Quality of life measures are most useful in breast cancer clinical trials using non-biomedical interventions. The authors recommend including QOL measures as secondary endpoints in adjuvant therapy trials for vulnerable populations or when minimal survival difference is expected.
Researchers at Rothamsted Research and ICARDA developed a method to account for spatial trend in single crop field trials, improving accuracy on line performance estimates. The new approach can significantly enhance precision in estimating crop yield and characteristics.
Researchers at the University of Texas Health Science Center San Antonio found that resveratrol stimulates the expression of adiponectin, a hormone with wide-ranging benefits for obesity-related medical complications. This discovery provides important information on the development of novel therapeutic drugs for these diseases.
A lack of safety procedures was identified as a factor behind the Deepwater Horizon disaster. Norwegian regulation, which relies on internal control and trust between companies and unions, is more robust than the US model, with fewer near-accidents resulting in disasters.
The IUPUI School of Science has received a $943,000 NSF grant to establish an Undergraduate Research Mentoring in the Biological Sciences program. The two-year fellowships will provide students from underrepresented groups with research experience and mentorship in biosignaling.
A national survey found that 76% of people would take a predictive test to learn about their future health risks, with willingness to pay varying by disease type and accuracy. Respondents were more likely to pay for tests related to breast and prostate cancer, and were willing to alter lifestyle choices after receiving positive results.
Scientists have pinpointed the type of cell responsible for brain tumors known as oligodendrogliomas, a category of malignant brain tumors. The tumor originates in and spreads through glial progenitor cells, which are often referred to as 'daughter' cells of stem cells.
The University of California, Riverside has developed a seedless mandarin variety called Tango, which is virtually free from seeds and diseases. The fruit, created through an induced mutation process, boasts a deep orange color and tangy-sweet flavor.
Researchers found that nearly 95.6% of 3,271 civilian WTC survivors reported posttraumatic stress symptoms and 15% screened positive for PTSD two years after the disaster. The study identified five predictors of PTSD: late evacuation initiation, high floor exposure, dust cloud exposure, personal horror, and employer fatalities.
Scientists at Harvard University have made a groundbreaking discovery about biofilm colonies, which exhibit an unprecedented ability to repel liquids and vapors. The researchers believe that the secret to their resiliency lies in their unique liquid-repellent surface.
A new study by Stanford researchers found that many prescriptions for atypical antipsychotic medications lack strong evidence, yet these drugs can cause serious side effects like weight gain, diabetes, and heart disease. The study also identified a significant amount of off-label use, with $6 billion spent on such prescriptions in 2008.
A study discovered a microRNA-TP53 circuit that explains the link between chromosome deletion and less aggressive forms of CLL. MicroRNAs miR-15a and miR-16-1 inhibit tumor-suppressing gene TP53, while its increased expression leads to indolent CLL. This mechanism may also contribute to chemotherapy resistance.
A study by St. Michael's Hospital researchers found that people with fatty liver disease are three times more likely to suffer a stroke than those without the condition. High levels of liver enzymes were also found in adults who had an acute stroke, suggesting a potential link between the two.
Holger Puchta aims to control inheritance in plants to improve crop properties using nature's existing gene pool and cutting-edge techniques like genome sequencing and DNA scissors. The ERC grant will support his five-year project.
Rice University researchers settle a long-standing controversy in polymer dynamics by proving that flexibility enhances the mobility of stiff filaments. The study shows that nanotubes and other fine filaments can navigate through crowded environments and fixed networks with ease, paving the way for new sensing technologies.
VIB-K.U. Leuven scientists have decoded a potential new anti-cancer mechanism by normalizing abnormal tumor blood vessels through HRG, which prevents metastasis and enhances chemotherapy efficiency. This mechanism offers alternative possibilities for cancer treatment.
A study published in BioScience finds strong correlations between energy consumption per person and gross domestic product per person across countries and over time. Researchers conclude that increasing energy supply is necessary to meet projected world population growth without compromising living standards.
Scientists from UT Health Science Center San Antonio discovered a relationship between phosphoinositide kinases and calcium ions in nerve cells, which could lead to treatments for neurological disorders. The study's findings have implications for epilepsy, stroke, dementia, hypertension, mental illness, and other diseases.
The American Mathematical Society will award numerous prestigious prizes to recognize outstanding achievements in mathematics. These awards include the AMS Steele Prize, which honors lifetime achievement and mathematical exposition.
Most college students fail to grasp fundamental scientific principles like the carbon cycle and conservation of matter, leading to inaccurate explanations and environmental issue ignorance. The study calls for improved teaching methods to enhance students' understanding of essential biological concepts.
A new study published in Science Translational Medicine found that a drug called AFQ056, developed by Novartis Pharmaceuticals, showed promising results in treating Fragile X syndrome. The treatment improved symptoms in some patients with a specific DNA marker, and was well-tolerated without safety problems.
A Rice University researcher says the new logo could generate more brand loyalty among new customers in Asian markets, which tend to value collectivist and interdependent cultures. The study found that rounded logos are more acceptable in these cultures than angular ones.
A Jackson Laboratory research team has identified a mutation in a gene essential for correct protein-processing, which disrupts cellular development and growth. The study found that defects in the chaperone proteins lead to photoreceptor degeneration, central nervous system abnormalities, and male infertility.
Researchers identify a key process leading to brain cell death in Parkinson's disease, offering hope for slowing progression and diagnosis. Blocking this process preserves parkin function and spares neurons.