Researchers from NIH and King's College London create a reference resource for scientists studying autoimmune disorders, identifying 19 immune traits regulated by more than 240 genetic changes. This database may help design future studies and develop new treatments.
Researchers at Uppsala University have discovered a novel origin of the lymphatic system, challenging the long-held dogma that it forms via sprouting from veins. The new findings may lead to innovative treatments for conditions such as lymphedema and tissue trauma.
Unique proteins called tapirins found in heat-loving bacteria bind tightly to cellulose, enabling the breakdown of plant cell walls and conversion into liquid biofuels. The discovery paves the way for more efficient methods of converting plant matter into biofuels.
Researchers at Salk Institute have developed a new method to convert cells from x-linked SCID patients into stem cell-like state, fix the genetic mutation and prompt corrected cells to successfully generate NK cells in the laboratory. This technique could lead to a more effective and less invasive treatment for this devastating disease.
Researchers report that aligning work schedules with employees' biological clocks can improve sleep duration and quality, as well as social jetlag and general wellbeing. The study found that flexible work schedules reduced stress and improved satisfaction with leisure time.
The National Nanotechnology Initiative has published a report on the commercialization of carbon nanotubes, outlining common themes and potential future research priorities. The report identifies the need for increased efforts in manufacturing, quality control, and scale-up to produce CNT-based bulk materials with improved properties.
Researchers at Rockefeller University found that the Hepatitis C virus binds to miRNA-122, altering gene activity in infected liver cells. This interaction may contribute to liver damage and cancer progression.
A rare subtropical storm, 90Q, has formed off the southeastern coast of Brazil. The system features fragmented banding and is moving south-southeast at 5 knots.
Researchers found that cancer drug epothilone reduces scar tissue and stimulates growth in damaged nerve cells, promoting neuronal regeneration. The study suggests a potential new treatment for spinal cord injuries.
Researchers propose two novel gas-sensing systems to measure intestinal gases, which may contribute to gastrointestinal diseases. These non-invasive methods could provide medical devices that reduce medical costs and improve healthcare system efficiency.
Scientists have discovered a combination of fullerene derivatives and glucosamine that reduces cell damage and inflammation after a stroke. This breakthrough could lead to the development of new treatments for cerebrovascular accidents.
Researchers have developed a molecule-making machine that can assemble complex small molecules at the click of a mouse, automating a process previously done by highly trained chemists. This breakthrough has the potential to greatly speed up and enable new drug development and other technologies.
Researchers found increased pocket depth and clinical attachment loss in patients with rheumatoid arthritis, highlighting the link between gum disease and joint inflammation. The study also identified Porphyromonas gingivalis antibodies as biomarkers for identifying patients who may benefit from periodontal treatment.
A study published in JAMA Oncology found high rates of inappropriate imaging for both prostate cancer and breast cancer, suggesting that regional culture and infrastructure play a role in health care utilization patterns. The researchers estimated that 30% of healthcare resources in the US do not improve patient health.
A new study by researchers at San Diego State University found that limiting fruit flies' eating hours can prevent aging- and diet-related heart problems. Flies on a time-restricted feeding schedule slept better, didn't gain as much weight and had healthier hearts than those that ate anytime.
Researchers develop novel approach to target bacterial lipids, labeling and sparing healthy cells. The new strategy exploits covalent chemistry of lipids, enabling selective recognition and labeling of bacterial cells.
A study published in PLOS Genetics has identified a gene, ISL1, associated with classic bladder exstrophy, a rare congenital anomaly of the urinary tract. The discovery is significant for understanding the disease's development and may lead to preventive measures during pregnancy.
A team of scientists suggests that hydrothermal processes at the rock-water boundary could produce methane in Enceladus' ocean. Analyzing Cassini data, they propose two possible explanations for the moon's methane abundance: one involving hydrothermal activity and another based on ice formation/melting cycles.
A new study reveals that actresses face career decline if they work with less connected, homogeneous groups featuring mostly men, highlighting the need for diverse networks outside their circle
A new system using sound waves helps detect structural defects in pipes, engines, and nuclear power plants. Researchers have developed a non-destructive testing method that could also be applied to medical imaging and seismology.
Researchers at MIT have developed a method to stimulate brain tissue using external magnetic fields and injected magnetic nanoparticles. The approach can provide an implant-free means of providing brain stimulation and mapping, potentially treating neurological diseases such as Parkinson's disease.
