Scientists have discovered a stable version of a 'trophy molecule' and found its bonding properties to be surprisingly similar to those of chromium, molybdenum, and tungsten. This finding could aid in the extraction and separation of radioactive material from nuclear waste.
Mutations in lamin genes cause hereditary diseases like Emery-Dreifuss Muscular dystrophy and dilated cardiomyopathy by altering nuclear structure and gene expression. Restoring MKL1 activity may be a productive intervention mechanism for these devastating diseases.
The study estimates that annual net carbon uptake by these trees is 21 million tons and $1.5 billion in economic benefit. Urbanization has led to declining urban tree cover nationwide, with approximately 4 million trees lost annually.
A study by Thomas Jefferson University researchers found that amplification of the Stat5 gene in prostate cancer cells leads to excess oncogenic protein, driving cancer spread. Gene amplification and protein levels increased with metastasis and castration therapy resistance.
AFOSR-funded research has led to the development of a new, environmentally benign propellant that is twice as powerful as hydrazine. This 'green' propellant reduces toxicity and offers improved safety properties.
Researchers found that all modern helmets provided significantly more protection than vintage leather helmets, reducing concussion risk by up to 96%. Modern helmets with lower star ratings had greater peak accelerations than higher-rated ones, highlighting the importance of helmet testing methodologies.
The study found a significant increase in the number of older Finnish adults with fall-induced TBI from 1970 to 2011, with an age-adjusted incidence rate that rose by 289% among women and 315% among men. The total number of individuals affected also increased considerably.
A recent study found that women are more likely to undergo percutaneous nephrolithotomy (PCNL), a minimally invasive procedure to remove medium to large kidney stones. The study also discovered an increase in blood infection and overall complications, with sepsis incidence doubling from 1.2% to 2.4%.
Researchers found that exposure to sunlight lowers blood pressure and improves overall health by reducing the risk of heart attack and stroke. The study's results suggest that the benefits of sunlight outweigh the risks of skin cancer.
A team of Duke researchers has discovered a previously unknown molecular network that regulates cell death and contributes to breast cancer drug resistance. The study found that high levels of the protein MDM2 block cell death signals, leading to drug resistance in breast cancer cells treated with lapatinib.
A new PLOS Collection evaluates the effectiveness of maternal, newborn, and child health interventions in low- and middle-income countries. The study reveals that some coverage indicators can be measured accurately, while others require further investigation to ensure valid results.
A study published in Biomacromolecules has identified a blend of natural fibers like cellulose and silk as a potential scaffold for stem cells to form into chondrocytes, the cells that produce healthy cartilage. The blend provides complex chemical and mechanical cues that induce stem cell differentiation without the need for expensive ...
A study found that robot-assisted partial nephrectomy is a safe operation with superior results compared to open and laparoscopic surgery. However, it also involves more excessive hospital charges, despite no cost-savings.
Researchers found that bats react strongly to all contact calls, regardless of familiarity. However, when presented with a call from a known bat multiple times, they showed a stronger response to other partners from their social group. This suggests individual evaluation of the voice, indicating recognition of conspecifics by sound.
Researchers found that certain bacteria can rapidly adapt to nanosilver's antimicrobial action, leading to the emergence of new resistant strains. This has significant implications for the widespread use of nanosilver in medicine and environmental applications.
Researchers developed a mathematical model to represent HIV-infected cell reproduction, revealing significant uncontrolled replication in sanctuary sites. The discovery implies current antiretroviral therapies may not be as complete in suppressing HIV as previously thought.
Researchers have discovered a new way to create stable three-dimensional magnetic vortices in nanometer-scale systems, which can be used as antennas for wireless data transmission. The discovery could lead to improved performance and stability in applications such as mobile communications and Wi-Fi.
A study found that increasing detection intervals in ICDs reduces unnecessary therapies, shocks, and hospitalizations while maintaining appropriate shock frequency. The long-detection strategy may be a useful approach for ICD recipients to reduce unfavorable outcomes.
A study found that interspinous spacers have a lower complication rate than spinal fusion, but patients receiving spacers are more likely to require repeated back surgery. The researchers compared outcomes of three surgical treatment options for spinal stenosis in over 99,000 Medicare patients.
The Hastings Center has released a new set of guidelines for good care near the end of life, aiming to improve communication, pain management, and treatment decisions. The guidelines clarify what is ethically permissible in the US regarding life-sustaining technologies and provide practical guidance for healthcare professionals.
