Researchers at Mount Sinai School of Medicine have found a potential new treatment for osteonecrosis, a debilitating disease caused by steroid use. Injecting ACTH significantly reduced bone death in rabbits with osteonecrosis, promoting increased blood flow to bone cells and preventing cell death.
Researchers at Mount Sinai School of Medicine found that Alzheimer's pathology begins with Amyloid-Beta oligomers in the brain, rather than previously thought amyloid plaques. The study suggests that these clumps, not plaques, are toxic to brain cells and may be a major target for new treatments.
Researchers at Mount Sinai School of Medicine have discovered a genetic framework that can explain and predict adverse drug reactions, including heart arrhythmias. The framework, developed by Ravi Iyengar and his team, uses genetic information to identify potential risks for arrhythmias in patients taking certain medications.
Researchers at Mount Sinai School of Medicine found that epigenetic marks on human placentas change throughout pregnancy, potentially allowing for early diagnosis and prevention of complications. The study's findings suggest that genomic imprinting appears to be an ever-changing process in the placenta.
Researchers from Mount Sinai School of Medicine present studies on a potential new drug for multiple sclerosis and surprising trends showing reduced disease severity. The studies found that teriflunomide was safe and effective as part of combination therapy, reducing lesion size and volume in the brain.
A Mount Sinai study of over 400,000 people found that high fruit and vegetable consumption reduces cancer risk by only 3%, with benefits limited to certain populations. The researchers concluded that the association is weak and may not justify increased dietary recommendations.
A study published in Environmental Health Perspectives found that exposure to phenols, phthalates, and phytoestrogens may disrupt the timing of pubertal development in girls. High exposure to certain chemicals was associated with early breast development, while others were linked to delayed puberty.
Researchers at Mount Sinai Hospital found that meta-cognitive therapy significantly improved symptoms of attention deficit hyperactivity disorder (ADHD) in adults compared to supportive therapy. The study, published in the American Journal of Psychiatry, demonstrated the efficacy of a non-medication treatment for adult ADHD.
Researchers from Mount Sinai School of Medicine identified potential heart problems in responders on-site at the World Trade Center collapse. They found impaired diastolic function, particularly in middle-aged men, which can lead to shortness of breath and heart failure.
A recent study by Mount Sinai researchers demonstrates that skin cells found in human amniotic fluid can be efficiently 'reprogrammed' to pluripotency, a characteristic similar to human embryonic stem cells. This breakthrough has significant implications for stem cell research and patient care.
A study found that nearly 60% of hospice patients with implantable cardioverter defibrillators (ICDs) have the shocking function deactivated, despite potential benefits for their quality of life. ICDs can cause physical and psychological distress for patients and their families.
A study by Mount Sinai researchers found a connection between prenatal phthalate exposure and disruptive behaviors in children. Mothers with higher phthalate metabolite levels reported poorer behavioral profiles in their children, including conduct and externalizing problems.
A team of investigators analyzed 30 randomized trials of Vioxx and found a strong concern for cardiovascular events or death as early as December 2000. The analysis showed a 35-43% increased risk of cardiovascular events or death, highlighting the need for informed treatment decisions and public health efforts.
Researchers found that a lower-calorie diet slows development of age-related conditions such as Alzheimer's disease, while a high-calorie diet accelerates oxidative stress. Dietary restriction activates transcription factor CBP, which regulates cellular function.
The study utilizes a viral-based gene transfer system to make Nerve Growth Factor (NGF), which helps maintain nerve cell survival in the brain. Participants will receive CERE-110 via neurosurgery or placebo surgery and undergo thorough medical examinations and cognitive testing.
Researchers found that patients with more difficult-to-treat forms of hepatitis C are less likely to initiate treatment, with marital status and comorbidities being significant factors. Mount Sinai is now launching a program to increase support systems for patients, aiming to improve treatment rates.