Women with very low breast tissue density experience shorter disease-free survival and overall life expectancies compared to those with high-density breasts. A six-year follow-up study of 270 breast cancer patients found that lower breast tissue density is an independent poor prognostic factor for breast cancer.
Researchers found that different codons in the genetic code are deciphered at varying rates, affecting protein production. This knowledge can be used to manipulate gene expression and potentially treat illnesses by altering decoding rates.
High-ranking spotted hyenas have longer telomeres and better overall health compared to subordinates, according to a new study. The research suggests that social rank plays a significant role in aging and stress in wild mammals.
Researchers found that severe disruptions to healthcare systems during the Ebola outbreak led to a significant reduction in measles vaccinations. This could result in an additional 2,000 to 16,000 deaths if a measles epidemic were to occur in affected countries.
The Desyre architecture has been shown to reduce hospital costs and replacement rates of medical devices by using 28% less energy and 48% less chip area. This is achieved while offering a nine times lower hardware failure rate, making it an extremely reliable design for critical applications.
The HEART Pathway, a new protocol, helps emergency departments evaluate patients with acute chest pain more efficiently. It has been shown to reduce cardiac tests, early discharges, and hospital stays while maintaining patient safety.
A study predicts a rise in measles cases by 100,000 across West Africa due to Ebola-related health system disruptions, resulting in an additional 5,000 measles deaths. The research highlights the need for aggressive regional vaccination programs to counteract the steep downturn in immunization rates.
Research published in Genome Biology found that humans and other animals have acquired 'foreign' genes from microorganisms, suggesting ongoing gene transfer. The study identified 17 previously-reported genes and 128 additional foreign genes in the human genome, related to metabolism, immune responses, and more.
Researchers estimate that a large measles outbreak in West Africa could infect nearly twice as many people and kill thousands more due to significant decreases in vaccinations for childhood diseases. The Ebola crisis has led to a 45% increase in unvaccinated children, posing a substantial risk to public health.
Researchers will study genetic aspects of craniofacial asymmetries in cavefish to better understand human conditions like non-syndromic cleft palate. The project aims to identify specific genes and mutations causing facial asymmetry, with potential implications for understanding pigmentation changes in humans.
Researchers at UC San Diego have identified a gene variant in the SORL1 gene that may be used to predict people most likely to respond to an investigational therapy for Alzheimer's disease. The study found that variants of the gene confer some protection from AD and are associated with reduced beta amyloid peptide production in neurons.
Heavy teen cannabis use linked to changes in hippocampus, poor memory for life events. Young adults who abused cannabis as teens performed 18% worse on long-term memory tests than those who never used the drug.
Scientists at the University of Chicago and the University of Illinois have developed a new technique using gold nanoparticles to stimulate normal, non-genetically modified neurons with light. The technique shows great promise for potential therapeutic use in diseases such as macular degeneration.
A new study from NYU Langone Medical Center found that over 40% of low-risk prostate and breast cancer patients in certain US regions received inappropriate tests. The research suggests that regional culture and infrastructure play a significant role in the use of imaging tests, with some areas exhibiting more appropriate use than others.
A study by Massachusetts General Hospital researchers reveals that Interleukin-3 (IL-3) promotes the production of inflammatory monocytes and neutrophils, which contribute to the 'cytokine storm' that underlies sepsis. Higher IL-3 levels in human patients with sepsis are associated with a greater risk of death.
Researchers from German Institute of Human Nutrition discovered how brain activity encodes taste quality, with decoding possible within 175 milliseconds. The study aims to extend understanding of neuronal mechanisms and develop strategies for moderate deviant eating behavior.
A new study from Brigham Young University finds that loneliness and social isolation are major risk factors for mortality across all ages and income levels. The research analyzed data from over 3 million participants and found that the lack of social connections presents an added risk, while the existence of relationships provides a po...
Researchers found that prenatal yoga classes reduced depressive symptoms in pregnant women with mild to moderately depressed women. The study's results suggest that a larger randomized controlled trial is needed to confirm the findings.
The Wistar Institute has received a $1.1 million grant from the Jayne Koskinas Ted Giovanis Foundation to support the work of three scientists researching metastatic breast cancer. The researchers aim to develop novel targeted therapies by understanding the pathways essential to breast cancer cells.
