In a landmark international trial, teclistamab outperformed standard treatments in extending survival and remission for patients with relapsed multiple myeloma. Nearly 70% of patients remained disease-free after 18 months, and nearly two-thirds achieved complete remission.
Researchers propose a novel compound to inhibit cytochrome P450 function and suppress drug metabolism in tuberculosis treatment, reducing bacterial mutation and resistance. The compound targets enzymes released by the bacterium rather than the bacterium itself.
A recent study identified a new type of β-1,2-glucan-binding protein in bacteria, which binds cyclic β-1,2-glucans and has implications for understanding bacterial interactions with these complex molecules. The discovery opens up new avenues for developing biological pesticides to protect crops from pathogens.
Researchers at King's College London have developed a new approach called 'Efflux Resistance Breaker' (ERB), designed to overcome one way bacteria escape antibiotic treatment. This allows antibiotics to remain inside bacterial cells at higher concentrations, restoring their ability to kill bacteria even with resistance mechanisms present.
Researchers use a single rubidium atom trapped in an optical tweezer as a scanning probe to image fine structures of light patterns with spatial resolution surpassing the diffraction limit. The technique successfully visualizes both light intensity and polarization distributions at the nanoscale.
Researchers found that the right ventricle is better able to withstand loss of blood perfusion and oxygen supply during cardiac arrest, leading to longer preservation of its native electrical activity. The study's findings support the use of surface ECG signals to predict neurological recovery after hospital admission.
A study found that no social media restriction experiments have included people under the age of 16, making it impossible to know how bans will affect young people. Bans may also backfire by invading privacy, hurting marginalized people, and forcing teens to circumvent the ban.
A study published in Nature Communications reveals that phytic acid, found in plant-rich diets, activates a cellular regulator to maintain intestinal barrier function. This finding offers a promising natural solution for managing leaky gut and its link to chronic conditions.
GLP-1 RAs improve mitochondrial function, reduce oxidative stress, enhance autophagy, and attenuate inflammaging. They affect all 12 hallmarks of aging, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, insulin resistance, and dysbiosis.
A new study found limited evidence that front-of-pack food labels help lower sugar intake among disadvantaged groups. Simplified nutrition labels can influence consumer behavior overall, but their effectiveness for lower-income or disadvantaged populations is unclear.
A robot that catches itself when it falls has been developed using reinforcement learning and artificial intelligence. The system achieved an average success rate of 69.4 percent in arresting the robot's fall and returning it to a stable position.
The study reports a green ion-exchange, self-catalytic strategy for turning pulp-waste lignin into high-performance wood adhesives. The optimized LA/CA adhesive showed strong dry and wet performance, meeting Type I plywood requirements and reducing costs by up to 69.6% compared to petrochemical-based adhesives.
A new transfer learning framework connects two gait analysis tasks, predicting continuous gait cycle percentage and classifying discrete gait phases. The method achieved high F1-scores and efficiency, outperforming traditional approaches.
A novel fecal proteomics method confirms orangutan mothers breastfeed their offspring continuously until 6.5 years old. This prolonged breastfeeding supports the high survival of orangutan offspring and contributes to their slow reproductive strategy.
Jin-Quan Yu, a leading figure in synthetic organic chemistry, has been elected Fellow of the Royal Society for his groundbreaking work on C-H activation and development of chiral catalysts. His research has far-reaching applications in drug development and medical imaging.
Researchers from Kyushu University and DENSO IT Laboratory propose a new method to improve the accuracy of indirect Time-of-Flight (I-ToF) cameras by considering real-world sensor characteristics. The technology produces two tailored coding schemes that outperform conventional methods in terms of depth precision and stability, making i...
A University of Washington-led team found that bean plants release gases to attract predatory wasps, which prey on caterpillars. This defense mechanism is mediated by a protein called INR, showcasing the tiny actions of one protein affecting behavior and protecting plant health.
Researchers found the number of homeless encampment sweeps in Oakland significantly increased after the 2024 Supreme Court decision, with some sites being closed repeatedly. The analysis suggests that sweeps are dispersing people rather than addressing homelessness, pushing vulnerable individuals into more vulnerable neighborhoods.
Researchers at Scripps Research Institute developed an experimental vaccine that leads to broadly protective HIV antibodies in every rhesus macaque tested, a reliable outcome for vaccination alone.
Researchers found that repeated vaping can create harmful byproducts in high-puff electronic cigarettes, including methylglyoxal and glyoxal, which are associated with significant cell damage. The study suggests that users of heavily used devices may inhale higher levels of these compounds than those using fresh devices.
