Researchers found a specific region of the receptor interacts with signaling lipid PIP2, leading to desensitization. This discovery provides critical information on temperature regulation and opens new avenues for investigating membrane protein functions.
Researchers found no detectable levels of SV40 in 69 tumors tested using a highly sensitive assay. The study's protocol aimed to eliminate possible contamination from DNA vectors used in laboratories worldwide.
Researchers at Mount Sinai School of Medicine discovered that alpha-defensin-1, a protein found in cells, can directly inactivate HIV virus and block infection in vulnerable cells. The findings offer insight into the function of alpha-defensin-1 on both the virus and the cell, potentially leading to new avenues for prevention and therapy.
A study found that PRO 2000 gel reduced HIV and HSV infectivity by at least 1000-fold, with no significant inflammatory response. The results suggest a potential safe and effective vaginal microbicide for preventing sexually transmitted infections.
Scientists have made a breakthrough in understanding diabetic nephropathy by identifying CD36 as the probable trigger of kidney disease in diabetics. High glucose levels cause a change on the surface of cells, triggering the production of CD36, which leads to kidney cell death.
Researchers identified an inherited gene variant associated with a 50% increased risk of prostate cancer, revealing a new pathway for the disease's development. The study found that individuals carrying this variant face a higher risk of developing prostate cancer.
The SPORTIF V trial found ximelagatran effective in preventing strokes and systemic embolic events, but with higher mortality rates compared to warfarin. The study results suggest a solid clinical benefit for ximelagatran, but more research is needed to safely bring it to market.
A study by Mount Sinai School of Medicine found that mice fed a reduced carbohydrate diet slowed disease progression, with anti-amyloidogenic activities increased and plaque development prevented. The findings provide a possible mechanism for caloric reduction to prevent Alzheimer's disease.
A Mount Sinai School of Medicine study identifies the shared precursor cell, called the hemangioblast, in early mouse embryos. This finding provides strong proof for the existence of a common origin for vascular cells and hematopoietic cells.
Researchers at Mount Sinai School of Medicine discovered a new mechanism that contributes to the development of some breast and ovarian cancers, involving the Wnt pathway. Compounds blocking this receptor can make cancer cells more sensitive to agents that induce cell death.
Researchers at Mount Sinai present groundbreaking studies on prostate and breast cancer treatments, identifying genetic predictors for adverse side effects and developing tailored radiotherapy regimens. The studies aim to improve clinical trials and patient outcomes for these devastating diseases.
A study led by Mount Sinai School of Medicine researchers found that imidazole-4-acetic acid-ribotide may be a primary cause of high blood pressure and a molecular link to diabetes. The molecule binds to receptors in the brain, leading to elevated blood pressure, which can also impair insulin release.
A Mount Sinai study found that nearly three-quarters of WTC responders experienced upper respiratory issues, with half still experiencing symptoms eight months later. Over half had persistent psychological symptoms, with risks for PTSD four times that of the general male population.
A study published in the New England Journal of Medicine found that reducing allergens and tobacco smoke in the home can significantly reduce asthma symptoms in African-American and Hispanic children. The research involved over 900 children aged 5-11, who were randomly assigned to either an intervention group or a control group.
A study by Mount Sinai School of Medicine found that East Harlem grocery stores were less likely to stock diabetes-friendly foods compared to Upper East Side stores. The research highlights the need for healthier food options in underserved communities.
Dr. Capitulo has been recognized for her leadership and research in nursing education and patient-centered care. Her national fellowship includes a $30,000 grant to develop a model for navigating industry changes, building on her experience leading major redesign projects and creating patient-focused care models.
A groundbreaking study by Mount Sinai School of Medicine found that the combination of Pegasysα and Copegus significantly improved treatment response rates for patients co-infected with HCV and HIV. The study showed a sustained virological response rate of 40% among all patients, with even higher efficacy rates for those with genotypes...
A new study by Mount Sinai School of Medicine researchers found that combining three therapeutic modalities increases the percentage of high-risk patients who are free from recurrence after five years. A three-pronged approach that included brachytherapy, external beam radiation therapy and hormonal therapy produced an 86 percent rate ...
Immune cells that get trapped in atherosclerotic plaques attract more immune cells, setting up a cycle that leads to continued progression of the disease. Monocytes take up permanent residence in plaques due to altered differentiation factors.
A nationwide survey found that approximately 11 million people in the US have food allergies, with shellfish being the most commonly reported severe allergy in adults. The study also revealed that seafood allergies often begin later in life, with a prevalence of at least 2.5% among adults and 0.8% among children.
Researchers found that among patients with confirmed Crohn's disease, clinical decisions based on capsule endoscopy findings improved outcomes in 95% of patients. Capsule endoscopy was also 100 percent effective in excluding a diagnosis of Crohn's disease.
A study by Mount Sinai School of Medicine found that brachytherapy effectively treats prostate cancer while preserving quality of life. The research team followed 255 patients with prostate cancer treated with I-125 and reported minimal urinary symptoms, preserved potency, and reduced bleeding.
The FREEDOM trial will investigate the impact of cardiovascular disease in diabetics and develop new approaches to management and treatment. The study aims to provide clear guidelines on procedures for diabetic patients, including CABG and angioplasty with stents.
Researchers identified a genetic mutation in one gene that increases the risk of autism by approximately doubling it, according to Dr. Joseph Buxbaum's study published in the American Journal of Psychiatry.
A study analyzing SPORTIF III and V trials found that ximelagatran is at least as effective as warfarin in preventing strokes and systemic embolic events in men and women with atrial fibrillation. The analysis also showed lower bleeding rates for ximelagatran, particularly among women.
A multinational trial found that the combination of Pegasys and Copegus significantly increased sustained virological response rates in patients co-infected with HIV and Hepatitis C. The study reported 40% overall efficacy, including 62% efficacy for genotype 2 and 3 patients.
A new vaccine for genital herpes is being tested in a clinical trial, aiming to protect women against this sexually transmitted infection. The vaccine has passed preliminary safety and effectiveness testing and is now enrolling approximately 7,550 healthy female volunteers between 18-30 years old.
Researchers are testing a gene therapy approach called tumor immunization, which involves delivering the IL12 gene to cancer cells to trigger an immune response. The method has shown promise in laboratory and animal studies, with up to 20% of animals experiencing complete tumor eradication.
Researchers from Mount Sinai Hospital identified a key role for the hippocampus in forming episodic memories. The study used rats to examine brain activity while they searched for food in a maze, revealing place cells that signaled location alone and others sensitive to recent or impending events.