Researchers at Mount Sinai School of Medicine found that sorafenib increases overall survival by 44% compared to placebo in advanced liver cancer patients. The study also showed a significant delay in cancer progression.
Researchers at Mount Sinai School of Medicine have discovered a new window into the brain, revealing how addictive drugs trigger permanent changes in brain cells. The study's findings provide clues for targeting addiction with new drugs.
A tracking system helped improve rates of medical oncology consultation and reduce disparities in breast cancer treatment by notifying surgeons when their patients visited an oncologist. The new system also eliminated racial disparity in treatment, as minority women were less likely to receive underuse of adjuvant therapy.
Researchers at Mount Sinai School of Medicine have discovered a novel targeted gene therapy that simulates the pain-killing effect of opiate drugs, providing relief for more than three months after a single injection. The technique targets selectively the pain gate, avoiding unwanted side effects associated with opioid painkillers.
Researchers identified 7 anti-hypertensive drugs that significantly prevent beta-amyloid production, a key mechanism in Alzheimer's disease. These drugs, including Valsartan and Propranolol HCI, showed promise in preventing cognitive deterioration and memory loss in mice with Alzheimer's disease.
Researchers at Mount Sinai School of Medicine have identified taste receptors in the human intestines that sense glucose and regulate appetite. These receptors may lead to new treatments for obesity and diabetes by controlling blood sugar levels.
A new study conducted at Mount Sinai School of Medicine found that cyclical estrogen injections protected brain cells from age-related deterioration. The research suggests that a critical window of opportunity exists in which estrogen therapy may be helpful in preventing memory loss, and that timing is crucial.
A Phase II clinical trial suggests that extracorporeal photopheresis (ECP) is effective in treating clinically active Crohn's disease, with a 50% response rate after 3 months of treatment. Patients who responded to ECP therapy experienced notable improvements in disease symptoms and signs within six weeks.
Research grants aim to reduce suffering for seriously ill patients and their caregivers, with studies focusing on communication, treatment advances, and caregiving support. The initiative supports clinician investigators conducting patient-oriented research in palliative care.
Researchers at Mount Sinai School of Medicine have developed a new imaging technology using multi-detector computed tomography (CT) and a novel contrast agent N1177 to detect high-risk plaque. This may help physicians diagnose a heart attack before it occurs, preventing cardiac events.
A $12.5 million grant from Charles Bronfman will establish the Charles Bronfman Institute for Personalized Medicine, transforming medical practice with genomics-based strategies for disease detection and treatment. The gift will seed a $30 million initiative to advance personalized medicine at Mount Sinai.
A new study found that ibuprofen significantly raises the risk of heart attacks in high-risk cardiovascular patients taking aspirin for osteoarthritis. The Mount Sinai researchers' findings underscore the importance of considering NSAID interactions with aspirin in these patients.
Dr. John H. Morrison has received a $5 million MERIT Award to support his research on brain cell adaptability and its impact on age-related cognitive decline. This recognition highlights the strength of Mount Sinai faculty during a challenging time for researchers.
Dr. John A. Martignetti received a $6.1 million grant to investigate the potential therapeutic role of siRNA in metastatic prostate cancer. The award aims to improve survival and reduce side effects and death for men with advanced prostate cancer.
Researchers developed a new imaging technique to capture the movement of white blood cells in real-time, allowing for a better understanding of Sickle Cell disease. The technique, called digital multi-channel videomicroscopy, has the potential to aid investigations and develop therapeutics for this debilitating disease.
Children born with low birth weight are more likely to develop depression and social dysfunction if they experience child abuse, according to a recent study. The study found that those who suffered both low birth weight and child abuse had significantly poorer outcomes than those who experienced either adversity alone.
Researchers found that modifying the 1918 flu virus's hemagglutinin receptor binding site reduced its ability to transmit in ferrets. The study suggests that understanding this molecular mechanism could lead to the development of novel drugs to stop influenza transmission and prevent epidemics.
