Close monitoring of small renal tumors can be an alternative to surgery, with low rates of tumor growth or death observed. The study's findings suggest that actively monitoring these tumors in high-risk patients may prove safer than immediate surgery.
A clinical trial found that animal-assisted therapy significantly improved the emotional well-being and quality of life of adult cancer patients. The study, published in Journal of Community and Supportive Oncology, involved 37 patients who received daily visits from certified therapy dogs during their treatment.
Researchers developed a scoring system using biomarkers to predict patient response to GVHD treatment, allowing for personalized treatment approaches. The new system may identify patients who require experimental treatments and those who are over-treated.
Researchers identified 53 existing drugs that can hinder Ebola virus entry into human cells, including cancer drugs and antibiotics. This study may lead to rapid development of treatments against Ebola infection.
A new study suggests that MMP-2 protein plays a signaling role in the immune system, accelerating wound healing in some cases while exacerbating inflammatory diseases like cancer and autoimmune disorders. The protein's mechanisms may be leveraged to develop novel treatments for these conditions.
Researchers at Mount Sinai Hospital discovered that bisphosphonates block abnormal growth signals passed through the human EGF receptors, which drive some tumors. The study suggests that bisphosphonates could be used to prevent or treat lung, breast, and colon cancers.
A genetic marker in the SHROOM3 gene has been found to be associated with increased fibrosis and function loss in kidney transplants. Researchers hope this discovery will lead to improved screening of potential donors and development of new drugs to prevent disease progression.
A study led by Mount Sinai researchers found that the clipping of histone protein H3.3 silences genes regulating cell division and duplication, potentially limiting abnormal cell growth in tumors. This discovery has implications for understanding cellular senescence and its role in cancer prevention.
Researchers at Mount Sinai aim to re-create patients' ocular stem cells to restore vision, eliminating the need for immunosuppressive drugs. The grant will support efforts to discover new stem cell therapies and develop biomaterials for engrafting patient-owned stem cells.
Researchers found that administering stem cell factor directly into damaged heart muscle after a heart attack can help repair and regenerate injured tissue. The study showed improved cardiac function, reduced cell death, and increased regeneration of heart tissue blood vessels.
A new study found that training medical students to use handheld ultrasound devices enhances the accuracy of their physical diagnosis. Medical students who received personalized lessons on using handheld echocardiography technology showed a 58% correct diagnosis rate, compared to 40% for those with standard training.
A new study published in the Journal of Allergy and Clinical Immunology found a strong link between peanut exposure in household dust and the development of peanut allergies, particularly among children with eczema. The research suggests that exposure to peanut proteins through impaired skin barriers may trigger allergic reactions.
A new study by Mount Sinai Heart and CNIC in Spain reveals two waves of heart muscle inflammation after a heart attack, contradicting previous consensus. The researchers discovered the first wave occurs immediately after the attack and subsides, followed by a second wave that arises a week later.
A Mount Sinai study found that vital exhaustion increases the risk of first-time cardiovascular disease by 36%, affecting otherwise healthy people. The researchers investigated 11 prospective studies involving 60,610 participants and found a significant association between vital exhaustion and cardiovascular disease.
Researchers found that even brief oxycodone exposure can impair cognitive flexibility in rats, leading to maladaptive decision-making. The study suggests that this 'cognitive hangover' may contribute to drug addiction.
A recent study published in Nature found that a specific brain protein called beta-catenin influences how the brain manages stress and depression. The research suggests that activating this protein may provide a new model of treating depression by bolstering resilience against stress.
Researchers developed a DNA regulatory technique that modifies a single gene to control its expression and behavioral consequences. The study showed that changes in this gene reduced drug and stress responses in mice, indicating a potential new approach to treating addiction and depression.
Researchers discovered over 70 additional likely ASD genes, with small differences in as many as 1,000 genes contributing to autism risk. The study found three pathways required for healthy development linked to greater autism risk, including chromatin remodeling.
A recent study published in PNAS found that pre-existing differences in immune system sensitivity to stress can increase the risk of developing stress-related depression or anxiety. The research suggests that interleukin-6 may be a key factor in this increased risk.
A Mount Sinai-led research team has discovered a new kind of stem cell that can become either a liver cell or a blood vessel cell, contradicting current theory on organ development. This discovery may hold clues to the origins of and future treatment for liver cancer.
A study at Mount Sinai Hospital reveals that a set of molecules linked to insulin signaling in the brain may indicate an increased risk of developing diabetes. The researchers identified a key mechanism by which these molecules affect BCAA breakdown in the liver.
A study published in Journal of Clinical Investigation found that skin exposure to peanut proteins can lead to sensitization and severe allergic reactions in mice. Researchers believe this mechanism may explain why peanut allergies are a common cause of food allergy in children.
Researchers found that patients with Multiple Sclerosis (MS) can safely tolerate treatment with cells cultured from human placental tissue. Early signals also suggest the potential for repairing damaged nerve tissues, offering a new frontier in treatment for the disease.
A new experimental PET tracer effectively diagnoses chronic traumatic encephalopathy (CTE) while patients are still alive. The technology differentiates CTE from other forms of dementia, enabling estimates of prevalence and risk. This breakthrough improves diagnosis and treatment for athletes and others exposed to repeated head trauma.
A new study found that watching violent images causes different brain activity in people with and without aggressive traits. Participants with aggressive tendencies had less brain activity in the orbitofrontal cortex while watching violent movies, but increased blood pressure.
A novel polypill with a fixed-dose combination of blood thinner, cholesterol-lowering drug, and angiotensin-converting-enzyme inhibitor shows promise in increasing patient adherence to treatment following a myocardial infarction. The study found that patients were more likely to take their medication when given as a polypill compared t...