A new study highlights how women credit themselves in joint success, finding that they undervalue their contributions when working with men but not with other women. The research contributes to a body of work on stereotypes affecting women in the workplace and underscores how gender influences individual performance expectations.
The new guideline provides detailed direction on treatment options for prostate cancer patients, including adjuvant and salvage radiotherapy recommendations. It emphasizes the importance of informed consent and patient education on potential side effects and benefits of radiation therapy.
A Swedish study found that children whose parents sucked on their pacifiers had a lower risk of eczema at 1.5 years old. The researchers believe that oral commensal microbes are transferred from parent to infant when they suck on the same pacifier, promoting healthy maturation of the immune system.
A study by Johns Hopkins researchers has discovered a connection between restless legs syndrome (RLS), insomnia and brain chemistry, suggesting that high levels of glutamate may be the key to understanding the condition. The findings could lead to a new approach in treating RLS and potentially other forms of insomnia.
A recent study reveals that Europeans are genetically linked over the past thousand years, tracing back to nearly the same set of ancestors. The research found subtle local differences in genetic sequences among European populations.
A Cleveland Clinic study found that only 42% of deaths after angioplasty were caused by the procedure itself, highlighting the need for a more accurate reporting system. The researchers argue that alternative outcome reporting mechanisms should be considered to better reflect quality and performance.
Scientists discover that Pseudomonas aeruginosa modifies elongation factor-Tu to mimic phosphorylcholine, enabling it to adhere to and invade human cells. This modification could represent a new strategy to inhibit the bacterium's virulence.
Researchers at the University of Pittsburgh have discovered a potential treatment for deadly, drug-resistant bacterial infections that uses the same approach as HIV to infect cells. The new antibiotic, called engineered cationic antimicrobial peptides (eCAPs), has shown rapid destruction of bacteria resistant to standard antibiotics.
Researchers at UT Southwestern Medical Center found that a marker panel can predict which patients are more likely to experience cancer recurrence after bladder removal. The study identifies patients who could benefit from follow-up chemotherapy to improve treatment outcomes.
A minimally invasive procedure called VATS-LCSD has been shown to be effective in treating refractory cardiac arrhythmias in children. Almost three-quarters of symptomatic patients responded well to the treatment, with 55% becoming arrhythmia-free after sympathectomy.
Researchers discovered that combining a few microRNAs enhances anti-breast cancer activity without the unwanted side effects of amplifying a single microRNA. This technique targets tumor-specific genes while sparing healthy tissue.
Researchers have developed a new technique to improve the use of nanoparticles as a drug delivery system. The study found that smaller particles degrade faster in the body than predicted by in vitro measurements. By understanding this degradation, a mathematical model can be developed to optimize nanoparticle-based therapeutic systems.
A new study found that Black women with breast cancer are three times more likely to delay treatment for over 90 days compared to white women. Low satisfaction with doctor communication is a significant reason for this delay, which increases the risk of mortality from the disease.
A systematic review of longitudinal studies found that intimate partner violence nearly doubled the odds of subsequent depression in women. Conversely, women with depression were at increased risk of experiencing intimate partner violence.
A study reveals how viral protein 40 allows Ebola to leave host cells and spread infection, paving the way for new drug candidates. Mutating VP40's C-terminal domain reduces its effectiveness in binding to plasma membranes.
Researchers found that hyperglycemia promotes the production of inflammatory cells, which contribute to plaque build-up in blood vessels. Treating diabetic mice with a drug that lowers blood sugar levels reduced circulating monocyte and neutrophil numbers and allowed plaques to heal.
Researchers at the Salk Institute have identified TR4 as a protein that drives the formation of pituitary tumors in Cushing's disease, which could lead to a new therapeutic approach for this potentially life-threatening disorder. The study found that targeting this pathway could benefit treatment of CD.
Research identifies a key gene that regulates both protection against bacterial infection and excessive blood clotting, leading to potential new treatments for deep-vein thrombosis. The study found that inhibiting the enzyme could offer hope to patients prone to clots.
A new study published in PLOS Biology found that Europeans are closely related, sharing nearly the same set of ancestors within a thousand years. The researchers used DNA data from over 2,000 individuals to detect subtle local trends and historic migrations, revealing patterns of demographic shifts and cultural influences.
Scientists have found that certain omega-3 and omega-6 fatty acids regulate the cardiac function of hibernating animals, ensuring a regular heartbeat. Hibernators show higher levels of these fatty acids in their heart tissue compared to non-hibernating animals.
