Researchers presented landmark studies on newly diagnosed multiple myeloma, revealing key biological processes and disease mechanisms. Two combination therapy strategies showed high response rates in patients with difficult-to-treat myeloma.
New tools, MEGENA and SuperExactTest, help genomics researchers study hierarchical organization patterns in complex networks and compare large sets of data. These tools were published in PLoS Computational Biology and Scientific Reports.
Immune cells called Langerhans cells can uniquely repair DNA damage caused by radiotherapy, making them resistant to treatment. Researchers found that mimicking immunotherapy drugs can block this ability, preventing immune response and improving radiation therapy effectiveness.
A city-wide coalition launched by NYC DOHMH and Mount Sinai resulted in a 40% increase in colorectal cancer screening rates over four years. Screening rates rose from 42% in 2003 to 62% in 2007, with significant reductions in disparities based on ethnicity.
A study found that group therapy significantly improves cardiovascular health by promoting healthy behaviors, including smoking cessation and increased physical activity. The intervention improved cardiovascular risk factors in 67% of participants compared to 56% in the control group.
Researchers at Mount Sinai Hospital found seven barriers to implementing an integrated family-based health promotion program for children and caregivers in Harlem, including knowledge gaps on social determinants of chronic diseases and cultural sensitivity. The study suggests actions to address these barriers could be effective in impr...
Scientists developed JEDI T-cells to visualize immune responses and model disease states, enabling targeted cell depletion and advancing immunotherapy in cancer care. This breakthrough has implications for autoimmune diseases and brain malignancies like glioblastoma.
Researchers have developed an online database called Hair-GEL that provides a bird's eye view of hair follicle formation. By analyzing the genetic activity of skin cells during fetal development, scientists can gain insights into how stem cells and niche cells interact to form functional hair follicles.
A study led by Mount Sinai researchers identifies zinc finger protein 217 (ZFP217) as a factor that regulates stem cell self-renewal and differentiation, potentially balancing medically useful qualities for therapeutic applications. The discovery builds on understanding epigenetic mechanisms controlling gene expression.
Researchers used data analysis to identify three distinct subtypes of patients with type 2 diabetes, each associated with different clinical characteristics and genetic variants. The study suggests a novel approach that can be applied to virtually any disease, potentially leading to more effective diagnosis and treatment.
A study published in Annals of Internal Medicine found that the average total cost for deceased patients with dementia was $287,038 in the last five years of life, significantly higher than those who died from other causes. Out-of-pocket spending for dementia patients was 81% higher.
A study at Mount Sinai found that inhibiting a family of epigenetic brain proteins, known as BETs, can induce an autism-like syndrome in mice. This links environmental factors to gene transcription and may provide insights into the disease's pathology.
Scientists engineered stem cells with PTPN11 mutations to recreate JMML, clarifying early events in its development and providing new targets for drug design. This 'leukemia in a dish' model can help improve treatment options for patients with this rare blood cancer.
A multicenter clinical trial led by Mount Sinai researchers found that brodalumab achieved a 100 percent reduction in psoriasis symptoms, exceeding the results of ustekinumab. The study demonstrated that targeting the IL-17 receptor is highly effective in treating moderate to severe plaque psoriasis.
Researchers have discovered a molecule produced by skeletal muscle that increases bone mass and strength. This finding has significant implications for treating sarcopenia and osteoporosis, two conditions that often occur together.
Researchers have developed ImmuNet, an online tool that uses public experiments and machine learning algorithms to predict new immune pathway interactions and disease-associated genes. The tool accelerates the understanding of immunological mechanisms and diseases, ultimately leading to improved treatment options.
A study found that repeated exposure to anesthesia during infancy can alter emotional behavior, which persists for at least five months. The research used a rhesus monkey model and found that exposed subjects exhibited anxious behaviors compared to healthy controls.
A study at Mount Sinai Hospital found that antidepressants regulate chronic pain and depression through actions in the nucleus accumbens, a key brain reward center. The research discovered a gene (RGS9) controlling molecular adaptations for recovery from pain and depression.
Research suggests retinal changes can serve as measures of brain pathology in schizophrenia, predicting disease risk and progression. The findings may help guide future treatment adjustments.
Researchers found that teeth can provide a chronological record of exposure to chemicals, including iron, from fetal development. This technology can help track the impact of pollution on health globally and potentially link early life exposures to neurodegenerative diseases like Parkinson's and Alzheimer's.
A recent study published in Molecular Aspects of Medicine has identified genetic markers that link an increased risk for developing both type 2 diabetes and Alzheimer's disease. The research, led by Dr. Giulio Maria Pasinetti, found specific genetic variations associated with higher susceptibility to both conditions.
Researchers found a correlation between hippocampal activity and movement through abstract social space, suggesting a common mechanism for coding physical space, time, and social relationships. The study's findings may yield new insights into psychiatric disorders like schizophrenia and depression.
Researchers discovered a new epigenetic mechanism in brain cells that enables genetic adaptation to the environment through histone turnover. Histone replacement, or turnover, allows genes to be switched on and off in response to external stimuli.
Researchers found that afamelanotide significantly improves pain-free sun exposure and quality of life in patients with erythropoietic protoporphyria. The treatment reduced the number of phototoxic reactions and improved overall quality of life, offering patients increased daily functionality.
Researchers have developed a new approach to build nearly complete genomes by combining high-throughput DNA sequencing with genome mapping. The methodology enabled the detection of complex forms of genomic variation, critically important for their association with human disease.
A new study found annual low-dose CT screening to be safe and effective for identifying pre-cancerous lung nodules. The study identified cases of cancer in participants with nonsolid lung nodules, which can progress to invasive cancer.