The study found that gram-positive bacteria, including staph and strep infections, accounted for 95 percent of endophthalmitis cases. The findings suggest better treatment with targeted antibiotics, but also highlight increasing resistance to certain antibiotics.
A study published in Cell Host & Microbe reveals how the Ebola virus blocks the body's first line of defense against infection. By targeting a specific protein called eVP24, the virus cripples the immune system's ability to respond effectively, allowing it to mass-produce itself and trigger a deadly response.
Researchers at Mount Sinai Hospital discovered a biomarker linked to PTSD development, centered around the glucocorticoid receptor. This receptor is found in stressed animals with PTSD and may be targeted for new treatments.
Researchers at Mount Sinai School of Medicine developed an effective treatment for the rare disorder, which causes continuous feelings of swaying or rocking. The treatment re-adapts the vestibulo-ocular reflex, a mechanism in the inner ear that maintains balance, and achieves significant recovery rates in patients.
Researchers have identified over 100 locations in the human genome associated with the risk of developing schizophrenia, pointing to genetic variations that make people vulnerable to psychiatric disease. The study's findings could lead to new approaches to treating the disorder and inform drug development for acute need.
A recent study led by researchers at the Icahn School of Medicine at Mount Sinai found that nearly 60% of autism risk is caused by inherited variant genes common in the population. Rare genetic factors, such as de novo mutations, also contribute to the disorder, but only account for a small fraction of total risk.
A study found that variations in the TANC1 gene are associated with a greater risk of radiation-driven side effects in prostate cancer patients. The research team developed a predictive genomic test to optimize treatment plans, allowing for improved quality of life for many cancer survivors.
A study found that genetic mutations in liver cells drive tumor formation in iCCA, with mutant proteins impairing liver cell development and increasing the risk of metastasis. Researchers discovered a potential treatment option by targeting IDH1/2 mutations, opening a new line of investigation for biomarkers and life-saving decisions.
A study found that Lavado cocoa extract reduces β-amyloid formation, which damages nerve cells in Alzheimer's disease. The extract also rescues synaptic function, a potential target for an effective Alzheimer's disease drug.
Researchers at the Icahn School of Medicine at Mount Sinai found that mammals do not use RNAi to fight viruses, contrary to previous studies. Instead, they use microRNAs, which are part of a different defense system based on interferons, signaling proteins made by immune cells.
Researchers at Mount Sinai Hospital discovered that a protein called Sirtuin1 (SIRT1) is essential for maintaining healthy aging of blood stem cells. The study found that loss of SIRT1 leads to impaired regeneration and resembles aged, defective stem cells in mouse models.
Researchers at Mount Sinai present promising findings on innovative treatments for recurrent ovarian cancer, molecular profiling of bile duct and gallbladder cancers, and adjuvant therapy for melanoma. The studies demonstrate encouraging results for patients with these rare and often fatal diseases.
Researchers at Mount Sinai Hospital have re-examined multiple sclerosis (MS) clinical course descriptions to provide a framework for both clinical research and ongoing clinical care. The proposed 2013 revisions include improved clinical descriptive terminology, MRI imaging, and analysis of fluid biomarkers.
Researchers at Mount Sinai present landmark studies on an immune response in prostate cancer tumors, effects of paternal age on live birth rates and treatment modalities for benign prostatic hyperplasia. The studies demonstrate complexities of immunotherapy and its impact on survival rates and fertility outcomes.
Researchers found high prevalence of hypertension and elevated cholesterol among HIV patients, with low rates of control. The study recommends greater emphasis on cardiology in HIV treatment and research to optimize heart disease risk factor management.
A study published in Neuron found that subtle changes in inhibitory signaling can affect how animals respond to drugs like cocaine. Researchers identified SNX27 as a promising target for treating addiction by regulating the excitability of dopamine neurons.
Researchers at the Mount Sinai Hospital identified subtle changes in inhibitory signaling in the reward pathway, affecting how animals respond to drugs like cocaine. The study highlights sorting nexin 27 as a promising target for treating addiction and may lead to new therapeutic options.
The LEADLESS study found that the leadless pacemaker demonstrated overall device performance comparable to conventional pacemakers, with no infections or failures to sense, pace, or communicate. The device's benefits may allow for less patient discomfort and device complications.
Researchers at Mount Sinai identified a new technique to expand hematopoietic stem cells in cord blood, making them more useful for adult patients. This study has important implications for patients battling blood cancers and the success of life-saving stem cell transplants.
A large family study found that genetic relatedness in families increases the risk of autism spectrum disorder, while unique environmental factors also play a significant role. The study used a population-based sample of over two million Swedish children and revealed a strong link between genetic and environmental influences.
Researchers have identified the RAF1 gene as a cause of childhood-onset dilated cardiomyopathy, a progressive and potentially fatal heart condition. The study found that patients with this genetic variant showed increased activity of the protein mTOR, which can be inhibited with FDA-approved drugs.
A study of almost 2,500 families found that genetic alterations in shared biological pathways are a significant risk factor for autism spectrum disorders (ASD). Individuals with ASD had more CNVs affecting genes involved in brain development and synapse function.
Researchers found that activating neurons instead of dampening them opens a new avenue to mimic and promote natural resilience. The study suggests a conceptually novel therapeutic strategy for treating depression.
The National Institutes of Health has awarded Mount Sinai a $26 million contract to support pandemic preparedness and advance the understanding of flu biology. Researchers will conduct animal surveillance studies, analyze virus-host interactions, and develop new vaccines.