Researchers used a new method combining observations and climate models to project future warming, finding 63% of uncertainty came from single sources such as climate sensitivity. The study suggests that exceeding 6 degrees warming is unlikely, while exceeding 2 degrees is very likely for business-as-usual emissions.
Researchers discovered a 15-month wind pattern that explains El Niño's close ties to the annual cycle. This unusual atmospheric pattern triggers droughts and floods in various regions. The study suggests that improved climate models will improve El Niño forecasts.
Researchers discovered a new gene associated with congenital heart disease, specifically atrial septal defect (ASD), which may help improve genetic counselling and understanding of normal development. The study involved over 2,000 patients and found a strong association between the Msx1 gene and risk of ASD.
Researchers from CSHL have identified key circuit elements that contribute to 'stay or go' decisions in the anterior cingulate cortex. The activity of specific inhibitory neurons, SOM and PV neurons, correlates with start and end of foraging behavior in mice.
Researchers at the University of Adelaide have developed a new one-step process called 'clonetegration' that simplifies the production of designer bacteria. This faster method enables multiple rounds of genetic engineering on the same bacteria and simultaneous integration of multiple genes, accelerating therapeutic drug development.
A large scientific study has discovered two new genes associated with severe seizure disorders in infants and children. The finding will lead to new tests to diagnose these conditions and promises to improve outcomes for affected families.
The RELAX-AHF trial demonstrated serelaxin's efficacy in relieving dyspnea in HFpEF patients, particularly within the first 24 hours. The VIVIDD trial also showed vildagliptin to be non-inferior to placebo in improving LVEF in HFrEF patients with type 2 diabetes.
Researchers at Stanford University School of Medicine have identified mutations in genes that encode chromatin regulators, which may contribute to the development of sporadic ALS. The study found 25 de novo mutations, including five in chromatin regulatory proteins, which could serve as potential therapeutic targets.
Researchers have identified a protein responsible for controlling the growth of gigantic synapses in the auditory part of the brain. These massive synapses allow for rapid signal transmission, outpacing other neuronal circuits by a fraction of a millisecond, enabling humans to pinpoint sound sources with remarkable accuracy.
Researchers develop a new method to model large biomolecules in their native state using X-ray flash data, providing insights into protein structures and dynamic behavior. This technique promises to solve the shapes of more than 80,000 proteins in a static state and offer clues on individual components of mixtures.