A new brain imaging test can detect Alzheimer's disease pathology in twice as many people before symptoms appear. The test uses a new tau PET tracer that identifies more tau-positive cases than the current standard, leading to better decisions about who is on an Alzheimer's trajectory.
A major clinical trial found ocrelizumab significantly slows disability progression and preserves hand and upper-limb function in people with primary progressive multiple sclerosis. The study included over 1,000 patients across 22 countries and showed a 30% lower risk of disability progression.
Researchers found biomarkers for Alzheimer's disease that correlated with minor cognitive differences in midlife adults. These biomarkers, measuring tau and amyloid plaque, were associated with a greater chance of cognitive decline, particularly in processing speed and executive function.
A study found that 14 million workdays are lost annually due to menopause, while women rely on online misinformation for medical advice. The authors advocate for open conversation and inclusive approaches to combat stigma and support women's health during this transition.
A blood test can identify signs of Alzheimer's Disease decades before symptoms appear, suggesting early detection and potential treatment. A new brain imaging test also detects Alzheimer's Disease biomarkers earlier than the current standard, improving diagnosis and treatment options.
A new species of raptor-like dinosaur, Kank australis, has been unearthed from southern Patagonia, Argentina, and is believed to have grown up to three meters long. The discovery provides insight into the fish-eating habits of theropod dinosaurs, challenging common portrayals of raptors as terrestrial predators.
Research from the University of Texas at Austin found that pandemic loan fraud explained 22.5% of average housing price increases in 2020-2021. This type of fraud hurt individuals who bought houses at inflated prices, and had secondary effects on auto title registrations and other economic indicators.
A new Northwestern University study finds that most proposed US lithium mines could face significant water shortages, posing challenges to the country's growing industry. Climate change and competition for resources exacerbate existing water stress in areas like southern California and Nevada.
A new study by the Child Mind Institute found that more than one in four youth with mental health and neurodevelopmental concerns experienced negative online experiences, including cyberbullying and harassment. Despite this, only 20% of these incidents were reported through platform tools.
The Phase 3 SUNRISE trial shows that tezepelumab nearly triples the likelihood of reducing daily oral corticosteroid dose in patients with severe, oral corticosteroid-dependent asthma. Patients treated with tezepelumab achieve greater reductions in oral steroid use while maintaining asthma control and improving key clinical outcomes.
Research found that African elephants are a keystone species for dung beetles in Kenya's savannas, with their removal causing a collapse in beetle populations and ecosystem functions. The study highlights the importance of considering the conservation value of species beyond just charismatic animals.
Ochsner Health celebrated its 23rd Annual Research Week from May 18 through May 21, featuring scientific findings and recognized excellence in discovery and patient outcomes. The week also showcased award-winning lectures and presentations on cancer biology, precision medicine, and innovative clinical trials.
Scientists have discovered a previously unknown mechanism that transfers heat into the deep ocean, even when surface water temperatures remain stable. The study reveals an abrupt 5°C warming in intermediate waters at 800 meters depth over the past 11,000 years, linked to changes in Southern Hemisphere ocean-atmosphere circulation.
Scientists analyzed vast botanical data to understand why some exotic plants become invasive pests. They found that the timing of flowering is crucial and depends on climate conditions, with native species adapting to local environments and invasive species thriving in milder regions.
A new model shows that the processivity of motors helps break symmetry in chromosomes, driving deformation from a ball to a cylinder shape. The model explains structural patterns like chromosomal jets and provides insights into eukaryotic chromosome replication.
A new framework, SUVA, enables organizations to measure and adjust AI chatbots' social preferences, improving their performance in customer complaints and other human-AI interactions. By understanding an LLM's existing tendencies, organizations can decide whether an available model already fits its values and usage scenarios.
Researchers at UCLA Health have identified a brain region called the ventromedial prefrontal cortex (vmPFC) that regulates memory integration. The vmPFC acts as a quality control checkpoint, preventing memories from getting mixed up when they are significantly different or far apart in time.
A new poll by Physicians Committee for Responsible Medicine finds that most men consider a carnivore diet to be 'masculine' and would change their diet if it put their health at risk. The survey also found that consuming meat is linked to an increased risk of heart disease, erectile dysfunction, and reduced fertility.
Agricultural science educators in Tennessee and Nebraska benefit from professional development programs to create VR content and lessons. The programs aim to improve agricultural literacy and increase student interest in these careers through experiential learning.
Researchers used game theory to identify promising porous carbon materials made from agricultural and industrial waste. The study found that certain samples, such as rice straw-KOH-level 2, performed well in terms of surface area and pore volume, making them suitable for applications in soil amendment, water conservation, and pollutant...