Researchers used MRI to detect macrophages in arterial walls, which indicate inflammation and cardiovascular disease. The study found a 79% increase in detection compared to baseline images, suggesting a potential noninvasive screening tool for heart attack risk.
A study published in Clinical Gastroenterology and Hepatology found that stool DNA testing can detect colorectal cancer with 88% accuracy, regardless of its stage or location. This non-invasive screening test offers a patient-friendly alternative to traditional colonoscopy.
A new study published in the journal Obstetrics & Gynecology found that midtrimester amniocentesis is associated with a lower risk of miscarriage than previously reported, with a rate of approximately 1 in 1,600 pregnancies. The study refutes the typically quoted 0.5% pregnancy loss rate and suggests it may be even lower than 0.1%.
The Mount Sinai Medical Center will receive a $400,000 grant to develop and disseminate a curriculum educating health professionals about rational prescribing. The grant aims to promote critical thinking and healthy skepticism among healthcare providers, enabling them to make evidence-based prescribing decisions.
A recent Mount Sinai School of Medicine study suggests that physicians are crucial in helping low-income and uninsured seniors save money on prescription drugs. By prescribing generic versions of cardiovascular medications, doctors can significantly reduce medication costs for patients and Medicare beneficiaries.
A study published in Nature found that the reconstructed 1918 influenza virus induces a potent immune system response in mice, yet fails to prevent severe lung disease and death. Researchers hope to understand the trajectory of this infection and develop targeted therapies for other viral infections.
A new study found that moderate consumption of Cabernet Sauvignon reduces AD-type â-amyloid neuropathology and memory deterioration in mice. The findings support epidemiological evidence suggesting moderate wine consumption may help prevent Alzheimer's clinical dementia.
A study published in the American Journal of Epidemiology found no increased risk of pregnancy loss related to drinking water disinfection by-products. The research, led by David A. Savitz, Ph.D., used data from 2,409 women and 258 pregnancy losses, concluding that tap water DBPs do not pose a measurable risk to fetal health.
A study found that cyclin D1 gene overexpression is associated with better survival outcomes and increased sensitivity to the cancer-fighting drug bortezomib in breast cancer patients. This is because it suppresses the activity of another gene, STAT3, which promotes cell growth and prevents tumor cells from dying.
A new study found that variations of the OLIG2 gene are strongly associated with schizophrenia. The gene plays a crucial role in myelin production and is coordinated with other genes involved in myelination and schizophrenia development. This causal link may help researchers develop new therapeutic targets for the debilitating illness.
A landmark study found that routine follow-up by a nurse improved heart failure patients' functionality and reduced hospitalizations. The study showed significant benefits for both African-American and Hispanic communities, with nurse-managed patients experiencing fewer limitations in physical activities.
A recent study by Mount Sinai School of Medicine identifies a faulty enzyme, IDE, that breaks down beta-amyloid peptides. Boosting IDE activity may reverse beta-amyloid peptide accumulation and provide a new angle for preventing AD dementia.
The Mount Sinai Global Health Center has received a $1 million grant to develop faculty and finance curriculum, conduct international research, and build partnerships with NGOs. The grant will help train medical students in global health and provide humanitarian aid support.
The grant aims to improve care for patients with chronic illnesses by redesigning medical education. Two new programs, Seniors as Mentors and Chronic Care Team, will be implemented to teach students about caring for chronically ill patients.
Research shows that dietary caloric restriction, particularly low carbohydrate intake, can reduce beta-amyloid peptides and promote a longevity program in the brain. This study suggests that calorie restriction may be a potential preventive strategy for Alzheimer's Disease.
A novel stool testing technique has been developed, showing high sensitivity (88%) in detecting colon cancer. The new test is more sensitive than previous versions, making it easier to perform and potentially leading to better patient outcomes.