A new study published in Neurology found that physically active seniors with small areas of brain damage did not experience a drop-off in movement abilities. In fact, those who were most active showed no decline despite high levels of brain damage, suggesting physical activity creates a 'reserve' to protect motor abilities.
A Yale-led study found that donated kidneys with acute injury are associated with delayed graft function but not poor long-term transplant outcomes. The research suggests that injured kidneys could be used for transplants, potentially increasing the number of available organs and improving survival rates for patients on dialysis.
Scientists at OIST Graduate University found that cell groups in the neostriatum do not communicate with each other and are less interconnected. The discovery has implications for studying diseases like Parkinson's, which affects motor control.
A new method called TFUMseq enables researchers to study the functions of hard-to-grow bacteria that contribute to the gut microbiome. The tool allows for the identification of genes that enhance microbial fitness and provides insights into how bacteria colonize living organisms.
Researchers analyze particle jets from lead ion collisions to understand quark-gluon plasma properties. The study reveals that high-energy jets are suppressed, contradicting some theoretical models.
Researchers found that patients who received blood transfusions at a higher haemoglobin level had fewer serious complications and deaths after cardiac surgery. The study challenges current guidelines and health policy, suggesting that a more liberal approach to transfusion may be safer and more cost-effective
Researchers at Johns Hopkins Medicine have created a 3D model of the ORC protein machine, which helps prepare DNA for duplication. The model reveals that ORC is not always 'on' as previously thought, and no one knows how it turns on and off.
Researchers found that young mice don't possess cellular machinery for regeneration after weaning, leading to reduced insulin secretion and replication of beta cells. A new developmental step in beta cell maturation is triggered by dietary change from high-fat milk to chow.
Research on the Bristol Pound found it fosters social bonds by shaping interactions and feelings of trust among users, promoting local business support and community cohesion. The study's findings have implications for designing future payment systems that prioritize social connectivity.
A new system designed by researchers from Brown and Johns Hopkins universities aims to assess computer vision systems' ability to understand the context of an image. The 'visual Turing test' evaluates how well computers can recognize subtle details, such as people walking together and having a conversation.
Researchers from The Children's Hospital of Philadelphia found that infant BMI-childhood obesity relationship is strong in African-American children. A better understanding of infancy growth patterns can lead to more effective early efforts at obesity prevention.
The discovery of modified white-tailed eagle talons at the Krapina Neandertal site reveals evidence of jewelry-making skills among human predecessors. The findings indicate that Neandertals acquired eagle talons for symbolic purposes around 130,000 years ago.
Researchers use a cylindrical rotating system to study turbulent convection, disproving the idea that transitions from one state of turbulence to another are smooth. Their findings suggest that symmetry changes must be sharp, contradicting Lev Landau's theory.
Tropical Cyclone Olwyn has formed in the Southern Indian Ocean and is forecast to make landfall near Cape Cuvier in Western Australia. The cyclone is intensifying and moving south-southwest at 12 knots, with maximum sustained winds of 55 knots.
NASA's Suomi NPP satellite captured an image of Tropical Cyclone Nathan as it formed a cyclonic loop near the eastern coast of Queensland's Cape York Peninsula. The storm is expected to strengthen over the next day and a half due to decreasing vertical wind shear and warm sea surface temperatures.
A study led by Drs. Kelleher and Shen discovered that presenilin-1 mutations decrease gamma-secretase activity, leading to age-dependent death of neurons and neurodegeneration. The findings may transform the way scientists design drugs for inherited Alzheimer's disease.
Researchers found that boiling pasta releases some gluten proteins, while others persist throughout cooking and digestion. This discovery could lead to new strategies for managing wheat allergies and celiac disease.
A comparative analysis by MIT researchers reveals mutations in the Indian H1N1 flu viruses that make them distinct from the 2009 vaccine strain. The study highlights the need for updated vaccination strategies to account for potential new viruses.
A new study projects that large coastal populations in Asia and Africa will face the highest exposure to future sea level rise and storm surge flooding. Coastal areas with high population density, such as China, India, and Indonesia, are most vulnerable.
A study published in Evolution and Human Behaviour found that women are more attracted to war heroes than regular soldiers or men who display heroic traits in other fields. The researchers also discovered that heroism in combat increases women's levels of sexual attraction towards male soldiers, but not in disaster zones.