Dogs with lower urine ammonia-to-creatinine ratios may experience faster kidney disease progression, higher fatality rates, and shorter survival times. UACR levels also may represent an earlier marker of acid dysregulation before more obvious changes in blood tests.
Researchers at UTHealth Houston have been awarded a five-year, $3.3 million grant to extend the Dating it Safe study from 15 to 20 years. The study aims to determine how adolescent behaviors impact adult mental health and relationships.
A new study found that excavated urban soils in South Korea emit measurable amounts of CO2 and CH4, highlighting a previously overlooked climate cost. Researchers suggest simple practices like soil capping and biochar amendment could be integrated into construction workflows to mitigate these emissions.
The CDL Healthcare Delivery stream will support early-stage ventures building technology to reduce costs, improve patient outcomes, and accelerate innovation in real clinical environments. Founders will have access to University Hospitals as a living laboratory, testing their technologies with clinicians and caregivers.
A new study found that pairing biochar with beneficial Bacillus bacteria can improve phosphorus availability in soil, reshape the root-zone microbial community, and strengthen root architecture. This leads to increased fruit-cluster branching and a 23.53% increase in cherry tomato yield.
Researchers found that obesity alters the biological changes in breast cancer cells, enabling them to survive and thrive. The study's findings could improve prediction and treatment of invasive breast cancer, reducing overtreatment and unnecessary treatments.
Researchers at OSU found that taller buildings and those with flammable exterior materials produce more embers, which can cause 90% of structure losses. The study aimed to predict how fires will spread and design resilient buildings against wildfires.
Researchers from Ohio State University Comprehensive Cancer Center present new findings on a hospital program that redistributes unused oral cancer drugs donated by patients. The program helps patients avoid treatment delays caused by insurance issues, shipping problems or cost, and has been shown to reduce drug delays by six days.
Experts from medicine, psychology, and geography will discuss the links between climate change and mental health, highlighting specific perspectives from South Africa and Germany. The webinar aims to integrate mental health into climate and health strategies.
Researchers created a microscopic, nonlinear light source that can be switched on, off or tuned to a particular intensity by an electrical 'knob'. The device is just 200 nanometers wide and has a controllable active area of two-to-six nanometers, enabling faster and more efficient optical switching.
Researchers recreated the maternal-embryo interface using a novel co-culture system and mapped lipid metabolic dynamics during early implantation. Arachidonic acid metabolism is essential for embryo attachment, endometrial receptivity, and trophoblast development.
A large aging cohort study found that regular dietary habits, particularly protein-rich foods, can influence physical functioning later in life. Adults with lower protein intake were more likely to develop reduced muscle strength and difficulty performing everyday activities over time.
A pioneering training program equips health workers with effective conversation skills to address vaccine hesitancy, resulting in improved attitudes towards vaccination. The program has already upskilled over 400 health workers across the UK, leading to increased confidence and better vaccine conversations.
Researchers at Helmholtz-Zentrum Dresden-Rossendorf have developed biobased spintronics using iron, cellulose, and starch to create sustainable magnetic field sensors. These sensors achieve levels of sensitivity comparable to commercial solutions and can be safely degraded or recycled.
Researchers developed a liquid reactive ink that can print copper onto surfaces without oxidation or corrosion, enabling faster, cheaper, and more sustainable electronic production. The breakthrough has the potential to revolutionize the conductive ink industry by replacing expensive metals with copper.
A new approach to guiding spin waves around sharp corners has been developed, resulting in a significant boost in signal strength. The innovation uses a two-dimensional magnonic crystal with a copper film perforated with holes, creating a 'complete magnonic bandgap' that reflects spin waves.
Recent studies indicate an extension of dry seasons and changes in rainfall patterns in the Amazon, with some predictions surpassing decades' projections. Climate models show intensified water deficits, particularly in southwestern regions under high greenhouse gas emission scenarios.
A new study examines farmer risk preferences when dealing with climate impacts, finding that attitudes toward uncertainty vary widely among farmers. The researchers suggest that different types of programs or policies could be targeted to each group, depending on their level of risk aversion and management decisions.
Researchers found that mirror-image forms of chiral molecules behave differently due to asymmetric magnetic field strengths. This discovery supports a theory about how life began on Earth, proposing that magnetized surfaces played a key role in the emergence of biological molecules.
Activated memory B cells can recognize and target ovarian cancer cells, producing effective antibodies. The discovery advances the development of vaccines and therapies based on immune memory against cancer.