Researchers have developed a new approach to build nearly complete genomes by combining high-throughput DNA sequencing with genome mapping. The methodology enabled the detection of complex forms of genomic variation, critically important for their association with human disease.
A new study found annual low-dose CT screening to be safe and effective for identifying pre-cancerous lung nodules. The study identified cases of cancer in participants with nonsolid lung nodules, which can progress to invasive cancer.
Researchers at Mount Sinai discovered that high levels of protein H2A.Z.2 promote abnormal growth in melanoma cells, making it a potential target for cancer treatment. The study's findings suggest that blocking this protein could effectively block tumor growth and kill melanoma cells.
The research team created a single-molecule, real-time sequencing method to detect and phase DNA methylation in bacteria. They found that individual bacterial populations have distinct subpopulations with different gene expression patterns, which may contribute to increasing antibiotic resistance.
Researchers from Mount Sinai Health System will present updates on a lymphoma vaccine clinical trial and new treatment strategies in relapsed multiple myeloma. Preliminary results show patients achieving partial or complete clinical remissions, including those with advanced stage disease.
A study found that hospice use was linked to fewer depressive symptoms in surviving spouses, with benefits lasting a year after death. The research team analyzed data from over 1,000 deceased patients and their surviving spouses, suggesting high-quality care can have a positive impact on caregivers as well.
A study led by Mount Sinai researchers compares flu viruses to the measles virus to identify key genes that can't be changed. This could lead to the development of universal flu vaccines and improved protection against emerging viral threats.
A new study by Mount Sinai researchers found that large urban hospitals in densely populated regions of Washington DC, New York State, California, Maryland, and New Jersey have lower patient satisfaction scores due to demographic bias. The authors propose an adjustment formula to mitigate this bias, which, when applied to New York Stat...
Researchers from Mount Sinai presented a first successful 3D printed trachea, as well as studies on increased mortality in black patients after esophageal cancer surgery and the potential benefits of surgical resection for myasthenia gravis. These findings highlight the importance of personalized medicine and access to specialized care.
A new study found that patients with AIDS have a four-fold increase in the risk of developing intermediate-stage age-related macular degeneration, compared to those without HIV. The study suggests that chronic immune activation and systemic inflammation may contribute to this increased risk.
A three-year analysis by Mount Sinai researchers found that early palliative care interventions can improve geriatric emergency care, decreasing hospital lengths-of-stay and costs. The approach is shown to have reduced ICU admissions for patients aged 65 and older by 1.4%.
Researchers at Icahn School of Medicine at Mount Sinai have developed a gene therapy approach that targets and corrects genetic mutations linked to heart failure. The treatment uses molecular scissors to cut out diseased genes and replace them with normal ones, restoring healthy cardiac cell function.
Researchers found nearly double bacterial diversity among Yanomami Amerindians compared to industrialized countries, and higher than other remote populations exposed to modern practices. The study suggests a link between antibiotic usage, western diet, and reduced bacterial diversity.
A new stem cell disease model reveals how a protein known to prevent tumor growth in most cases may drive bone cancer when genetic changes cause its overproduction. The study focused on rare genetic disease Li-Fraumeni Syndrome, which increases the risk of many cancers, including osteosarcoma.
Researchers developed a new approach to identify reliable blood biomarkers for Parkinson's disease, which may lead to early diagnosis and targeted treatments. The study found RNA signatures that correlate with the disease-causing mutations in the LRRK2 gene.
A study led by researchers from Mount Sinai Hospital shows that a nanotherapeutic medicine can halt the growth of artery plaque cells and suppress inflammation, leading to reduced heart attack risk. The therapy uses high-density lipoprotein (HDL) to target inflamed immune cells in arterial plaques.
Researchers found that a protein called senataxin plays a crucial role in moderating the inflammatory response to certain viral infections. This discovery may lead to new avenues for treating neurological diseases like ALS and ataxia, which are associated with persistent inflammation.
Researchers reprogrammed mature blood cells from patients with myelodysplastic syndrome (MDS) into induced pluripotent stem cells (iPSCs) to study the genetic origins of MDS. The study found a critical region on chromosome 7 associated with the disease, identifying candidate genes that may cause MDS.
A new study published in the Journal of the American College of Cardiology found that adding two non-invasive imaging tests to traditional cardiovascular disease risk factor assessment can more accurately predict a healthy patient's future risk of heart attack, stroke, or premature death. The study identified subclinical atherosclerosi...
A study published in Nature Medicine found that a novel drug candidate, harmine, can drive human insulin-producing beta cells to multiply and triple the number of beta cells in mice. This breakthrough could potentially lead to more effective treatment for diabetes.
A new study by Mount Sinai St. Luke's and Mount Sinai Roosevelt found that having a high sense of purpose in life is associated with a 23% reduced risk of death from all causes and a 19% lower risk of heart attack, stroke, or coronary artery bypass surgery. Developing a sense of purpose could protect heart health.
A new sequencing technology called Mseek provides a deeper understanding of how genes in mitochondria influence inherited diseases such as diabetes, heart disease, and cancer. By accurately identifying heteroplasmy in mtDNA, researchers can better explain individual risks and potentially develop new therapeutic targets.
Researchers found that patients who received chemotherapy after bladder cancer surgery had improved overall survival rates compared to those who underwent surgery alone. The study analyzed over 5,600 patients and demonstrated a significant reduction in mortality risk.
A growth hormone called IGF-1 has been shown to improve social impairment and restrictive behaviors in children with Phelan-McDermid syndrome, a disorder associated with autism. The treatment showed significant improvement in social withdrawal and repetitive behaviors compared to placebo.
