Researchers at Mount Sinai School of Medicine found that $6.7 billion was spent on unnecessary tests or medications, with brand-name statins accounting for 86% of the cost. Excess spending included blood work, bone density scans, and antibiotic prescriptions.
Research reveals 11 genomic regions associated with mental illness, including six previously unknown areas. The findings provide fresh insight into the causes of schizophrenia and bipolar disorder, potentially leading to new treatment options.
A new study from Mount Sinai School of Medicine reveals that thyroid-stimulating hormone (TSH) directly influences bone growth, contrary to its usual thyroid functions. The findings suggest TSH may be a novel method for addressing bone production and could lead to innovative treatments for osteoporosis.
Researchers used MRI and PET/CT to prove the efficacy of dalcetrapib in preventing atherosclerosis progression and reducing vascular inflammation over 24 months. The study found significant reductions in atherosclerotic disease progression and arterial inflammation, suggesting a promising new treatment for cardiovascular disease.
Researchers at Mount Sinai School of Medicine have identified SUMO1 as a potential therapeutic target for treating and preventing the progression of heart failure. Gene therapy with SUMO1 improved cardiac function in human and pig hearts, suggesting its critical role in pathogenesis.
A long-term study of WTC workers found a high incidence of asthma, PTSD, depression, and other conditions. Over one in five responders had multiple health problems, and nearly 10% experienced symptoms of all three.
A new study predicts a 7.3% increase in asthma-related emergency room visits for children in the NYC metropolitan area by 2030 due to climate change. The research, led by Dr. Perry Sheffield, used regional and atmospheric chemistry models to simulate ozone levels and their impact on air quality.
Researchers at Mount Sinai School of Medicine will identify genetic markers for each patient enrolled in the study, inputting them into electronic medical records for tailored treatment. The study aims to improve management of heart disease risk factors and prevent onset.
A study published in PLOS ONE found that pharmaceutical advertisements in biomedical journals are often non-compliant with FDA guidelines, failing to provide critical safety and efficacy information. The study's findings highlight the need for improved regulation of pharmaceutical marketing.
Researchers at Mount Sinai School of Medicine found that motion sickness on tilting trains can be eliminated by adjusting the timing of when cars tilt as they enter and leave curves. In a predictive mode based on GPS signals, passengers experienced no discomfort despite faster tilts.
Researchers have identified how the SorCS1 gene controls amyloid-beta generation in the brain, contributing to both Alzheimer's disease and type 2 diabetes. The study reveals that SorCS1 regulates the movement of amyloid precursor protein (APP) within cells.
A recent study conducted at Mount Sinai School of Medicine found that introducing baked milk products into the diets of children with milk allergies accelerated the rate at which they outgrew their allergy. After five years, 47% of children in the experimental group could tolerate unheated milk products, compared to 22% in a control gr...
Researchers at Mount Sinai School of Medicine developed a gene therapy called SERCA2a that stabilized or improved cardiac function in people with severe heart failure. Patients receiving the high-dose therapy experienced substantial clinical benefit and significantly reduced cardiovascular hospitalizations.
Researchers at Mount Sinai School of Medicine discovered a cellular signaling pathway governing fat tissue and vascular smooth muscle differentiation. Elevated PDGFRβ signaling inhibits the formation of fat cells, offering new therapeutic targets for preventing obesity and cardiovascular disease.
Researchers discovered a hyperactive Wnt signaling pathway in human sarcoma cells, which increases cell growth and proliferation by increasing CDC25A gene expression. This suggests that medications targeting the Wnt pathway may be effective in treating human sarcomas.
A recent study published in PLOS ONE found that ancestral genetic heritage is not fixed at the individual level for African-American and Hispanic patients, but rather varies widely within each group. This research challenges traditional ethnic labels and highlights the importance of considering individual genotypes in personalized medi...
