Researchers found that brain insulin suppresses lipolysis, a process breaking down triglycerides and releasing fatty acids, which worsens diabetes. Impaired brain insulin signaling can lead to a vicious cycle of inflammation and insulin resistance.
A study found that Medicare costs in the last six months of life are driven more by patient characteristics such as ability to function and family support than regional factors. Patient impairment or decline was a strong predictor of higher Medicare costs, accounting for ten percent of variation.
Researchers at Mount Sinai School of Medicine found a direct correlation between elevated troponin and creatine phosphokinase levels and increased risk of death, even among those who initially recover well from CABG surgery.
Mount Sinai researchers have identified insulin-like growth factor II (IGF-II) as a potential therapeutic target for enhancing long-term memory and preventing its loss. IGF-II, a gene expressed during brain development that declines with aging, was found to improve long-term memory in rats by promoting stable LTP.
A Mount Sinai study found a significant increase in the rate of 'sarcoid-like' granulomatous pulmonary disease among World Trade Center (WTC) responders compared to pre-9/11 FDNY personnel. The condition was associated with environmental exposures and lung function abnormalities.
Researchers at Mount Sinai School of Medicine developed a web-based screening tool to assess Traumatic Brain Injury (TBI) in war veterans. The Brain Injury Screening Questionnaire (BISQ) is a low-cost, anonymous tool that detects symptoms such as sleep disturbances, irritability, and memory problems.
Researchers at Mount Sinai School of Medicine have discovered a protein that suppresses the progression of malignant melanoma by regulating an oncogene called CDK8. The study found that when macroH2A is present in early-stage melanoma, it slows down the disease's growth and metastasis.
Mount Sinai researchers create mouse model to investigate the impact of a single SHANK3 gene mutation on nerve cell communication and social behavior. The study identifies impaired communication and altered plasticity in nerve cells, providing critical insight into the development of autism spectrum disorders.
AnaLisa DiFeo will investigate microRNA profiles and their association with chemotherapy sensitivity in ovarian cancer tumors. Her research aims to identify new drug targets for overcoming chemoresistance and improving treatment outcomes.
Researchers found that oxytocin enhances positive attachment memories and boosts recall of mothers' care, but can also intensify negative memories. The study suggests oxytocin plays a key role in human attachment by modulating early childhood memories.
A unique program in East Harlem helps middle school students learn practical health skills, resulting in increased interest in college attendance and medical careers. The MedStart Summer Enrichment Program improves student knowledge of diseases prevalent in their community, such as asthma and diabetes.
Researchers found that 98% of the US population lives within 60 minutes of a hospice provider, suggesting access is not a barrier to enrollment. However, more research is needed to determine why many patients and families avoid hospice care at end-of-life.
Researchers found that pregnant women who consumed peanuts during pregnancy had infants with strong sensitivity to peanuts. The study suggests a potential risk factor for peanut allergy in infants, highlighting the need for further research.
Researchers at Mount Sinai School of Medicine identified a novel regulatory mechanism controlling protein TCF3, essential for embryonic development and potentially leading to cancer diagnosis and therapy. This discovery may enable early detection of cancers and develop drugs targeting the modified TCF3.
A new program led by Mount Sinai School of Medicine aims to address the unmet mental health needs of inner-city children and their families. The Center for Collaborative Inner-City Child Mental Health Services Research will utilize a multidisciplinary approach to overcome barriers such as waiting lists, stigma, and poverty.
Mount Sinai researchers discovered a hormone receptor linked to several malignant tumor types, suggesting a new diagnostic or therapeutic target. The receptor's presence may be used to improve cancer detection and develop imaging agents that can visualize early tumors.
Researchers found that activation of D1 and D2 neurons in the nucleus accumbens region of the brain exert opposite effects on cocaine reward. Activation of D1 neurons increases cocaine reward, while activation of D2 neurons decreases it. This imbalance may lead to chronic exposure to cocaine resulting in decreased activity in D2 neurons.
Dr. Douglas A. Jabs has been recognized by the American Academy of Ophthalmology with the Jackson Memorial Lecture for his decades-long study on cytomegalovirus retinitis and its interaction with HIV. His research aims to improve clinical outcomes in patients with AIDS and CMV retinitis.
Researchers found a common denominator between Type 2 diabetes and Alzheimer's disease: PGC-1, a key regulator of glucose. Decreased PGC-1 levels may contribute to Alzheimer's disease progression by promoting beta-secretase degradation.
Mount Sinai School of Medicine is leading a $16.5 million grant program to develop nanotechnology tools for diagnosing and treating cardiovascular disease. The center aims to utilize nanotechnology to better prevent and treat atherosclerosis, heart attack, and heart failure.
A team of researchers has identified a gene, MTHFD1L, that appears to increase the risk of developing late-onset Alzheimer's disease. The study found individuals with the variation may be nearly twice as likely to develop the disease compared to those without the variation.
Researchers found that patients disenrolling from hospice care had nearly five times the healthcare costs of those remaining with hospice. This is due to increased hospitalizations and emergency department visits.
Researchers found that oxytocin selectively improves social cognitive abilities in less socially proficient individuals but has little effect on those who are more socially proficient. The study suggests oxytocin may hold potential for treating social deficits in people with disorders marked by deficits in social functioning.
A new computational method, ChIP Enrichment Analysis (ChEA), helps streamline gene expression experiment analysis and identifies potential drug targets. The database integrates results from ChIP-seq and ChIP-chip experiments, providing a better understanding of transcription factor regulation and disease development.
Researchers at Mount Sinai School of Medicine have discovered a new mechanism behind craniofrontonasal syndrome (CFNS) and cleft palate. A mutation in the ephrin-B1 gene causes cell proliferation anomalies, leading to facial malformations.
