Researchers at Mount Sinai School of Medicine have discovered a major mechanism underlying the development of tolerance to chronic morphine treatment. They identified changes in the brain and spinal cord that occur during the development of morphine tolerance, providing a therapeutic target for preventing it.
Researchers at Mount Sinai School of Medicine have gained atomic-level insight into how organisms synthesize their major form of chemical energy using the enzyme ATP synthase. The discovery provides a clearer understanding of how these nano-machines function, including the role of water molecules in the rotary mechanism of ATP synthesis.
Researchers found that hospitalized patients with dysphagia averaged a 40% longer hospital stay than those without the condition. Dysphagia is severely underreported and can lead to complications such as aspiration pneumonia and increased end-of-life costs.
The Mount Sinai team has developed a way to visualize coronary artery plaques using multi-color computed tomography (CT), which will lead to better and earlier diagnosis of cardiovascular disease. By harnessing high-density lipoproteins (HDL) and injecting gold particles into mice, researchers were able to see the location of vulnerabl...
Researchers at Mount Sinai School of Medicine are expanding their studies on immunotherapies for peanut and egg allergy through a renewed $29.9 million grant from the NIH. The team is also investigating new treatments, including a peanut protein patch applied to the skin to treat peanut allergy.
Researchers identified a new signaling pathway between TACI and MyD88 that regulates the immune response. This interaction may cause both protective antibodies against infections and excessive immune reactions in autoimmune diseases.
A study published in Orthopedics found that patients who underwent knee or hip replacement surgery experienced a statistically significant decrease in weight and body mass index (BMI) after surgery. Notably, patients who were obese prior to surgery had the most significant post-surgical weight reductions.
Researchers found that people with APOE ε4/ε4 gene type have differently shaped brain protein deposits compared to those with the neutral risk gene type. The findings suggest that different shapes might respond differently to treatments, supporting a hypothesis that APOE genotype changes amyloid structure.
Researchers at Mount Sinai School of Medicine identified a new way diseases develop through understanding how cells control gene expression. They found that protein DPF3b plays a critical role in the transcription process for muscle growth and heart development.
Children in Uganda have high levels of lead poisoning due to proximity to a landfill, with 20.5% of children having elevated blood lead levels, posing developmental risks.
A survey by Mount Sinai School of Medicine found that 91% of physicians believe 'defensive medicine' is necessary due to malpractice concerns. The study suggests that tort reform can decrease unnecessary testing and rising healthcare costs.
Researchers found that carvedilol can lessen the degenerative impact of Alzheimer's disease and promote healthy memory functions in mice. The study suggests that certain antihypertensive drugs already available to the public may independently influence memory functions.
Researchers at Mount Sinai School of Medicine discovered that DNA polymerase eta, an enzyme helping cells replicate despite sun damage, is structured differently in people with XPV. This finding sets the stage for research into therapies to protect XPV patients from skin cancers.
Researchers found that the 2009 H1N1 influenza vaccine may also protect against the lethal 1918 Spanish influenza virus, alleviating bioterrorism concerns. The study demonstrates cross-protection, showing that people vaccinated against H1N1 may also be protected against 1918.
Researchers have identified new autism susceptibility genes, including SHANK2 and SYNGAP1, which may lead to earlier diagnosis and better treatments. The study found that these genes are involved in synapse-related pathways and cellular proliferation, providing insights into possible common pathological mechanisms.
Researchers at Mount Sinai School of Medicine have differentiated human stem cells into heart cells with cardiomyopathy. The study provides a foundation for developing drug therapies to stop or slow the disease.
A recent study published in the New England Journal of Medicine found that most physicians and American Medical Association (AMA) members opposed the AMA's position on coverage expansions. The survey of 5,157 physicians revealed only 12.5% supported the AMA's views, with notable disparities based on specialty, income, and demographics.
Researchers at Mount Sinai School of Medicine have discovered a novel component of the influenza virus that may be the key to developing a universal anti-viral treatment. By inhibiting this component, replication and spread of the virus can be slowed or halted.
A new gene therapy called SERCA2a has been shown to be safe and effective in reversing advanced heart failure by stimulating the production of an enzyme that enables the heart to pump more effectively. Patients who received SERCA2a demonstrated improvements in symptoms, heart function, and severity of heart failure.
Researchers found men with ED had a 54% greater likelihood of high-risk CACS compared to those without ED. The study suggests ED is an independent risk factor for future cardiovascular disease.
Researchers at Mount Sinai School of Medicine have developed a new influenza vaccine that targets the HA globular head, bringing science closer to a universal influenza vaccine. The vaccine was shown to be effective against multiple strains in mice, with all vaccinated mice surviving and unvaccinated mice dying.
Researchers at Mount Sinai School of Medicine have discovered that bone marrow cells play a crucial role in fighting respiratory viruses. The study found that cells produced by the bone marrow migrate to the lungs to help fight infection and produce infection-fighting proteins.
Researchers at Mount Sinai School of Medicine identified a drug that improves communication between nerve cells in mice with Phelan-McDermid Syndrome. The treatment restores normal nerve cell function and adaptation to stimulation.
A nationwide telephone survey found that peanut allergies in children more than tripled from 1.4% in 1997 to 4.2% in 2008. The prevalence of combined peanut or tree nut allergies also increased, with 2.1% reported in 2008 compared to 0.6% in 1997.
Researchers at Mount Sinai School of Medicine have found a potential new treatment for osteonecrosis, a debilitating disease caused by steroid use. Injecting ACTH significantly reduced bone death in rabbits with osteonecrosis, promoting increased blood flow to bone cells and preventing cell death.
