Studies found that individuals with dementia and TBI may have distinct clinical characteristics, such as higher fluency and verbal memory scores. Additionally, elderly patients with TBI are at higher risk of premature death due to underlying health conditions or complications after injury.
Researchers at Mount Sinai Hospital are collaborating with the New York Stem Cell Foundation to use stem cells to gain a better understanding of Alzheimer's disease. The project aims to identify causes and cures for the common form of AD, using reprogrammed skin cells into brain cells.
Researchers have developed nanomedicines that home specifically to damaged tissue to repair it, preventing tissue damage in inflammatory conditions. These tiny, targeted drug particles have the potential to treat chronic diseases without side effects.
Researchers at Mount Sinai are studying spasmodic dysphonia, a neurological disorder characterized by vocal cord spasms. The team aims to identify new drug targets and diagnostic biomarkers using advanced neuroimaging methodologies.
A large-scale trial by The Mount Sinai Medical Center found that combination therapy did not improve clinical benefits over single drug treatment in multiple sclerosis patients, but reduced the development of new lesions. Combination therapy with Glatiramer Acetate and Interferon Beta-1a showed a reduction in MRI lesion accumulation.
A team of researchers found that a specific histone variant, macroH2A, prevents normal cells from being reprogrammed into cells resembling stem cells. This discovery has broad implications for how cells change during both normal and disease development.
A study published in Health Affairs found that Medicare patients who enrolled in hospice received better care at a significantly lower cost to the government. The study, led by researchers at Mount Sinai, showed annual savings of $2.4 million to $6.4 million for the government.
A new study published in Science Translational Medicine has found a strong link between binge drinking and the development of insulin resistance, which can lead to Type 2 diabetes. The research suggests that alcohol disrupts insulin-receptor signaling, causing inflammation in the brain and increasing the risk of metabolic disorders.
Researchers at Mount Sinai have discovered that the flu virus can essentially tell time, with a clock that dictates when it multiplies, infects cells, and spreads. This finding provides a novel design platform for the flu vaccine and could lead to new antiviral drugs that target the virus's internal clock.
Mount Sinai researchers have developed a playbook for treating fibrotic diseases, which are responsible for 45% of all deaths in the industrialized world. They've identified promising experimental drugs and biomarkers that will facilitate testing of new treatments.
A recent Mount Sinai survey reveals that nearly 1 in 3 children with food allergies are bullied, leading to increased stress levels and lower quality of life. The study highlights the importance of parents, school personnel, and physicians being aware of bullying in this population.
Researchers have identified numerous new genes associated with autism spectrum disorder using high-throughput sequencing technology. This discovery confirms that the genetic origins of autism are complex and may involve hundreds of mutations.
Pomalidomide, a new immunomodulatory drug, demonstrates significant increases in progression-free survival and overall survival for patients with relapsed and treatment-resistant multiple myeloma. The study found improved outcomes in both younger and older patients, offering a promising new option to extend survival.
Researchers found point-of-care ultrasound to be highly specific (97%) and sensitive (92%) for diagnosing pneumonia, outperforming the traditional method of auscultation by stethoscope. Ultrasound can also detect small pneumonias that a chest x-ray may miss, making it a valuable tool in pediatric care.
A survey of US hospices found that restrictive policies limit access to hospice care for patients requiring costly treatments. Reforming Medicare reimbursement rates and eligibility requirements is necessary to support patients and their providers.
A study published in Nature Neuroscience reveals that social isolation can reduce myelin production in mice, affecting the formation of new oligodendrocytes and leading to behavioral changes. Reintroduction into a social group reverses these effects, suggesting environmental factors play a crucial role in maintaining healthy nerve cells.
Researchers identified hundreds of regions in the human genome with unique chromatin structures that control cognitive behavior and expression. These findings provide new insights into diseases like Alzheimer's and autism.
