A study published in the American Journal of Epidemiology found no increased risk of pregnancy loss related to drinking water disinfection by-products. The research, led by David A. Savitz, Ph.D., used data from 2,409 women and 258 pregnancy losses, concluding that tap water DBPs do not pose a measurable risk to fetal health.
A study found that cyclin D1 gene overexpression is associated with better survival outcomes and increased sensitivity to the cancer-fighting drug bortezomib in breast cancer patients. This is because it suppresses the activity of another gene, STAT3, which promotes cell growth and prevents tumor cells from dying.
A new study found that variations of the OLIG2 gene are strongly associated with schizophrenia. The gene plays a crucial role in myelin production and is coordinated with other genes involved in myelination and schizophrenia development. This causal link may help researchers develop new therapeutic targets for the debilitating illness.
A landmark study found that routine follow-up by a nurse improved heart failure patients' functionality and reduced hospitalizations. The study showed significant benefits for both African-American and Hispanic communities, with nurse-managed patients experiencing fewer limitations in physical activities.
A recent study by Mount Sinai School of Medicine identifies a faulty enzyme, IDE, that breaks down beta-amyloid peptides. Boosting IDE activity may reverse beta-amyloid peptide accumulation and provide a new angle for preventing AD dementia.
The Mount Sinai Global Health Center has received a $1 million grant to develop faculty and finance curriculum, conduct international research, and build partnerships with NGOs. The grant will help train medical students in global health and provide humanitarian aid support.
The grant aims to improve care for patients with chronic illnesses by redesigning medical education. Two new programs, Seniors as Mentors and Chronic Care Team, will be implemented to teach students about caring for chronically ill patients.
Research shows that dietary caloric restriction, particularly low carbohydrate intake, can reduce beta-amyloid peptides and promote a longevity program in the brain. This study suggests that calorie restriction may be a potential preventive strategy for Alzheimer's Disease.
A novel stool testing technique has been developed, showing high sensitivity (88%) in detecting colon cancer. The new test is more sensitive than previous versions, making it easier to perform and potentially leading to better patient outcomes.
Researchers found that a high-caloric ketogenic diet slowed ALS progression in mice by promoting mitochondrial energy production and membrane stabilization. The study suggests that dietary interventions may offer new therapeutic options for ALS patients.
A new clinical trial launched by Mount Sinai aims to determine whether a combination therapy is more effective than individual treatments in slowing or halting progression of Relapsing-Remitting Multiple Sclerosis. The study will recruit 1000 patients and assess the impact of treatment over 36 months.
Patients with asthma often view their condition as a temporary health problem, leading to inadequate treatment and poor disease control. A study found that nearly half of hospitalised asthma patients believed they only had asthma when symptoms appeared.
Mount Sinai School of Medicine researchers identified three proteins found in lower concentration in ALS patients' cerebral spinal fluid, showing 95% accuracy in diagnosing the disease. Early testing may provide relief from symptoms years earlier than current methods.
A study found that Alzheimer's patients with a history of depression have more rapid cognitive decline and greater brain changes, including tangles and plaques in the hippocampus. The findings suggest that identifying potential mechanisms linking geriatric depression to AD may lead to new treatment strategies.
Scientists identify Langerhans cell precursor cells and protein Csf-1 essential for their transformation. This discovery may lead to new therapies for patients with Langerhans histocytosis, a rare disease affecting approximately 200,000 children annually.
The sympathetic nervous system plays a crucial role in regulating hematopoietic stem cell mobilization. Researchers found that defects in the transmission of signals via this system can stall stem cell movement. Drugs that stimulate the sympathetic nervous system restored stem cell movement in mice with impaired ability to respond to n...
A study published in Nature reveals that a molecular mechanism directs cells to migrate to the correct location within the developing neural tube of vertebrates. The research, conducted by Mount Sinai School of Medicine, identifies specific molecules involved in restoring polarity and guiding cell migration.
Researchers found that prolonged exposure to low levels of particulate matter (PM2.5) increases the risk of heart disease by accelerating atherosclerosis and causing vascular inflammation in mice. The study used real-world exposure to airborne pollutants to demonstrate the link between air pollution and cardiovascular disease.
A new study reveals that palliative care programs are increasingly available in US hospitals, particularly in larger institutions and those affiliated with not-for-profit organizations. The growing demand for quality of life and relief from suffering is driving the expansion of these programs.
Researchers at Mount Sinai School of Medicine have developed a new gene therapy technique that permanently corrects genetic diseases like PKU by inserting genes into specific sequences between existing genes. The technique was tested on mice and successfully cured the disease with just three intravenous injections.
Researchers reconstructed the 1918 flu virus using reverse genetics, a technique developed by Mount Sinai School of Medicine researchers. The study reveals that the virus is extremely virulent in mice and grows rapidly in human lung cells.
The National Children's Study will follow over 100,000 children from birth to age 21 to examine the impact of environmental factors on child health. The study aims to improve the lives of children in Queens and inform child health guidance and policy nationwide.
Researchers at Mount Sinai School of Medicine identify a new way cells replicate through damaged DNA by using the protein Rev1 as a template. This discovery opens up a new area of study with potential innovative approaches to cancer prevention and treatment.
The Mount Sinai School of Medicine has been awarded significant NIH funding to support its stem cell research efforts. Researchers will focus on developing methods to genetically modify stem cells and studying the molecular signals that cause them to differentiate into red blood cells.
Researchers have found that disruption of the Foxp2 gene affects the ability of infant rodents to emit ultrasonic vocalizations, which is crucial for social communication. The study suggests that Foxp2 subsumes communication across species, enabling researchers to learn about human speech and articulation.
