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Science News for May 25, 2007


High pretreatment PSA velocity predicts worse outcome

A study found that men with a high rate of increase in prostate-specific antigen (PSA) levels before treatment have a higher risk of death from prostate cancer. Elevated PSA velocity was a stronger predictor of poor prognosis than other single indicators, such as biopsy Gleason scores or advanced disease categories.

SourceWiley·JournalCancer·DateMay 25, 2007

Adult stem cells from human cord umbilical cord blood successfully engineered to make insulin

Researchers have successfully engineered adult stem cells from human cord blood to produce insulin, a potential breakthrough in treating type 1 diabetes. The discovery uses complex signals produced by embryonic mouse pancreas to direct adult stem cells into islet-like cells, producing C-peptide and insulin.

Most pediatric chemotherapy mistakes reach patients

A comprehensive study found that 85% of pediatric chemotherapy errors reached patients, with most common mistakes involving improper dosing and timing. The antimetabolite class of chemotherapeutic agents was most frequently associated with errors, highlighting the need for targeted medication administration safeguards.

SourceWiley·JournalCancer·DateMay 25, 2007

Aggressive treatment for whiplash does not promote faster recovery

A new study examines patterns of care for whiplash patients and finds that increasing the intensity of care is associated with slower recovery. The researchers suggest that early aggressive treatment may delay recovery by encouraging passive coping strategies, rather than improving outcomes.

SourceWiley·JournalArthritis Care & Research·DateMay 25, 2007

New insights into chronic inflammation and atherosclerosis

A study of coronary artery surgery survivors found that patients with inflammatory rheumatic diseases like rheumatoid arthritis and lupus had more chronic inflammatory cell infiltration in their aortic walls. Smoking was also independently associated with increased inflammation, particularly in the inner adventitia.

SourceWiley·JournalArthritis & Rheumatism·DateMay 25, 2007