Scientists found that hepatocyte-like cells derived from iPS cells exhibit 80% similar gene expression to those from embryonic stem cells, but less than that of real human liver cells. The study suggests that further adaptation is needed for iPSC-derived hepatocytes to be used in treating liver diseases.
Researchers estimate lifetime risk of rheumatoid arthritis for both sexes using data from the Rochester Epidemiology Project. The study finds that 8.4% of women and 5.1% of men will develop an inflammatory autoimmune disease in their lifetime.
A study found that maternal depression affects the health-related quality of life of children with epilepsy, but this impact is modulated by family resources and functioning. The accumulation of supportive resources for both mothers and children with epilepsy can lead to improved outcomes over time.
Researchers found that communities of similar-looking catfish often comprise multiple species, highlighting the hidden diversity and complexity of neotropical freshwater ecosystems. The discovery has significant implications for environmental conservation, as many rivers are facing large-scale development and habitat destruction.
The IceCube observatory, located in the crystal clear ice of the South Pole, has been completed as a world-first large-scale neutrino telescope. The telescope will investigate the sources and properties of neutrinos, which originate in spectacular phenomena in the universe.
Researchers discover that PML limits cancer cell division, and its absence allows tumors to grow uncontrollably. The presence of PML molecules can be detected, enabling diagnosis of malignant tumors.
Researchers found evidence of oxygen-poor ocean conditions lasting 2-4 million years after the first appearance of animals, suggesting fluctuating oxygen levels may have driven rapid evolutionary turnover during the Cambrian Period. This study provides new insights into how early life evolved and flourished on Earth.
A new study found that physical activity is associated with a lower risk of overall mortality and prostate cancer-specific mortality in men with prostate cancer. Men who did more vigorous activity had the lowest risk of dying from the disease.
Cardiologists at UConn Health Center have identified a protein fragment that can predict heart attack, allowing for earlier diagnosis and potentially life-saving treatment. The discovery could also lead to the development of new therapies to block cell death and preserve heart muscle function.
Researchers discovered interplay between genetic and persistence mechanisms in bacteria, leading to novel effective treatments for multi-drug resistant (MDR) infections. Persistence cells are temporarily hyper-resistant to antibiotics, causing treatment failure and contributing to chronic bacterial infections.
A study finds that community-based co-management is key to sustaining aquatic resources and the livelihoods of communities depending on them. Co-management involves sharing responsibility for resources between governments and users, leading to successful and sustainable fisheries worldwide.
A Scripps Research chemist devised a new method to quantify changes in proteins resulting from stress, which could provide insights into disease progression and treatment. The technique focuses on cysteine S-hydroxylation, allowing researchers to monitor protein modifications at the individual cysteine site.
Scientists in China have created a more eco-friendly and cost-effective way to produce deuterium-depleted drinking water, which may be beneficial for human health. The new technique uses a platinum catalyst to efficiently remove deuterium from water, reducing levels from 150 ppm to 125 ppm.
Researchers create material with sections that independently respond to different temperature stimuli, enabling complex mechanical articulations. The development has numerous applications in industries such as shipping and food storage.
Studded winter tires grind away at road surfaces, generating dust particles linked to inflammation and diseases such as heart disease. Researchers found specific protein changes in cells related to road dust exposure, which could help understand the link between pavement dust and heart disease.
A new study confirms that two doses of the varicella, or chickenpox, vaccine provide excellent protection in children against this highly contagious and, in some cases, severe disease. The study found that the effectiveness of two doses of vaccine was 98.3 percent in protecting against varicella, significantly higher than one dose.
Scientists have identified a protein biomarker that predicts the efficacy of hepatitis C treatment, enabling improved patient management. The discovery of IP-10 as a prognostic biomarker could lead to the development of a diagnostic test to distinguish between effective and ineffective treatments.
Patients transported by helicopter from accident scenes are more likely to survive than those brought to trauma centers by ground ambulance. Despite being more severely injured, they require less hospital resource utilization and ultimately fare better than those transported by ground.
A new MRI technique has been developed that enables full three-dimensional brain scans in less than half a second, significantly reducing the scanning time. This breakthrough, made possible by combining two technical improvements, will have an immediate impact on research institutions worldwide and the Human Connectome Project.
A recent study found that the number of women dying from complications of anesthesia during childbirth has plummeted 59 percent, thanks to better monitoring and medical techniques. The risks associated with general anesthesia have been dramatically reduced, but regional anesthetic-related deaths have slightly increased.
