measures, such as forced vital capacity percent (FVC%).
Researchers at Ohio State University have made a groundbreaking discovery on how water molecules interact with proteins, revealing that they slow down to connect with proteins. The study provides an early result in explaining essential biological functions like protein folding and enzyme catalysis.
A new candidate biomarker, galectin-3, has been identified as a potential marker for heart failure diagnosis and prognosis. Elevated levels of this inflammatory protein can help diagnose heart failure and identify patients at risk of dying within 60 days.
Prisons in the US are woefully ill-prepared for a flu pandemic, putting the public at risk. Nearly 85% of prisoners will be released within a year, carrying diseases like HIV and tuberculosis with them.
Researchers found a unique genetic mutation that makes people susceptible to herpes simplex virus-1, leading to viral encephalitis. The study challenges current thinking on how genes work with infections, providing new insights into the immune system's response to pathogens.
Scientists used holotomography to study arabidopsis seed's internal structures, discovering a network of voids that may store oxygen for efficient germination. The technique reveals the seed's three-dimensional organization and circulation system, opening new research avenues.
In a study led by Johns Hopkins Medicine, researchers discovered that patients with chronic sinusitis who failed to respond to treatment had severely decreased immune function and lower production of key proteins. The findings suggest new treatment targets for this condition affecting an estimated 32 million Americans.
Scientists sequenced the first complete tree genome, poplar, to develop sustainable plantation forestry and biofuels production. The research identified over 45,000 protein-coding genes and 93 genes associated with cellulose production.
Panic disorder affects up to 5% of the population, causing recurrent anxiety attacks and agoraphobia. Anti-depressants and cognitive-behavioural therapy (CBT) are effective treatments, but less than half of those in need receive care due to barriers such as diagnosis difficulties and insurance coverage issues.
The Ames Laboratory will collaborate with Iowa State University and Sandia National Laboratory to develop software that enables access to three of the world's most important computational chemistry codes. The project aims to accelerate scientific discovery in areas such as energy, climate change, and materials science.
Researchers found that slow theta oscillations tune into high-gamma waves, allowing areas of the brain to coordinate activity and transmit information. This coupling enables top-down executive processes like attention and memory to be connected to low-level perceptions and actions.
A recent study published in PLOS Genetics has identified two distinct genetic profiles among modern Europeans, which can be used to control for ancestry in genetic studies. The findings have significant implications for understanding the distribution of genetic variation in European populations and their impact on disease research.
The Lancet has published profiles of the 13 WHO Director-General election candidates, highlighting their relevant experience and achievements. The journal will continue to follow the campaign and publish detailed statements from the candidates on its website.
Researchers have developed two new technologies to measure cell growth in the laboratory, one for monitoring drug effects on cancer cells and another for testing multiple cell types or dosages simultaneously. This breakthrough could lead to more accurate assessments of cancer treatments and improved drug development.
Researchers found that patients with advanced squamous cell carcinoma of the head and neck whose tumor samples over-expressed p53 protein were significantly more likely to respond to Advexin therapy than those with low p53 protein. The study suggests that p53 overexpression may be a predictive biomarker for Advexin efficacy.
Scientists create radioactively tagged molecules for positron emission tomography (PET) scans, providing insights into addiction and brain function. The radiotracers help monitor drug distribution and receptor activity in the brain, revealing key factors in addiction.
Researchers at MIT have found a unique cloud forest in Oman where trees extract moisture from passing clouds, but the ecosystem is under threat from over-grazing camels. The trees' ability to collect water from fog may not be enough to recover if the camels continue to eat too much foliage.
Researchers have successfully unraveled the first tree genome, that of the poplar, revealing approximately 45,000 genes. This knowledge can help accelerate bio-ethanol production and improve trees' efficiency in processing biomass for paper and energy.
A Kansas State University research team has received a four-year, $1 million grant to conduct curiosity-driven nanoscience and technology research. The team, led by distinguished professor Chris Sorensen, aims to develop new particles with unique properties that can be used to create novel materials.
A study published in Child Development found that children aged 5-11 who read stories about friendships between their group and a stigmatized group had more favorable views of the group. The stories emphasized the commonalities between the characters, leading to increased understanding and reduced prejudice.
Researchers at the University of Illinois College of Medicine identified a molecule that plays a critical role in lung tissue recovery following severe injury. The study found that FoxM1, a protein controlling cell proliferation, is involved in endothelial regeneration and barrier integrity restoration.
A study by Purdue University researchers has identified unusual genetic traits in voles that challenge current scientific understanding. The vole's unique genetic makeup, including its ability to insert DNA into the nucleus, could have important implications for human genetics and gene therapy.
Researchers found that imatinib can block the development of disease in a mouse model of rheumatoid arthritis, providing hope for a new treatment. Additionally, studying adrenomedullin's effect on female mice revealed that reduced expression may severely decrease fertility. Meanwhile, a study on TNF-alpha discovered that it decreases e...