Researchers at The Mount Sinai School of Medicine presented a study demonstrating IRX4204's ability to alleviate cognitive decline in animal models of Alzheimer's disease. The compound also prevents neuropathological features associated with abnormal tau processing, a common feature of Parkinson's disease with dementia.
Overeating can cause a malfunction in brain insulin signaling, leading to increased fatty acid levels, inflammation, and worsened insulin resistance. The study suggests that the brain's response plays a crucial role in developing type 2 diabetes, making it a potential target for improving insulin function.
Researchers have discovered potential new targets for treating depression by modulating dopamine cells and the innate immune system in mice. Increasing activity of dopamine neurons produced depressed behavior, while inhibiting them eased symptoms.
A six-gene signature has been identified that can predict survival in men with aggressive prostate cancer. The test uses blood samples and shows promise for determining the course of action for patients, clinical trial eligibility, and targeted studies.
Researchers at Mount Sinai School of Medicine have shown that large doses of vitamin C can stimulate bone formation and prevent bone loss in animal models. The study suggests that vitamin C may be a promising therapeutic agent for treating osteoporosis, particularly in developing nations where treatment options are limited.
Researchers found that a protein called BDNF is inhibited in opioid addiction, unlike cocaine where it's enhanced. The study identified two genes, sox11 and gadd45g, which mediated the brain's response to morphine, preventing reward and addiction.
A study has identified 12 genetic markers associated with erectile dysfunction in prostate cancer patients treated with radiation. The findings may help clinicians predict complications and develop therapies to alleviate side effects.
Researchers at Mount Sinai identified reliable predictors of pain in inpatients, enabling interdisciplinary teams to develop targeted intervention plans. These plans resulted in decreased pain levels and increased patient satisfaction across various departments, with reported pain levels decreasing by 3.6% per quarter.
Researchers Stuart Aaronson and Ross Cagan received a $351,713 grant from the National Cancer Institute to investigate signaling pathways responsible for Wnt oncogene addiction. They aim to discover potent drugs that can disrupt this addiction in tumor cells, increasing the efficacy of therapy for Wnt-activated human cancers.
Researchers identify a subpopulation of cancer stem cells that display resistance to chemotherapy and contribute to tumor progression. The study suggests a new therapeutic strategy by targeting these cancer stem cells with a combination of standard chemotherapy and signaling pathway inhibitors.
A study found that 25% of Medicare recipients spent more on out-of-pocket healthcare expenses than their total assets during the last five years of life. The average spending was $38,688, with the top quarter of participants spending $101,791.
Researchers at Mount Sinai School of Medicine have identified the genetic cause of Winchester syndrome, a rare and fatal bone disease, by studying frozen skin cells taken from a child in 1969. The MT1-MMP gene mutation leads to severe arthritis and osteoporosis, rendering patients incapable of movement without assistance.
A new study suggests that a dual-action polyclonal antibody may offer more effective protection against osteoporosis by slowing bone destruction and building bone. This novel approach has the potential to be safer than existing treatments.
Researchers found that mice exposed to methyl-glyoxal, a heat-processed food compound, developed abdominal weight gain, insulin resistance, and type 2 diabetes. A diet high in MG reduced SIRT1 and AGER1 levels, impairing glucose metabolism.
Researchers at Mount Sinai School of Medicine discovered that an enzyme called HDAC2 is involved in reducing the efficacy of antipsychotic drugs in schizophrenic patients. The team found that inhibiting HDAC2 can improve therapeutic effects of antipsychotics and prevent drug resistance.
Latrepirdine, a compound initially rejected for Alzheimer's treatment, shows promise in animal models by reducing neurodegeneration-related proteins and activating autophagy. The study suggests potential benefits in treating or preventing disorders associated with high levels of alpha-synuclein.
A team of researchers at Mount Sinai School of Medicine found that Aurora A (Aurka) activates p53 by phosphorylation, promoting ESC self-renewal. The study provides insight into the role of Aurka in embryonic stem cell regulation and cancer development.