Researchers at Mount Sinai School of Medicine found that BPA released from plastic resins used in pediatric dentistry is detectable in saliva after placement in children's mouths. The team recommends using alternative BPA derivatives and taking precautions to reduce exposure.
Researchers at Mount Sinai School of Medicine have discovered a major mechanism underlying the development of tolerance to chronic morphine treatment. They identified changes in the brain and spinal cord that occur during the development of morphine tolerance, providing a therapeutic target for preventing it.
Researchers at Mount Sinai School of Medicine have gained atomic-level insight into how organisms synthesize their major form of chemical energy using the enzyme ATP synthase. The discovery provides a clearer understanding of how these nano-machines function, including the role of water molecules in the rotary mechanism of ATP synthesis.
Researchers found that hospitalized patients with dysphagia averaged a 40% longer hospital stay than those without the condition. Dysphagia is severely underreported and can lead to complications such as aspiration pneumonia and increased end-of-life costs.
The Mount Sinai team has developed a way to visualize coronary artery plaques using multi-color computed tomography (CT), which will lead to better and earlier diagnosis of cardiovascular disease. By harnessing high-density lipoproteins (HDL) and injecting gold particles into mice, researchers were able to see the location of vulnerabl...
Researchers at Mount Sinai School of Medicine are expanding their studies on immunotherapies for peanut and egg allergy through a renewed $29.9 million grant from the NIH. The team is also investigating new treatments, including a peanut protein patch applied to the skin to treat peanut allergy.
Researchers identified a new signaling pathway between TACI and MyD88 that regulates the immune response. This interaction may cause both protective antibodies against infections and excessive immune reactions in autoimmune diseases.
A study published in Orthopedics found that patients who underwent knee or hip replacement surgery experienced a statistically significant decrease in weight and body mass index (BMI) after surgery. Notably, patients who were obese prior to surgery had the most significant post-surgical weight reductions.
Researchers found that people with APOE ε4/ε4 gene type have differently shaped brain protein deposits compared to those with the neutral risk gene type. The findings suggest that different shapes might respond differently to treatments, supporting a hypothesis that APOE genotype changes amyloid structure.
Researchers at Mount Sinai School of Medicine identified a new way diseases develop through understanding how cells control gene expression. They found that protein DPF3b plays a critical role in the transcription process for muscle growth and heart development.
Children in Uganda have high levels of lead poisoning due to proximity to a landfill, with 20.5% of children having elevated blood lead levels, posing developmental risks.
A survey by Mount Sinai School of Medicine found that 91% of physicians believe 'defensive medicine' is necessary due to malpractice concerns. The study suggests that tort reform can decrease unnecessary testing and rising healthcare costs.
Researchers found that carvedilol can lessen the degenerative impact of Alzheimer's disease and promote healthy memory functions in mice. The study suggests that certain antihypertensive drugs already available to the public may independently influence memory functions.
Researchers at Mount Sinai School of Medicine discovered that DNA polymerase eta, an enzyme helping cells replicate despite sun damage, is structured differently in people with XPV. This finding sets the stage for research into therapies to protect XPV patients from skin cancers.
Researchers found that the 2009 H1N1 influenza vaccine may also protect against the lethal 1918 Spanish influenza virus, alleviating bioterrorism concerns. The study demonstrates cross-protection, showing that people vaccinated against H1N1 may also be protected against 1918.
Researchers have identified new autism susceptibility genes, including SHANK2 and SYNGAP1, which may lead to earlier diagnosis and better treatments. The study found that these genes are involved in synapse-related pathways and cellular proliferation, providing insights into possible common pathological mechanisms.
Researchers at Mount Sinai School of Medicine have differentiated human stem cells into heart cells with cardiomyopathy. The study provides a foundation for developing drug therapies to stop or slow the disease.
A recent study published in the New England Journal of Medicine found that most physicians and American Medical Association (AMA) members opposed the AMA's position on coverage expansions. The survey of 5,157 physicians revealed only 12.5% supported the AMA's views, with notable disparities based on specialty, income, and demographics.
Researchers at Mount Sinai School of Medicine have discovered a novel component of the influenza virus that may be the key to developing a universal anti-viral treatment. By inhibiting this component, replication and spread of the virus can be slowed or halted.
A new gene therapy called SERCA2a has been shown to be safe and effective in reversing advanced heart failure by stimulating the production of an enzyme that enables the heart to pump more effectively. Patients who received SERCA2a demonstrated improvements in symptoms, heart function, and severity of heart failure.
Researchers found men with ED had a 54% greater likelihood of high-risk CACS compared to those without ED. The study suggests ED is an independent risk factor for future cardiovascular disease.
Researchers at Mount Sinai School of Medicine have developed a new influenza vaccine that targets the HA globular head, bringing science closer to a universal influenza vaccine. The vaccine was shown to be effective against multiple strains in mice, with all vaccinated mice surviving and unvaccinated mice dying.
Researchers at Mount Sinai School of Medicine have discovered that bone marrow cells play a crucial role in fighting respiratory viruses. The study found that cells produced by the bone marrow migrate to the lungs to help fight infection and produce infection-fighting proteins.
Researchers at Mount Sinai School of Medicine identified a drug that improves communication between nerve cells in mice with Phelan-McDermid Syndrome. The treatment restores normal nerve cell function and adaptation to stimulation.
A nationwide telephone survey found that peanut allergies in children more than tripled from 1.4% in 1997 to 4.2% in 2008. The prevalence of combined peanut or tree nut allergies also increased, with 2.1% reported in 2008 compared to 0.6% in 1997.