Researchers found that a high-caloric ketogenic diet slowed ALS progression in mice by promoting mitochondrial energy production and membrane stabilization. The study suggests that dietary interventions may offer new therapeutic options for ALS patients.
A new clinical trial launched by Mount Sinai aims to determine whether a combination therapy is more effective than individual treatments in slowing or halting progression of Relapsing-Remitting Multiple Sclerosis. The study will recruit 1000 patients and assess the impact of treatment over 36 months.
Patients with asthma often view their condition as a temporary health problem, leading to inadequate treatment and poor disease control. A study found that nearly half of hospitalised asthma patients believed they only had asthma when symptoms appeared.
Mount Sinai School of Medicine researchers identified three proteins found in lower concentration in ALS patients' cerebral spinal fluid, showing 95% accuracy in diagnosing the disease. Early testing may provide relief from symptoms years earlier than current methods.
A study found that Alzheimer's patients with a history of depression have more rapid cognitive decline and greater brain changes, including tangles and plaques in the hippocampus. The findings suggest that identifying potential mechanisms linking geriatric depression to AD may lead to new treatment strategies.
Scientists identify Langerhans cell precursor cells and protein Csf-1 essential for their transformation. This discovery may lead to new therapies for patients with Langerhans histocytosis, a rare disease affecting approximately 200,000 children annually.
The sympathetic nervous system plays a crucial role in regulating hematopoietic stem cell mobilization. Researchers found that defects in the transmission of signals via this system can stall stem cell movement. Drugs that stimulate the sympathetic nervous system restored stem cell movement in mice with impaired ability to respond to n...
A study published in Nature reveals that a molecular mechanism directs cells to migrate to the correct location within the developing neural tube of vertebrates. The research, conducted by Mount Sinai School of Medicine, identifies specific molecules involved in restoring polarity and guiding cell migration.
Researchers found that prolonged exposure to low levels of particulate matter (PM2.5) increases the risk of heart disease by accelerating atherosclerosis and causing vascular inflammation in mice. The study used real-world exposure to airborne pollutants to demonstrate the link between air pollution and cardiovascular disease.
A new study reveals that palliative care programs are increasingly available in US hospitals, particularly in larger institutions and those affiliated with not-for-profit organizations. The growing demand for quality of life and relief from suffering is driving the expansion of these programs.
Researchers at Mount Sinai School of Medicine have developed a new gene therapy technique that permanently corrects genetic diseases like PKU by inserting genes into specific sequences between existing genes. The technique was tested on mice and successfully cured the disease with just three intravenous injections.
Researchers reconstructed the 1918 flu virus using reverse genetics, a technique developed by Mount Sinai School of Medicine researchers. The study reveals that the virus is extremely virulent in mice and grows rapidly in human lung cells.
The National Children's Study will follow over 100,000 children from birth to age 21 to examine the impact of environmental factors on child health. The study aims to improve the lives of children in Queens and inform child health guidance and policy nationwide.
Researchers at Mount Sinai School of Medicine identify a new way cells replicate through damaged DNA by using the protein Rev1 as a template. This discovery opens up a new area of study with potential innovative approaches to cancer prevention and treatment.
The Mount Sinai School of Medicine has been awarded significant NIH funding to support its stem cell research efforts. Researchers will focus on developing methods to genetically modify stem cells and studying the molecular signals that cause them to differentiate into red blood cells.
Researchers have found that disruption of the Foxp2 gene affects the ability of infant rodents to emit ultrasonic vocalizations, which is crucial for social communication. The study suggests that Foxp2 subsumes communication across species, enabling researchers to learn about human speech and articulation.
A recent Mount Sinai study found that Hispanic patients with stage I non-small cell lung cancer have a significantly lower five-year survival rate of 54% compared to white patients at 62%. This disparity is largely attributed to unequal access to surgical resection, as well as higher rates of advanced-stage diagnosis.