A study published by researchers at Mount Sinai School of Medicine suggests that latrepirdine, a previously failed Alzheimer's drug, may be successful if tested on patients with earlier stages of the disease. The compound effectively stopped progression of memory deterioration and brain pathology in mouse models.
Researchers at Mount Sinai School of Medicine presented data on transoral robotic surgery outcomes for patients with head and neck cancer. The study found significant benefits in progression-free and overall survival rates for both smokers and nonsmokers, suggesting a promising treatment modality.
Researchers developed a new computational method to identify novel connections between genes, drugs and scientists. The approach analyzed large datasets to create gene-gene networks, connected co-prescribed drugs and side effects, and identified collaborations.
Mount Sinai researchers found that neutrophils boost antibody production and reprogram B-cells to create a potent immune response. This discovery has significant promise for developing vaccines against blood-borne infections and HIV.
A multi-center study of 55 children found that oral immunotherapy reduced allergic reactions, allowing most to consume eggs without symptoms. The therapy showed promise in desensitizing children to egg allergies, representing a promising therapeutic intervention.
Researchers at Mount Sinai Hospital found a link between increased risk of autism spectrum disorder (ASD) and family history of schizophrenia or bipolar disorder. The study suggests shared etiologic risk factors among these disorders, potentially leading to more similar understanding and treatment approaches.
A patient registry has yielded crucial data on the clinical features and outcomes of fibromuscular dysplasia (FMD), a non-inflammatory vascular disease. The study found that 91% of patients are women diagnosed in their prime of life, with an average delay in diagnosis of four years from symptom onset.
A study found that a simpler lifestyle with fresh foods and limited use of environmental chemicals can reduce exposure to EDCs. Researchers analyzed urine samples from OOM women and compared them to NHANES data, finding lower levels of BPA and phthalates in the former group.
A recent study found that young children with food allergies experience almost one allergic reaction per year, despite parental instructions on food avoidance. The study highlights the importance of educating parents and caregivers about avoiding allergenic foods and using epinephrine to treat severe reactions.
A study by Mount Sinai researchers found that the timing of ADHD medication impact on children's performance on standardized tests. The findings showed that starting medication within 12 months after fourth-grade test led to a decline of 0.3 percent in math compared to 9.4 percent for those who started treatment later.
A new intestinal gel formulation of levodopa/carbidopa has improved the duration of treatment benefits in people with advanced Parkinson's disease, reducing 'off' time and dyskinesia. The study found that the continuous delivery reduced 'off' time by nearly four hours, two hours more than standard oral formulations.
Researchers developed a multi-target approach to treat tumors using fruit flies, creating an investigational compound AD80 that targets multiple cancer genes. Tested in mouse models, AD80 proved far more effective and less toxic than standard cancer drugs.
Researchers at Mount Sinai School of Medicine are pioneering a new way to diagnose heart disease by focusing on fluid dynamics, not muscle mechanics. This approach uses advanced ultrasound techniques to visualize blood flow in the heart, providing clues for early detection and effective therapeutic interventions.
Researchers from Mount Sinai presented several landmark studies on late-stage cancer treatment trends, a promising multiple myeloma vaccine, and predictive models of soft tissue sarcomas, prostate, and bladder cancer. The studies aimed to identify factors associated with lack of treatment and explore new treatments for various cancers.
Researchers at Mount Sinai School of Medicine have found a potential treatment for craniosynostosis and acanthosis nigricans, two birth defects associated with Beare-Stevenson cutis gyrata syndrome. Inhibiting the protein p38 improved skull and skin defect outcomes in mouse models.
Researchers at Mount Sinai School of Medicine have developed a biosynthetic polyphenol that improves cognitive function in mice with Alzheimer's disease. The compound reduces brain neuropathology by preventing abnormal protein accumulation, promoting plasticity and benefits in learning and memory functions.