A clinical study found that cutting back on processed and fried foods, high in AGEs, reduces inflammation and restores natural defenses. The 'AGE-less diet' reduced blood AGE levels and improved biomarkers of vascular function by 60%, even in people with kidney disease.
Researchers found that first responders exposed to caustic dust and toxic pollutants after the 2001 World Trade Center attacks are twice as likely to have asthma. The study of 20,843 responders reveals a significant risk for this population.
Researchers at Mount Sinai School of Medicine report a promising result from the ADAGIO trial, finding that rasagiline may slow Parkinson's disease progression. The study used a novel design to examine the effect of early treatment on disease progression, and found benefits for patients starting therapy with rasagiline.
A new study by Mount Sinai researchers found that cognitive testing by telephone is as effective as in-person testing in evaluating cognition in elderly individuals. The study used well-established neuropsychological tests and involved 54 healthy women with an average age of 79.
Researchers at Mount Sinai School of Medicine have found that a natural compound called NIC5-15 may be a safe and effective treatment for mild to moderate Alzheimer's disease. The preliminary findings suggest that NIC5-15 can prevent the formation of beta-amyloid plaque, a key factor in cognitive decline.
A recent study by Mount Sinai faculty suggests that a gene associated with type-2 diabetes decreases in Alzheimer's disease dementia cases. The research found that promoting PGC-1 content in brain cells attenuates hyperglycemic-mediated β-amyloid production, linking type-2 diabetic metabolic defects to increasing dementia.
A new report card shows that the Midwest leads in palliative care access, while Southern and for-profit hospitals struggle. States like Vermont, Montana, and New Hampshire earned top grades for their palliative care programs, while Oklahoma, Alabama, and Mississippi received F's.
A new study found that hospitals can save significantly by implementing palliative care programs for seriously ill patients. Savings ranged from $279 to $374 per day and up to $2.5 million annually.
Researchers at Mount Sinai School of Medicine have developed a new gene silencing technology that can effectively suppress transcriptional expression of targeted genes in human cells, including those linked to various diseases. This breakthrough could pave the way for preventing diseases where gene dysfunction plays a role.
New research reveals that infection with the 1918 influenza virus granted survivors lifelong protection against the disease. Antibodies produced by these individuals proved effective in blocking the viral infection in mice.
Researchers at Mount Sinai School of Medicine found that sorafenib increases overall survival by 44% compared to placebo in advanced liver cancer patients. The study also showed a significant delay in cancer progression.
Researchers at Mount Sinai School of Medicine have discovered a new window into the brain, revealing how addictive drugs trigger permanent changes in brain cells. The study's findings provide clues for targeting addiction with new drugs.
A tracking system helped improve rates of medical oncology consultation and reduce disparities in breast cancer treatment by notifying surgeons when their patients visited an oncologist. The new system also eliminated racial disparity in treatment, as minority women were less likely to receive underuse of adjuvant therapy.
Researchers at Mount Sinai School of Medicine have discovered a novel targeted gene therapy that simulates the pain-killing effect of opiate drugs, providing relief for more than three months after a single injection. The technique targets selectively the pain gate, avoiding unwanted side effects associated with opioid painkillers.
Researchers identified 7 anti-hypertensive drugs that significantly prevent beta-amyloid production, a key mechanism in Alzheimer's disease. These drugs, including Valsartan and Propranolol HCI, showed promise in preventing cognitive deterioration and memory loss in mice with Alzheimer's disease.
Researchers at Mount Sinai School of Medicine have identified taste receptors in the human intestines that sense glucose and regulate appetite. These receptors may lead to new treatments for obesity and diabetes by controlling blood sugar levels.
A new study conducted at Mount Sinai School of Medicine found that cyclical estrogen injections protected brain cells from age-related deterioration. The research suggests that a critical window of opportunity exists in which estrogen therapy may be helpful in preventing memory loss, and that timing is crucial.