New policy proposals aim to reduce toxic chemical exposure and subsequent burden of disease on children, with estimated annual costs of $76.6 billion. The studies also found a statistically significant association between air pollution and infectious respiratory illness in children.
Research found that prenatal exposure to organophosphates negatively impacts perceptual reasoning and nonverbal problem-solving skills in early childhood. Mothers with a specific genotype associated with less efficient PON1 enzyme metabolization were particularly at risk.
Researchers from Mount Sinai School of Medicine have found that a ketogenic diet may reverse impaired kidney function in people with Type 1 and Type 2 diabetes. The study, published in PLoS ONE, also identified previously unreported genes associated with diabetes-related kidney failure whose expression was reversed by the diet.
Researchers found that a subgroup of PPMS patients can convert to PRMS, with faster disease progression and increased risk for sustained disability. The study emphasizes the need for clinicians to consider evaluating this subgroup differently in assessing prognosis and clinical course.
A consortium of researchers has identified four new genes associated with an increased risk of developing Alzheimer's disease. The study analyzed over 54,000 individuals and found that these genes contribute to the disease by disrupting brain biochemistry. Understanding the role of these genes could lead to the development of new treat...
Researchers at Mount Sinai School of Medicine found that patients with Alzheimer's disease have lower glucose utilization in the brain, detectable approximately 20 years prior to symptoms. The study suggests that novel therapies could prevent the onset of Alzheimer's by addressing mitochondrial impairment.
Researchers found that rhodopsin, a retina pigment, plays a role in detecting temperature sensations in fruit flies. The discovery reveals a new function of rhodopsin beyond its well-known role as a light sensor.
A study published in Cell reveals that lactate from astrocytes plays a crucial role in forming and maintaining long-term memories. The findings have significant implications for treating Alzheimer's disease, dementia, and diabetes.
Researchers found that brain insulin suppresses lipolysis, a process breaking down triglycerides and releasing fatty acids, which worsens diabetes. Impaired brain insulin signaling can lead to a vicious cycle of inflammation and insulin resistance.
A study found that Medicare costs in the last six months of life are driven more by patient characteristics such as ability to function and family support than regional factors. Patient impairment or decline was a strong predictor of higher Medicare costs, accounting for ten percent of variation.
Researchers at Mount Sinai School of Medicine found a direct correlation between elevated troponin and creatine phosphokinase levels and increased risk of death, even among those who initially recover well from CABG surgery.
Mount Sinai researchers have identified insulin-like growth factor II (IGF-II) as a potential therapeutic target for enhancing long-term memory and preventing its loss. IGF-II, a gene expressed during brain development that declines with aging, was found to improve long-term memory in rats by promoting stable LTP.
A Mount Sinai study found a significant increase in the rate of 'sarcoid-like' granulomatous pulmonary disease among World Trade Center (WTC) responders compared to pre-9/11 FDNY personnel. The condition was associated with environmental exposures and lung function abnormalities.
Researchers at Mount Sinai School of Medicine developed a web-based screening tool to assess Traumatic Brain Injury (TBI) in war veterans. The Brain Injury Screening Questionnaire (BISQ) is a low-cost, anonymous tool that detects symptoms such as sleep disturbances, irritability, and memory problems.
Researchers at Mount Sinai School of Medicine have discovered a protein that suppresses the progression of malignant melanoma by regulating an oncogene called CDK8. The study found that when macroH2A is present in early-stage melanoma, it slows down the disease's growth and metastasis.
Mount Sinai researchers create mouse model to investigate the impact of a single SHANK3 gene mutation on nerve cell communication and social behavior. The study identifies impaired communication and altered plasticity in nerve cells, providing critical insight into the development of autism spectrum disorders.
AnaLisa DiFeo will investigate microRNA profiles and their association with chemotherapy sensitivity in ovarian cancer tumors. Her research aims to identify new drug targets for overcoming chemoresistance and improving treatment outcomes.