Researchers at Mount Sinai School of Medicine found that Alzheimer's pathology begins with Amyloid-Beta oligomers in the brain, rather than previously thought amyloid plaques. The study suggests that these clumps, not plaques, are toxic to brain cells and may be a major target for new treatments.
Researchers at Mount Sinai School of Medicine have discovered a genetic framework that can explain and predict adverse drug reactions, including heart arrhythmias. The framework, developed by Ravi Iyengar and his team, uses genetic information to identify potential risks for arrhythmias in patients taking certain medications.
Researchers at Mount Sinai School of Medicine found that epigenetic marks on human placentas change throughout pregnancy, potentially allowing for early diagnosis and prevention of complications. The study's findings suggest that genomic imprinting appears to be an ever-changing process in the placenta.
Researchers from Mount Sinai School of Medicine present studies on a potential new drug for multiple sclerosis and surprising trends showing reduced disease severity. The studies found that teriflunomide was safe and effective as part of combination therapy, reducing lesion size and volume in the brain.
A Mount Sinai study of over 400,000 people found that high fruit and vegetable consumption reduces cancer risk by only 3%, with benefits limited to certain populations. The researchers concluded that the association is weak and may not justify increased dietary recommendations.
A study published in Environmental Health Perspectives found that exposure to phenols, phthalates, and phytoestrogens may disrupt the timing of pubertal development in girls. High exposure to certain chemicals was associated with early breast development, while others were linked to delayed puberty.
Researchers at Mount Sinai Hospital found that meta-cognitive therapy significantly improved symptoms of attention deficit hyperactivity disorder (ADHD) in adults compared to supportive therapy. The study, published in the American Journal of Psychiatry, demonstrated the efficacy of a non-medication treatment for adult ADHD.
Researchers from Mount Sinai School of Medicine identified potential heart problems in responders on-site at the World Trade Center collapse. They found impaired diastolic function, particularly in middle-aged men, which can lead to shortness of breath and heart failure.
A recent study by Mount Sinai researchers demonstrates that skin cells found in human amniotic fluid can be efficiently 'reprogrammed' to pluripotency, a characteristic similar to human embryonic stem cells. This breakthrough has significant implications for stem cell research and patient care.
A study found that nearly 60% of hospice patients with implantable cardioverter defibrillators (ICDs) have the shocking function deactivated, despite potential benefits for their quality of life. ICDs can cause physical and psychological distress for patients and their families.
A study by Mount Sinai researchers found a connection between prenatal phthalate exposure and disruptive behaviors in children. Mothers with higher phthalate metabolite levels reported poorer behavioral profiles in their children, including conduct and externalizing problems.
A team of investigators analyzed 30 randomized trials of Vioxx and found a strong concern for cardiovascular events or death as early as December 2000. The analysis showed a 35-43% increased risk of cardiovascular events or death, highlighting the need for informed treatment decisions and public health efforts.
Researchers found that a lower-calorie diet slows development of age-related conditions such as Alzheimer's disease, while a high-calorie diet accelerates oxidative stress. Dietary restriction activates transcription factor CBP, which regulates cellular function.
The study utilizes a viral-based gene transfer system to make Nerve Growth Factor (NGF), which helps maintain nerve cell survival in the brain. Participants will receive CERE-110 via neurosurgery or placebo surgery and undergo thorough medical examinations and cognitive testing.
Researchers found that patients with more difficult-to-treat forms of hepatitis C are less likely to initiate treatment, with marital status and comorbidities being significant factors. Mount Sinai is now launching a program to increase support systems for patients, aiming to improve treatment rates.
A clinical study found that cutting back on processed and fried foods, high in AGEs, reduces inflammation and restores natural defenses. The 'AGE-less diet' reduced blood AGE levels and improved biomarkers of vascular function by 60%, even in people with kidney disease.
Researchers found that first responders exposed to caustic dust and toxic pollutants after the 2001 World Trade Center attacks are twice as likely to have asthma. The study of 20,843 responders reveals a significant risk for this population.
Researchers at Mount Sinai School of Medicine report a promising result from the ADAGIO trial, finding that rasagiline may slow Parkinson's disease progression. The study used a novel design to examine the effect of early treatment on disease progression, and found benefits for patients starting therapy with rasagiline.
A new study by Mount Sinai researchers found that cognitive testing by telephone is as effective as in-person testing in evaluating cognition in elderly individuals. The study used well-established neuropsychological tests and involved 54 healthy women with an average age of 79.
Researchers at Mount Sinai School of Medicine have found that a natural compound called NIC5-15 may be a safe and effective treatment for mild to moderate Alzheimer's disease. The preliminary findings suggest that NIC5-15 can prevent the formation of beta-amyloid plaque, a key factor in cognitive decline.
A recent study by Mount Sinai faculty suggests that a gene associated with type-2 diabetes decreases in Alzheimer's disease dementia cases. The research found that promoting PGC-1 content in brain cells attenuates hyperglycemic-mediated β-amyloid production, linking type-2 diabetic metabolic defects to increasing dementia.
A new report card shows that the Midwest leads in palliative care access, while Southern and for-profit hospitals struggle. States like Vermont, Montana, and New Hampshire earned top grades for their palliative care programs, while Oklahoma, Alabama, and Mississippi received F's.
A new study found that hospitals can save significantly by implementing palliative care programs for seriously ill patients. Savings ranged from $279 to $374 per day and up to $2.5 million annually.
Researchers at Mount Sinai School of Medicine have developed a new gene silencing technology that can effectively suppress transcriptional expression of targeted genes in human cells, including those linked to various diseases. This breakthrough could pave the way for preventing diseases where gene dysfunction plays a role.
New research reveals that infection with the 1918 influenza virus granted survivors lifelong protection against the disease. Antibodies produced by these individuals proved effective in blocking the viral infection in mice.