Researchers found a communication intervention effective in reducing ICU stays for chronic patients but less so for surgical and neurological cases. The study highlights the need for tailored approaches to support families making critical decisions for their loved ones.
A study published in Journal of Nutrition found that breastfed adolescents had stronger leg muscles and better performance in horizontal jumping. Prolonged breastfeeding was associated with increased lower body explosive strength during adolescence.
Brain scans show children with ADHD struggle to control brain activity when bored, but perform better with incentives or medication. The study provides insight into the neural mechanisms underlying attention-deficit/hyperactivity disorder (ADHD).
This issue of GSA Bulletin explores river geomorphology, submarine landslides, and paleoclimatic analysis. Researchers examine the impact of a dome-building eruption on downstream channel aggradation in Oregon, as well as the age and genesis of the Sangamon/Loveland complex in the Lower Mississippi Valley.
A recent study published in the Journal of Advanced Nursing found that nearly a third of tablet fragments deviated from recommended dosages by 15% or more after being split. The practice is considered highly inaccurate and potentially dangerous, especially for tablets with narrow margins between therapeutic and toxic doses.
Researchers have discovered how a malfunctioning gene associated with Lou Gehrig's disease leads to nerve-cell death in mice. The study found that the gene, TDP-43, causes neurons to die when it is bound up outside the nucleus and depletes the cell of normally functioning TDP-43.
Psychologists at Jena University discovered that adapting to faces of older people can make a person appear younger. The study found that viewing multiple faces of the same age group can influence age perception and lead to estimates that are systematically wrong.
A study of over 2,100 individuals with multiple sclerosis found that women were 1.4 times more likely to carry the HLA gene variant associated with MS than men. The researchers also discovered that women with this gene variant were more likely to pass it on to other women in their families.
Researchers at Tel Aviv University discovered that the hornet's body shell can harvest solar power due to its unique structure. The yellow and brown stripes on the abdomen enable a photo-voltaic effect, converting solar radiation into electric energy.
A new, simplified method for producing large amounts of viral vector cassettes has been developed, overcoming previous limitations. This approach enables efficient packaging of single- or double-stranded AAV vectors and large AAV cassettes, paving the way for commercial production.
A pair of clinical trials found that two weeks of rifaximin treatment significantly reduced IBS symptoms, including bloating and abdominal pain. The benefits persisted for 10 weeks after treatment was stopped, suggesting a potential underlying cause of IBS: alterations in gut bacteria.
In a study by Ohio State University, consumers preferred to use few colors for an entire shoe design, with an average of only four colors used. They also favored identical or similar colors for different elements, avoiding contrasting color combinations. A small minority chose to highlight one element with a contrasting color.
A team of researchers from University of Missouri and Columbia University successfully regenerates complete shoulder joint surfaces in animals using the patient's own cells. The new technique eliminates the need for multiple surgeries to harvest and implant cells, making it a promising alternative to metal and plastic joints.
A new antibiotic therapy developed at Cedars-Sinai Medical Center has shown long-lasting relief from irritable bowel syndrome (IBS) symptoms, even after treatment is stopped. The study found that patients experienced significant relief from bloating, abdominal pain, and loose stools for up to 10 weeks.
Researchers found evidence of ancient ocean 'dead zones,' where oxygen levels were low, around 499 million years ago. This challenges the long-held assumption that oceans became oxygen-rich about 600 million years ago. The findings suggest that fluctuations in oxygen levels may have played a major role in shaping early animal evolution.
Leading climate economist William Nordhaus advocates for carbon taxes as a means to achieve significant emissions reductions, citing economic inefficiency and ineffectiveness of cap-and-trade systems. A carbon tax could also provide a revenue source to curb budget deficits while meeting environmental objectives.
A new study by Harvard T.H. Chan School of Public Health found that domestic violence against mothers increases the risk of death among female children, but not male children, in India. The researchers attribute this disparity to lower investment in girl children, leading to a higher mortality rate for girls.
A recent study by the Norwegian Institute of Public Health found that children in formal centre-based and family-based child care were less likely to be late talkers compared to those cared for at home. This effect was strongest between the ages of 1 to 1.5 years.
A new study found that supplementing antibiotics with high-dose vitamin D can significantly reduce the time needed for TB bacteria to clear from sputum culture by almost a week in patients with specific genetic profiles. The treatment improved response in those with the tt genotype of the TaqI vitamin D receptor polymorphism.
The Infectious Diseases Society of America has released its first-ever guidelines for the treatment of MRSA, which may mean not prescribing antibiotics for less complicated forms of infection. The guidelines address treatment of both common and invasive MRSA, a potentially deadly infection responsible for 18,000 deaths annually.