Researchers at Mount Sinai discovered that high levels of protein H2A.Z.2 promote abnormal growth in melanoma cells, making it a potential target for cancer treatment. The study's findings suggest that blocking this protein could effectively block tumor growth and kill melanoma cells.
The research team created a single-molecule, real-time sequencing method to detect and phase DNA methylation in bacteria. They found that individual bacterial populations have distinct subpopulations with different gene expression patterns, which may contribute to increasing antibiotic resistance.
Researchers from Mount Sinai Health System will present updates on a lymphoma vaccine clinical trial and new treatment strategies in relapsed multiple myeloma. Preliminary results show patients achieving partial or complete clinical remissions, including those with advanced stage disease.
A study found that hospice use was linked to fewer depressive symptoms in surviving spouses, with benefits lasting a year after death. The research team analyzed data from over 1,000 deceased patients and their surviving spouses, suggesting high-quality care can have a positive impact on caregivers as well.
A study led by Mount Sinai researchers compares flu viruses to the measles virus to identify key genes that can't be changed. This could lead to the development of universal flu vaccines and improved protection against emerging viral threats.
A new study by Mount Sinai researchers found that large urban hospitals in densely populated regions of Washington DC, New York State, California, Maryland, and New Jersey have lower patient satisfaction scores due to demographic bias. The authors propose an adjustment formula to mitigate this bias, which, when applied to New York Stat...
Researchers from Mount Sinai presented a first successful 3D printed trachea, as well as studies on increased mortality in black patients after esophageal cancer surgery and the potential benefits of surgical resection for myasthenia gravis. These findings highlight the importance of personalized medicine and access to specialized care.
A new study found that patients with AIDS have a four-fold increase in the risk of developing intermediate-stage age-related macular degeneration, compared to those without HIV. The study suggests that chronic immune activation and systemic inflammation may contribute to this increased risk.
A three-year analysis by Mount Sinai researchers found that early palliative care interventions can improve geriatric emergency care, decreasing hospital lengths-of-stay and costs. The approach is shown to have reduced ICU admissions for patients aged 65 and older by 1.4%.
Researchers at Icahn School of Medicine at Mount Sinai have developed a gene therapy approach that targets and corrects genetic mutations linked to heart failure. The treatment uses molecular scissors to cut out diseased genes and replace them with normal ones, restoring healthy cardiac cell function.
Researchers found nearly double bacterial diversity among Yanomami Amerindians compared to industrialized countries, and higher than other remote populations exposed to modern practices. The study suggests a link between antibiotic usage, western diet, and reduced bacterial diversity.
A new stem cell disease model reveals how a protein known to prevent tumor growth in most cases may drive bone cancer when genetic changes cause its overproduction. The study focused on rare genetic disease Li-Fraumeni Syndrome, which increases the risk of many cancers, including osteosarcoma.
Researchers developed a new approach to identify reliable blood biomarkers for Parkinson's disease, which may lead to early diagnosis and targeted treatments. The study found RNA signatures that correlate with the disease-causing mutations in the LRRK2 gene.
A study led by researchers from Mount Sinai Hospital shows that a nanotherapeutic medicine can halt the growth of artery plaque cells and suppress inflammation, leading to reduced heart attack risk. The therapy uses high-density lipoprotein (HDL) to target inflamed immune cells in arterial plaques.
Researchers found that a protein called senataxin plays a crucial role in moderating the inflammatory response to certain viral infections. This discovery may lead to new avenues for treating neurological diseases like ALS and ataxia, which are associated with persistent inflammation.
Researchers reprogrammed mature blood cells from patients with myelodysplastic syndrome (MDS) into induced pluripotent stem cells (iPSCs) to study the genetic origins of MDS. The study found a critical region on chromosome 7 associated with the disease, identifying candidate genes that may cause MDS.
A new study published in the Journal of the American College of Cardiology found that adding two non-invasive imaging tests to traditional cardiovascular disease risk factor assessment can more accurately predict a healthy patient's future risk of heart attack, stroke, or premature death. The study identified subclinical atherosclerosi...
A study published in Nature Medicine found that a novel drug candidate, harmine, can drive human insulin-producing beta cells to multiply and triple the number of beta cells in mice. This breakthrough could potentially lead to more effective treatment for diabetes.
A new study by Mount Sinai St. Luke's and Mount Sinai Roosevelt found that having a high sense of purpose in life is associated with a 23% reduced risk of death from all causes and a 19% lower risk of heart attack, stroke, or coronary artery bypass surgery. Developing a sense of purpose could protect heart health.
A new sequencing technology called Mseek provides a deeper understanding of how genes in mitochondria influence inherited diseases such as diabetes, heart disease, and cancer. By accurately identifying heteroplasmy in mtDNA, researchers can better explain individual risks and potentially develop new therapeutic targets.
Researchers found that patients who received chemotherapy after bladder cancer surgery had improved overall survival rates compared to those who underwent surgery alone. The study analyzed over 5,600 patients and demonstrated a significant reduction in mortality risk.
A growth hormone called IGF-1 has been shown to improve social impairment and restrictive behaviors in children with Phelan-McDermid syndrome, a disorder associated with autism. The treatment showed significant improvement in social withdrawal and repetitive behaviors compared to placebo.
Research at The Mount Sinai Hospital found that cocaine users have impaired brain circuits for predicting emotional loss, making it difficult to learn from unfavorable outcomes. This impairment may underlie disadvantageous decision-making in individuals with substance use disorder.
Researchers discovered that gene NR2F1 induces dormancy in tumor cells when activated, preventing rapid growth and division. Combining azacytidine and retinoic acid significantly increased NR2F1 activity, leading to improved therapeutic outcomes.