Researchers found that two enzyme paradigms - free and complexed enzymes - use different mechanisms to degrade biomass at the nanometer scale. Combining these systems enhances catalytic performance, suggesting an optimal strategy may already exist.
Harvard researchers have discovered a novel hormone that regulates glucose production in the liver, offering new avenues for treating type 2 diabetes. The study found that switching off this hormone improves glucose metabolism, providing a potential therapeutic target.
IDIBELL has licensed a patent for a repositioned drug to treat X-linked adrenoleukodystrophy, a rare neurodegenerative disease. The patented product has shown promise in laboratory studies, but further research is needed before its application can be considered.
A new study found that adults with depression and certain antidepressant medications are more likely to develop Clostridium difficile infections, a serious and costly hospital-associated infection. Individuals with major depression were 36% more likely to develop the infection than those without depression.
Researchers from NREL evaluated CSP systems with thermal energy storage within the CAISO system to estimate operational factors such as fuel cost, emissions, and reliability. The analysis found significant value in dispatchable CSP, particularly when providing reserve power, which can be turned on or off during high or low demand periods.
A study of 3,690 older adults found that even short-term use of strong anticholinergics causes memory problems. Taking multiple drugs with weaker anticholinergic effects also has a negative impact on cognition over time.
The US Centers for Disease Control and Prevention (CDC) presents promising strategies to curb the use of indoor tanning devices. These methods aim to tackle not only the risk factors linked with indoor tanning but also the broader social determinants that may drive such behavior.
Researchers at North Carolina State University have developed a new oxygen carrier that enables chemical looping combustion of natural gas up to 70 times faster. This process captures carbon dioxide while producing water vapor and energy.
Researchers at the University of Arizona used a state-of-the-art DNA sequencing technique to determine the genetic mutations causing severe epilepsies in seven out of ten previously undiagnosed children. The study found 15 mutations in nine children, seven of which are known or likely to cause epilepsy.
A study by American Academy of Sleep Medicine links diet composition with daytime sleepiness and alertness in healthy adults. Higher fat consumption is associated with increased objective daytime sleepiness, whereas higher carbohydrate intake is linked to increased alertness.
Researchers at Johns Hopkins Medicine report that a once-daily tablet containing Ambrosia artemisiifolia major allergen 1 effectively blocks ragweed allergy symptoms, reducing need for anti-allergy drugs by 27%. The pill is a convenient alternative to weekly or monthly allergy shots.
Researchers found that vagus nerve stimulation brings about changes in brain metabolism weeks or months before patients begin to feel better. The treatment was able to improve symptoms of depression in 9 out of 13 participants, with significant changes in brain metabolism occurring far in advance of any improvement in mood.
A recent UCLA study found that adolescents who purchased Subway meals consumed nearly as many calories as they did at McDonald's. The researchers also noted that both restaurants' meals likely contribute to overeating and obesity.
The Bill & Melinda Gates Foundation has awarded a $2.9 million grant to Aeras, Oxford University, and Okairos to develop novel vaccines against tuberculosis, HIV, and malaria. The collaboration aims to create scalable methods for large-scale production of multiple chimpanzee adenovirus vector constructs.
Research Fellows Mike Himmel and David Ginley honored for innovation impacts in energy systems integration and commercialization of NREL technologies. NREL has added 29 new CRADAs, attracting $8 in private investment for every dollar invested.
A recent study suggests that age-related atrophy of the medial temporal lobe (MTL) may contribute to difficulties in processing and remembering everyday events. The researchers found that older adults with MTL atrophy performed poorly in separating and chunking events, which can impact memory for everyday activities.
Researchers at the University of California - San Francisco have developed a type of human brain cell called medial ganglionic eminence (MGE) cell that grows seamlessly when transplanted into mice. These cells have the potential to treat several types of neurodevelopmental and neurodegenerative disorders, including Parkinson's disease,...
Researchers have demonstrated that chaotic systems can store more light than ordered ones in optical cavities, with applications for quantum optics and solar cells. The study found a six-fold increase in energy storage in chaotic cavities, outperforming classical counterparts.
A new species of bone-headed dinosaur, Acrotholus audeti, has been identified from Alberta, Canada, representing the oldest known bone-headed dinosaur in North America. The discovery provides valuable insights into the evolution and diversity of small plant-eating dinosaurs.
Hospitals should require mandatory physical examination, drug testing, or both before medical staff appointments. Random alcohol-drug testing programs and policies for routine testing in sentinel events leading to patient death are also recommended.