Scientists report that household sewage has nearly 20% more energy potential than previously estimated, offering a new avenue for extracting methane, hydrogen, and other fuels from wastewater. The discovery could transform treatment facilities into energy sources, reducing their energy drain.
Researchers found no significant difference in polyphenol content between organically grown and conventionally grown onions, carrots, and potatoes. Organic farming methods are still considered beneficial for animal welfare and environmental protection.
Bacteria, specifically Enterobacter hormaechei, found in excised atherosclerotic plaque tissue of patient who suffered a heart attack. The data suggest that chronic infection may underlie the process of atherosclerosis.
A study published in Journal of Infectious Diseases found that children who received two doses of the varicella vaccine had a 95% lower risk of developing chicken pox. The effectiveness of two doses was 98.3%, significantly higher than one dose at 86%.
New research shows vitamin D can speed up antibiotic treatment of tuberculosis (TB), clearing bacteria from the lungs in just 5 weeks for certain patients. Vitamin D deficiency is a common problem among TB patients, and those with a specific genetic type of vitamin D receptor responded better to supplementation.
The study aims to assess how hip replacement affects older adults' ability to work, thereby easing financial pressure on pension systems. The research will examine data from various studies to compare patients who received a hip replacement with those who didn't.
A Rhode Island Hospital study found that culturing the nose is more likely to reveal MRSA than other body sites, and a strong correlation exists between nasal MRSA quantity and colonization at other sites. The researchers suggest screening the nose and groin for MRSA yields the highest yield.
Researchers at Newcastle University found that the compounds in green tea are more effective against key triggers of Alzheimer's development when digested by enzymes in the gut. The study also suggests that these compounds have anti-cancer properties, slowing down the growth of tumour cells.
The Damon Runyon Cancer Research Foundation has awarded grants totaling $1.9M to 12 early-career researchers conducting innovative cancer research. The fellowships provide independent funding to support novel projects and enable recipients to pursue careers in cancer research.
Research analyzing California hospital data found extreme obesity significantly increased risk of death from 2009 H1N1. Half of hospitalized patients over 20 were obese, with nearly three-fold increased odds of death compared to non-obese counterparts.
Researchers found that gesturing while talking changes how people think by providing a visual clue to their mental state. This effect is particularly pronounced when discussing abstract concepts like mathematics or physics.
The new simulator will take into account the unique physics of fluid flow and storage in shale gas reservoirs. OU researchers aim to address concerns about water production and its impact on shallow aquifers.
Using thermostatic mixer valves can significantly reduce bath water temperatures, reducing the risk of scalding in children. The study found that families with TMVs had temperatures up to 11°C cooler than those without, and were within the recommended 46°C limit.
Researchers at Mount Sinai School of Medicine developed a web-based screening tool to assess Traumatic Brain Injury (TBI) in war veterans. The Brain Injury Screening Questionnaire (BISQ) is a low-cost, anonymous tool that detects symptoms such as sleep disturbances, irritability, and memory problems.
Community-based co-management is a promising solution for sustaining world's fisheries, according to new study. The approach shares responsibility between government and users, fostering social cohesion, clear incentives, and protected areas.
A new smart grid system aims to optimize energy use, allowing consumers to control their appliances and use electricity during off-peak hours. The proposed 'time of use' pricing strategy could lead to significant cost savings for US households.
Researchers in India have found that various kitchen waste water filtration systems can produce clean water suitable for agricultural or horticultural use. Ceramic microfiltration membrane systems with physicochemical treatments such as biotreatment and adsorption showed promising results, removing up to 98% of BOD and 99% of COD.
University of Illinois researchers create an acoustic cloak that hides underwater objects from detection, using metamaterials to manipulate sound waves. The technology has potential applications in military stealth, soundproofing, and medical imaging.
A new study published in the Journal of Bone and Joint Surgery found that personal motivation is a crucial factor in determining how quickly patients return to work following total knee replacement surgery. Motivated patients were able to return to work an average of 8.9 weeks after surgery, while those with lower motivation took longe...
A team of researchers from the University of Notre Dame and The Nature Conservancy has successfully validated their environmental DNA (eDNA) technique for detecting invasive Asian carp in the Chicago-area waterway. This breakthrough method, which uses genetic material from aquatic organisms to identify species presence, has been hailed...
Researchers imaged graphene grain boundaries using diffraction imaging electron microscopy, revealing that impurities are responsible for fluctuating electrical conductivity. Larger grains do not improve conductivity as previously thought, highlighting the importance of controlling impurities in graphene growth.