A Phase II clinical trial suggests that extracorporeal photopheresis (ECP) is effective in treating clinically active Crohn's disease, with a 50% response rate after 3 months of treatment. Patients who responded to ECP therapy experienced notable improvements in disease symptoms and signs within six weeks.
Research grants aim to reduce suffering for seriously ill patients and their caregivers, with studies focusing on communication, treatment advances, and caregiving support. The initiative supports clinician investigators conducting patient-oriented research in palliative care.
Researchers at Mount Sinai School of Medicine have developed a new imaging technology using multi-detector computed tomography (CT) and a novel contrast agent N1177 to detect high-risk plaque. This may help physicians diagnose a heart attack before it occurs, preventing cardiac events.
A $12.5 million grant from Charles Bronfman will establish the Charles Bronfman Institute for Personalized Medicine, transforming medical practice with genomics-based strategies for disease detection and treatment. The gift will seed a $30 million initiative to advance personalized medicine at Mount Sinai.
A new study found that ibuprofen significantly raises the risk of heart attacks in high-risk cardiovascular patients taking aspirin for osteoarthritis. The Mount Sinai researchers' findings underscore the importance of considering NSAID interactions with aspirin in these patients.
Dr. John H. Morrison has received a $5 million MERIT Award to support his research on brain cell adaptability and its impact on age-related cognitive decline. This recognition highlights the strength of Mount Sinai faculty during a challenging time for researchers.
Dr. John A. Martignetti received a $6.1 million grant to investigate the potential therapeutic role of siRNA in metastatic prostate cancer. The award aims to improve survival and reduce side effects and death for men with advanced prostate cancer.
Researchers developed a new imaging technique to capture the movement of white blood cells in real-time, allowing for a better understanding of Sickle Cell disease. The technique, called digital multi-channel videomicroscopy, has the potential to aid investigations and develop therapeutics for this debilitating disease.
Children born with low birth weight are more likely to develop depression and social dysfunction if they experience child abuse, according to a recent study. The study found that those who suffered both low birth weight and child abuse had significantly poorer outcomes than those who experienced either adversity alone.
Researchers found that modifying the 1918 flu virus's hemagglutinin receptor binding site reduced its ability to transmit in ferrets. The study suggests that understanding this molecular mechanism could lead to the development of novel drugs to stop influenza transmission and prevent epidemics.
Researchers used MRI to detect macrophages in arterial walls, which indicate inflammation and cardiovascular disease. The study found a 79% increase in detection compared to baseline images, suggesting a potential noninvasive screening tool for heart attack risk.
A study published in Clinical Gastroenterology and Hepatology found that stool DNA testing can detect colorectal cancer with 88% accuracy, regardless of its stage or location. This non-invasive screening test offers a patient-friendly alternative to traditional colonoscopy.
A new study published in the journal Obstetrics & Gynecology found that midtrimester amniocentesis is associated with a lower risk of miscarriage than previously reported, with a rate of approximately 1 in 1,600 pregnancies. The study refutes the typically quoted 0.5% pregnancy loss rate and suggests it may be even lower than 0.1%.
The Mount Sinai Medical Center will receive a $400,000 grant to develop and disseminate a curriculum educating health professionals about rational prescribing. The grant aims to promote critical thinking and healthy skepticism among healthcare providers, enabling them to make evidence-based prescribing decisions.
A recent Mount Sinai School of Medicine study suggests that physicians are crucial in helping low-income and uninsured seniors save money on prescription drugs. By prescribing generic versions of cardiovascular medications, doctors can significantly reduce medication costs for patients and Medicare beneficiaries.
A study published in Nature found that the reconstructed 1918 influenza virus induces a potent immune system response in mice, yet fails to prevent severe lung disease and death. Researchers hope to understand the trajectory of this infection and develop targeted therapies for other viral infections.
A new study found that moderate consumption of Cabernet Sauvignon reduces AD-type â-amyloid neuropathology and memory deterioration in mice. The findings support epidemiological evidence suggesting moderate wine consumption may help prevent Alzheimer's clinical dementia.