A team of researchers has produced cyclopeptides that imitate the HNK-1 carbohydrate from human natural killer cells, stimulating axon growth in motor neuron cell cultures. These glycomimetics could be a promising starting point for developing treatments for spinal cord injuries.
The International Astronomical Union has named the newly discovered dwarf planet Eris and its moon Dysnomia. The name Eris was proposed by Michael Brown and accepted unanimously by the Working Group for Planetary System Nomenclature and the Committee for Small Body Nomenclature.
A study by Kathleen Caron and colleagues found that reduced expression of gene AM in female mice leads to severely decreased fertility and fetal growth issues. This suggests a potential link between altered AM expression in humans and impaired fertility.
Researchers found that a single genetic assay can predict response to different targeted therapies in gastrointestinal stromal tumors. Patients with exon 9 mutations or wild-type genes may benefit more from Sutent, while those with exon 11 mutations may require longer Gleevec treatment.
Several chemistry professors successfully implemented kitchen chemistry experiments in their distance learning courses, achieving impressive results. Students made accurate measurements using common household items like baking soda and vinegar, improving their understanding of qualitative analysis, paper chromatography, and density.
A new study reveals that white children attending primarily white schools are more likely to attribute negative intentions to African-American children than those in diverse school settings. Children from diverse backgrounds were more optimistic about cross-race friendships.
A new 'superlens' has been integrated into a microscope to visualize two-dimensional objects, such as holes in gold films. This innovation increases the resolution beyond the wavelength of light, allowing for previously impossible imaging of ultra-small objects.
A climatologist and a political scientist argue that planning for droughts can minimize losses. In contrast, the US still reacts to droughts as unexpected emergencies, wasting resources. Experts call for a shift in perspective and proactive risk management.
A team of researchers has captured images of molecular motors' structural changes using electron microscopy. The findings provide insights into the mechanisms behind these tiny molecules' movements, which power cellular processes like cell division.
A new study suggests injecting sulfates into the stratosphere could slow down global warming and provide more time to reduce greenhouse gas emissions. The approach has been shown to stabilize climate for up to 20 years, but geoengineering is not a panacea and mitigation alone can also address ocean acidification issues.
A growing concern among Americans is the rising cost of healthcare and access to medical services. The Lancet editorial calls for a comprehensive solution to address these issues, with a focus on improving the healthcare system for all Americans.
The partnership aims to address pediatric health concerns through groundbreaking scientific research and monitoring disease, with the goal of finding long-term solutions for childhood obesity and type 2 diabetes. The collaboration will also support increased awareness and education on these critical health issues.
Researchers developed culturally sensitive cartoons to measure aggressive behavior in African American inner city schoolgirls. The cartoon versions were found to be as valid as written descriptions in measuring how these girls interpret social situations.
A team of archaeologists has uncovered a previously unknown system of writing on a stone block in Veracruz, Mexico, believed to be the earliest in the New World. The Cascajal block dates back to around 900 BCE and features a distinct script with poetic couplets, challenging existing knowledge of Mesoamerican civilization.
The Cassini spacecraft has detected a massive ethane cloud surrounding Titan's north pole, contradicting previous assumptions of extensive ethane clouds and surface liquids. The discovery suggests that ethane may be 'snowing' onto the surface, forming methane lakes below.
Genomatix Software GmbH has won a $1.6 million BioChance grant to research RNAi mediated regulatory networks. The two-year project will expand its competence in this field, complemented by academic partners from LMU Munich and DKFZ Heidelberg.
Researchers have successfully created a nanoscale system to control the Kondo effect in semiconductor materials. The two-quantum-dot system exhibits interesting behavior, including filtering the effect of current leads and studying pseudo-gapped systems and correlations.
Researchers discovered how Myc oncoprotein drives tumor angiogenesis in pancreatic cancer by inducing IL-1beta expression. Blocking IL-1beta activity can thwart tumor angiogenesis, offering experimental evidence for cancer drug therapies targeting this pathway.
Researchers discovered that estrogen receptor alpha (ERalpha) binds to a novel enhancer in the cyclin D1 gene (CCND1), promoting estrogen-responsive cell proliferation. This basic understanding may lead to the development of improved therapies for patients with breast cancer.
The Burroughs Wellcome Fund is providing $1.292 million to support Project Suc-SEED, a partnership between CIIT and the ACS to recruit underrepresented students for Ph.D.s in chemistry. The project aims to build on the success of Project SEED, which has placed 36 national award winners in science competitions.
The Georgia Guidebook for Pedestrian Planning provides a vision, goals, and objectives for pedestrian planning in the state. The guidebook aims to enhance safety, create seamless integration of pedestrian facilities, and encourage a pedestrian-friendly environment.
ACTOS demonstrated significant improvements in reducing the risk of heart attacks, strokes, and cardiovascular death in high-risk patients with type 2 diabetes. The study showed a 23% reduction in heart attacks and an 18% reduction in combined risk of cardiovascular death, nonfatal heart attack, or nonfatal stroke.