A recent Mount Sinai study found that Hispanic patients with stage I non-small cell lung cancer have a significantly lower five-year survival rate of 54% compared to white patients at 62%. This disparity is largely attributed to unequal access to surgical resection, as well as higher rates of advanced-stage diagnosis.
Researchers found a specific region of the receptor interacts with signaling lipid PIP2, leading to desensitization. This discovery provides critical information on temperature regulation and opens new avenues for investigating membrane protein functions.
Researchers found no detectable levels of SV40 in 69 tumors tested using a highly sensitive assay. The study's protocol aimed to eliminate possible contamination from DNA vectors used in laboratories worldwide.
Researchers at Mount Sinai School of Medicine discovered that alpha-defensin-1, a protein found in cells, can directly inactivate HIV virus and block infection in vulnerable cells. The findings offer insight into the function of alpha-defensin-1 on both the virus and the cell, potentially leading to new avenues for prevention and therapy.
A study found that PRO 2000 gel reduced HIV and HSV infectivity by at least 1000-fold, with no significant inflammatory response. The results suggest a potential safe and effective vaginal microbicide for preventing sexually transmitted infections.
Scientists have made a breakthrough in understanding diabetic nephropathy by identifying CD36 as the probable trigger of kidney disease in diabetics. High glucose levels cause a change on the surface of cells, triggering the production of CD36, which leads to kidney cell death.
Researchers identified an inherited gene variant associated with a 50% increased risk of prostate cancer, revealing a new pathway for the disease's development. The study found that individuals carrying this variant face a higher risk of developing prostate cancer.
The SPORTIF V trial found ximelagatran effective in preventing strokes and systemic embolic events, but with higher mortality rates compared to warfarin. The study results suggest a solid clinical benefit for ximelagatran, but more research is needed to safely bring it to market.
A study by Mount Sinai School of Medicine found that mice fed a reduced carbohydrate diet slowed disease progression, with anti-amyloidogenic activities increased and plaque development prevented. The findings provide a possible mechanism for caloric reduction to prevent Alzheimer's disease.
A Mount Sinai School of Medicine study identifies the shared precursor cell, called the hemangioblast, in early mouse embryos. This finding provides strong proof for the existence of a common origin for vascular cells and hematopoietic cells.
Researchers at Mount Sinai School of Medicine discovered a new mechanism that contributes to the development of some breast and ovarian cancers, involving the Wnt pathway. Compounds blocking this receptor can make cancer cells more sensitive to agents that induce cell death.
Researchers at Mount Sinai present groundbreaking studies on prostate and breast cancer treatments, identifying genetic predictors for adverse side effects and developing tailored radiotherapy regimens. The studies aim to improve clinical trials and patient outcomes for these devastating diseases.
A study led by Mount Sinai School of Medicine researchers found that imidazole-4-acetic acid-ribotide may be a primary cause of high blood pressure and a molecular link to diabetes. The molecule binds to receptors in the brain, leading to elevated blood pressure, which can also impair insulin release.
A Mount Sinai study found that nearly three-quarters of WTC responders experienced upper respiratory issues, with half still experiencing symptoms eight months later. Over half had persistent psychological symptoms, with risks for PTSD four times that of the general male population.
A study published in the New England Journal of Medicine found that reducing allergens and tobacco smoke in the home can significantly reduce asthma symptoms in African-American and Hispanic children. The research involved over 900 children aged 5-11, who were randomly assigned to either an intervention group or a control group.
A study by Mount Sinai School of Medicine found that East Harlem grocery stores were less likely to stock diabetes-friendly foods compared to Upper East Side stores. The research highlights the need for healthier food options in underserved communities.
Dr. Capitulo has been recognized for her leadership and research in nursing education and patient-centered care. Her national fellowship includes a $30,000 grant to develop a model for navigating industry changes, building on her experience leading major redesign projects and creating patient-focused care models.
A groundbreaking study by Mount Sinai School of Medicine found that the combination of Pegasysα and Copegus significantly improved treatment response rates for patients co-infected with HCV and HIV. The study showed a sustained virological response rate of 40% among all patients, with even higher efficacy rates for those with genotypes...
A new study by Mount Sinai School of Medicine researchers found that combining three therapeutic modalities increases the percentage of high-risk patients who are free from recurrence after five years. A three-pronged approach that included brachytherapy, external beam radiation therapy and hormonal therapy produced an 86 percent rate ...
Immune cells that get trapped in atherosclerotic plaques attract more immune cells, setting up a cycle that leads to continued progression of the disease. Monocytes take up permanent residence in plaques due to altered differentiation factors.
A nationwide survey found that approximately 11 million people in the US have food allergies, with shellfish being the most commonly reported severe allergy in adults. The study also revealed that seafood allergies often begin later in life, with a prevalence of at least 2.5% among adults and 0.8% among children.
Researchers found that among patients with confirmed Crohn's disease, clinical decisions based on capsule endoscopy findings improved outcomes in 95% of patients. Capsule endoscopy was also 100 percent effective in excluding a diagnosis of Crohn's disease.
A study by Mount Sinai School of Medicine found that brachytherapy effectively treats prostate cancer while preserving quality of life. The research team followed 255 patients with prostate cancer treated with I-125 and reported minimal urinary symptoms, preserved potency, and reduced bleeding.
The FREEDOM trial will investigate the impact of cardiovascular disease in diabetics and develop new approaches to management and treatment. The study aims to provide clear guidelines on procedures for diabetic patients, including CABG and angioplasty with stents.
Researchers identified a genetic mutation in one gene that increases the risk of autism by approximately doubling it, according to Dr. Joseph Buxbaum's study published in the American Journal of Psychiatry.