Research at The Mount Sinai Hospital found that cocaine users have impaired brain circuits for predicting emotional loss, making it difficult to learn from unfavorable outcomes. This impairment may underlie disadvantageous decision-making in individuals with substance use disorder.
Researchers discovered that gene NR2F1 induces dormancy in tumor cells when activated, preventing rapid growth and division. Combining azacytidine and retinoic acid significantly increased NR2F1 activity, leading to improved therapeutic outcomes.
Close monitoring of small renal tumors can be an alternative to surgery, with low rates of tumor growth or death observed. The study's findings suggest that actively monitoring these tumors in high-risk patients may prove safer than immediate surgery.
A clinical trial found that animal-assisted therapy significantly improved the emotional well-being and quality of life of adult cancer patients. The study, published in Journal of Community and Supportive Oncology, involved 37 patients who received daily visits from certified therapy dogs during their treatment.
Researchers developed a scoring system using biomarkers to predict patient response to GVHD treatment, allowing for personalized treatment approaches. The new system may identify patients who require experimental treatments and those who are over-treated.
Researchers identified 53 existing drugs that can hinder Ebola virus entry into human cells, including cancer drugs and antibiotics. This study may lead to rapid development of treatments against Ebola infection.
A new study suggests that MMP-2 protein plays a signaling role in the immune system, accelerating wound healing in some cases while exacerbating inflammatory diseases like cancer and autoimmune disorders. The protein's mechanisms may be leveraged to develop novel treatments for these conditions.
Researchers at Mount Sinai Hospital discovered that bisphosphonates block abnormal growth signals passed through the human EGF receptors, which drive some tumors. The study suggests that bisphosphonates could be used to prevent or treat lung, breast, and colon cancers.
A genetic marker in the SHROOM3 gene has been found to be associated with increased fibrosis and function loss in kidney transplants. Researchers hope this discovery will lead to improved screening of potential donors and development of new drugs to prevent disease progression.
A study led by Mount Sinai researchers found that the clipping of histone protein H3.3 silences genes regulating cell division and duplication, potentially limiting abnormal cell growth in tumors. This discovery has implications for understanding cellular senescence and its role in cancer prevention.
Researchers at Mount Sinai aim to re-create patients' ocular stem cells to restore vision, eliminating the need for immunosuppressive drugs. The grant will support efforts to discover new stem cell therapies and develop biomaterials for engrafting patient-owned stem cells.
Researchers found that administering stem cell factor directly into damaged heart muscle after a heart attack can help repair and regenerate injured tissue. The study showed improved cardiac function, reduced cell death, and increased regeneration of heart tissue blood vessels.
A new study found that training medical students to use handheld ultrasound devices enhances the accuracy of their physical diagnosis. Medical students who received personalized lessons on using handheld echocardiography technology showed a 58% correct diagnosis rate, compared to 40% for those with standard training.
A new study published in the Journal of Allergy and Clinical Immunology found a strong link between peanut exposure in household dust and the development of peanut allergies, particularly among children with eczema. The research suggests that exposure to peanut proteins through impaired skin barriers may trigger allergic reactions.
A new study by Mount Sinai Heart and CNIC in Spain reveals two waves of heart muscle inflammation after a heart attack, contradicting previous consensus. The researchers discovered the first wave occurs immediately after the attack and subsides, followed by a second wave that arises a week later.
A Mount Sinai study found that vital exhaustion increases the risk of first-time cardiovascular disease by 36%, affecting otherwise healthy people. The researchers investigated 11 prospective studies involving 60,610 participants and found a significant association between vital exhaustion and cardiovascular disease.
Researchers found that even brief oxycodone exposure can impair cognitive flexibility in rats, leading to maladaptive decision-making. The study suggests that this 'cognitive hangover' may contribute to drug addiction.
A recent study published in Nature found that a specific brain protein called beta-catenin influences how the brain manages stress and depression. The research suggests that activating this protein may provide a new model of treating depression by bolstering resilience against stress.
Researchers developed a DNA regulatory technique that modifies a single gene to control its expression and behavioral consequences. The study showed that changes in this gene reduced drug and stress responses in mice, indicating a potential new approach to treating addiction and depression.
Researchers discovered over 70 additional likely ASD genes, with small differences in as many as 1,000 genes contributing to autism risk. The study found three pathways required for healthy development linked to greater autism risk, including chromatin remodeling.
A recent study published in PNAS found that pre-existing differences in immune system sensitivity to stress can increase the risk of developing stress-related depression or anxiety. The research suggests that interleukin-6 may be a key factor in this increased risk.
A Mount Sinai-led research team has discovered a new kind of stem cell that can become either a liver cell or a blood vessel cell, contradicting current theory on organ development. This discovery may hold clues to the origins of and future treatment for liver cancer.
A study at Mount Sinai Hospital reveals that a set of molecules linked to insulin signaling in the brain may indicate an increased risk of developing diabetes. The researchers identified a key mechanism by which these molecules affect BCAA breakdown in the liver.
A study published in Journal of Clinical Investigation found that skin exposure to peanut proteins can lead to sensitization and severe allergic reactions in mice. Researchers believe this mechanism may explain why peanut allergies are a common cause of food allergy in children.
Researchers found that patients with Multiple Sclerosis (MS) can safely tolerate treatment with cells cultured from human placental tissue. Early signals also suggest the potential for repairing damaged nerve tissues, offering a new frontier in treatment for the disease.
A new experimental PET tracer effectively diagnoses chronic traumatic encephalopathy (CTE) while patients are still alive. The technology differentiates CTE from other forms of dementia, enabling estimates of prevalence and risk. This breakthrough improves diagnosis and treatment for athletes and others exposed to repeated head trauma.