Researchers found that oxytocin enhances positive attachment memories and boosts recall of mothers' care, but can also intensify negative memories. The study suggests oxytocin plays a key role in human attachment by modulating early childhood memories.
A unique program in East Harlem helps middle school students learn practical health skills, resulting in increased interest in college attendance and medical careers. The MedStart Summer Enrichment Program improves student knowledge of diseases prevalent in their community, such as asthma and diabetes.
Researchers found that 98% of the US population lives within 60 minutes of a hospice provider, suggesting access is not a barrier to enrollment. However, more research is needed to determine why many patients and families avoid hospice care at end-of-life.
Researchers found that pregnant women who consumed peanuts during pregnancy had infants with strong sensitivity to peanuts. The study suggests a potential risk factor for peanut allergy in infants, highlighting the need for further research.
Researchers at Mount Sinai School of Medicine identified a novel regulatory mechanism controlling protein TCF3, essential for embryonic development and potentially leading to cancer diagnosis and therapy. This discovery may enable early detection of cancers and develop drugs targeting the modified TCF3.
A new program led by Mount Sinai School of Medicine aims to address the unmet mental health needs of inner-city children and their families. The Center for Collaborative Inner-City Child Mental Health Services Research will utilize a multidisciplinary approach to overcome barriers such as waiting lists, stigma, and poverty.
Mount Sinai researchers discovered a hormone receptor linked to several malignant tumor types, suggesting a new diagnostic or therapeutic target. The receptor's presence may be used to improve cancer detection and develop imaging agents that can visualize early tumors.
Researchers found that activation of D1 and D2 neurons in the nucleus accumbens region of the brain exert opposite effects on cocaine reward. Activation of D1 neurons increases cocaine reward, while activation of D2 neurons decreases it. This imbalance may lead to chronic exposure to cocaine resulting in decreased activity in D2 neurons.
Dr. Douglas A. Jabs has been recognized by the American Academy of Ophthalmology with the Jackson Memorial Lecture for his decades-long study on cytomegalovirus retinitis and its interaction with HIV. His research aims to improve clinical outcomes in patients with AIDS and CMV retinitis.
Researchers found a common denominator between Type 2 diabetes and Alzheimer's disease: PGC-1, a key regulator of glucose. Decreased PGC-1 levels may contribute to Alzheimer's disease progression by promoting beta-secretase degradation.
Mount Sinai School of Medicine is leading a $16.5 million grant program to develop nanotechnology tools for diagnosing and treating cardiovascular disease. The center aims to utilize nanotechnology to better prevent and treat atherosclerosis, heart attack, and heart failure.
A team of researchers has identified a gene, MTHFD1L, that appears to increase the risk of developing late-onset Alzheimer's disease. The study found individuals with the variation may be nearly twice as likely to develop the disease compared to those without the variation.
Researchers found that patients disenrolling from hospice care had nearly five times the healthcare costs of those remaining with hospice. This is due to increased hospitalizations and emergency department visits.
Researchers found that oxytocin selectively improves social cognitive abilities in less socially proficient individuals but has little effect on those who are more socially proficient. The study suggests oxytocin may hold potential for treating social deficits in people with disorders marked by deficits in social functioning.
A new computational method, ChIP Enrichment Analysis (ChEA), helps streamline gene expression experiment analysis and identifies potential drug targets. The database integrates results from ChIP-seq and ChIP-chip experiments, providing a better understanding of transcription factor regulation and disease development.
Researchers at Mount Sinai School of Medicine have discovered a new mechanism behind craniofrontonasal syndrome (CFNS) and cleft palate. A mutation in the ephrin-B1 gene causes cell proliferation anomalies, leading to facial malformations.
Researchers at Mount Sinai School of Medicine found that BPA released from plastic resins used in pediatric dentistry is detectable in saliva after placement in children's mouths. The team recommends using alternative BPA derivatives and taking precautions to reduce exposure.